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Highly sensitive nanozyme strip:An effective tool for forensic material evidence identification

Nano Research 2024年第3期17卷 1785-1791页

作者： Juanji Hong Zhanjun Guo Dihan Duan Yi Zhang Xin Chen yongjiu li Zheng Tu Lei Feng Lei Chen Xiyun Yan lizeng Gao Minmin liang Demin Duan Experimental Center of Advanced Materials School of Materials Science&EngineeringBeijing Institute of TechnologyBeijing 100081China College of Bioscience and Biotechnology Shenyang Agricultural UniversityShenyang 110866China Chongqing kangjuquanhong biology science and technology Co. ltdChongqing 400026China Key Laboratory of Forensic Genetics Institute of Forensic ScienceMinistry of Public SecurityBeijing 100038China CAS Engineering Laboratory for Nanozyme Key Laboratory of BiomacromoleculesInstitute of BiophysicsChinese Academic of ScienceBeijing 100101China

During criminal case investigations,blood evidence tracing is critical for criminal ***,the blood stains are often cleaned or covered up after the crime,resulting in trace residue and difficult ***,a highly sensitive and specific method for the rapid detection of human blood stains remains *** solve this problem,we established a nanozyme-based strip for rapid detection of blood evidence with high sensitivity and *** construct reliable nanozyme strips,we synthesized CoFe_(2)O_(4) nanozymes with high peroxidase-like activity by scaling up to gram level,which can be supplied for six million tests,and conjugated antibody as a detection probe in nanozyme *** developed CoFe_(2)O_(4) nanozyme strip can detect human hemoglobin(HGB)at a concentration as low as 1 ng/mL,which is 100 times lower than the commercially available colloidal gold strips(100 ng/mL).Moreover,this CoFe_(2)O_(4) nanozyme strip showed high generality on 12 substrates and high specificity to human HGB among 13 animal blood ***,we applied the developed CoFe_(2)O_(4) nanozyme strip to successfully detect blood stains in three real cases,where the current commercial colloidal gold strip failed to *** results suggest that the CoFe_(2)O_(4) nanozyme strip can be used as an effective on-scene detection method for human blood stains,and can further be used as a long-term preserved material evidence for traceability inquiry.

关键词： CoFe_(2)O_(4)nanozyme nanozyme strip peroxidase-like activity human hemoglobin blood evidence

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Synthesis of Titanium Carbide Particle in Laser Melted-pool in situ

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Journal of Wuhan University of Technology(Materials Science) 2019年第6期34卷 1315-1320页

作者： ZHOU Lei liU Yanhui DONG Shuaijun ZHU lingjie li yongjiu School of Materials Engineering Shanghai University of Engineering ScienceShanghai 201620China

The titanium carbide phase was synthesized in laser melted-pool in situ as the reinforced particles of nickel based composite coating on Ti-6Al-4V alloy surface using the nickel and graphite blending powder by laser cladding. The microstructure investigation showed that the petals-shaped particles and granular particles were two main morphology of titanium carbide particles. And a few spiral-shaped titanium carbide pattern and eutectic titanium carbide appeared on the cross-sections of the coating. The spiral-shaped titanium carbide pattern composed of some slender arc-shape titanium carbide particles and the eutectic titanium carbide was fine. The morphology and distribution of the spiral-shaped titanium carbide patterns and eutectic titanium carbide confirmed that their growth mechanism was the dissolution-precipitation mechanism and was affected by the convection behavior of the laser melted pool. The spiral-shaped titanium carbide pattern would precipitate out the high-temperature melts under high-speed convection. The eutectic titanium carbide would precipitate out when the melts stopped convection or dropped to eutectic temperature.

关键词： titanium carbide composite coating laser cladding microstructure titanium alloy

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Enhancing Deep Learning Soil Moisture Forecasting Models by Integrating Physics-based Models

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Advances in Atmospheric Sciences 2024年第7期41卷 1326-1341页

作者： Lu li yongjiu DAI Zhongwang WEI Wei SHANGGUAN Nan WEI Yonggen ZHANG Qingliang li Xian-Xiang li School of Atmospheric Sciences Sun Yat-sen UniversityGuangzhou 510275China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Guangzhou 510275China Guangdong Province Key Laboratory for Climate Change and Natural Disaster Studies Guangzhou 510275China Institute of Surface-Earth System Science School of Earth System ScienceTianjin UniversityTianjin 300072China College of Computer Science and Technology Changchun Normal UniversityChangchun 130123China

Accurate soil moisture(SM)prediction is critical for understanding hydrological ***-based(PB)models exhibit large uncertainties in SM predictions arising from uncertain parameterizations and insufficient representation of land-surface *** addition to PB models,deep learning(DL)models have been widely used in SM predictions ***,few pure DL models have notably high success rates due to lacking physical ***,we developed hybrid models to effectively integrate the outputs of PB models into DL models to improve SM *** this end,we first developed a hybrid model based on the attention mechanism to take advantage of PB models at each forecast time scale(attention model).We further built an ensemble model that combined the advantages of different hybrid schemes(ensemble model).We utilized SM forecasts from the Global Forecast System to enhance the convolutional long short-term memory(ConvLSTM)model for 1–16 days of SM *** performances of the proposed hybrid models were investigated and compared with two existing hybrid *** results showed that the attention model could leverage benefits of PB models and achieved the best predictability of drought events among the different hybrid ***,the ensemble model performed best among all hybrid models at all forecast time scales and different soil *** is highlighted that the ensemble model outperformed the pure DL model over 79.5%of in situ stations for 16-day *** findings suggest that our proposed hybrid models can adequately exploit the benefits of PB model outputs to aid DL models in making SM predictions.

关键词： soil moisture forecasting hybrid model deep learning ConvLSTM attention mechanism

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陈旧颅骨的DNA检验

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刑事技术 2024年第5期49卷 514-518页

作者：李永久张广峰窦雪丽刘洪迪彭柱刘志芳凃政公安部鉴定中心北京100038 汕头市公安局广东汕头515011

陈旧颅骨DNA含量低且降解严重,一直是法医DNA检验的难点之一。本文介绍了一种改善陈旧颅骨DNA检验效果的方法,在几起陈旧颅骨案件DNA检验中,从取材部位的选择、脱钙液浓缩与回收、大体系提取纯化等方面对DNA提取进行优化,成功获得常染... 详细信息

陈旧颅骨DNA含量低且降解严重,一直是法医DNA检验的难点之一。本文介绍了一种改善陈旧颅骨DNA检验效果的方法,在几起陈旧颅骨案件DNA检验中,从取材部位的选择、脱钙液浓缩与回收、大体系提取纯化等方面对DNA提取进行优化,成功获得常染色体和Y染色体STR多态性检验结果。结果表明:颞骨岩部可作为陈旧颅骨检验优选的取材部位,与颅骨其他部位相比成功率较高;此外,在骨粉脱钙环节,利用Amicon Ultra-1510K离心超滤管可去除脱钙液中大量的水分和离子等小分子,从而将大分子DNA截留回收,有效降低了DNA损耗量;另外,陈旧颅骨DNA质量较差,提高骨粉使用量、增加提取纯化体系也能明显提升DNA回收量。本方法提高了陈旧颅骨的DNA回收量和质量,可为后续类似陈旧骨骼、牙齿DNA检验提供借鉴。

关键词：法医物证学陈旧颅骨颞骨岩部 DNA提取脱钙液回收

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“温和”差异裂解法在性侵积案检验中的应用

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刑事技术 2024年第3期49卷 313-317页

作者：彭柱徐珍陈俊颖赵禾苗刘洪迪李永久严安心凃政公安部鉴定中心北京100038 遵义市公安司法鉴定中心贵州遵义563000

本文通过分享一起性侵积案的检验过程及成功经验,总结出一种独特的“温和”差异裂解法,为处理陈旧混合斑检材提供一种新的解决方案。生物检材为案发时受害人穿的秋裤,前期PSA确证实验的结果为阳性,并通过一步裂解法获得了比较完整的男... 详细信息

本文通过分享一起性侵积案的检验过程及成功经验,总结出一种独特的“温和”差异裂解法,为处理陈旧混合斑检材提供一种新的解决方案。生物检材为案发时受害人穿的秋裤,前期PSA确证实验的结果为阳性,并通过一步裂解法获得了比较完整的男女混合DNA分型,随后通过常规的差异裂解法仅能获得上清女性分型,沉淀部分未获得有效分型结果。经过多次摸索,尝试将第一步女性成分裂解条件变为:裂解液1 mL,蛋白酶K(protease K,PK)工作浓度50μg/mL,37℃裂解20 min;女性成分消化结束后,沉淀洗涤次数调整为1 mL超纯水洗涤1次,最终成功获得了单一女性及单一男性的DNA分型。后续利用模拟的男女混合斑样本对该方法进行进一步测试,发现当混合斑中男女成分的比例不超过1∶40时,该方法具有良好的效果。

关键词：法医物证学混合斑差异裂解精子细胞短串联重复

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Research of the Activity of Earthquakes Induced by Water Injection of Salt Mining in Changning County,Sichuan Province

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Earthquake Research in China 2009年第2期23卷 170-179页

作者： Ruan Xiang Cheng Wanzheng Zhang yongjiu li Jun Chen Yin Earthquake Administration of Sichuan Province Chengdu 610041 China

According to information from on-the-spot investigations, the tectonics of salt mining areas and digital seismic records, we studied the activity of earthquakes induced by water pumping in and out of the salt mines in Shuanghe town, Changning county, Sichuan Province. The study found that the rates of water injection and extraction in the Shuanghe salt mining region were evenly matched before April 2006 and earthquake activity was stable. On the other hand, shallow small and moderate earthquake numbers increased sharply after the water injection rate became much larger than the water extraction rate. Large injection over a long time may causes the permeation of water through pre-existing small fractures and micro-cracks in the Changning anticlinal and accelerate the rupture of micro tectonic formations in nearby regions, inducing small earthquake swarm activity. The Q value calculated by using digital earthquake records indicates a relatively inhomogeneous medium in this area. The results of the accurate location of small earthquakes show that sources are relatively shallow and are concentrated at a depth of 2km to 3km. Focal mechanism solutions reveal a normal dip-slip character of shallow earthquakes. All of these show certain characteristics of earthquake activity induced by water injection.

关键词： Induced earthquake Water injection of salt mining Changning county, Sichuan Province

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Effects of traditional Chinese medicine on treatment outcomes in severe COVID-19 patients:a single-centre study

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Chinese Journal of Natural Medicines 2024年第1期22卷 89-96页

作者： XIAO yongjiu li Binbin liU Chang HUANG Xiuyu MA ling QIAN Zhirong ZHANG Xiaopeng ZHANG Qian li Dunqing CAI Xiaoqing YAN Xiangyong LUO Shuping XIANG Dawei XIAO Kun Emergency Department the 940th Hospital of Jiont Logistics Support Force of Chinese People’s Liberation ArmyLanzhou 730050China Scientific Research Center the Seventh Affiliated HospitalSun Yat-sen UniversityShenzhen 518000China School of Medicine Nankai universityTianjin 300000China Department of Cardiology the 940th Hospital of Joint Logistics Support Force of Chinese People’s Liberation ArmyLanzhou 730050China Department of Radiation Oncology Fujian Medical University Union HospitalFuzhou 350000China Department of Traditional Chinese Medicine the 940th Hospital of Joint Logistics Support Force of Chinese People’s Liberation ArmyLanzhou 730050China Department of Geriatric Diseases the Seventh Medical Center of Chinese PLA General HospitalBeijing 100700China Health and Sport Administration Muskingum UniversityOhioanUSA Laboratory of Vaccine and Antibody Engineering Beijing Institute of BiotechnologyBeijing 100071China Department of Pulmonary and Critical Care Medicine the 940th Hospital of Joint Logistics Support Force of Chinese People’s Liberation ArmyLanzhou 730050China Center of Pulmonary&Critical Care Medicine Chinese People’s Liberation Army(PLA)General HospitalBeijing 100853China

As the search for effective treatments for COVID-19 continues,the high mortality rate among critically ill patients in Intensive Care Units(ICU)presents a profound *** study explores the potential benefits of traditional Chinese medicine(TCM)as a supplementary treatment for severe COVID-19.A total of 110 critically ill COVID-19 patients at the Intensive Care Unit(ICU)of Vulcan Hill Hospital between Feb.,2020,and April,2020(Wuhan,China)participated in this observational *** patients received standard supportive care protocols,with a subset of 81 also receiving TCM as an adjunct *** characteristics during the treatment period and the clinical outcome of each patient were closely monitored and *** findings indicated that the TCM group exhibited a significantly lower mortality rate compared with the non-TCM group(16 of 81 vs 24 of 29;0.3 vs 2.3 person/month).In the adjusted Cox proportional hazards models,TCM treatment was associated with improved survival odds(P<0.001).Furthermore,the analysis also revealed that TCM treatment could partially mitigate inflammatory responses,as evidenced by the reduced levels of proinflammatory cytokines,and contribute to the recovery of multiple organic functions,thereby potentially increasing the survival rate of critically ill COVID-19 patients.

关键词： COVID-19 Pneumonia Novel coronavirus Critically ill Traditional Chinese medicine Clinical outcome

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Health Inspection and Safety Assessment for a Long Span Arch Bridge

Health Inspection and Safety Assessment for a Long Span Arch...

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2004安全科学与技术国际会议

作者： WANG Zhenling TANG Jishun QIAN yongjiu & li li ( School of Civil Engineering Southwest Jiaotong University Chengdu 610031 Sichuan China)

The reinforced concrete arch bridge over the Jialingjiang River with the common length of 775m has been used for nearly 30 years. Parts of the structure have been damaged due to corrosion, growing axl

关键词： bridge nondestructive detection loading test safety assessment

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门式刚架轻型房屋钢结构端板连接的有限元与试验分析

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土木工程学报 2004年第7期37卷 6-12,34页

作者：施刚石永久王元清李少甫陈宏清华大学

结合门式刚架轻型房屋钢结构中普遍应用的端板连接方式 ,本文对梁柱节点和梁拼接节点进行了试验和有限元分析 ,对外伸式端板连接的承载力和转动刚度特性进行了研究 ,讨论了我国现行规范关于外伸式端板连接的设计方法中存在的问题 ,同时... 详细信息

结合门式刚架轻型房屋钢结构中普遍应用的端板连接方式 ,本文对梁柱节点和梁拼接节点进行了试验和有限元分析 ,对外伸式端板连接的承载力和转动刚度特性进行了研究 ,讨论了我国现行规范关于外伸式端板连接的设计方法中存在的问题 ,同时给出了改进建议 ,特别是提出了在建立钢结构节点刚度分类标准方面应该注意的问题。根据比较分析的结果 ,本文还提出了一种新的外伸式端板连接螺栓拉力分布模型及相应的设计方法 ,试验证明 ,该方法在保证安全可靠的前提下 ,能够更好地符合螺栓端板连接的实际受力状态。

关键词：端板连接外伸式节点刚度

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基于可调铒纤激光器的温度测量系统研究

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光通信技术 2018年第5期42卷 24-28页

作者：武永久李小方王旭刘玉芳河南师范大学物理与材料科学学院河南新乡453007 河南师范大学电子与电气工程学院河南新乡453007

实验研究了基于分布式布喇格反射镜(Distributed Bragg Reflectors,DBR)光纤激光器结构的光纤光栅传感系统,采用可调光纤法布里-珀罗(Fabry-Perot,F-P)滤波器和光纤环行器构成的可调反射腔镜对传感光栅进行波长扫描,实现了对光纤光栅温... 详细信息

实验研究了基于分布式布喇格反射镜(Distributed Bragg Reflectors,DBR)光纤激光器结构的光纤光栅传感系统,采用可调光纤法布里-珀罗(Fabry-Perot,F-P)滤波器和光纤环行器构成的可调反射腔镜对传感光栅进行波长扫描,实现了对光纤光栅温度的传感解调。与采用宽带光源、可调光纤F-P滤波器的光纤光栅温度传感解调系统进行了对比研究。实验结果表明,采用可调光纤激光器传感解调的温度测量系统具有解调速度更快,系统稳定性更强的优点。

关键词：光纤激光器可调法布里-珀罗滤波器光纤布喇格光栅传感解调

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