检索结果-南通市图书馆

Sex-biased single-cell genetic landscape in mice with autism spectrum disorder

Journal of Genetics and Genomics 2024年第3期51卷 338-351页

作者： Qian Zhang yongjie Wang Jie Tao Ruixue Xia Yijie Zhang Zhirui liu Jiwei Cheng Department of Neurology and Central Laboratory Putuo HospitalShanghai University of Traditional Chinese MedicineShanghai 200062China School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang 311121China Department of Respiratory and Critical Care Medicine Henan University Huaihe HospitalKaifengHenan 475099China

Autistic spectrum disorder(ASD)is a male-biased,heterogeneous neurodevelopmental disorder that affects approximately 1%e2%of the population.Prenatal exposure to valproic acid(VPA)is a recognized risk factor for ASD,but the cellular and molecular basis of VPA-induced ASD at the single-cell resolution is unclear.Here,we aim to compare the cellular and molecular differences in the hippocampus between male and female prenatal mice with ASD at the single-cell transcriptomic level.The transcriptomes of more than 45,000 cells are assigned to 12 major cell types,including neurons,glial cells,vascular cells,and immune cells.Cell type-specific genes with altered expression after prenatal VPA exposure are analyzed,and the largest number of differentially expressed genes(DEGs)are found in neurons,choroid plexus epithelial cells,and microglia.In microglia,several pathways related to inflammation are found in both males and females,including the tumor necrosis factor(TNF),nuclear factor kappa B(NF-kB),toll-like receptor(TLR),and mitogen-activated protein kinase(MAPK)signaling pathways,which are important for the induction of autistic-like behavior.Additionally,we note that several X-linked genes,including Bex1,Bex3,and Gria3,were among the male-specific DEGs of neurons.This pioneering study describes the landscape of the transcriptome in the hippocampus of autistic mice.The elucidation of sexual differences could provide innovative strategies for the prevention and treatment of ASD.

关键词： Autistic spectrum disorder(ASD) Sex Single cell Neurons Microglia

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Structural Control of the Getang Carlin-Type Gold Deposit in Southwest China

引用

Journal of Earth Science 2024年第2期35卷 536-552页

作者： Guoping Zeng Xinlu Hu Diwei Luo Jianzhong liu Shuzhen Yao yongjie Jin Wuhan Center China Geological SurveyWuhan430205China Central South China Innovation Center for Geosciences Wuhan430205China Faculty of Earth Resources China University of GeosciencesWuhan430074China Geological Party 105 Guizhou Bureau of Geology and Mineral Exploration&DevelopmentGuiyang550018China

The Getang is a representative Carlin-type gold deposit in Southwest China.It has a proven reserve of about 30 tonnes at an average grade of 5.1 g/t Au.The orebodies occur as strat-abound lenses,and are structurally controlled by shallow NWW-and NE-trending fold-fault systems and the unconformity between the Upper and Middle Permian.In this study,the regional-and deposit-scale structural investigations,joints and finite strain measurements,and stress and dynamic analysis were conducted with an aim to reveal the structural process of the Getang gold deposit and clarify the relationship between the gold mineralization and structures.Three phases of deformation were identified in the deposit:(1)paleokarst was generated by a crustal uplift when the Youjiang Basin experienced extension at the end of the Middle Permian,laying the foundation for the unconformity;(2)the NW-trending structures were formed under a NNE-SSW compression during the Indochina-South China collision(Indosinian orogeny)in Triassic;(3)the NE-trending structures were generated or reactivated under a NW-SE-oriented compression during the Yanshanian intracontinental orogeny.The unconformity recorded two episodes of tectonic evolution in the NNE-SSW and NW-SE directions.Structural analyses and geochronology data suggest that the Getang gold deposit was formed as a result of tectonic transition from compression to extension during the Yanshanian intracontinental orogeny.

关键词： Carlin-type gold deposit structural features finite strain Getang Southwest China economy geology geochemistry

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effective peroxydisulfate activation by CQDs-MnFe_(2)O_(4)@ZIF-8 catalyst for complementary degradation of bisphenol A by free radicals and non-radical pathways

引用

Chinese Chemical Letters 2024年第5期35卷 371-379页

作者： Shuo Li Xinran liu yongjie Zheng Jun Ma Shijie You Heshan Zheng College of Chemistry and Chemical Engineering Qiqihar UniversityQiqihar 161006China State Key Laboratory of Urban Water Resource and Environment School of EnvironmentHarbin Institute of TechnologyHarbin 150090China

The present study reported fabrication of novel carbon quantum dots-MnFe_(2)O_(4)@ZIF-8(CQDs-MFO@ZIF-8)by using co-precipitation hydrothermal method for activation of peroxydisulfate(PDS)to degrade bisphenol A(BPA),one of important emerging organic pollutants in water environment.CQDs-MFO@ZIF-8 served as a highly efficient thermal activated PDS catalyst with high catalytic degradation efficiency,reusability and stability.The catalyst achieved almost completely removal of 20.0 mg/L BPA within 5.0 min,and the degradation efficiency remained higher than 83%after 5 consecutive cycles.Free radicals(^(·)OH,SO_(4)^(·-)and^(·)O_(2)^(-))and non-free radicals((1)O_(2))were generated in the thermal PDS-activation system,in which singlet oxygen((1)O_(2))played a dominant role in the degradation of BPA.The potential toxicity of BPA degradation intermediates was analyzed upon the culture of E.coli and Chlorella sorokiniana by using Ecological Structure-Activity Relationship Model(ECOSAR)program.The catalytic performances of BPA degradation by CQDs-MFO@ZIF-8 were evaluated for treatment of different practical water samples to further verify the feasibility of practical applications.This study provides proof-in-concept demonstration of new nanomaterials for enhanced catalytic water decontamination.

关键词： Bisphenol A Degradation Peroxydisulfate ^(1)O_(2) Toxicity analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Review on degradation mechanism and health state estimation methods of lithium-ion batteries

引用

Journal of Traffic and Transportation Engineering(English Edition) 2023年第4期10卷 578-610页

作者： Yongtao liu Chuanpan liu yongjie liu Feiran Sun Jie Qiao Ting Xu School of Automobile Chang'an UniversityXi'an 710064China College of Transportation Engineering Chang'an UniversityXian 710064China

State of health(SOH)estimation is important for a lithium-ion battery(LIB)health state management system,and accurate estimation of SOH is influenced by the degree of degradation of the LIB.However,considering the complex electrochemical reactions within Li electrons and the influence of many external factors on internal reactions,it is difficult to accurately estimate the SOH based on the surface state characteristics of the battery(including current,voltage,and temperature).Thus,in this study,the knowledge graph method is employed to analyze keyword co-occurrences and citations in the literature on LIB degradation and SOH estimation to determine research hotspots.Based on the research trends,findings regarding the internal and external degradation mechanisms and influencing factors of(LIBs)are reorganized,and chemical and physical degradation processes,including solid electrolyte interface(SEI)layer formation,fracture,Li plating,and dendrite formation,are systematically introduced based on the modeling perspective.The interrelationships between these degradation factors and their effects on capacity and power decay as well as their correlation with SOH estimation are evaluated.Additionally,a comparative analysis of existing SOH estimation methods is presented,and the applicable scenarios and technical problems of each method are summarized.The key issues such as model simplification,estimation methods based on random data,and second-life SOH are also analyzed and discussed.The results show that the estimation results of methods mixing multiple models tend to be more accurate.Finally,the development trend of SOH estimation methods under complex degradation conditions and usage scenarios is analytically discussed.

关键词： Lithium-ion battery Stateof health Estimation Degradation Knowledge graph

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Determining origins of satellite breakup events in LEO region

引用

Astrodynamics 2023年第4期7卷 465-476页

作者： yongjie liu Yu Jiang Hengnian Li Zongbo Huyan Hongchao Wang State Key Laboratory of Astronautic Dynamics Xi'an Satellite Control CenterXi'an 710043China

Currently,a surge in the number of spacecraft and fragments is observed,leading to more frequent breakup events in low Earth orbits(LEOs).The causes of these events are being identified,and specific triggers,such as collisions or explosions,are being examined for their importance to space traffic management.Backward propagation methods were employed to trace the origins of these types of breakup events.Simulations were conducted using the NASA standard breakup model,and satellite Hitomi’s breakup was analyzed.Kullback-Leibler(KL)divergences,Euclidean 2-norms,and Jensen-Shannon(JS)divergences were computed to deduce potential types of breakups and the associated fragmentation masses.In the simulated case,a discrepancy of 22.12 s between the estimated and actual time was noted.Additionally,the breakup of the Hitomi satellite was estimated to have occurred around UTC 1:49:26.4 on March 26,2016.This contrasts with the epoch provided by the Joint Space Operation Center,which was estimated to be at 1:42 UTC±11 min.From the findings,it was suggested that the techniques introduced in the study can be effectively used to trace the origins of short-term breakup events and to deduce the types of collisions and fragmentation masses under certain conditions.

关键词： breakup collision explosion Kullback-Leibler(KL)divergence Jensen-Shannon(JS)divergence

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of ultrasonic peening treatment on the fatigue behaviors of a magnesium alloy up to very high cycle regime

引用

Journal of Magnesium and Alloys 2022年第3期10卷 659-673页

作者： Yao Chen Fulin liu Chao He Lang Li Chong Wang yongjie liu Qingyuan Wang Failure Mechanics and Engineering Disaster Prevention and Mitigation Key Laboratory of Sichuan Province Sichuan UniversityChengdu 610065China MOE Key Laboratory of Deep Earth Science and Engineering College of Architecture and EnvironmentSichuan UniversityChengdu 610065China Institute for Advanced Study Chengdu UniversityChengdu 610106China

Ultrasonic fatigue tests are performed on a magnesium alloy with and without ultrasonic peening treatment(UPT).Surface enhancement layer leads to the complete change of crack initiation sites.However,crack initiation mechanism keeps the same and results in a single-faceted morphology at crack initiation site.Microcracks initiate as Mode Ⅱ crack within the original grain,but deflect to Mode I crack outside of the original cracked grain.A threshold SIF value is proposed to evaluate the retarding effect of grain boundary on microcrack propagation.Outside of the original cracked grain,Mode I crack propagation below the threshold ΔK_(σ-th) is responsible for the formation of fine granular area(FGA,a nano-grain layer).Based on the Numerous Cyclic Pressing(NCP) model,it is proposed that crack type should be another necessary condition for the formation of FGA.

关键词： Ultrasonic peening treatment Very-high-cycle fatigue Crack initiation mechanism Fine granular area Nanograins.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of long-period stacking ordered structure on very high cycle fatigue properties of Mg-Gd-Y-Zn-Zr alloys

引用

Journal of Magnesium and Alloys 2023年第8期11卷 2811-2822页

作者： Xiangyu WANG Chao HE Xue Li Lang LI yongjie liu Qingyuan WANG Key Laboratory of Deep Earth Science and Engineering Ministry of EducationCollege of Architecture and EnvironmentSichuan UniversityChengdu 610065China Failure Mechanics&Engineering Disaster Prevention and Mitigation Key Laboratory of Sichuan ProvinceSichuan UniversityChengdu 610065China School of Architecture and Civil Engineering Chengdu UniversityChengdu 610106China

Magnesium alloys with a long-period stacking ordered(LPSO)structure usually possess excellent static strength,but their fatigue behaviors are poorly understood.This work presents the effect of the LPSO structure on the crack behaviors of Mg alloys in a very high cycle fatigue(VHCF)regime.The LPSO lamellas lead to a facet-like cracking process along the basal planes at the crack initiation site and strongly prohibit the early crack propagation by deflecting the growth direction.The stress intensity factor at the periphery of the faceted area is much higher than the conventional LPSO-free Mg alloys,contributing higher fatigue crack propagation threshold of LPSO-containing Mg alloys.Microstructure observation at the facets reveals a layer of ultrafine grains at the fracture surface due to the cyclic contact of the crack surface,which supports the numerous cyclic pressing model describing the VHCF crack initiation behavior.

关键词： Fatigue crack initiation Long-period stacking ordered structure Mg alloys Ultrafine grains Very high cycle fatigue

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Room-temperature ferromagnetism and piezoelectricity in metalfree 2D semiconductor crystalline carbon nitride

引用

Nano Research 2024年第6期17卷 5670-5679页

作者： Yong Wang Dingyi Yang Wei Xu yongjie Xu Yu Zhang Zixuan Cheng Yizhang Wu Xuetao Gan Wei Zhong Yan liu Genquan Han Yue Hao Wide Bandgap Semiconductor Technology Disciplines State Key Laboratory School of MicroelectronicsAcademy of Advanced Interdisciplinary ResearchXidian UniversityXi’an 710071China Emerging Device and Chip Laboratory Hangzhou Institute of TechnologyXidian UniversityHangzhou 311200China INRS Centre for Energy Materials and Telecommunications1650 Boul.Lionel BouletVarennesQC J3X 1P7Canada National Laboratory of Solid State Microstructures Collaborative Innovation Center of Advanced Microstructures and Jiangsu Provincial Key Laboratory for NanotechnologyNanjing UniversityNanjing 210093China School of Education Jiangsu Open UniversityNanjing 210036China Department of Physics Shaanxi University of Science and TechnologyXi’an 710021China Department of Applied Physical Sciences The University of North Carolina at Chapel HillChapel HillNC 27514USA Key Laboratory of Light Field Manipulation and Information Acquisition Ministry of Industry and Information Technologyand Shaanxi Key Laboratory of Optical Information TechnologySchool of Physical Science and TechnologyNorthwestern Polytechnical UniversityXi'an 710129 China

Two-dimensional(2D)materials that combine ferromagnetic,semiconductor,and piezoelectric properties hold significant potential for both fundamental research and spin electronic devices.However,the majority of reported 2D ferromagnetic-semiconductor-piezoelectric materials rely on d-electron systems,which limits their practical applications due to a Curie temperature lower than room temperature(RT).Here,we report a high-crystallinity carbon nitride(CCN)material based on sp-electrons using a chemical vapor deposition *** exhibits a band gap of 1.8 eV and has been confirmed to possess substantial in-plane and out-of-plane piezoelectricity.Moreover,we acquired clear evidences of ferromagnetic behavior at room temperature.Extensive structural characterizations combined with theoretical calculations reveal that incorporating structural oxygen into the highly ordered heptazine structure causes partial substitution of nitrogen sites,which is primarily responsible for generating room-temperature ferromagnetism and piezoelectricity.As a result,the strain in wrinkles can effectively modulate the domain behavior and piezoelectric potential at room temperature.The addition of RT ferromagnetic-semiconductor-piezoelectric material based on sp-electrons to the family of two-dimensional materials opens up numerous possibilities for novel applications in fundamental research and spin electronic devices.

关键词： crystallinity carbon nitride room-temperature ferromagnetism piezoelectricity magnetic force microscopy density functional theory(DFT)calculations

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

RNA‑Sequencing Reveals Gene Expression and Pathway Signatures in Umbilical Cord Blood Affected by Birth Delivery Mode

引用

Phenomics 2023年第3期3卷 228-242页

作者： yongjie liu Kun Sun Yuexin Gan Han liu Juehua Yu Wei Xu Lin Zhang Dan Chen Ministry of Education and Shanghai Key Laboratory of Children’s Environmental Health Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Shenzhen Bay Laboratory Shenzhen 518107China Department of Obstetrics and Gynaecology The International Peace Maternity and Child Health HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200025China Centre for Experimental Studies and Research The First Affiliated Hospital of Kunming Medical UniversityKunming 650032China Department of Immunology School of Basic Medical SciencesFudan UniversityShanghai 200032China Department of Gynecology Third Xiangya Hospital of Central South UniversityChangsha 410013China Shanghai Fosun Pharmaceutical Industrial Development Co.LtdShanghai 200233China

Cesarean section(CS)confers increased risk of type I diabetes,asthma,inflammatory bowel disease,celiac disease,over-weight and obesity,etc.,in the offspring.However,the underlying mechanism remains unknown.To investigate the influence of CS on gene expression in cord blood,we have performed RNA-sequencing followed by single-gene analysis,gene set enrichment analysis,gene co-expression network analysis,and interacting genes/proteins analysis in eight full-term infants born by elective CS and eight matched vaginally delivered(VD)infants.Crucial genes identified above were further vali-dated in another 20 CS and 20 VD infants.We found for the first time that mRNA expression of genes involved in immune response(IL12A,INFG,IL1B,TNF,MIF,IL4,CA1,IFI27,HLA-DOB and EPHB1)and metabolism(DLK1,CYP2A6 and GATM)were significantly influenced by CS.Notably,serum TNF-αand IFN-γwere remarkably up-regulated in the CS infants(p=5.0×10^(–4)and 3.0×10^(–3),respectively)compared to the VD infants.It is biologically plausible that CS may exert adverse impacts on offspring health through influencing expression of genes in the above processes.These findings will help understand the potential underlying mechanisms of the adverse health impacts of CS and identify biomarkers for future health of offspring born with different delivery modes.

关键词： Cesarean section Immune response Metabolism Ribosome Ephrin receptor signaling pathway

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Antimony Potassium Tartrate Stabilizes Wide-Bandgap Perovskites for Inverted 4-T All-Perovskite Tandem Solar Cells with Efficiencies over 26%

引用

Nano-Micro Letters 2023年第7期15卷 204-217页

作者： Xuzhi Hu Jiashuai Li Chen Wang Hongsen Cui yongjie liu Shun Zhou Hongling Guan Weijun Ke Chen Tao Guojia Fang Key Laboratory of Artificial Micro/Nano Structures of Ministry of Education School of Physics and TechnologyWuhan UniversityWuhan 430072People’s Republic of China

Wide-bandgap(WBG)perovskites have been attracting much attention because of their immense potential as a front light-absorber for tandem solar cells.However,WBG perovskite solar cells(PSCs)generally exhibit undesired large open-circuit voltage(VOC)loss due to light-induced phase segregation and severe non-radiative recombination loss.Herein,antimony potassium tartrate(APTA)is added to perovskite precursor as a multifunctional additive that not only coordinates with unbonded lead but also inhibits the migration of halogen in perovskite,which results in suppressed non-radiative recombination,inhibited phase segregation and better band energy alignment.Therefore,a APTA auxiliary WBG PSC with a champion photoelectric conversion efficiency of 20.35%and less hysteresis is presented.They maintain 80%of their initial efficiencies under 100 mW cm^(-2)white light illumination in nitrogen after 1,000 h.Furthermore,by combining a semi-transparent WBG perovskite front cell with a narrow-bandgap tin–lead PSC,a perovskite/perovskite four-terminal tandem solar cell with an efficiency over 26%is achieved.Our work provides a feasible approach for the fabrication of efficient tandem solar cells.

关键词： Perovskite solar cell Tandem Wide bandgap Multifunctional additive

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：