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Silencing of the long non-coding RNA LINC00265 triggers autophagy and apoptosis in lung cancer by reducing protein stability of SIN3A oncogene

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Oncology Research 2024年第7期32卷 1185-1195页

作者： XIAOBI HUANG CHUNYUAN chen YONGYANG chen HONGLIAN ZHOU yonghua chen ZHONG HUANG YULIU XIE BAIYANG LIU YUDONG GUO ZHIXIONG YANG GUANGHUA chen WENMEI SU Department of Pulmonary Oncology Affiliated Hospital of Guangdong Medical UniversityZhanjiang524001China Department of Thoracic Surgery Affiliated Hospital of Guangdong Medical UniversityZhanjiang524001China Department of Orthopedics Affiliated Hospital of Guangdong Medical UniversityZhanjiang524001China Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-Communicable Diseases Affiliated Hospital of Guangdong Medical UniversityZhanjiang524001China

Background:Long non-coding RNAs are important regulators in cancer biology and function either as tumor suppressors or as oncogenes.Their dysregulation has been closely associated with tumorigenesis.LINC00265 is upregulated in lung adenocarcinoma and is a prognostic biomarker of this cancer.However,the mechanism underlying its function in cancer progression remains poorly understood.Methods:Here,the regulatory role of LINC00265 in lung adenocarcinoma was examined using lung cancer cell lines,clinical samples,and xenografts.Results:We found that high levels of LINC00265 expression were associated with shorter overall survival rate of patients,whereas knockdown of LINC00265 inhibited proliferation of cancer cell lines and tumor growth in xenografts.Western blot andﬂow cytometry analyses indicated that silencing of LINC00265 induced autophagy and apoptosis.Moreover,we showed that LINC00265 interacted with and stabilized the transcriptional co-repressor Switch-independent 3a(SIN3A),which is a scaffold protein functioning either as a tumor repressor or as an oncogene in a context-dependent manner.Silencing of SIN3A also reduced proliferation of lung cancer cells,which was correlated with the induction of autophagy.These observations raise the possibility that LINC00265 functions to promote the oncogenic activity of SIN3A in lung adenocarcinoma.Conclusions:Ourﬁndings thus identify SIN3A as a LINC00265-associated protein and should help to understand the mechanism underlying LINC00265-mediated oncogenesis.

关键词： LINC00265 Autophagy Lung adenocarcinoma(LUAD) Cancer progression Switch-independent 3a(SIN3A)

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Erratum to:Efficient and stable perovskite solar cells by build-inπ-columns and ionic interfaces in covalent organic frameworks

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Nano Research 2024年第5期17卷 4639-4640页

作者： Riming Nie Xiaokai chen Zhongping Li Weicun Chu Si Ma Changqing Li Xiaoming Liu yonghua chen Zhuhua Zhang Wanlin Guo State Key Laboratory of Mechanics and Control of Mechanical Structures Key Laboratoryfor Itligent Nano Materials and Devices of the Ministry of EducationInstitute for Frontier ScienceNanjing University of Aeronautics and AstronauticsNarnjing 210016China Department of Chemical and Biomolecular Engineering Yonsei Universit50 Yonsei roSeodaemun-guSeoul 120749Republic of Korea College of Chemistry jilin UniversityChangchun 130012China Department of Energy and Chemical Engineering Ulsan National Instute of Science and Technology(UNIST)50 UNIST-gilEonyang-eupUju-gunUlsan 44919Republic of Korea Key Laboratory of Flexible Electronics(KLoFE) School of Flexible Electronics(Future Technologies)&Institute of Advanced Materials(IAM)Nanjing Tech University(Nanjing Tech)Nanjing 211816China

Erratum to Nano Research,2023,16(7):9387-9397 htps:/oi.or/0.100/1274-023-5603-040(1)One sentence in the article was unfortunately mispresented on page 9392.Instead of As shown in Fig.S19 in the ESM,the A2/A2 values of... 详细信息

关键词： COF columns perovskite

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Constraint Learning-based Optimal Power Dispatch for Active Distribution Networks with Extremely Imbalanced Data

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CSEE Journal of Power and Energy Systems 2024年第1期10卷 51-65页

作者： yonghua Song Ge chen Hongcai Zhang State Key Laboratory of Internet of Things for Smart City and Department of Electrical and Computer Engineering University of MacaoMacao 999078China School of Electrical and Computer Engineering Purdue UniversityWest LafayetteIN 47907 USA

Transition towards carbon-neutral power systems has necessitated optimization of power dispatch in active distribution networks(ADNs)to facilitate integration of distributed renewable generation.Due to unavailability of network topology and line impedance in many distribution networks,physical model-based methods may not be applicable to their operations.To tackle this challenge,some studies have proposed constraint learning,which replicates physical models by training a neural network to evaluate feasibility of a decision(i.e.,whether a decision satisfies all critical constraints or not).To ensure accuracy of this trained neural network,training set should contain sufficient feasible and infeasible samples.However,since ADNs are mostly operated in a normal status,only very few historical samples are infeasible.Thus,the historical dataset is highly imbalanced,which poses a significant obstacle to neural network training.To address this issue,we propose an enhanced constraint learning method.First,it leverages constraint learning to train a neural network as surrogate of ADN's model.Then,it introduces Synthetic Minority Oversampling Technique to generate infeasible samples to mitigate imbalance of historical dataset.By incorporating historical and synthetic samples into the training set,we can significantly improve accuracy of neural network.Furthermore,we establish a trust region to constrain and thereafter enhance reliability of the solution.Simulations confirm the benefits of the proposed method in achieving desirable optimality and feasibility while maintaining low computational complexity.

关键词： Deep learning demand response distribution networks imbalanced data optimal power flow

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Deciphering the high-carbonization-temperature triggered enzymatic activity of wool-derived N,S-co-doped carbon nanosheets

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Chinese Chemical Letters 2024年第3期35卷 182-188页

作者： Jiachen Zhao Deshuai Yu Jianmin chen Shihao Lin yonghua Tang Chaoyu Fan Dongfang Zhou Youhui Lin Department of Physics Research Institute for Biomimetics and Soft MatterFujian Provincial Key Laboratory for Soft Functional Materials ResearchXiamen UniversityXiamen 361005China School of Pharmacy and Medical Technology Putian UniversityPutian 351100China Key Laboratory of Mental Health of the Ministry of Education NMPA Key Laboratory for Research and Evaluation of Drug Metabolism&Guangdong Provincial Key Laboratory of New Drug ScreeningSchool of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China Key Laboratory of Pharmaceutical Analysis and Laboratory Medicine(Putian University) Fujian Province UniversityPutian 351100China

It is well-established that high carbonization temperature will trigger the enzyme-like activity of carbon-based materials.However,the catalytic mechanism is still ambiguous,which hinders the further rational design of nanomaterials as enzyme mimics.Hereby,N,S-rich carbonized wool nanosheets(CWs)were synthesized at different pyrolysis temperatures.As expected,only CWs treated with high-temperature possess intrinsic oxidase-and peroxidase-like activities.Meanwhile,density functional theory(DFT)calculations demonstrate that graphitic nitrogen and the co-existence of nitrogen and sulfur in the carbon matrix serve as the active sites for the enzyme-like process.More importantly,combining theoretical calculations and experimental observations,the high-temperature triggered catalytic mechanism can be ascribed to the fact that an appropriate high-temperature maximizes the graphitization degree to a certain extent,at which most of the catalytic active sites are well retained rather than evaporating.Moreover,coupling with excellent photothermal conversion efficiency and catalytic performance,CWs can be applied to photothermal-catalytic cancer therapy under near-infrared region(NIR)light irradiation.We believe this work will contribute to understanding the catalytic mechanism of carbon-based nanozymes and promote the development of new biomedical and pharmaceutical applications.

关键词： Carbon-based nanozyme Catalytic mechanism Density functional theory High-temperature carbonization

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Development of Slippery Liquid-Infused Porous Surface on AZ31 Mg Alloys for Corrosion Protection

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Acta Metallurgica Sinica(English Letters) 2023年第2期36卷 229-236页

作者： Wenhui Yao yonghua chen Yanning chen Liang Wu Bin Jiang Fusheng Pan College of Materials Science and Engineering Chongqing UniversityChongqing400044China National Engineering Research Center for Magnesium Alloys Chongqing UniversityChongqing400044China

The relatively poor corrosion resistance remarkably limits the wide applications of Mg alloys in practice,although they possess many attractive properties,like low density,high specific strength,and good biocompatibility.The formation of a protective coating can effectively suppress the corrosion.In this work,a slippery liquid-infused porous surface(SLIPS),with good surface hydrophobicity,stability,and self-healing property,was formed on AZ31 Mg alloys.The development of SLIPS requires suitable porous micro/nanostructures.Layered double hydroxide(LDH),with effective corrosion resistance for Mg alloys,was a good candidate to accommodate the liquid lubricant.Especially,different temperatures were applied to in situ form MgAl-LDH on AZ31 Mg alloys.The results showed that the temperature of 120℃was the best condition for the SLIPS to provide good corrosion protection for Mg alloys,with the lowest corrosion current density of 3.19×10^(-9)A cm^(−2).In addition,the SLIPS performed well in the long-term immersion test and abrasion test.The AZ31 Mg alloys with superior corrosion resistance and good mechanical and chemical stability can be extensively applied in areas of automotive,electronics,and aerospace.

关键词： Mg alloy Hydrothermal temperature Corrosion protection Slippery liquid-infused porous surface Hydrophobicity Surface stability

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The opportunities and challenges of ionic liquids in perovskite solar cells

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Journal of Energy Chemistry 2023年第2期77卷 157-171,I0005页

作者： Jian Yang Jianfei Hu Wenhao Zhang Hongwei Han yonghua chen Yue Hu Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074HubeiChina Key Laboratory of Flexible Electronics(KLOFE)&Institution of Advanced Materials(IAM) Nanjing Tech University(NanjingTech)30 South Puzhu RoadNanjing 211816JiangsuChina

Metal halide perovskite solar cells(PSCs)have shown great potential to become the next generation of photovoltaic devices due to their simple fabrication techniques,low cost,and soaring power conversion efficiency(PCE).However,mismatched with the quickly updated PCEs,the improvement of device stability is challenging and still remains a critical hurdle in the path to commercialization.Recently,ionic liquids(ILs)have been found to play multiple roles in obtaining efficient and stable PSCs.These ILs usually consist of large organic cations and organic or inorganic anions,which have weak electrostatic attraction and are generally liquid at around 100℃.ILs are almost non-volatile,non-flammable,with high ionic conductivity and excellent thermal and electrochemical stability.The roles of ILs in PSCs vary with their composition,that is,the types of anions and cations.In this review,we summarize the roles of anions and cations in terms of precursor solutions,additives,perovskite/charge transport layer interface engineering,and charge transport layers.This article aims to set up a structure–property-stability-performance correlations conferred by the IL in PSC and provide assistance for the anion and cation selection for improving the quality of perovskite film,optimizing interface contact,reducing defect states,and improving charge extraction and transport characteristics.Finally,the application of IL in PSCs is discussed and prospected.

关键词： Perovskite solar cells Ionic liquid Anions and cations Additive Interface engineering

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A universal ionic liquid solvent for non-halide lead sources in perovskite solar cells

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Journal of Energy Chemistry 2022年第8期31卷 445-451,I0012页

作者： Yue chen Yamin Xu Jin Liu Yuexin Lin Jianfei Hu chensi Cao Yingdong Xia yonghua chen Key Laboratory of Flexible Electronics(KLOFE)and Institute of Advanced Materials(IAM) Nanjing Tech UniversityNanjing 211816JiangsuChina

Replacing lead iodide(PbI_(2))with suitable non-halides lead source has been found to be an effective method to control crystallization and fabricate high-performance perovskite solar cells(PSCs).However,the solubility of non-halide lead sources is highly limited by traditional solvents due to the chemical interaction limitation.Here,we report a series of non-halide lead sources(e.g.,lead acetate(PbAc_(2)),lead sulfate(PbSO_(4)),lead carbonate(PbCO_(3)),lead nitrate(Pb(NO_(3))_(2)),lead formate(Pb(HCOO)_(2))and lead oxalate(PbC_(2)O_(4)))can be well dissolved in an ionic liquid solvent methylammonium acetate(MAAc).We found that the universal strong coordination of C=O with lead ion(Pb^(2+))and the formation of hydrogen bonds were observed in perovskite precursor solution.This allows the dissolution of non-halide lead salts and is able to produce perovskite film with smooth,compact,and full coverage crystal grain.The power conversion efficiency(PCE)of 14.48%,19.21%,and 20.13%in PSCs based on PbSO_(4),PbAc_(2),and PbCO_(3) was achieved,respectively,in the absence of any additives and passivation agents.This study demonstrates the universality of ionic liquid for the preparation of PSCs based on nonhalides lead sources.

关键词： Efficiency Non-halide lead Precursor components Perovskite solar cells Universality

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Cardiovascular risk burden,dementia risk and brain structural imaging markers:a study from UK Biobank

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General Psychiatry 2024年第1期37卷 94-102页

作者： Yaying Cao Gaohong Zhu chengwu Feng Jing chen Wei Gan Yuan Ma yonghua Hu Klodian Dhana Trudy Voortman Jie Shen Ting Li Yan Zheng Changzheng Yuan Geng Zong Department of Food Nutrition and Health School of Medicine and HealthHarbin Institute of TechnologyHarbinHeilongjiangChina CAS Key Laboratory of Nutrition Metabolism and Food SafetyShanghai Institute of Nutrition and HealthChinese Academy of SciencesShanghaiChina Department of Nuclear Medicine First Affiliated Hospital of Kunming Medical UniversityKunmingYunnanChina Neurology Department Zhongshan Hospital Affliated with Fudan UniversityShanghaiChina Medical Research Council Population Health Research Unit University of OxfordOxfordUK Department of Genetics Novo Nordisk Research Centre OxfordOxfordUK Harvard University T H Chan School of Public Health BostonMassachusettsUSA Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijingChina Department of Internal Medicine Rush University Medical CenterChicagolinoisUSA Department of Epidemiology rasmus MCUniversity Medical Center RotterdamRotterdamThe Netherlands Division of Human Nutrition and Health Wageningen University&ResearchWageningenThe Netherlands School of Public Health the Second Afliated HospitalZhejiang University School of MedicineHangzhouZhejiangChina First Afiliated Hospital of Kunming Medical University KunmingYunnanChina State Key Laboratory of Genetic Engineering School f ife SCciencesFudan UniversityShanghaiChina Ministry of Education Key Laboratory of Public Health Safety School of Public HealthFudan UniversityShanghaiChina The Key Laboratory of Inteligent Preventive Medicine of Zhejang Province HangzhouZhejiangChina Shanghai Jiao Tong University Affiliated Sixth People's Hospital ShanghaiChina

Background Cardiovascular risk burden is associated with dementia risk and neurodegeneration-related brain structure,while the role of genetics and incident cardiovascular disease(CVD)remains unclear.Aims To examine the association of overall cardiovascular risk burden with the risk of major dementia subtypes and volumes of related brain regions in a large sample,and to explore the role of genetics and CVD onset.Methods A prospective study among 354 654 participants free of CVD and dementia(2006-2010,mean age 56.4 years)was conducted within the UK Biobank,with brain magnetic resonance imaging(MRl)measurement availablefor 15104participants since 2014.CVD risk burden was evaluated by the Framingham General Cardiovascular Risk Score(FGCRS).Dementia diagnosis was ascertained from inpatient and death register data.Results Overamedian 12.0-yearfollow-up,3998 all-cause dementia cases were identified.Higher FGCRS was associated with increasedall-cause dementia risk after adjusting for demographic,major lifestyle,clinical factors and the polygenic risk score(PRS)of Alzheimer's disease.Comparing the high versus low tertile of FGCRS,the odds ratios(ORs)and 95%confidence intervals(Cls)were 1.26(1.12 to 1.41)for all-cause dementia,1.67(1.33 to 2.09)for Alzheimer's disease and 1.53(1.07 to 2.16)for vascular dementia(all p_(treng)<0.05).Incident stroke and coronary heart disease accounted for 14%(95%Cl:9% to 21%)of the association between FGCRS and all-cause dementia.Interactions were not detected for FGCRS and PRS on the risk of any dementia subtype.We observed an 83%(95%Cl:47%to 128%)higher all-cause dementia risk comparing the high-high versus low-low FGCRS-PRS category.For brain volumes,higher FGCRS was associated with greater log-transformed white matter hyperintensities,smaller cortical volume and smaller grey matter volume.Conclusions Our findings suggest that the positive association of cardiovascular risk burden with dementia risk also applies to major dementia subtypes.The association of cardiovascular risk burden wit

关键词： Cardiovascular diagnosis burden

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Stabilizing wide-bandgap halide perovskites through hydrogen bonding

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Science China Chemistry 2022年第8期65卷 1650-1660页

作者： Lei Tao Xiaoqin Du Jianfei Hu Shixuan Wang chen Lin Qi Wei Yingdong Xia Guichuan Xing yonghua chen Key Laboratory of Flexible Electronics(KLOFE)&Institution of Advanced Materials(IAM) Nanjing Tech University(Nanjing Tech)Nanjing 211816China Joint Key Laboratory of the Ministry of Education Institute of Applied Physics and Materials Engineering University of MacaoMacao SAR 999078China

Wide-bandgap(WBG)perovskites have emerged as promising materials for the construction of perovskite/silicon tandem solar cells.However,poor long-term operational stability due to the notorious photo-induced halide segregation is commonly observed.Here,we report the synthesis of stable~1.73 eV MA-based mixed I/Br WBG perovskites by ionic liquid solvent,methylammonium acetate(MAAc).The special internal hydrogen bond(N–H…I and N–H…Br)environment in the ionic liquid MAAc solvent over traditional N,N-dimethylformamide/dimethyl sulfoxide solvent stabilizes the diffusion of halide ions.This allows the suppression of the halide segregation in the mixed I/Br WBG perovskite film,which is previously suggested to be difficult.The hydrogen bonds also enable excellent decoupling of the crystal nucleation and growth process.Finally,a champion device efficiency of 20.59%is achieved,which is one of the highest reports,with improved ambient air,heat,and light stability.

关键词： wide-bandgap perovskite hydrogen bonds perovskite solar cells ionic liquid

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Multi-objective optimization design of anti-roll torsion bar using improved beluga whale optimization algorithm

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Railway Sciences 2024年第1期3卷 32-46页

作者： yonghua Li Zhe chen Maorui Hou Tao Guo School of Locomotive and Rolling Stock Engineering Dalian Jiaotong UniversityDalianChina Railway Science and Technology Research and Development Center China Academy of Railway Sciences Corporation LimitedBeijingChina CRCC Tangshan Railway Vehicles Co Ltd. CRRC Tangshan Co LtdTangshanChina

Purpose – This study aims to reduce the redundant weight of the anti-roll torsion bar brought by thetraditional empirical design and improving its strength and stiffness.Design/methodology/approach – Based on the finite element approach coupled with the improved belugawhale optimization (IBWO) algorithm, a collaborative optimization method is suggested to optimize the designof the anti-roll torsion bar structure and weight. The dimensions and material properties of the torsion bar weredefined as random variables, and the torsion bar’s mass and strength were investigated using finite elements.Then, chaotic mapping and differential evolution (DE) operators are introduced to improve the beluga whaleoptimization (BWO) algorithm and run case studies.Findings – The findings demonstrate that the IBWO has superior solution set distribution uniformity,convergence speed, solution correctness and stability than the BWO. The IBWO algorithm is used to optimizethe anti-roll torsion bar design. The error between the optimization and finite element simulation results wasless than 1%. The weight of the optimized anti-roll torsion bar was lessened by 4%, the maximum stress wasreduced by 35% and the stiffness was increased by 1.9%.Originality/value – The study provides a methodological reference for the simulation optimization process ofthe lateral anti-roll torsion bar.

关键词： Anti-roll torsion bar Multi-objective optimization IBWO Chaotic mapping Differential evolution

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