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The proposed role of MSL-lncRNAs in causing sex lability of female poplars

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Horticulture Research 2023年第5期10卷 29-37页

作者： Jinyan Mao Suyun Wei Yingnan Chen yonghua yang Tongming Yin State Key Laboratory for Tree Genetics and Breeding Co-Innovation Center for Sustainable Forestry in Southern ChinaKey Laboratory of Tree Genetics and Biotechnology of Educational Department of ChinaKey Laboratory of Tree Genetics and Breeding of Jiangsu ProvinceNanjing Forestry UniversityNanjing210037China Institute for Plant Molecular Biology State Key Laboratory of Pharmaceutical BiotechnologySchool of Life SciencesNanjing UniversityNanjing 210023China

Labile sex expression is frequently observed in dioecious plants,but the underlying genetic mechanism remains largely *** plasticity is also observed in many Populus *** we carried out a systematic study on a maleness-promoting gene,MSL,detected in the Populus deltoides *** results showed that both strands of MSL contained multiple cis-activating elements,which generated long non-coding RNAs(lncRNAs)promoting *** female *** did not have the male-specific MSL gene,a large number of partial sequences with high sequence similarity to this gene were detected in the female poplar *** on sequence alignment,the MSL sequence could be divided into three partial sequences,and heterologous expression of these partial sequences in Arabidopsis confirmed that they could promote *** activation of the MSL sequences can only result in female sex lability,we propose that MSL-lncRNAs might play a role in causing sex lability of female poplars.

关键词： female similarity alignment

Metformin for cancer prevention

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Frontiers of Medicine 2011年第2期5卷 115-117页

作者： yonghua yang School of Pharmacy Fudan UniversityShanghai 201203China

Metformin,a safe and inexpensive drug widely used to lower blood glucose in type 2 diabetics,is the most popular anti-diabetic drug in the United States with more than 42 million prescriptions in *** was developed from the French lilac plant(Galega officinalis)in the 1950s and was approved by the FDA in the mid-1990s as *** is also increasingly being used in the treatment of various diseases not directly related to diabetes,such as polycystic ovarian syndrome(PCOS),non-alcoholic fatty liver disease(NAFLD),premature puberty[1],and cardiovascular diseases[2].Recently,metformin has been attracting much attention as a potential anti-cancer agent to act across a broad spectrum of cancers[3].

关键词： prevention Metformin NAFLD

Sex effect on growth performance and marker-aided sex discrimination of seedlings of Populus deltoides

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Journal of Forestry Research 2023年第5期34卷 1639-1645页

作者： Yingnan Chen Huaitong Wu Xiaogang Dai Weiqiang Li Yu Qiu yonghua yang Tongming Yin Co-Innovation Center for Sustainable Forestry in Southern China Key Laboratory of Tree Genetics and Biotechnology of Educational Department of ChinaKey Laboratory of Tree Genetics and Sivilcultural Sciences of Jiangsu ProvinceNanjing Forestry UniversityNanjing 210037People’s Republic of China Institute for Plant Molecular Biology State Key Laboratory of Pharmaceutical BiotechnologySchool of Life SciencesNanjing UniversityNanjing 210023People’s Republic of China

Sex has a significant effect on various traits among dioecious *** this analysis of the sex effect on the radial growth and wood density of numerous 20-yearold trees of Populus deltoides growing in a common garden,male trees performed better than the females in radial growth,but sex did not significantly affect wood *** rate and wood density were weakly negatively *** selection is also critical for controlling seed-hair pollution from *** ***,because the juvenile period of *** lasts for years,a reliable technique to determine the sex of juveniles has been *** we developed a marker-aided technique to discriminate the sexes of *** *** study provides essential information on target traits and a highly desirable genetic toolkit for accelerate breeding programs for this important tree species.

关键词： Sex effect Wood quality Growth performance Marker-aided selection Sex discrimination

Trimming of N-Glycans by the Golgi-Localized α-1,2-Mannosidases, MNS1 and MNS2, Is Crucial for Maintaining RSW2 Protein Abundance during Salt Stress in Arabidopsis

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Molecular Plant 2018年第5期11卷 678-690页

作者： Chuanfa Liu Guanting Niu Huchen Zhang Yafei Sun Shubin Sun Fugen Yu Shan Lu yonghua yang Jianming Li Zhi Hong State Key Laboratory of Pharmaceutical Biotechnology NJU Advanced Institute for Life Sciences (NAILS) School of Life Sciences Nanjing University Nanjing 210023 China State Key Laboratory of Crop Genetics and Germplasm Enhancement College of Resources and Environmental Science Nanjing Agricultural University Nanjing 210095 China Department of Molecular Cellular and Developmental Biology University of Michigan Ann Arbor MI 48109 USA Shanghai Center for Plant Stress Biology Shanghai Institutes for Biological Sciences The Chinese Academy of Sciences Shanghai 201602 China

Asparagine （Asn/N）-Iinked glycans are important for protein folding, trafficking, and endoplasmic reticulum-associated degradation in eukaryotes. The maturation of glycoproteins involves the trimming of mannosyl residues by mannosidases and addition of other sugar molecules to three-branched N-glycans in the Golgi. However, the biological importance of Golgi-mediated mannose trimming is not fully understood. Here, we show that abolishment of two functionally redundant mannosidases, MNS1 and MNS2, responsible for α-1,2-mannose trimming on the A and C branches of plant N-glycans lead to severe root growth inhibition under salt stress conditions in Arabidopsis. In contrast, mutants with defects in the biosynthesis of the oligosaccharide precursor displayed enhanced salt tolerance in the absence of mannose trimming. However, mutation in EBS3, which is required for the formation of the branched N-glycan precursor, suppressed the salt-sensitive phenotype of mnsl mns2 double mutant. Interestingly, we observed that cellulose biosynthesis was compromised in mnsl mns2 roots under high salinity. Consistently, abundance of a membrane anchored endo-13-1,4-endoglucanase （RSW2/KOR） that plays a key role in cellulose biosynthesis and its mutant variant rsw2-1 were modulated by α-1,2-mannose trimming under salt stress. Overexpression of RSW2 could partially rescue the salt-sensitive phenotype of mnsl mns2. Taken together, these results suggest that MNS1/2-mediated mannose trimming of N-glycans is crucial in modulating glycoprotein abundance to withstand salt stress in plants.

关键词： N-glycan Golgi α-mannosidase I salt tolerance Arabidopsis

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软因素：中国经济发展的根本原因

南京社会科学 2009年第1期 17-22页

作者：杨永华华南师范大学经济与管理学院教授、博导广州510631

改革开放以来中国经济持续快速发展的原因是一个令人着迷的题目,提出了不少假设,然而很遗憾的是,这些原因都是根据硬因素得出的结论。硬因素虽然符合发展经济学的经典理论,但是与中国实际相差甚远。本文认为,探索中国经济发展的原因不... 详细信息

改革开放以来中国经济持续快速发展的原因是一个令人着迷的题目,提出了不少假设,然而很遗憾的是,这些原因都是根据硬因素得出的结论。硬因素虽然符合发展经济学的经典理论,但是与中国实际相差甚远。本文认为,探索中国经济发展的原因不仅根据硬因素理论,还要根据软因素理论,因而得出解放思想、中国特色社会主义理论是改革开放以来中国经济持续快速发展的根本原因的结论。

关键词：经济发展硬因素软因素解放思想中国特色社会主义理论

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与剥削泛化论商榷

马克思主义研究 2010年第1期 139-144页

作者：杨永华华南师范大学经济与管理学院

在剥削问题的讨论中出现了一种把剥削泛化的倾向,就是作者把自己认为的所有不公平不合理的经济和非经济现象都称为剥削。于是得出劳动剥削资本,智力劳动剥削体力劳动,技术密集型企业剥削劳动密集型企业,消费者剥削生产者,以及生产者剥... 详细信息

在剥削问题的讨论中出现了一种把剥削泛化的倾向,就是作者把自己认为的所有不公平不合理的经济和非经济现象都称为剥削。于是得出劳动剥削资本,智力劳动剥削体力劳动,技术密集型企业剥削劳动密集型企业,消费者剥削生产者,以及生产者剥削消费者,等等。剥削泛化论把全社会每一个人都看成剥削者或被剥削者,这是不符合马克思的剩余价值理论和历史唯物主义原理,是对社会主义市场经济现实的曲解。

关键词：剥削剥削阶级剩余价值历史唯物主义

论柏拉图-孟子定理和卓炯定理在政治经济学中的地位

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学术研究 2005年第9期 10-15页

作者：杨永华华南师范大学经济与管理学院

在文化性和技术性的层面上,马克思主义经济学和西方经济学、古代经济思想有若干相同或者近似的研究方法和理论观点。如柏拉图-孟子定理、斯密定理和卓炯定理都是用分工来论证商品交换的必要性,都在分工的基础上构成自己的经济学理论体... 详细信息

在文化性和技术性的层面上,马克思主义经济学和西方经济学、古代经济思想有若干相同或者近似的研究方法和理论观点。如柏拉图-孟子定理、斯密定理和卓炯定理都是用分工来论证商品交换的必要性,都在分工的基础上构成自己的经济学理论体系。充分认识和理解分工理论的重要性,对于政治经济学建设有重要的理论意义。

关键词：马克思主义经济学柏拉图-孟子定理斯密定理卓炯定理社会分工

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论马克思的公有制实现形式理论

广东社会科学 2005年第6期 23-28页

作者：杨永华华南师范大学经济与管理学院广州510631

马克思的公有制理论包括资本所有权归属理论和实现形式理论。公有制实现形式理论的核心是所有权与经营权的分离形式。公有制与市场经济相容的关键不在于所有权,而在于所有制的实现形式。国有企业改革的实质,不是否定国家所有制,而是调... 详细信息

马克思的公有制理论包括资本所有权归属理论和实现形式理论。公有制实现形式理论的核心是所有权与经营权的分离形式。公有制与市场经济相容的关键不在于所有权,而在于所有制的实现形式。国有企业改革的实质,不是否定国家所有制,而是调整国家所有制的实现形式。判断混合所有制的性质不能只根据资本所有权的归属,而是要分析其实现形式。

关键词：马克思公有制公有制实现形式国有企业

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马克思关于技术变迁的演化经济思想

经济学家 2007年第4期 65-70页

作者：杨勇华华南师范大学经济管理学院广东广州510006

几乎所有的演化经济学家都承认,马克思的确是位有着丰富演化思想的经济学家,而这一点在其有关技术变迁的理论中表现得尤为突出。马克思在关于技术与社会的关系、关于技术的本质、关于技术进步的累积过程和选择过程,以及关于技术消失的... 详细信息

几乎所有的演化经济学家都承认,马克思的确是位有着丰富演化思想的经济学家,而这一点在其有关技术变迁的理论中表现得尤为突出。马克思在关于技术与社会的关系、关于技术的本质、关于技术进步的累积过程和选择过程,以及关于技术消失的考察中都广泛地应用了生物学隐喻研究方法,蕴含着丰富而深邃的演化经济思想和洞见,这也为后人继续研究和发展一种技术变迁的演化理论指明了方向。

关键词：马克思技术变迁演化