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Frontiers of Chemical Science and Engineering 2022年第1期16卷 64-71页

作者： Yan Shi Fangjun Huo yongkang yue Caixia Yin Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education Institute of Molecular ScienceShanxi UniversityTaiyuan 030006China College of Food Sciences Shanxi Normal UniversityLinfen 041004China Research Institute of Applied Chemistry Shanxi UniversityTaiyuan 030006China

Heterocyclic compound quinoline and its derivatives exist in natural compounds and have a broad spectrum of biological *** play an important role in the design of new structural entities for medical ***,indoles and their derivatives are found widely in *** acids,alkaloids and auxin are all derivatives of indoles,as are dyes,and their condensation with aldehydes makes it easy to construct reaction sites for nucleophilic addition *** this work,we combine these two groups organically to construct a rapid response site(within 30 s)for H_(2)S,and at the same time,a ratiometric fluorescence response is presented throughout the process of H_(2)S *** such,the lower detection limit can reach 55.7 nmol/L for H_(2)*** addition,cell imaging shows that this probe can be used for the mitochondrial targeted detection of endogenous and exogenous H_(2)***,this probe application was verified by imaging H_(2)S in nude mice.

关键词： heterocyclic compound hydrogen sulfide ratiometric mitochondrial targeted

Rearrangement regulated cysteine fluorescent probe for cellular oxidative stress evaluation induced by copper(Ⅱ)

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Chinese Chemical Letters 2020年第11期31卷 2970-2974页

作者： Na Zhou Fangjun Huo yongkang yue Kaiqing Ma Caixia Yin Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education Institute of Molecular ScienceShanxi UniversityTaiyuan 030006China Research Institute of Applied Chemistry Shanxi UniversityTaiyuan 030006China

Cysteine(Cys)plays an important role in regulating cellular redox *** due to the constant changes in the concentration of Cys in organisms,fast response sensors are urgent required for practical *** this work,a fluorescent probe with a fast response was developed by linking coumarin derivatives containingα,β-unsaturated ketones to *** PET effect made the system *** the probe reacted with Cys,the bond between the coumarin derivative and the NBD was cut off,meanwhile a rapid rearrangement and reactive site passivation *** two fluorophores with the same emission peak are released,among them,strong fluorescence signal of NBD ***,although the similar reaction occurred for Hcy,the rate of NBD derivative rearrangement was slow,in a short time,fluorescence signal was still *** for GSH,cleavage could occur,but no rearrange within the NBD molecule due to GSH with large *** of strong fluorescent emission,this probe was successfully used in biological imaging about cell and *** importantly,the probe was successfully used to evaluate the oxidative stress caused by copper(Ⅱ)in living *** fluorescence strategy and application will provide a new way of studying intracellular oxidative stress processes and damage.

关键词： Cysteine Rearrangement In vivo imaging Oxidative stress Copper(Ⅱ)

Distinguishable multi-substance detection based on three-channel NIR fluorescent probe in physiology and pathology of living cells and zebrafish

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Chinese Chemical Letters 2021年第12期32卷 3870-3875页

作者： Sha Li Fangjun Huo yongkang yue Kaiqing Ma Ying Wen Caixia Yin Institute of Molecular Science Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of EducationShanxi UniversityTaiyuan 030006China Research Institute of Applied Chemistry Shanxi UniversityTaiyuan 030006China

Mitochondria is the main organelle for the production of reactive sulfur species(RSS), such as homocysteine(Hcy), cysteine(Cys), glutathione(GSH) and sulfur dioxide(SO_(2)). These compounds participate in a large number of physiological processes and play an extremely important role in maintaining the balance of life systems. Abnormal concentration and metabolism are closely related to many diseases. Due to their similarities in chemical properties, it is challenging to develop a single fluorescent probe to distinguish them simultaneously. Here, we synthesized the probe PI-CO–NBD with three fluorophores, NBD-Cl and benzopyranate as the reaction sites of GSH/Cys/Hcy and SO_(2), respectively. Three biothiols all could cleavage ether bond to release benzopyrylium and coumarin moiety, which emitted red and blue fluorescence,but Cys/Hcy also could do intramolecular rearrangement after nucleophilic substitution, resulting in yellow fluorescence. Thus the probe can distinguish Cys/Hcy and GSH. Subsequently, only SO_(2)could quench red fluorescence by adding C=C of benzopyrylium. The probe also could localize well in mitochondria by oxonium ion for all kinds of cells. The probe not only could detect above sulfur-containing active substances of intracellular and extracellular but also monitor the level of them under oxidative stress and apoptosis process in living cells and zebrafish.

关键词： Mitochondrial-targeted Discrimination detection Distinguishable Multi-substance Three channels

A special o-dialdehyde fluorescent probe simultaneously sensing Hcy,GSH and its application in living cells and zebrafish imaging

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Chinese Chemical Letters 2021年第9期32卷 2873-2876页

作者： Yongbin Zhang Yu Zhang yongkang yue Jianbin Chao Fangjun Huo Caixia Yin Shanxi Key Laboratory of Functional Molecules Research Institute of Applied ChemistryShanxi UniversityTaiyuan 030006China School of Chemistry and Chemical Engineering Shanxi UniversityTaiyuan 030006China Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education Institute of Molecular ScienceShanxi UniversityTaiyuan 030006China Scientific Instrument Center Shanxi UniversityTaiyuan 030006China

The development of fluorescent probes enabling to distinguish Cys,Hcy and GSH has always been a considerable challenge,in particular the distinction of Hcy and other two biothiols,because Hcy has a very similar structure with Cys and a relatively lower concentration in living *** this work,a special o-dialdehyde fluorescent probe,quinoline-2,3-dicarboxaldehyde(QDA),has been synthesized and demonstrated superior performance in differentiating detection of Hcy and GSH,which is different from the previous reported o-dialdehyde probes specifically detecting ***,the probe can selectively distinguish Hcy and GSH from different signal channels in living cells and zebrafish,meaning it has great potential in biological *** finding will provide a novel idea for the design of fluorescent probes to distinguish biothiols.

关键词： o-Dialdehyde Distinguish Hcy GSH Bioimaging

HSA shrinkage optimizes the photostability of embedded dyes fundamentally to amplify their efficiency as photothermal materials

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Chinese Chemical Letters 2024年第8期35卷 211-216页

作者： yongkang yue Zhou Xu Kaiqing Ma Fangjun Huo Xuemei Qin Kuanshou Zhang Caixia Yin Department Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education Institute of Molecular ScienceShanxi UniversityTaiyuan 030006China Department Modern Research Center for Traditional Chinese Medicine Shanxi UniversityTaiyuan 030006China Research Institute of Applied Chemistry Shanxi UniversityTaiyuan 030006China State Key Laboratory of Quantum Optics and Quantum Optics Devices Institute of Opto-ElectronicsShanxi UniversityTaiyuan 030006China

Focused on the performance promotion of organic small molecular dyes based photothermal agents via non-chemical modification,we found that heat-assisted binding of human serum albumin(HSA)to the dye causes shrinkage of the protein and encapsulate the dye to form *** revolutionizes the photostability of small molecule dyes which further improves their photothermal conversion effi-ciency and tumor ablation performance as photothermal agents *** this work,the obtained photothermal agent named HSA-P2-T could accumulate in tumor and induce 22℃enhancement of the tumor in xenograft models upon ultra-low dose(0.1 W/cm^(2))laser irradiation,which,as far as we know,is the lowest laser dose used in vivo photothermal *** HSA-P2-T,we realized tumor ablation upon twice intravenous injections of the nanoparticles and four photothermal treatments.

关键词： Photothermal therapy Cyanine dyes Photostability Albumin Encapsulation

Subcellular Cysteine Ultrafast Lighting

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Subcellular Cysteine Ultrafast Lighting

第十一届全国化学生物学学术会议

作者： yongkang yue Fangjun Huo Caixia Yin Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education Key Laboratory of Materials for Energy Conversion and Storage of Shanxi ProvinceInstitute of Molecular ScienceShanxi University Research Institute of Applied Chemistry Shanxi University

The three biological thiols（Cys, Hcy and GSH） can be effectively distinguished by fluorescent probes supported by their p Ka values of sulfydryl induced nucleophilic reaction activities differences of-SH in aqueous solution.[1] Comparing with solutional detection process, the accelerated cellular labelling dynamic bring mysterious point for us to illustrate the biological fact in cells. We utilized two synthesized sub-cellular targetable Cys specific fluorescent probes Ly-1 and Mito-1 to study the reaction dynamic in solutions and in cells and proposed a radical mechanism of the sub-cellular Cys lighting process.[2]

关键词： Cysteine sub-cellular fluorescent probe ultra-fast imaging

来源： cnki会议评论

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硫醇亲核反应及其荧光识别研究

中国科学：化学 2017年第2期47卷 249-257页

作者：岳永康霍方俊阴彩霞化学生物学与分子工程教育部重点实验室能量转换与存储材料山西省重点实验室山西大学分子科学研究所太原030006 山西大学应用化学研究所太原030006

生物小分子硫醇以其重要的生理学和病理学作用受到科学家们的广泛关注.近些年来,利用荧光探针对其浓度的测定方法得到了极大的发展.本文以硫醇亲核反应机理为主线,对本课题组近年来在硫醇探针的设计及其识别性能研究方面的工作进行了系... 详细信息

生物小分子硫醇以其重要的生理学和病理学作用受到科学家们的广泛关注.近些年来,利用荧光探针对其浓度的测定方法得到了极大的发展.本文以硫醇亲核反应机理为主线,对本课题组近年来在硫醇探针的设计及其识别性能研究方面的工作进行了系统总结,并讨论了硫醇荧光探针今后的设计思路和重点研究方向.

关键词：硫醇亲核反应荧光探针成像识别

色烯衍生物的合成及其在生物硫醇检测中的应用

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山西大学学报(自然科学版) 2017年第3期40卷 527-532页

作者：阴彩霞岳永康霍方俊化学生物学与分子工程教育部重点实验室能量转换与存储材料山西省重点实验室山西大学分子科学研究所山西大学应用化学研究所

合成了一个色烯衍生物并将其应用于生物硫醇的识别检测。基于"硫醇-色烯点击化学",该探针对生物硫醇表现出高的特异性和灵敏性,其对Hcy的检出限为7.6×10;mol/L。

关键词：色烯硫醇点击化学

Targeting capabilities of engineered extracellular vesicles for the treatment of neurological diseases

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Neural Regeneration Research 2025年第11期20卷 3076-3094页

作者： Xinyu Yang Xiangyu Gao Xiaofan Jiang Kangyi yue Peng Luo Department of Neurosurgery Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina

Recent advances in research on extracellular vesicles have significantly enhanced their potential as therapeutic agents for neurological *** to their therapeutic properties and ability to cross the blood–brain barrier,extracellular vesicles are recognized as promising drug delivery vehicles for various neurological conditions,including ischemic stroke,traumatic brain injury,neurodegenerative diseases,glioma,and ***,the clinical application of natural extracellular vesicles is hindered by their limited targeting ability and short clearance from the *** address these limitations,multiple engineering strategies have been developed to enhance the targeting capabilities of extracellular vesicles,thereby enabling the delivery of therapeutic contents to specific tissues or ***,this review aims to highlight the latest advancements in natural and targeting-engineered extracellular vesicles,exploring their applications in treating traumatic brain injury,ischemic stroke,Parkinson's disease,Alzheimer's disease,amyotrophic lateral sclerosis,glioma,and ***,we summarized recent clinical trials involving extracellular vesicles and discussed the challenges and future prospects of using targeting-engineered extracellular vesicles for drug delivery in treating neurological *** review offers new insights for developing highly targeted therapies in this field.

关键词： Alzheimer's disease amyotrophic lateral sclerosis engineered extracellular vesicles glioma ischemic stroke neurological diseases Parkinson's disease psychosis targeted drug delivery traumatic brain injury

Curcumin in gastric cancer treatment:A commentary on mechanistic insights and future directions

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 265-267页

作者： Xin-yue Wei Wen-Bo Cao Sai-Jun Mo Zhi-Yan Sun Department of Pathophysiology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001Henan ProvinceChina School of Basic Medical Science Zhengzhou UniversityZhengzhou 450001Henan ProvinceChina Department of Basic Science of Oncology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001Henan ProvinceChina Department of Special Service No.988 Hospital of the Joint Service Support Force of PLAZhengzhou 450042Henan ProvinceChina

The study by Yang et al presents a comprehensive investigation into the thera-peutic potential of curcumin for gastric cancer(GC).Using network pharma-cology,the researchers identified 48 curcumin-related genes,31 of which overlap with GC *** genes,including ESR1,EGFR,CYP3A4,MAPK14,CYP1A2,and CYP2B6,are linked to poor survival in GC *** docking con-firmed strong binding affinity of curcumin to these *** vitro experiments demonstrated that curcumin effectively inhibits the growth and proliferation of BGC-823,suggesting its therapeutic potential in GC through multiple targets and pathways.

关键词： Curcumin Gastric cancer Network pharmacology Mechanism of action In vitro experiments