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Huangqi Guizhi Wuwu Decoction suppresses inflammation and bone destruction in collagen-induced arthritis mice

Chinese Herbal Medicines 2024年第2期16卷 274-281页

作者： Jiamin Bao yongjia song Minghui Hang Hao Xu Qiang Li Pengyu Wang Tao Chen Mengxiong Xia Qi Shi Yongjun Wang Xiaoyun Wang Qianqian Liang School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghai 201203China Longhua Hospital Shanghai University of Traditional Chinese MedicineShanghai 200032China Spine Institute Shanghai University of Traditional Chinese MedicineShanghai 200032China Key Laboratory of Theory and Therapy of Muscles and Bones Ministry of EducationShanghai University of Traditional Chinese MedicineShanghai 201203China Shanghai Research Institute of Acupuncture and Meridian Shanghai University of Traditional Chinese MedicineShanghai 200032China

Objective: Rheumatoid arthritis(RA) is a chronic inflammatory and destructive arthritis, characterized by inflammatory infiltration and bone destruction. Huangqi Guizhi Wuwu Decoction(HGWD) is traditional Chinese medicine, which has been applied in the treatment of RA in clinical. The aim of this study was to investigate the therapeutic effect of HGWD on collagen-induced arthritis(CIA) mouse ***: DBA/1J female mice were used to establish the collagen-induced arthritis(CIA) model. HGWD was administered intragastrically once a day for four weeks starting on the 22nd day after the first immunization. The body weight, hind paw thickness and clinical score were measured every five days. Gait analysis, histopathological staining, enzyme-linked immunosorbent assay(ELISA), ultrasound imaging and micro-computed tomography imaging were performed to determine the effects of HGWD treatment on inflammation and bone structure in this model. Moreover, Real-time PCR and Western blot analysis were used to detect inflammatory factors m RNA and protein levels after HGWD intervention in RAW264.7 ***: HGWD attenuated symptoms of arthritis, suppressed inflammatory synovium area and the serum levels of inflammatory factors, inhibited joint space enlargement in the knee and ankle joints,reduced numbers of osteoclasts, protected bone destruction, as well as improved motor *** decreased the expression of m RNA for inflammatory factors and the protein expression levels of p-NF-ΚB and ***: These results suggested that HGWD suppresses inflammation, attenuates bone erosion and maintains motor function in collagen-induced arthritis mice.

关键词： bone destruction collagen-induced arthritis Huangqi Guizhi Wuwu Decoction inflammation rheumatoid arthritis

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从气虚血瘀探讨铁死亡与椎动脉型颈椎病的关系

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上海中医药杂志 2024年第6期58卷 40-43,52页

作者：王凯宋永嘉宋敏甘肃省人民医院骨科甘肃兰州730000 甘肃中医药大学中医临床学院甘肃兰州730000

从气虚血瘀探讨铁死亡与椎动脉型颈椎病(CSA)的关系。椎动脉遭受刺激、压迫后的缺血、缺氧状态是CSA发生的病理基础。中医认为CSA的关键病机是气虚血瘀,气虚推动无力,瘀血内停,血液流变学指标改变,病理产物积聚,容易触发血管内皮细胞铁... 详细信息

从气虚血瘀探讨铁死亡与椎动脉型颈椎病(CSA)的关系。椎动脉遭受刺激、压迫后的缺血、缺氧状态是CSA发生的病理基础。中医认为CSA的关键病机是气虚血瘀,气虚推动无力,瘀血内停,血液流变学指标改变,病理产物积聚,容易触发血管内皮细胞铁死亡,加重病情进展。从气虚血瘀病机与铁死亡理论探讨CSA的中医药防治,为CSA的临床诊治提供新思路。

关键词：椎动脉型颈椎病气虚血瘀血管内皮细胞铁死亡血管微环境中医理论作用机制

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Normal compression wave scattering by a permeable crack in a fluid-saturated poroelastic solid

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Acta Mechanica Sinica 2017年第2期33卷 356-367页

作者： yongjia song Hengshan Hu John W. Rudnicki Department of Astronautics and Mechanics Harbin Institute of Technology Harbin 150001 China Department of Civil and Environmental Engineering Northwestern University Evanston Illinois 60208 USA Department of Mechanical Engineering Northwestern University Evanston Illinois 60208 USA

A mathematical formulation is presented for the dynamic stress intensity factor (mode I) of a finite permeable crack subjected to a time-harmonic propagating longitudinal wave in an infinite poroelastic solid. In particular, the effect of the wave-induced fluid flow due to the presence of a liquid-saturated crack on the dynamic stress intensity factor is analyzed. Fourier sine and cosine integral transforms in conjunction with Helmholtz potential theory are used to formulate the mixed boundary-value problem as dual integral equations in the frequency domain. The dual integral equations are reduced to a Fredholm integral equation of the second kind. It is found that the stress intensity factor monotonically decreases with increasing frequency, decreasing the fastest when the crack width and the slow wave wavelength are of the same order. The characteristic frequency at which the stress intensity factor decays the fastest shifts to higher frequency values when the crack width decreases.

关键词： Poroelasticity Biot's theory Finite crack Dynamic stress intensity factor

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Annulation Cascades of Cyclosulfonium Salts and Alkenes towards Sulfur-Containing N-Heterocycles by Visible Light/Copper Catalysis

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Chinese Journal of Chemistry 2024年第14期42卷 1637-1643页

作者： Jie Ma Xufeng Li Yuqing Chen yongjia Shi Xiuyan song Jian Lv Daoshan Yang Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science MOECollege of Chemistry and Molecular EngineeringQingdao University of Science and TechnologyQingdaoShandong266042 China Zhejiang Wansheng Co. Ltd.LinhaiZhejiang317000 China National Engineering Research Center of Low-Carbon Processing and Utilization of Forest Biomass Nanjing Forestry UniversityNanjingJiangsu210037 China

Although,great achievements have been made in the synthesis of heterocycles using radical addition/cyclization strategy,developing versatile alkyl radical precursors,especially the non-stabilized long chain alkyl radicals for this strategy still remains a huge ***,we report an efficient annulation cascade reaction between cyclosulfonium salts and alkenes for the synthesis of sulfur-containing N-heterocycles by visible light/copper catalysis under mild *** C—S bond cleavage/radical cascade reaction delivers a variety of corresponding N-heterocycles containing aryl alkyl thioether motifs with good functional group ***,the current system could be used for the late-stage functionalization of complex bioactive molecules.

关键词： Visible light Radical reactions C-C coupling Sulfur heterocycles Photoredox catalysis

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含随机指向狭缝流体饱和岩石中的弹性波

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科学通报 2023年第26期68卷 3529-3542页

作者：宋永佳胡恒山哈尔滨工业大学航天科学与力学系哈尔滨150001

波致扩散被认为是引起地震波频散和衰减的主要原因之一,它也可以看作是弹性波遇夹杂通过模式转换产生的散射慢纵波.本文将流体饱和孔隙介质中狭缝对弹性波的散射问题归结为位错密度的积分方程,结合散射问题的严格数学解和Foldy-Lax均匀... 详细信息

波致扩散被认为是引起地震波频散和衰减的主要原因之一,它也可以看作是弹性波遇夹杂通过模式转换产生的散射慢纵波.本文将流体饱和孔隙介质中狭缝对弹性波的散射问题归结为位错密度的积分方程,结合散射问题的严格数学解和Foldy-Lax均匀化格式,建立了含随机指向狭缝流体饱和岩石的等效黏弹性模型.为消除求解积分方程耗时较长、不便于反演应用的缺点,本文基于散射远场的低、高频渐近解,利用分支函数近似法建立了背景岩石弹性和渗透率、孔隙流体性质、狭缝参数以及频率与等效黏弹性模量的简单显式函数关系.研究表明,在波致扩散主导的频段内,横波具有与纵波同量级的速度频散和衰减.横波衰减随流体体积模量增加而单调增加,而纵波先增加、后降低.此外,低频纵波速度对流体体积模量敏感,而横波速度对流体模量变化不敏感,说明含裂缝孔隙介质中同样满足流体替代方程.流度主要影响纵横波的峰频,这与定向狭缝的情况相同.本文模型克服了双孔模型不能预测横波速度频散和衰减的局限性,所得结论为联合利用纵、横波特性提取岩石裂缝参数和流体性质提供了理论基础.

关键词：狭缝孔隙岩石双孔结构频散衰减

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基于3d Max的水库库容计算

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陕西水利 2024年第2期 10-12,15页

作者：宋永嘉姜文尚罗飞华北水利水电大学河南郑州450046

水库库容是水利工程建设和运营管理中不可忽略的重要参数之一,引入3d Max软件,对比传统库容计算方法与地理信息处理软件ArcGIS、Global Mapper进行库容计算,旨在摆脱传统数据分析与公式计算,保证精确性的同时,直观地展示水库水位变化过... 详细信息

水库库容是水利工程建设和运营管理中不可忽略的重要参数之一,引入3d Max软件,对比传统库容计算方法与地理信息处理软件ArcGIS、Global Mapper进行库容计算,旨在摆脱传统数据分析与公式计算,保证精确性的同时,直观地展示水库水位变化过程。结果表明:3d Max能够精确地进行库容计算,且对水库各水位淹没地势情况进行直观展示,可为施工建设提供有效参考。

关键词：水库库容 ArcGIS Global Mapper 3d Max

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改进的求解裂纹问题中指数函数对偶积分的倍数因子积分法

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Acta Mechanica Sinica 2022年第6期38卷 117-127,I0003页

作者：宋永佳陆彦楠胡恒山 Department of Astronautic Science and Mechanics Harbin Institute of TechnologyHarbin 150001China

裂纹问题通常可归结为对偶积分方程,可通过将位移积分方程展开为类Chebyshev多项式或Jacobi多项式形式的级数来求解.通过构造一个适定的线性代数方程组来确定展开系数的施密特倍数因子积分法是最受欢迎的方法之一.然而,由于线性方程组... 详细信息

裂纹问题通常可归结为对偶积分方程,可通过将位移积分方程展开为类Chebyshev多项式或Jacobi多项式形式的级数来求解.通过构造一个适定的线性代数方程组来确定展开系数的施密特倍数因子积分法是最受欢迎的方法之一.然而,由于线性方程组的矩阵元素是从二重积分计算出来的,施密特方法的数值计算效率较低.本文提出了一种改进方法来构造线性方程组,以便有效地确定展开系数.改进技术是在将某些倍数因子应用于牵引积分方程,然后在“源”区域上积分得到的方程后发展起来的.该操作将矩阵元素简化为单重积分.文章通过数值算例证明了此方法的计算精度高,且效率高.尤其该方法只需要施密特方法计算时间的1/5左右.因此该方法可以用于代替施密特方法并有望在解决裂纹问题中发挥作用.

关键词： Crack Dual integral equations Schmidt’s method Multiplying-factor integration

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The Persistence and Zonal Scale of Atmospheric Dipolar Modes

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Advances in Atmospheric Sciences 2024年第3期41卷 478-492页

作者： Jie song State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics(LASG) Institute of Atmospheric Physics(IAP)Chinese Academy of SciencesBeijing 100029China

This study investigates the relationship between the persistence and the zonal scale of atmospheric dipolar modes(DMs). Results from the daily data of ERA5 and the long-term output of an idealized atmospheric model show that the atmospheric DMs with a broader(narrower) zonal scale dipolar structure possess a longer(shorter) persistence. A detailed vorticity budget analysis indicates that the persistence of a hemispheric-scale DM(1/1 DM) and a regional or sectoral DM(1/8 DM) in the model both largely rely on the persistence of the nonlinear eddy forcing. Linear terms can indirectly reduce the persistence of the anomalous nonlinear eddy forcing in a 1/8 DM by modifying the baroclinicity via the arousal of anomalous vertical motions. Therefore, the atmospheric DMs with a broader(narrower) zonal scale possess a longer(shorter) persistence because the effects of the linear terms are less(more) pronounced when the atmospheric DMs have better(worse) zonal symmetry. Further analyses show that the positive eddy feedback effect is weak or even absent in a 1/8DM and the high-frequency eddy forcing acts more like a concomitant phenomenon rather than a leading driving factor for a 1/8 DM. Thus, the hemispheric-scale DM and the regional or sectoral DMs are different, not only in their persistence but also in their dynamics.

关键词： NAM NAO eddy feedback persistence linear term

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Identification of Linear Systems Using Binary Sensors with Random Thresholds

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Journal of Systems Science & Complexity 2024年第3期37卷 907-923页

作者： HUANG Zhiyong song Qijiang School of Mathematics Renmin University of ChinaBeijing 100872China School of Mathematics Sino-French InstituteRenmin University of ChinaBeijing 100872China

In this paper,the problem of identifying autoregressive-moving-average systems under random threshold binary-valued output measurements is *** the help of stochastic approximation algorithms with expanding truncations,the authors give the recursive estimates for the parameters of both the linear system and the binary *** reasonable conditions,all constructed estimates are proved to be convergent to the true values with probability one,and the convergence rates are also established.A simulation example is provided to justify the theoretical results.

关键词： α-mixing binary sensor quantized system stochastic approximation stochastic thresh-old strongly consistent system identification

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Chemical vapor deposition making better lithium-sulfur batteries

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Science Bulletin 2024年第13期69卷 2013-2016页

作者： Yingze song Lixian song Menglei Wang Wenlong Cai State Key Laboratory of Environment-Friendly Energy Materials School of Materials and ChemistrySouthwest University of Science and TechnologyMianyang 621010China School of Material Science and Engineering Henan University of TechnologyZhengzhou 450001China Department of Advanced Energy Materials College of Materials Science and EngineeringSichuan UniversityChengdu 610064China

The burgeoning demand for modern electronic devices and electric vehicles has driven the development of efficient,reliable,and environmentally friendly batteries[1,2].Lithium–sulfur(Li–S)batteries with high theoretical capacity(1672 mA h g1)and energy density(2600 W h kg1),have garnered significant interest in both academic and industrial research[3,4].However,the widespread production and commercialization of Li–S batteries are impeded by the inherent characteristics of sulfur and lithium,along with their complex electrochemical ***,challenges such as the polysulfide shuttle effect and the slow kinetics of the sulfur nucleation/decomposition reaction hinder capacity utilization and cycling *** overcome these challenges,innovative electrocatalyst strategies aimed at enhancing activity have been explored.

关键词： lithium overcome cycling

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