检索结果-南通市图书馆

Determining structural ensembles of flexiblemulti-domaTn proteins using small-angle X-rayscattering and molecular dynamics simulations

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Protein & Cell 2015年第8期6卷 619-623页

作者： yonghui zhang Bin Wen Junhui Peng Xiaobing Zuo Qingguo Gong Zhiyong zhang Hefei National Laboratory for Physical Science at Microscale and School of Life Sciences University of Science and Technology of China Hefei 230026 China Advanced Photon Source Argonne National Laboratory Chicago IL 60437 USA

Dear Editor, A multi-domain protein consists of two or more well-folded domains connected by flexible linkers, which may lead to large scale inter-domain motions related to the protein function. Therefore, it is appropriate to represent a flexible multi-domain protein by an ensemble of structures contain- ing multiple conformational states （Bernad5 and Blackledge, 2010）. Although X-ray crystallography is currently the most popular technique for structure determination, it would be rather challenging to solve structure of such a flexible multi- domain protein since it is hard to obtain high-quality crystals if the protein does not stabilize in a dominant conformation.

关键词： Nuclear Magnetic Resonance Domain Orientation Nuclear Magnetic Resonance Structure Root Mean Square Deviation SAXS Data

Natural Sesquiterpenoids, Diterpenoids, Sesterterpenoids, and Triterpenoids with Intriguing Structures from 2017 to 2022

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2023年第22期41卷 3115-3132页

作者： Xiaotian zhang Meijia Zheng Aimin Fu Qin Li Chunmei Chen Hucheng Zhu yonghui zhang Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation School of PharmacyTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China

This review covers the isolation,structural determination,plausible biosynthetic pathways,and biological activities of 166 natural terpenoids including 57 sesquiterpenoids,65 diterpenoids,15 sesterterpenoids,and 29 tr... 详细信息

关键词： Sesquiterpenoids Diterpenoids Sesterterpenoids Triterpenoids Structura scaffolds Biosynthetic pathways Structure elucidation Drug discovery

阶梯治疗儿童侵袭性复发性呼吸道乳头状瘤病1例

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中华耳鼻咽喉头颈外科杂志 2024年第8期59卷 867-871页

作者：鲁媛媛于振坤张永辉张庆宇胡慧英梁思萍周玉洁赵腾潘宇飞南京医科大学附属明基医院耳鼻咽喉头颈外科南京210019 南京医科大学附属明基医院影像科南京210019

患者,女,16岁,因“进行性声嘶加重、呼吸道乳头状瘤反复复发15年”入院。患者自1岁时出现声嘶外院就诊,喉镜示:喉肿物(复发性喉乳头状瘤?),遂行支撑喉镜下喉肿物切除术(具体术式不详),术后病理:喉乳头状瘤。术后4个月余复发,再次手术治... 详细信息

患者,女,16岁,因“进行性声嘶加重、呼吸道乳头状瘤反复复发15年”入院。患者自1岁时出现声嘶外院就诊,喉镜示:喉肿物(复发性喉乳头状瘤?),遂行支撑喉镜下喉肿物切除术(具体术式不详),术后病理:喉乳头状瘤。术后4个月余复发,再次手术治疗;后每间隔1~4个月复发并给予手术治疗,直至10岁;10~12岁手术间隔为1年;12~14岁时手术间隔约半年;14~15岁时手术间隔约3个月;共计接受手术40余次。15岁后乳头状瘤病变范围逐渐扩大,于2022年5月我院就诊。查体:喉部多发乳头状瘤,声带黏连,喉狭窄,肺内乳头状瘤播散。入院后,为患者制订阶梯治疗方案:先行全身贝伐珠单抗治疗(4次),喉部及肺内乳头状瘤病灶均明显缩小;后行经支撑喉镜CO 2激光喉乳头状瘤切除术+光动力治疗(3次),至今术后19个月喉部乳头状瘤未复发。目前进一步定期随访中。

关键词：乳头状瘤病喉乳头状瘤贝伐珠单抗肿物切除术支撑喉镜阶梯治疗喉狭窄光动力治疗

Diversity and Geographical Pattern of Altitudinal Belts in the Hengduan Mountains in China

在线全文

学校读者我要写书评

暂无评论

Journal of Mountain Science 2010年第2期7卷 123-132页

作者： YAO yonghui zhang Baiping HAN Fang, PANG Yu Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Beo'ing 100101 China.

This paper analyses the diversity and spatial pattern of the altitudinal belts in the Hengduan Mountains in China. A total of 7 types of base belts and 26 types of altitudinal belts are identified in the study region. The main altitudinal belt lines, such as forest line, the upper limit of dark coniferous forest and snow line, have similar latitudinal and longitudinal spatial patterns, namely, arched quadratic curve model with latitudes and concave quadratic curve model along longitudinal direction. These patterns can be together ealled as ＂Hyperbolic-paraboloid model＂, revealing the complexity and speciality of the environment and ecology in the study region. This result further validates the hypnosis of a common quadratic model for spatial pattern of mountain altitudinal belts proposed by the authors. The spatial pattern of altitudinal belts is closely related with moisture-related exposure effect in the Hengduan Mountains. Different combinations （spectra） of altitudinal belts and different base belt types appear in windward and leeward flanks and even in the same flanks of different ranges. This is closely related with the parallel mountain ranges of the Hengduan Mountains, which, at nearly right angle with the moving direction of prevailing moisture-laden air masses from west and east, hold up the warm and humid monsoon wind from moving into the core region and result in different moisture conditions in windward and leeward flanks. However, how to quantitatively describe the moisture-related exposure effect needs further study. In addition, the data quality and data accuracy at present also affect to some extent the result of quantitative modeling and should be improved with RS/GIS in the future.

关键词： Hengduan Mountains Altitudinal belt spectra Exposure effect Quadratic model

Effect of nitric oxide synthase inhibitor N^G-nitro-L-arginine on the content of amino acid in ischemic brain tissues of rats

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2006年第4期1卷 309-312页

作者： Jianxin zhang Huixin zhang Lanfang Li Qinzeng zhang yonghui Li Department of Pharmacology Hebei Academy of Medical Sciences Shijiazhuang 050021Hebei Province China

BACKGROUND： Nitric oxide synthase （NOS） inhibrtors have been widely used to investigate the role of NO on cerebral ischemic injury, but the results are controversial. Moreover, it has been considered to aggravate the ischemic neuronal damage with the release of excessively excitatory amino acids （EAA） during cerebral ischemia. On the other hand, some inhibitory amino acid is suggested to be important for the neuronal protection against ischemic brain damage. Our study has recently showed that treatment with the NOS inhibitor NG-nitro-L-arginine （L-NA） reduced focal cerebral ischemic damage. The effect of L-NA on the contents of excitatory and inhibitory amino acid in the rat brain following cerebral ischemia is still unclear. OBJECTIVE： By evaluating the effect of NOS inhibitor, L-NA on the contents of aspartate, glutamate, glycine and γ-aminobutyric acid （GABA） in striatum, hippocampus and cortex in the rat brain following cerebral ischemia respectively, to investigate the beneficial effect of L-NA on cerebral ischemic injury and the possible mechanism. DESIGN： A randomized and controlled experiment SETTING ： Department of Pharmacology, Hebei Academy of Medical Sciences MATERIALS： A total of 42 male healthy SD rats （grade Ⅱ, weighting 250-300 g） were provided by the Experimental Animal Center of Hebei Province （Certification： 04036）. Aspartate, glutamate, glycine, GABA, L-NA and 2,3,5-triphenyltetrazolium chloride （TTC） were obtained from Sigma Chemicals Co, St Louis, MO, USA. HPLC-ultraviolet detector system consisted of Agilent 1100 HPLC. METHODS： The experiment was carried out in Department of Pharmrcology, Hebei Academy of Medical Sciences from June 2005 to June 2006. Rats were randomly divided into three groups： sham-operated group （n = 6）, ischemic group （n = 18）, L-NA group （n = 18）. The model of focal cerebral ischemia in rat was prepared with intraluminal line occlusion methods. In sham-operated rats, the external carotid artery was surgically pr

关键词： acid Effect of nitric oxide synthase inhibitor N^G-nitro-L-arginine on the content of amino acid in ischemic brain tissues of rats

在线全文

学校读者我要写书评

暂无评论

耐高温茂金属催化剂催化乙烯与降冰片烯共聚

合成树脂及塑料 2024年第3期41卷 7-10,20页

作者：张永辉葛腾杰牟祥升窦洪鑫闫冰曹晨刚姜涛天津科技大学化工与材料学院天津300457 中国石油天然气股份有限公司石油化工研究院大庆化工研究中心黑龙江大庆163714

合成了一种用于乙烯与降冰片烯高温溶液共聚合的高活性耐高温茂金属催化剂,研究了反应温度、茂金属催化剂浓度、n(Al)∶n(Zr)、降冰片烯浓度等对催化剂活性的影响,并对乙烯-降冰片烯共聚物进行了分析和表征,确定了制备乙烯-降冰片烯共... 详细信息

合成了一种用于乙烯与降冰片烯高温溶液共聚合的高活性耐高温茂金属催化剂,研究了反应温度、茂金属催化剂浓度、n(Al)∶n(Zr)、降冰片烯浓度等对催化剂活性的影响,并对乙烯-降冰片烯共聚物进行了分析和表征,确定了制备乙烯-降冰片烯共聚物的高温溶液聚合工艺条件。结果表明:反应温度为140℃时,催化剂活性高达6.7×10^(6)g/(mol·h),催化剂寿命达到30 min以上。最佳聚合条件:反应温度为140℃,茂金属催化剂浓度为6×10^(-5)mol/L,乙烯压力为1 MPa,n(Al)∶n(Zr)为250,n(B)∶n(Zr)为1.1,反应时间为30 min;最佳聚合条件下共聚物中的降冰片烯插入率达34.44%(y),密度约为0.98 g/cm^(3),玻璃化转变温度为135.8℃。

关键词：茂金属催化剂乙烯-降冰片烯共聚物溶液聚合相对分子质量分布熔体流动速率

维普期刊数据库博看期刊

1972-2021年江苏省启东市结直肠癌发病流行趋势分析

在线全文

学校读者我要写书评

暂无评论

中国肿瘤 2024年第6期33卷 445-450页

作者：丁璐璐陈建国张永辉徐源佑陈永胜王军朱健启东市人民医院/启东肝癌防治研究所/南通大学附属启东医院江苏启东226200

[目的]分析江苏省启东市1972-2021年全人群结直肠癌发病流行趋势。[方法]基于启东市癌症登记病例数据库,提取1972-2021年结直肠癌发病登记资料,计算粗发病率、中国人口标化率(中标率)、世界人口标化率(世标率)、35~64岁截缩率、0~74岁... 详细信息

[目的]分析江苏省启东市1972-2021年全人群结直肠癌发病流行趋势。[方法]基于启东市癌症登记病例数据库,提取1972-2021年结直肠癌发病登记资料,计算粗发病率、中国人口标化率(中标率)、世界人口标化率(世标率)、35~64岁截缩率、0~74岁累积发病率、累积发病风险等。用Joinpoint Regression Program 4.***.1.0软件进行回归分析,计算结直肠癌发病率平均年度变化百分比(average annual percentage change,AAPC)。[结果]启东市1972-2021年共计发生结直肠癌11956例,占同期全部恶性肿瘤发病例数的8.11%;结直肠癌粗发病率为21.31/10万,中标率为8.18/10万,世标率为13.14/10万,35~64岁截缩率为19.34/10万,0~74岁累积发病率为1.55%,结直肠癌累积发病风险为1.54%。其中男性发病6176例,粗发病率、中标率、世标率分别为22.33/10万、9.18/10万、14.83/10万;女性发病5780例,粗发病率、中标率、世标率分别为20.33/10万、7.28/10万、11.64/10万。平均发病年龄1972年为60.27岁,1996年为64.52岁,至2021年上升为69.04岁,50年期间平均发病年龄为66.78岁。时间趋势结果显示1972-2021年男女合计、男性及女性粗发病率的AAPC分别为5.703%、6.511%及4.910%,上升趋势均有统计学意义(P均<0.001);中标率的AAPC分别为2.577%、3.283%及1.819%,上升趋势均有统计学意义(P均<0.001);世标率的AAPC分别为2.773%、3.470%、2.043%,上升趋势均有统计学意义(P均<0.001)。1972-2021年启东市结直肠癌各年龄组粗发病率随年龄增长而不断升高,45~54岁年龄组粗发病率的AAPC为2.543%(P=0.002),55~64岁年龄组AAPC为3.278%(P<0.001),65~74岁年龄组AAPC为2.845%(P<0.001),75岁及以上年龄组AAPC为3.413%(P<0.001),上述各年龄组结直肠癌粗发病率上升趋势均有统计学意义。[结论]启东市结直肠癌发病率呈现上升趋势,应针对重点人群做好防控措施,将45岁以上人群作为结直肠癌重点关注对象,推进重点人群结直肠癌筛查项目,提高早诊早治率,并且积极开展全民健康生活方式宣传活动,减少结直肠癌危险因素暴露,以降低启东市结直肠癌的发病水平。

关键词：结直肠癌发病率趋势流行病学江苏

宫腔镜冷刀微剪分离术后宫腔灌注粒细胞集落刺激因子对重度宫腔粘连患者的影响

在线全文

学校读者我要写书评

暂无评论

中国计划生育和妇产科 2024年第7期16卷 53-56页

作者：张永会胡红娟钱艳平云南省中医医院妇科云南昆明650021

目的分析宫腔镜冷刀微剪分离术后宫腔灌注粒细胞集落刺激因子(granulocyte colonystimulating factor,G-CSF)对重度宫腔粘连(intrauterine adhesions,IUA)患者的影响。方法回顾性选取2021年3月至2022年8月云南省中医医院重度IUA患者380... 详细信息

目的分析宫腔镜冷刀微剪分离术后宫腔灌注粒细胞集落刺激因子(granulocyte colonystimulating factor,G-CSF)对重度宫腔粘连(intrauterine adhesions,IUA)患者的影响。方法回顾性选取2021年3月至2022年8月云南省中医医院重度IUA患者380例,所有患者均接受宫腔镜冷刀微剪分离术及雌孕激素序贯治疗,依照治疗方案分组,术后接受节育器干预为对照组(180例),术后接受节育器+宫腔灌注G-CSF干预为观察组(200例)。比较两组疗效、治疗前后宫腔镜下子宫内膜美国生育协会(AFS)评分、子宫内膜厚度、子宫动脉及内膜血流参数[子宫动脉搏动指数(PI)、阻力指数(RI)、子宫内膜血管化血流指数(VFI)、血管化指数(VI)],观察两组治疗后6个月的复发率和妊娠率。结果观察组术后3个月总有效率(96.50%)高于对照组(89.44%),差异有统计学意义(P0.05)。结论宫腔镜冷刀微剪分离术后宫腔灌注G-CSF可有效改善重度IUA患者宫腔粘连情况、子宫内膜厚度、子宫动脉及内膜血流参数,降低复发风险。

关键词：宫腔镜微剪分离术粒细胞集落刺激因子重度宫腔粘连血流参数复发

Secure Multigroup Multicast Communication Systems via Intelligent Reflecting Surface

在线全文

学校读者我要写书评

暂无评论

China Communications 2021年第3期18卷 39-51页

作者： Weiping Shi Jiayu Li Guiyang Xia Yuntian Wang Xiaobo Zhou yonghui zhang Feng Shu School of Electronic and Optical Engineering Nanjing University of Science and TechnologyNanjing 210094China School of Information and Communication Engineering Hainan UniversityHaikou 570228China School of Physics and Electronic Engineering Fuyang Normal UniversityFuyang 236037China School of Electronic and Electrical Engineering Shangqiu Normal UniversityShangqiu 476000China

This paper considers a secure multigroup multicast multiple-input single-output(MISO)communication system aided by an intelligent reflecting surface(IRS).Specifically,we aim to minimize the transmit power at Alice via jointly optimizing the transmit beamformer,artificial noise(AN)vector and phase shifts at the IRS subject to the secrecy rate constraints as well as the unit modulus constraints of IRS phase *** tackle the optimization problem,we first transform it into a semidefinite relaxation(SDR)problem,and then alternately update the transmit beamformer and AN matrix as well as the phase shifts at the *** order to reduce the high computational complexity,we further propose a low-complexity algorithm based on second-order cone programming(SOCP).We decouple the optimization problem into two sub-problems and optimize the transmit beamformer,AN vector and the phase shifts alternately by solving two corresponding SOCP *** results show that the proposed SDR and SOCP schemes require half or less transmit power than the scheme without IRS,which demonstrates the advantages of introducing IRS and the effectiveness of the proposed methods.

关键词： intelligent reflecting surface multigroup multicast transmit beamformer secrecy rate phase shifts