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Genome-wide in vitro and in vivo RNAi screens reveal Fer3 to be an important regulator of kkvtranscription in Drosophila

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Insect Science 2022年第3期29卷 614-630页

作者： Xiangzhao Yue yongkang liang Zhishuang Wei Jun Lv Yongjin Cai Xiaobin Fan Wenqing Zhang Jie Chen Guangdong Provincial Key Laboratory of High Technology for Plant Protection Plant Protection Research InstituteGuangdong Academy of Agricultural SciencesGuangzhouChina State Key Laboratory of Biocontrol School of Life SciencesSun Yat-sen UniversityGuangzhouChina College of Life Sciences Shangrao Normal UniversityShangraoJiangxi ProvinceChina

Krotzkopf verkehrt(kkv)is a key enzyme that catalyzes the synthesis of chitin,an important component of the Drosophila epidermis,trachea,and other ***,we report the use of comprehensive RNA interference(RNAi)analyses to search for kkv transcriptional regulators.A cell-based RNAi screen identified 537 candidate kkv regulators on a genome-wide *** use of transgenic Drosophila lines expressing RNAi constructs enabled in vivo validation,and we identified six genes as potential kkv transcriptional *** of the kkvDsRed signal,an in vivo reporter indicating kkv promoter activity,was observed when the expression of Akirin,NFAT,48 related 3(Fer3),or Autophagy-related 101(Atg101)was knocked down in Drosophila at the 3rd-instar larval stage;whereas we observed disoriented taenidial folds on larval tracheae when Lines(lin)or Autophagy-related 3 (Atg3)was knocked down in the ***3,in particular,has been shown to be an important factor in the activation of kkv transcription via specific binding with the kkv *** genes involved in the chitin synthesis pathway were widely affected by the downregulation of ***,Atg101,Atg3,Akirin,Lin,NFAT,Pnr,and Abd-A showed that the potential complex mechanism of kkv transcription is regulated by an interaction network with bithorax complex *** study revealed the hitherto unappreciated diversity of modulators impinging on kkv transcription and opens new avenues in the study of kkv regulation and chitin biosynthesis.

关键词： chitin biosynthesis Fer3 genome-wide RNAi kkv transcriptional regulator

全身性与腹腔内联合双向化疗在进展期胃癌患者根治术后腹膜复发转移中的应用效果及生存获益分析

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消化肿瘤杂志（电子版） 2024年第1期16卷 82-87页

作者：梁松江频王传军梁永康张同方鲁修明李小祺安徽医科大学附属六安医院(六安市人民医院)普通外科安徽六安237000

目的分析全身性与腹腔内联合双向化疗在进展期胃癌患者根治术后腹膜复发转移中的应用效果及生存获益情况。方法回顾性选取2018年1月至2020年12月安徽医科大学附属六安医院收治的106例进展期胃癌根治术后腹膜复发转移患者的临床资料,根... 详细信息

目的分析全身性与腹腔内联合双向化疗在进展期胃癌患者根治术后腹膜复发转移中的应用效果及生存获益情况。方法回顾性选取2018年1月至2020年12月安徽医科大学附属六安医院收治的106例进展期胃癌根治术后腹膜复发转移患者的临床资料,根据化疗方式的不同进行分组,接受腹腔内联合双向化疗的57例患者纳入观察组,接受全身性化疗的49例患者纳入对照组。比较两组患者腹膜癌指数(peritoneal cancer index,PCI)评分、毒副反应、生活质量及生存获益情况。结果化疗后,观察组PCI评分低于对照组,差异有统计学意义(P0.05);观察组化疗后症状、躯体和情绪功能、整体生活质量和单项测量项目评分均高于对照组(P<0.05);观察组2年生存率(38.60%)高于对照组(18.37%),差异有统计学意义(P<0.05);观察组中位无复发生存时间为15个月,对照组为8个月,差异有统计学意义(P<0.05)。结论相比于全身性化疗,将腹腔内联合双向化疗应用于进展期胃癌患者根治术后腹膜复发转移的治疗中,可提高生存率和生活质量,延长无复发生存时间,未明显增加毒副反应。

关键词：腹腔双向化疗进展期胃癌腹膜复发转移生存情况

Full sexual maturity-cycle exposure to environmentally relevant concentrations of 17β-estradiol decreases reproductive capacity of zebrafish

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Journal of Environmental Sciences 2024年第3期137卷 580-592页

作者： yongkang Zhang Yuanjun Jiang Qian Sun Meng Li Sheng Chen Jingyu liang Chunsheng Liu College of Fisheries Huazhong Agricultural UniversityWuhan 430070China School of Environmental Studies China University of GeosciencesWuhan 430074China

17β-Estradiol(E2)has been widely detected in natural water and treatment with E2 induces potential endocrine disrupting effects in ***,effects on fish fecundity and steroid system after treatment with environmentally relevant concentrations of E2 for the full sexual maturation cycle remain *** this study,zebrafish were treatment with 0,10 or100 ng/L E2 from embryo to adult stage,and effects on gonadal development and differentiation,steroid hormone levels,transcription of genes associated with the hypothalamic-pituitary-gonadal-liver(HPG)axis in adults and fertilization rate of offspring were *** results showed that treatment with E2 lead to increased number of feminization in *** females,E2 decreased cumulative amount of spawning and inhibited the maturation of *** males,E2 inhibited the maturation and motility of sperm,as well as decreased the movement speed of *** adverse effects on sperm might be responsible for the reduced fertilization observed in *** addition,treatment with E2 changed the levels of steroid hormones in zebrafish gonad and altered the transcriptional levels of genes associated with HPG axis,which is responsible for the regulation of germ cells maturation and gonadal development in ***,these results suggested that treatment with environmentally relevant concentrations of E2 for the full sexual maturity cycle resulted in adverse effects on reproduction in zebrafish.

关键词： Environmental estrogen Zebrafish Fecundity Gonadal development Endocrine disruption

兆声功率密度对同轴兆声辅助喷射电沉积镍的影响

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电镀与涂饰 2024年第1期43卷 1-6页

作者：翟科周丰梁勇康马仕豪李腾楠杜立群河北大学质量技术监督学院河北保定071002 大连理工大学高性能精密制造国家重点实验室辽宁大连116024

[目的]金属微器件在电沉积过程中往往会产生较大的残余应力,对微器件的尺寸精度、力学性能和良率产生不利影响。[方法]为降低镀层的残余应力,在喷射电沉积镍过程中施加同轴兆声辅助。研究了兆声功率密度对Ni镀层形貌、表面粗糙度、显微... 详细信息

[目的]金属微器件在电沉积过程中往往会产生较大的残余应力,对微器件的尺寸精度、力学性能和良率产生不利影响。[方法]为降低镀层的残余应力,在喷射电沉积镍过程中施加同轴兆声辅助。研究了兆声功率密度对Ni镀层形貌、表面粗糙度、显微硬度和残余应力的影响。[结果]施加同轴兆声辅助后,所得Ni镀层的宏观和微观形貌都有所变差,表面粗糙度略微增大,显微硬度变化不大,但残余应力显著降低。当兆声功率密度为10 W/cm2时,Ni镀层的残余应力最低,比无兆声辅助时所得Ni镀层低了37.75%。[结论]在电沉积过程中施加兆声辅助能够有效降低镀层的残余应力。

关键词：微器件喷射电沉积镍残余应力兆声辅助功率密度

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Current-perpendicular-to-plane transport properties of 2D ferromagnetic material CrTe2

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CHINESE PHYSICS B 2024年第9期33卷 535-539页

作者： Wang, Jin Liu, Yu Wang, Taikun Xu, yongkang Wang, Shuanghai He, Kun Deng, Yafeng Yan, Pengfei He, liang Nanjing Univ Sch Elect Sci & Engn Nanjing 210023 Peoples R China Nanjing Univ State Key Lab Spintron Suzhou 215163 Peoples R China

Heterostructures of van der Waals (vdW) ferromagnetic materials have become a focal point in research of low-dimensional spintronic devices. The current direction in spin valves is commonly perpendicular to the plane (CPP). However, the transport properties of the CPP mode remain largely unexplored. In this work, current-in-plane (CIP) mode and CPP mode for CrTe2 thin films are carefully studied. The temperature-dependent longitudinal resistance transitions from metallic (CIP) to semiconductor behavior (CPP), with the electrical resistivity of CPP increased by five orders of magnitude. More importantly, the transport properties of the CPP can be categorized into a single-gap tunneling-through model with the activation energy (E-a) of similar to 1.34 meV/gap at 300-150 K, the variable range hopping model with a linear negative magnetoresistance at 150-20 K, and weak localization region with a nonlinear magnetic resistance below 20 K. This study explores the vertical transport in CrTe2 materials for the first time, contributing to understand its unique properties and to pave the way for its potential in spin valve devices.

关键词： 2D vdW CrTe2 current-perpendicular-to-plane negative magnetic resistance

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企业技术创新能力与服务能力耦合评价研究

科技管理研究 2016年第24期36卷 48-53页

作者：梁永康杨水利西安理工大学经济与管理学院陕西西安710054

技术创新能力与服务能力是制造企业核心能力系统中两个重要内容。研究发现两者之间存在互相作用、相互影响的耦合关系;在企业知识资产的作用下,通过共有的知识基础、共有的知识载体以及两者间的知识交流来实现彼此间联系。从"投入-产出... 详细信息

技术创新能力与服务能力是制造企业核心能力系统中两个重要内容。研究发现两者之间存在互相作用、相互影响的耦合关系;在企业知识资产的作用下,通过共有的知识基础、共有的知识载体以及两者间的知识交流来实现彼此间联系。从"投入-产出"角度分别构建技术创新能力与服务能力的评价指标体系,利用"三系数法"可计算出两者的耦合协调程度。研究为企业评价和调控两者间的互动关系提供理论依据。

关键词：技术创新能力服务能力耦合协调度制造企业

Decreased soil pH weakens the positive rhizosphere effect on denitrification capacity

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Pedosphere 2024年第5期 905-915页

作者： Jun WANG Zongxiang ZHANG Fei liang Zhao CHE yongkang WEN Manyu ZHANG Wenjun JIN Zhaorong DONG He SONG College of Agronomy Anhui Agricultural University Key Laboratory of Arable Land Quality Monitoring and Evaluation Ministry of Agriculture and Rural Affairs Institute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural Sciences (CAAS) College of Resources and Environmental Sciences China Agricultural University

The stimulating effect of rhizosphere on denitrification is considered to be an unavoidable loss of soil nitrogen（N） and detrimental to crop N use efficiency,which is regulated by crop growth and soil properties. Soil acidification, occurring rapidly in many intensive farming lands, affects both crop growth and soil properties, thereby altering rhizosphere effect on denitrification. However, the mechanism by which soil acidification regulates rhizosphere denitrification still remains unclear. Here, we determined the denitrification capacity（DC） and associated community compositions of nirK-and nirS-type denitrifiers in maize rhizosphere and bulk soils at four acidity gradients（pH = 6.8, 6.1, 5.2, and 4.2）. Results showed that the stimulating effect of rhizosphere on DC strongly depended on soil pH. Compared to bulk soil, rhizosphere soil had significantly higher DC at pH 5.2, but not at pH of 4.2. With increasing soil acidity, the stimulation of rhizosphere on DC（calculated as the difference in DC between rhizosphere and bulk soils） decreased from 8.01 to 0.01 mg N ***, soil acidification significantly reduced the differences in dissolved organic carbon（DOC） and abundance of key nirK-type denitrifier taxa between rhizosphere and bulk soils, both of which were positively related to the stimulation of rhizosphere on DC. These findings demonstrated that soil acidification could weaken the positive rhizosphere effect on denitrification via regulated C availability and associated nirK-type denitrifier community, potentially reducing N loss risk in rhizosphere soil. The independent role of soil p H should be fully considered when modelling N behaviour in plant-soil systems.

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制造企业服务化转型影响因素扎根研究

科技进步与对策 2016年第8期33卷 101-105页

作者：杨水利梁永康西安理工大学经济与管理学院陕西西安710054

以16个服务化转型的制造企业案例为样本,运用扎根理论研究方法,深入挖掘制造企业服务化转型影响因素。研究发现了15项主要影响因素,类属于7大主范畴,包括产业链角色、战略规划、领导者能力、资源整合能力、技术创新能力、技术服务能力... 详细信息

以16个服务化转型的制造企业案例为样本,运用扎根理论研究方法,深入挖掘制造企业服务化转型影响因素。研究发现了15项主要影响因素,类属于7大主范畴,包括产业链角色、战略规划、领导者能力、资源整合能力、技术创新能力、技术服务能力、商业模式创新。从"决策—能力—模式"3个层面构建作用机理模型,阐释了各因素对企业服务化转型的作用过程。研究结论有助于制造企业厘清服务化转型的影响因素,为企业转型提供理论支持。

关键词：服务化影响因素技术创新技术服务扎根理论

Analysis and experimental study on resistance-increasing behavior of composite high efficiency autonomous inflow control device

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Petroleum Science 2024年第2期21卷 1290-1304页

作者： liang-liang Dong Yu-Lin Zhang School of Mechatronic Engineering Southwest Petroleum UniversityChengdu610500SichuanChina State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu610500SichuanChina Oil and Gas Equipment Technology Sharing and Service Platform of Sichuan ProvinceChengdu610500SichuanChina

Bottom water coning is the main reason to reduce the recovery of horizontal bottom water reservoir. By water coning, we mean the oil-water interface changes from a horizontal state to a mound-shaped cone and breaks through to the wellbore. Autonomous inflow control device(AICD) is an important instrument maintain normal production after bottom water coning, however, the resistance increasing ability of the swirl type AICD is insufficient at present, which seriously affects the water control effect. Aiming this problem, this paper designs a multi-stage resistance-increasing and composite type AICD. The separation mechanism of oil-water two phases in this structure, the resistance form of oil-water single phase and the resistance-increasing principle of water phase are analyzed. Establishing the dual-phase multi-stage separation and resistance-increasing model, and verified by measuring the throttling pressure drop and oil-water volume fraction of the AICD, it is found that the composite type AICD has the effect of ICD and AICD at the same time, which can balance the production rate of each well section at the initial stage of production, delay the occurrence of bottom water coning. In the middle and later stages of production, water-blocking can be effectively increased to achieve water control and stable *** structural sensitivity analysis, the influence law of various structural parameters on the water control performance of composite AICD was obtained. The simulation calculation results show that,compared with the existing swirl type AICD, composite AICD has higher sensitivity to moisture content,the water phase throttling pressure drop is increased by 4.5 times on average. The composite AICD is suitable for the entire stage of horizontal well production.

关键词： Water control Flow separation Flow resistance-increasing AICD device Simulation and experiment