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Genes & Diseases 2024年第4期11卷 102-105页

作者： yongjie xu Haixia xu Xiaofang Cheng Nuo Chen Yaling Wang Yueru Huang Jiahua Guo Yueqian Zheng Mengjia Zhang Chuunyu Du Cunzhen Zhao Cencen Li Pengpeng Zhang College of Life Science Xinyang Normal UniversityXinyangHenan 464000China Institute for Conservation and Utilization of Agro-Bioresources in Dabie Mountain Xinyang Normal UniversityXinyangHenan 464000China

Heterogeneous nuclear ribonucleoprotein K(hnRNPK)is a predominantly nuclear RNA-binding protein that can bind to DNA or RNA through three KH domains and interact with multiple proteins by interactive region.These binding activities enable hnRNPK to link the function in a wide array of diverse cellular processes,such as chromatin remodeling,gene transcription,RNA metabolism,protein translation,DNA repair,and cell signal transduction,thereby playing crucial roles in many biological processes,including development,axonal regeneration,spermatogenesis,cell cycle,apoptosis,differentiation,and carcinogenesis.

关键词： inhibited metabolism carcinogenesis

Room-temperature ferromagnetism and piezoelectricity in metalfree 2D semiconductor crystalline carbon nitride

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Nano Research 2024年第6期17卷 5670-5679页

作者： Yong Wang Dingyi Yang Wei xu yongjie xu Yu Zhang Zixuan Cheng Yizhang Wu xuetao Gan Wei Zhong Yan Liu Genquan Han Yue Hao Wide Bandgap Semiconductor Technology Disciplines State Key Laboratory School of MicroelectronicsAcademy of Advanced Interdisciplinary ResearchXidian UniversityXi’an 710071China Emerging Device and Chip Laboratory Hangzhou Institute of TechnologyXidian UniversityHangzhou 311200China INRS Centre for Energy Materials and Telecommunications1650 Boul.Lionel BouletVarennesQC J3X 1P7Canada National Laboratory of Solid State Microstructures Collaborative Innovation Center of Advanced Microstructures and Jiangsu Provincial Key Laboratory for NanotechnologyNanjing UniversityNanjing 210093China School of Education Jiangsu Open UniversityNanjing 210036China Department of Physics Shaanxi University of Science and TechnologyXi’an 710021China Department of Applied Physical Sciences The University of North Carolina at Chapel HillChapel HillNC 27514USA Key Laboratory of Light Field Manipulation and Information Acquisition Ministry of Industry and Information Technologyand Shaanxi Key Laboratory of Optical Information TechnologySchool of Physical Science and TechnologyNorthwestern Polytechnical UniversityXi'an 710129 China

Two-dimensional(2D)materials that combine ferromagnetic,semiconductor,and piezoelectric properties hold significant potential for both fundamental research and spin electronic devices.However,the majority of reported 2D ferromagnetic-semiconductor-piezoelectric materials rely on d-electron systems,which limits their practical applications due to a Curie temperature lower than room temperature(RT).Here,we report a high-crystallinity carbon nitride(CCN)material based on sp-electrons using a chemical vapor deposition *** exhibits a band gap of 1.8 eV and has been confirmed to possess substantial in-plane and out-of-plane piezoelectricity.Moreover,we acquired clear evidences of ferromagnetic behavior at room temperature.Extensive structural characterizations combined with theoretical calculations reveal that incorporating structural oxygen into the highly ordered heptazine structure causes partial substitution of nitrogen sites,which is primarily responsible for generating room-temperature ferromagnetism and piezoelectricity.As a result,the strain in wrinkles can effectively modulate the domain behavior and piezoelectric potential at room temperature.The addition of RT ferromagnetic-semiconductor-piezoelectric material based on sp-electrons to the family of two-dimensional materials opens up numerous possibilities for novel applications in fundamental research and spin electronic devices.

关键词： crystallinity carbon nitride room-temperature ferromagnetism piezoelectricity magnetic force microscopy density functional theory(DFT)calculations

Model-based automated testing of JavaScript Web applications via longer test sequences

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Frontiers of Computer Science 2022年第3期16卷 53-66页

作者： Pengfei GAO yongjie xu Fu SONG Taolue CHEN School of Information Science and Technology ShanghaiTech UniversityShanghai 201210China Department of Computer Science University of SurreyGuildford GU27XHUK

JavaScript has become one of the most widely used languages for Web development.Its dynamic and event-driven features make it challenging to ensure the correctness of Web applications written in JavaScript.A variety of dynamic analysis techniques have been proposed which are,however,limited in either coverage or scalability.In this paper,we propose a simple,yet effective,model-based automated testing approach to achieve a high code-coverage within the time budget via testing with longer event sequences.We implement our approach as an open-source tool LJS,and perform extensive experiments on 21 publicly available benchmarks.On average,LJS is able to achieve 86.5%line coverage in 10 minutes.Compared with JSDEP,a state-of-the-art breadth-first search based automated testing tool enriched with partial order reduction,the coverage of LJS is 11%-19%higher than that of JSDEP on real-world large Web applications.Our empirical findings support that proper longer test sequences can achieve a higher code coverage in JavaScript Web application testing.

关键词： model-based testing automated testing JavaScript Web applications

Sex disparity of lung cancer risk in non-smokers:a multicenter population-based prospective study based on China National Lung Cancer Screening Program

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Chinese Medical Journal 2022年第11期135卷 1331-1339页

作者： Zheng Wu Fengwei Tan Zhuoyu Yang Fei Wang Wei Cao Chao Qin xuesi Dong Yadi Zheng Zilin Luo Liang Zhao Yiwen Yu yongjie xu Jiansong Ren Jufang Shi Hongda Chen Jiang Li Wei Tang Sipeng Shen Ning Wu Wanqing Chen Ni Li Jie He Office of Cancer Screening National Cancer CenterNational Clinical Research Center for CancerCancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Key Laboratory of Cancer Data Science Chinese Academy of Medical SciencesBeijing 100021China Department of Thoracic Surgery National Cancer CenterNational Clinical Research Center for CancerCancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China PET-CT Center National Cancer CenterNational Clinical Research Center for CancerCancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Epidemiology Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Jiangsu Key Lab of Cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Cancer Personalized MedicineNanjing Medical UniversityNanjingJiangsu 211166China Department of Diagnostic Radiology National Cancer CenterNational Clinical Research Center for CancerCancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China.

Background: Non-smokers account for a large proportion of lung cancer patients, especially in Asia, but the attention paid to them is limited compared with smokers. In non-smokers, males display a risk for lung cancer incidence distinct from the females-even after excluding the influence of smoking;but the knowledge regarding the factors causing the difference is sparse. Based on a large multicenter prospective cancer screening cohort in China, we aimed to elucidate the interpretable sex differences caused by known factors and provide clues for primary and secondary prevention.Methods: Risk factors including demographic characteristics, lifestyle factors, family history of cancer, and baseline comorbidity were obtained from 796,283 Chinese non-smoking participants by the baseline risk assessment completed in 2013 to 2018. Cox regression analysis was performed to assess the sex difference in the risk of lung cancer, and the hazard ratios (HRs) that were adjusted for different known factors were calculated and compared to determine the proportion of excess risk and to explain the existing risk factors.Results: With a median follow-up of 4.80 years, 3351 subjects who were diagnosed with lung cancer were selected in the analysis. The lung cancer risk of males was significantly higher than that of females;the HRs in all male non-smokers were 1.29 (95% confidence interval [CI]: 1.20-1.38) after adjusting for the age and 1.38 (95% CI: 1.28-1.50) after adjusting for all factors, which suggested that known factors could not explain the sex difference in the risk of lung cancer in non-smokers. Known factors were 7% (|1.29-1.38|/1.29) more harmful in women than in men. For adenocarcinoma, women showed excess risk higher than men, contrary to squamous cell carcinoma;after adjusting for all factors, 47% ([1.30-1.16]/[1.30-1]) and 4% ([7.02-6.75]/[7.02-1])) of the excess risk was explainable in adenocarcinoma and squamous cell carcinoma. The main causes of gender differences in lung cancer risk were lifestyle factors, baseline

关键词： Lung cancer Non-smoker Sex disparity Excess risk Risk factor

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PTFE/Cu材料动态压缩特性

粉末冶金技术 2024年第2期42卷 153-158,164页

作者：汤雪志王志军张雪朋徐永杰中北大学机电工程学院太原030051 重庆红宇精密工业集团有限公司重庆402760

通过冷等静压和冷压烧结制备出六种不同密度的聚四氟乙烯(polytetrafluoroethylene,PTFE)/Cu复合材料,并采用霍普金森系统研究了密度和制备方法对PTFE/Cu动态力学性能影响。结果表明,冷压烧结试样在其烧结过程中发生纵向膨胀,导致密度降... 详细信息

通过冷等静压和冷压烧结制备出六种不同密度的聚四氟乙烯(polytetrafluoroethylene,PTFE)/Cu复合材料,并采用霍普金森系统研究了密度和制备方法对PTFE/Cu动态力学性能影响。结果表明,冷压烧结试样在其烧结过程中发生纵向膨胀,导致密度降低,且试样表面生成一层金属膜;冷压烧结试样的动态压缩性能优于冷等静压试样;冷压烧结后的PTFE/Cu材料中PTFE晶体发育更好,对Cu颗粒包裹力更大,界面结合力更高,提升了冷压烧结PTFE/Cu材料的力学性能。

关键词： PTFE/Cu复合材料冷等静压冷压烧结动态压缩性能

Disparities in the global burden of tracheal,bronchus,and lung cancer from 1990 to 2019

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Chinese Medical Journal Pulmonary and Critical Care Medicine 2023年第1期1卷 36-45页

作者： Chenran Wang Zheng Wu yongjie xu Yadi Zheng Zilin Luo Wei Cao Fei Wang xuesi Dong Chao Qin Liang Zhao Changfa Xia Fengwei Tan Wanqing Chen Ni Li Jie He Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Thoracic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Chinese Academy of Medical Sciences Key Laboratory for National Cancer Big Data Analysis and Implementation Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Background:Tracheal,bronchus,and lung(TBL)cancer imposes a high disease burden globally,and its pattern varies greatly across regions and countries.This study aimed to explore the global burden and temporal trends of TBL cancer from 1990 to 2019.Methods:Data on incidence,mortality,and disability-adjusted life years(DALYs)metrics(number,crude rate,and age-standardized rates),and the attributable risk fraction of DALY of TBL cancer from 1990 to 2019 in 21 Global Burden of Disease(GBD)regions,four World Bank income regions,204 countries and territories,and the globe were obtained from the up-to-date GBD 2019 study.We applied estimated annual percentage changes(EAPCs)to the age-standardized incidence rate(ASIR),age-standardized mortality rate(ASMR),and age-standardized DALY rate(ASDR)to quantify the temporal trends of the TBL cancer burden from 1990-2019.Associations of EAPC of age-standardized rates with universal health coverage(UHC)index at the national level were evaluated with Pearson correlation analysis.Results:Globally,approximately 2,260,000 new TBL cancer cases,2,042,600 deaths,and 45,858,000 DALYs were reported in 2019.Combination of all modifiable risk factors,behavioral,environmental,and metabolic risk factors accounted for 79.1%,66.4%,33.3%,and 7.9%of global lung cancer DALYs,respectively.The overall ASIR(EAPC:-0.1[95%confidence interval[CI]:-0.2,-0.1]),ASMR(EAPC:-0.3[95%CI:-0.4,-0.3]),and ASDR(EAPC:-0.7[95%CI:-0.7,-0.6])decreased from 1990 to 2019.The highest mortality rate of TBL cancer occurred in the>85-year-old age group for both sexes among high-income countries(HICs)and upper-middle-income countries(UMCs),and in males aged 80-84 years and females aged>85 years in lower middle-income countries(LMCs).HICs experienced the largest declines in ASIR(-12.6%),ASMR(-20.3%),and ASDR(-27.8%)of TBL cancer between 1990 and 2019,while UMCs had the highest increases in ASIR(16.7%)and ASMR(8.0%)over the period.Eleven(52.4%),14(66.7%),and 15(71.4%)regions of the 21 GBD regions experienced descending trends in ASI

关键词： Lung cancer Incidence Mortality Disability-adjusted life years Temporal trends

药型罩结构对线型聚能装药侵彻性能影响的仿真研究

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兵器装备工程学报 2024年第3期45卷 128-134页

作者：王晓东徐永杰郑娜娜王昊中北大学机电工程学院太原100081 重庆红宇精密工业集团有限公司重庆402760 陆军装备部驻北京地区军事代表局驻长治地区军事代表室山西长治046000

为研究药型罩结构对线型聚能装药的影响,采用有限元软件LS-DYNA对不同截顶高度的锥顶、平顶与圆顶结构的线型聚能装药侵彻45钢靶板的过程进行了仿真分析。结果表明:不同结构的线型药型罩对线型聚能装药射流的成形与侵彻性能造成较大影响... 详细信息

为研究药型罩结构对线型聚能装药的影响,采用有限元软件LS-DYNA对不同截顶高度的锥顶、平顶与圆顶结构的线型聚能装药侵彻45钢靶板的过程进行了仿真分析。结果表明:不同结构的线型药型罩对线型聚能装药射流的成形与侵彻性能造成较大影响;平顶结构线型聚能装药在截顶高度为16 mm时有最优侵彻性能,较锥顶结构最大侵彻深度提升6.3%;圆顶结构线型聚能装药在截顶高位为10 mm时有最优侵彻性能,较锥顶结构最大侵彻深度提升15.6%。

关键词：线型聚能装药药型罩聚能装药有限元侵彻性能

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激光漫反射板防护效果研究

激光技术 2024年第2期48卷 223-228页

作者：张启鹏吴桐徐永杰刘明菊中国人民解放军63893部队洛阳471000

为了科学地评估激光漫反射板在激光角度欺骗干扰过程中的防护效果,采用坐标转换的方法,将导引头接收到的指示激光和干扰激光的能量密度放在同一坐标系进行比较,并计算出制导空域干扰覆盖率,分析了漫反射板和目标的法线方向差异对防护效... 详细信息

为了科学地评估激光漫反射板在激光角度欺骗干扰过程中的防护效果,采用坐标转换的方法,将导引头接收到的指示激光和干扰激光的能量密度放在同一坐标系进行比较,并计算出制导空域干扰覆盖率,分析了漫反射板和目标的法线方向差异对防护效果的影响。结果表明,对于典型立方体型目标,当漫反射板的法线与目标垂直面的法线方位相同、俯仰相差在0°~60°范围时,该垂直面的制导空域干扰覆盖率为100%,仅当漫反射板的法线与目标顶部水平面的法线方向完全相同时,该面的制导空域干扰覆盖才为100%;要实现全面的防护,需要根据激光来袭方向和可能的被照射面,设置多个漫反射板进行针对的防护。此研究方法和结果对于激光漫反射板的合理布设和使用有一定参考价值。

关键词：激光技术角度欺骗干扰干扰覆盖率漫反射板

基于地统计分析的核桃园土壤养分空间特征研究

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果树学报 2024年第5期41卷 968-979页

作者：徐雅雯吴文丰王其竹王代全徐朝煜陈万胜徐永杰湖北省林业科学研究院武汉430075 保康县核桃技术推广中心湖北襄阳441600

【目的】探究核桃园土壤养分的空间特征,了解土壤肥力状况,为核桃园管理单位划分提供依据,从而实现精准施肥。【方法】以湖北保康核桃园为研究对象,采用地统计学和内梅罗法相结合的方法,分析了110块样地的土壤pH值、养分空间特征及肥力... 详细信息

【目的】探究核桃园土壤养分的空间特征,了解土壤肥力状况,为核桃园管理单位划分提供依据,从而实现精准施肥。【方法】以湖北保康核桃园为研究对象,采用地统计学和内梅罗法相结合的方法,分析了110块样地的土壤pH值、养分空间特征及肥力水平。【结果】(1)保康县核桃园土壤pH均值为6.68,以中性和微酸性土壤为主,具有弱变异性;有机质、水解性氮、有效钾、有效磷含量(w,后同)均值分别为27.63 g·kg^(-1)、109.41 mg·kg^(-1)、125.43 mg·kg^(-1)和23.74 mg·kg^(-1),具中等变异。(2)中等肥力核桃园占78.3%,肥沃核桃园占20.7%,水解性氮是土壤肥力的主要限制因子;土壤肥力指数与核桃干果每666.7 m2产量呈显著正相关。(3)水解性氮、有效钾含量主要受自然结构的影响,呈现显著空间正向聚集性;有机质、有效磷含量受自然结构和人为因素的双重影响,具有空间正相关性,但空间聚集效应不显著。(4)海拔与水解性氮含量、有效磷含量、土壤肥力指数呈极显著正相关,与有机质含量呈显著正相关,而与有效钾含量无显著相关性。【结论】该地区土壤pH值适宜核桃生长,现存核桃园整体肥力中等偏上,提高土壤肥力能够增加核桃干果产量。土壤空间变异主要受自然结构的影响,其中海拔是影响土壤肥力的关键因素,可以作为核桃园管理单元划分的重要依据。在土壤管理中,需要增施氮肥以提高林地土壤综合肥力。

关键词：核桃地统计土壤养分空间分布特征

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儿童青少年大便性状与肠道菌群多样性的关联

中国学校卫生 2024年第1期45卷 104-109页

作者：王兵吴彦金慧皮雄娥刘伟许永杰赵刚浙江省杭州市疾病预防控制中心传染病防制所 310021 浙江省农业科学院植物保护与微生物研究所

目的研究便秘、腹泻和健康儿童青少年肠道菌群差异和多样性变化,探讨大便性状改变与肠道菌群的相关性,为儿童青少年时期的肠道微生态研究提供科学参考。方法2021年10月至2022年3月,采集杭州市某三甲医院收治的儿童青少年42例便秘患者、3... 详细信息

目的研究便秘、腹泻和健康儿童青少年肠道菌群差异和多样性变化,探讨大便性状改变与肠道菌群的相关性,为儿童青少年时期的肠道微生态研究提供科学参考。方法2021年10月至2022年3月,采集杭州市某三甲医院收治的儿童青少年42例便秘患者、37例腹泻患者和3所普通中小学43名健康者的粪便标本,提取粪便基因组DNA进行16S rRNA基因高通量测序,对测序结果开展分析。Alpha多样性分析中,3组之间的差异比较采用Kruskal-Wallis秩和检验,两两之间比较采用FDR多重检验校正。Beta多样性分析中,3组总的差异比较采用Adonis检验方法,两两比较采用ANOSIM检验方法。LEfSe分析中,通过LDA分析(线性回归分析)获得的LDA分值。结果Alpha多样性分析显示,腹泻组、便秘组和健康组之间的香农(Shannon)指数(4.01,3.81,4.19)和辛普森(Simpson)指数(0.05,0.06,0.04)差异均有统计学意义(H值分别为6.05,6.35,P值均0.1)。结论儿童青少年大便性状不同与肠道微生物种群结构变化有关。与健康组相比,便秘或腹泻时肠道菌群平衡被打破,优势菌群发生偏移,条件致病菌丰度较高。

关键词：粪便胃肠道细菌儿童青少年