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In Situ Investigation of Dynamic Silver Crystallization Driven by Chemical Reaction and Diffusion

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Research 2020年第1期2020卷 739-749页

作者： Ting Liu Xiangyu Dou yonghui xu Yongjun Chen Yongsheng Han State Key Laboratory of Multiphase Complex Systems Institute of Process EngineeringChinese Academy of Sciences100190 BeijingChina State Key Laboratory of Marine Resource Utilization in South China Sea Hainan University570228 HaikouChina School of Chemical Engineering University of Chinese Academy of Sciences100049 BeijingChina

Rational synthesis of materials is a long-term challenging issue due to the poor understanding on the formation mechanism of material structure and the limited capability in controlling nanoscale crystallization.The emergent in situ electron microscope provides an insight to this issue.By employing an in situ scanning electron microscope,silver crystallization is investigated in real time,in which a reversible crystallization is observed.To disclose this reversible crystallization,the radicals generated by the irradiation of electron beam are calculated.It is found that the concentrations of radicals are spatiotemporally variable in the liquid cell due to the diffusion and reaction of radicals.The fluctuation of the reductive hydrated electrons and the oxidative hydroxyl radicals in the cell leads to the alternative dominance of the reduction and oxidation reactions.The reduction leads to the growth of silver crystals while the oxidation leads to their dissolution,which results in the reversible silver crystallization.A regulation of radical distribution by electron dose rates leads to the formation of diverse silver structures,confirming the dominant role of local chemical concentration in the structure evolution of materials.

关键词： silver reversible crystallization

Analysis of factors affecting the prognosis of transcatheter arterial chemoembolization for hepatitis B-related hepatocellular carcinoma

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Journal of Interventional Medicine 2021年第2期4卷 66-70页

作者： Jiangping Cun yonghui xu Weidong Li Xingxiang Zhao Department of Radiology The Second Affiliated Hospital Kunming Medical University374 dianmian AvenueKunmingYunnanChina

Objectives:The purpose of this study was to investigate the prognostic factors for transcatheter arterial chemoembolization(TACE)for hepatitis B-related hepatocellular carcinoma(HCC).Materials and methods:The variables that may affect overall survival(OS),such as age,gender,AFP,Child Pugh classification,body mass index,HBV-DNA,Hbe Ag,tumor number,tumor diameter,BCLC stage,embolization method,ablation therapy,and targeted therapy,were analyzed by single factor and many factor COX regression.In addition,predictive factors of OS were stratified and a Kaplan-Meier survival curve was drawn.Results:Among the 136 patients,the median follow-up time was 14.5 months(range:2–72 months).HCC patients with the tumor diameter<3 cm had the highest survival rate,followed by patients with a tumor diameter of 3–5 cm;the survival rate of patients with the tumor diameter(greater than 5 cm)was the lowest.Among the BCLC stages,stage A patients had the highest survival rate,followed by stage B and stage C patients,which had the lowest survival rate.The survival rate of Child Pugh grade A patients was higher than those with Child Pugh grade B.Compared with patients who did not undergo ablation treatment,the survival rate of patients with combined ablation treatment was relatively high.The survival rate of patients receiving drug-eluting beads transarterial chemoembolization(DEB-TACE)treatment was higher than those receiving conventional transarterial chemoembolization(c TACE)treatment.Additionally,repeated TACE treatment improved the OS rate of patients.These six factors were related to patient prognosis and the differences were statistically significant(P<0.05).Conclusions:Tumor diameter,BCLC stage,TACE repetition,and TACE combined with ablation were independent prognostic factors of OS.

关键词： arterial prognosis transcatheter

伦理型领导对矿工避责行为的影响研究--一个链式中介模型

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中国安全生产科学技术 2024年第7期20卷 193-199页

作者：王莉景紫嫣徐永辉西安科技大学安全科学与工程学院陕西西安710054 中国电建集团北京勘测设计研究院有限公司北京100024

为研究伦理型领导对矿工避责行为的影响机制,构建多路径中介模型,探讨伦理型领导是如何通过影响矿工的状态责任感、组织认同、所处的制度环境及风险感知进而影响矿工避责行为的,并考量4个影响因素作为中介变量在伦理型领导与矿工避责行... 详细信息

为研究伦理型领导对矿工避责行为的影响机制,构建多路径中介模型,探讨伦理型领导是如何通过影响矿工的状态责任感、组织认同、所处的制度环境及风险感知进而影响矿工避责行为的,并考量4个影响因素作为中介变量在伦理型领导与矿工避责行为之间的中介作用。然后通过向煤矿发放问卷,构建结构方程模型验证理论假设。研究结果表明:伦理型领导能增强矿工的状态责任感、组织认同感和对制度规则的履行程度,而矿工的状态责任感、组织认同感和对制度规则的履行程度与矿工避责行为呈现显著负相关;状态责任感、组织认同、制度规则、风险感知4个中介变量在伦理型领导和矿工避责行为间起显著中介效应。研究结果可为煤矿企业通过优化领导方式、降低矿工进行避责行为可能性提供理论参考。

关键词：伦理型领导状态责任感组织认同制度规则风险感知避责行为

养殖水域Cu^(2+)胁迫对虹鳟MT2基因表达模式的影响

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环境科学与技术 2024年第2期47卷 96-103页

作者：周静卢军浩赵映灿徐永辉李湘茹巫佳俊权金强甘肃省生态环境科学设计研究院甘肃兰州730020 甘肃农业大学动物科学技术学院甘肃兰州730070

为了探究水体中铜离子胁迫对虹鳟(Oncorhynchus mykiss)MT2基因表达模式的影响,开发Metallothioneins作为检测水域生态中重金属铜污染的分子标志,该研究利用TA克隆法获得了虹鳟MT2基因的CDS序列,检测了MT2基因在虹鳟不同组织中的表达模... 详细信息

为了探究水体中铜离子胁迫对虹鳟(Oncorhynchus mykiss)MT2基因表达模式的影响,开发Metallothioneins作为检测水域生态中重金属铜污染的分子标志,该研究利用TA克隆法获得了虹鳟MT2基因的CDS序列,检测了MT2基因在虹鳟不同组织中的表达模式,以及Cu^(2+)胁迫(Cu^(2+)浓度75、150和300μg/L)后1、2、3和4 d和胁迫恢复1、2 d时间点的MT2基因表达动态。结果表明,虹鳟MT2基因CDS区长186 bp,编码62个氨基酸,具有典型的半胱氨酸(Cys)-X(1~3个)-半胱氨酸结构,属不稳定亲水性蛋白。虹鳟MT2基因序列与大西洋鲑的同源性最高且在肝脏中表达量最高,其次是脑和肠道。胁迫试验结果显示,MT2基因在肝脏和鳃中呈现先升高后降低的趋势,在头肾、脾脏和脑中呈现逐渐升高的趋势,且呈现一定的剂量依赖性,肠道MT2基因在胁迫2、3和4 d被显著抑制。胁迫恢复后,处理组肝脏、头肾、鳃、脑MT2基因表达量仍显著升高。综上,虹鳟MT2基因能在不同组织中被Cu^(2+)诱导表达,推测MT2基因在虹鳟抗重金属毒性中可能发挥着重要作用,且MT2基因表达量与铜离子的浓度相关,可以作为分子生物标志检测水域生态中的重金属铜污染。

关键词：虹鳟 MT2基因铜离子胁迫基因克隆表达模式

Fe-Zn alloy, a new biodegradable material capable of reducing RoS and inhibiting oxidative stress

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Regenerative Biomaterials 2024年第2期3卷 114-122页

作者： Shuaikang Yang Weiqiang Wang Yanan xu yonghui Yuan Shengzhi Hao School of Materials Science and Engineering Dalian University of TechnologyDalian 116024PR China Clinical Research Center for Malignant Tumor of Liaoning Province Cancer Hospital of Dalian University of TechnologyShenyang 110042PR China

Fe-based biodegradable materials have attracted significant attention due to their exceptional mechanical properties and favorable biocompatibility.Currently,research on Fe-based materials mainly focuses on regulating the degradation rate.However,excessive release of Fe ions during material degrada-tion will induce the generation of reactive oxygen species(ROS),leading to oxidative stress and ferroptosis.Therefore,the con-trol of RoS release and the improvement of biocompatibility for Fe-based materials are very important.In this study,new Fe-Zn alloys were prepared by electrodeposition with the intention of using Zn as an antioxidant to reduce oxidative damage during alloy degradation.Initially,the impact of three potential degra-dation ions(Fe^(2+),Fe^(3+),Zn^(2+))from the Fe-Zn alloy on human endothelial cell(EC)activity and migration ability was investigated.Subsequently,cell adhesion,cell activity,ROs production and DNA damage were assessed at various locations surrounding the alloy.Finally,the influence of different concentrations of Zn^(2+) in the medium on cell viability and ROS production was evaluated.High levels of ROS exhibited evident toxic effects on ECs and promoted DNA damage.As an antioxidant,Zn?+effectively reduced ROS production around Fe and improved the cell viability on its surface at a concentration of 0.04 mmol/l.These findings demonstrate that Fe-Zn alloy can attenuate the ROS generated from Fe degradation therebyenhancingcytocompatibility.

关键词： biodegradable iron Fe-Zn alloys reactive oxygen species oxidative stress cytocompatibility

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诱发药物性白癜风的相关药物及发病机制

临床皮肤科杂志 2024年第2期53卷 123-125页

作者：徐永慧陈佳玲董丹丹林玉凤王洁娣史建强广东医科大学附属医院皮肤科广东湛江524001 北京大学深圳医院皮肤科深圳518035

药物性白癜风是指系统应用或者局部使用某种药物后,皮肤出现色素脱失斑。药物性白癜风一般较少见,但近年来随着新药的不断问世和药品品种的增加,尤其是生物制剂应用的增加,药物性白癜风报道有增多的趋势。值得注意的是,药物性白癜风与... 详细信息

药物性白癜风是指系统应用或者局部使用某种药物后,皮肤出现色素脱失斑。药物性白癜风一般较少见,但近年来随着新药的不断问世和药品品种的增加,尤其是生物制剂应用的增加,药物性白癜风报道有增多的趋势。值得注意的是,药物性白癜风与寻常型白癜风在形态学与组织学上有些差异,而且部分药物性白癜风与原有疾病的预后有一定的相关性,一些可用于缓解寻常型白癜风患者疾病进展的药物在治疗其他疾病时,亦可诱发白癜风。该文就引起药物性白癜风的常见药物种类及其发病机制作一概述,为临床诊断提供参考。

关键词：白癜风药物发病机制

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铁死亡在皮肤疾病中的研究进展

中国皮肤性病学杂志 2024年第3期38卷 344-348页

作者：林玉凤李芳谷徐永慧董丹丹王倩黄亮梅史建强广东医科大学附属医院皮肤科广东湛江524001

铁死亡是一种铁依赖性的新型程序性细胞死亡方式,主要特征包括脂质过氧化、铁离子过载和活性氧堆积。铁死亡受胱氨酸/谷氨酸逆向转运体、谷胱甘肽过氧化物酶4、铁死亡抑制蛋白-1等多种因子及通路严密调控。铁死亡与多种疾病密切相关,本... 详细信息

铁死亡是一种铁依赖性的新型程序性细胞死亡方式,主要特征包括脂质过氧化、铁离子过载和活性氧堆积。铁死亡受胱氨酸/谷氨酸逆向转运体、谷胱甘肽过氧化物酶4、铁死亡抑制蛋白-1等多种因子及通路严密调控。铁死亡与多种疾病密切相关,本文综述了铁死亡的特征、机制以及铁死亡在皮肤疾病的最新研究进展,包括皮肤黑素瘤、皮肤鳞状细胞癌、系统性红斑狼疮、银屑病及其他皮肤病等,为皮肤疾病的诊疗提供新的思路。

关键词：铁死亡黑素瘤鳞状细胞癌系统性红斑狼疮银屑病皮肤疾病

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生物制剂在毛发红糠疹治疗中的应用

中国皮肤性病学杂志 2024年第2期38卷 223-226页

作者：徐永慧林玉凤陈佳玲董丹丹黄亮梅王倩史建强广东医科大学广东湛江524023 广东医科大学附属医院皮肤科广东湛江524000 北京大学深圳医院广东深圳518036

毛发红糠疹(PRP)是一种病因不明的以黄红色鳞屑性斑片及角化性毛囊性丘疹为特征的慢性炎症性皮肤病,在临床上可分为6种类型。治疗上主要以系统应用维A酸类药物及免疫抑制剂等传统治疗为主,长期使用易发生严重不良反应且有时治疗效果欠... 详细信息

毛发红糠疹(PRP)是一种病因不明的以黄红色鳞屑性斑片及角化性毛囊性丘疹为特征的慢性炎症性皮肤病,在临床上可分为6种类型。治疗上主要以系统应用维A酸类药物及免疫抑制剂等传统治疗为主,长期使用易发生严重不良反应且有时治疗效果欠佳。近年来一些学者使用生物制剂治疗PRP取得一定疗效,尤其是对于一些难治性的PRP患者,本文就生物制剂在PRP临床治疗中的应用作一综述。

关键词：毛发红糠疹治疗生物制剂单克隆抗体

Debris Flow Susceptibility Evaluation in Meizoseismal Region:A Case Study in Jiuzhaigou,China

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Journal of Earth Science 2024年第1期35卷 263-279页

作者： Yongwei Li Linrong xu yonghui Shang Shuyang Chen School of Civil Engineering Central South UniversityChangsha 410075China National Engineering Research Center of High-Speed Railway Construction Technology Central South UniversityChangsha 410075China School of Civil Engineering Central South University of Forestry and TechnologyChangsha 410004China

Jiuzhaigou is situated on a mountain-canyon region and is famous for frequent tectonic activities.An abundance of loose co-seismic landslides and collapses were produced on gullies after the Jiuzhaigou Earthquake on August 8,2017,which was served as material source for debris flow in later years.Debris flow appears frequently which are seriously endangering the safety of people's lives and properties.Even the earliest debris flow appeared in areas where no case ever reported before.The debris flow susceptibility evaluation(DFSE)is used for predicting the areas prone to debris flow,which is urgently required to avoid hazards and help to guide the strategy of preventive measures.Therefore,this work employs debris flow in Jiuzhaigou to reveal the characteristics of disaster-pregnant environment and to explore the application of machine learning in DFSE.Some new viewpoints are suggested:(i)Material density factor of debris flow is first adopted in this work,and it is proved to be a critical factor for triggering debris flows by sensitivity analysis method.(ii)Deep neural network and convolutional neural network(CNN)achieve relatively good area under the curve(AUC)values and are 0.021-0.024 higher than traditional machine learning methods.(iii)Watershed units combined with CNNbased model can achieve more accurate,reliable and practical susceptibility map.This work provides an idea for prevention of debris flow in mountainous lands.

关键词： machine learning earthquakes debris flow susceptibility convolutional neural network deep neural network watershed unit