检索结果-南通市图书馆

The effects of surface morphology on the aerosol performance of spray-dried particles within HFA 134a based metered dose formulations

引用

Asian Journal of Pharmaceutical Sciences 2015年第6期10卷 513-519页

作者： Feifei Yang Xiaobin Liu Wei Wang Chunyu Liu Lihui Quan Yonghong Liao Institute of Medicinal Plant Development(IMPLAD) Chinese Academy of Medical Sciences&Peking Union Medical CollegeNo.151 Malianwa North RoadHaidian DistrictBeijing 100193China

The aim of this study was to produce fine particles with different corrugated degree of surface by spray-drying and to investigate the effect of surface morphology on in vitro aerosol performance of the particles within HFA 134a based metered dose formulations.Compositions of rizatriptan and scutellarin were spray-dried using different spray-drying parameters,and particles were suspended within HFA 134a.The surface morphology were determined using scanning electron microscopy(SEM),while the aerodynamic performance of MDIs was evaluated using a next generation pharmaceutical impactor.The surface morphology of spraydried particles could vary from smooth to moderately corrugated,and to raisin-like depending upon spray-drying parameters and preparation compositions.In general,increasing inlet temperature,decreasing feed concentration and/or adding leucine to the feed solution tended to increase the corrugated degree of particle surface.Deposition results indicated that raisinlike particle based MDIs for all compositions of the two drugs produced significantly better aerodynamic performance in terms of fine particle fractions and mass median aerodynamic diameters relative to the formulations of the corresponding smooth or slightly corrugated particles when the particle compositions were the same.The present results demonstrated that wrinkled particles increased fine particle fractions within surfactant-free MDI formulations.

关键词： Spray-drying Raisin-like/wrinkled particles Metered dose inhaler Rizatriptan Scutellarin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

First Isolation and Characterization of Ochrobactrum anthropi from Pig

引用

Engineering 2020年第1期6卷 49-55页

作者： Shijiang Gu Ruiqing Hou Shengguo Gao Zhe Sun Xiangdong Li Lufeng Zhai Yunyun Jin Qiaoyan Zhu Yonghong Liao Kegong Tian National Research Center for Veterinary Medicine Luoyang 471000China College of Animal Science and Veterinary Medicine Henan Agricultural UniversityZhengzhou 450002China

One Gram-negative Bacillus was isolated from a brain sample of a pig with neurological symptoms.Pathological examination showed meningitis at necropsy. Ochrobactrum anthropi (O. anthropi) was successfully isolated from the brain sample and was confirmed by biochemical reaction results (API 20 NE) and gene sequencing. The strain was highly resistant to b-lactam antibiotics. Mice were experimentally infected with O. anthropi and showed typical meningitis. This is the first report on O. anthropi isolated from a pig, and indicates that O. anthropi may have a broader host spectrum of infection.

关键词： Ochrobactrum anthropi Pig brain

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Synthesis of two-dimensional transition metal dichalcogenides for electronics and optoelectronics

引用

InfoMat 2021年第4期3卷 362-396页

作者： Min Wu yonghong Xiao Yang Zeng Yuanliang Zhou Xiangbin Zeng Lining Zhang Wugang liao College of Electronic and Information Engineering Insitute of Microscale Opteletronics Shenzhen Engineering Laboratory of Phosphorene and OptoelectronicsSZU-NUS Collaborative Innovation Centre for Optoelectronic Science and TechnologyKey Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong ProvinceShenzhen UniversityShenzhenPeople's Republic of China Shenzhen Geim Graphene Center Tsinghua Berkeley Shenzhen Institute and Tsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhenPeople's Republic of China Laboratory for Optoeletronic Devices and Informnation Integration School of Optical and electronic InformationHuazhong Universty of Science and TechnologyWuhanPeople's Republic of China School of Electronic and Computer Engineering Peking UniversityShenzhenPeople's Republic of China

Tremendous efforts have been devoted to preparing the ultrathin two-dimensional(2D)transition-metal dichalcogenides(TMDCs)and TMDCS-based heterojunctions owing to their unique properties and great potential applications in next generation electronics and optoelectronics over the past decade.However,to fulfill the demands for practical applications,the batch production of 2D TMDCs with high quality and large area at the mild condi-tions is still a challenge.This feature article reviews the state-of-the art research progresses that focus on the preparation and the applications in elec-tronics and optoelectronics of 2D TMDCs and their van der Waals hetero-junctions.First,the preparation methods including chemical and physical vapor deposition growth are comprehensively outlined.Then,recent progress on the application of fabricated 2D TMDCs based materials is revealed with particular attention to electronic(eg,field effect transistors and logic circuits)and optoelectronic(eg,photodetectors,photovoltaics,and light emitting diodes)devices.Finally,the challenges and future prospects are considered based on the current advance of 2D TMDCs and related heterojunctions.

关键词： electronic and optoelectronic application transition metal dichalcogenides two-dimensional materials van der Waals heterojunctions

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Real-time rapid prediction of variations of Earth's rotational rate

引用

Chinese Science Bulletin 2008年第7期53卷 969-973页

作者： WANG QiJie liao DeChun ZHOU yonghong Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 China Graduate University of Chinese Academy of Sciences Beijing 100039 China School of Info-Physics and Geomatics Engineening Central South University Changsha 410083 China

Real-time rapid prediction of variations of the Earth's rotational rate is of great scientific and practical importance. However, due to the complicated time-variable characteristics of variations of the Earth's rotational rate (i.e., length of day, LOD), it is usually difficult to obtain satisfactory predictions by con-ventional linear time series analysis methods. This study employs the nonlinear artificial neural net-works (ANN) to predict the LOD variations. The topology of the ANN model is determined by minimizing the root mean square errors (RMSE) of the predictions. Considering the close relationships between the LOD variations and the atmospheric circulation movement, the operational prediction series of axial atmospheric angular momentum (AAM) is incorporated into the ANN model as an additional input in the real-time rapid prediction of LOD variations with 1-5 days ahead. The results show that the LOD pre-diction is significantly improved after introducing the operational prediction series of AAM into the ANN model.

关键词：地球转动频率变量预测方法地球科学

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

PtCoNi ternary intermetallic compounds anchored on Co,Ni and N co-doped mesoporous carbon:Synergetic effect between PtCoNi nanoparticles and doped mesoporous carbon promotes the catalytic activity

引用

Journal of Energy Chemistry 2023年第3期78卷 340-349,I0010页

作者： Chaozhong Li Weiyue Zhao Xueyi Lu Zhangsen Chen Bing Han Xiaorong Zhang Jiaxiang Chen Yijia Shao Junlang Huo Yuexiang Zhu yonghong Deng Shuhui Sun Shijun liao The Key Laboratory of Fuel Cell Technology of Guangdong Province&The Key Laboratory of New Energy Technology of Guangdong Universities School of Chemistry and Chemical EngineeringSouth China University of TechnologyGuangzhou 510641GuangdongChina School of Materials Sun Yat-sen UniversityShenzhen 518107GuangdongChina Centre énergie Matériaux et TélécommunicationsInstitute National de la Recherche ScientifiqueVarennesQuébec J3X 1P7Canada Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055GuangdongChina

Highly active and robust electrocatalysts are desired for proton exchange membrane fuel cells.Pt-based intermetallic compounds(IMCs) have been recognized as one of the most promising low-platinum catalysts for fuel cells(FCs).Herein,we report a high-performance IMCs by anchoring ordered PtCoNi ternary nanoparticles on the N,Co and Ni co-doped dodecahedral mesoporous carbon(DMC).While the introduced Co and Ni participate in the formation of PtCoNi IMCs,some of them are doped in the mesoporous carbon and coordinated by N to form Co-N_(y)/Ni-N_(z)dual active centers,which further enhances the electrocatalytic activity towards oxygen reduction reaction.Moreover,the addition of Ni results in a negative shift of the d-band center of Pt as compared to the Pt/DMC and Pt_(3)Co/DMC,making it easier to adsorb oxygen on the surface.As expected,our optimal sample Pt_(3)Co_(0.7)Ni_(0.3)/DMC exhibits excellent performance with mass activity and specific activity of 1.32 A mgPt-1and 1.98 mA cm^(-2)at 0.9 V,which are 7.33and 6.19 times that of commercial Pt/C,respectively.The Pt_(3)Co_(0.7)Ni_(0.3)/DMC also reveals much better cathodic performance in an H2-air single fuel cell than commercial Pt/C catalyst with a power density of0.802 W cm^(-2).This work provides critical sights into constructing efficient catalysts by ternary intermetallic strategy and synergetic effect between active components and support.

关键词： Ternary intermetallic compounds Oxygen reduction reaction Fuel cell Catalyst

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

POLARIZATION IMAGING AND SCATTERING MODEL OF CANCEROUS LIVER TISSUES

引用

Journal of Innovative Optical Health Sciences 2013年第3期6卷 91-98页

作者： DONGZHI LI HONGHUI HE NAN ZENG E DU RAN liao yonghong HE HUI MA Shenzhen Key Laboratory for Minimal Invasive Medical Technologies Graduate School at Shenzhen Tsinghua University Shenzhen 518055P.R.China Department of Physics Tsinghua University Beijing 100084P.R.China

We apply diferent polarization imaging techniques for cancerous liver tissues,and compare the relative contrasts for difference polarization imaging(DPI),degree of polarization imaging(DOPI)and rotating linear polarization imaging(RLPI).Experimental results show that a number of polarization imaging parameters are capable of differentiating cancerous cells in isotropic liver tisues.To analyze the contrast mechanism of the cancer:-sensitive polarization imaging parameters,we propose a scattering model cont aining two types of spherical scatterers and carry on Monte Carlo simula tions based on this bi-component model.Both the experimental and Monte Carlo simulated results show that the RLPI technique can provide a good imaging contrast of cancerous tissues.The bi-component scattering model provides a useful tool to ana-lyze the contrast mechanism of polarization imaging of cancerous tissues.

关键词： Polarization imaging liver cancerous tisues sca tering model Monte Carlo si mul ation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Influence of absorption in linear polarization imaging of melanoma tissues

引用

Journal of Innovative Optical Health Sciences 2014年第3期7卷 59-66页

作者： Dongzhi Li Honghui He Nan Zeng Weidong Xie Ran liao Jian Wu yonghong He Hui Ma Shenzhen Key Laboratory for Minimal Invasive Medical Technologies Graduate School at Shenzhen Tsinghua UniversityShenzhen 518055P.R.China Department of Physics Tsinghua University Beijing 100084P.R.Chinat

The contrast mechanism of different polarization imaging techniques for melanoma in mouse skin is st udied using both experiments and Monte Carlo simulations.Total intensity,linear polariz-ation diference imaging(DPI),degree of polarization imaging(DOPI)and'rotating linearpolarization imaging(RLPl)are applied and the relative contrasts of these polarization imagingmethods between the normal and cancerous tissues are compared.A two-layer absorption-scat-tering model is proposed to explain the contrast mechanism of the polarization imaging formelanoma.By taking into account of both scattering of symmetrical and asymmetrical scat terersand absorption of inter-scatterer medium,the two-layer model reproduces the relative con trastsfor polarization images observed in experiments.The simulation results also show that,theparameters of polarization imaging change more dramatically with the variation of absorption inthe bottom layer than the top layer.

关键词： Polarization imaging melanoma two-layer model Monte Carlo simulation.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A STUDY ON PENETRATION DEPTH OF POLARIZATION IMAGING

引用

Journal of Innovative Optical Health Sciences 2010年第3期3卷 177-181页

作者： RAN liao NAN ZENG DONGZHI LI TIANLIANG YUN yonghong HE HUI MA Laboratory of Optical Imaging and Sensing Graduate School at Shenzhen Tsinghua University Shenzhen 518055China Key Laboratory for Molecular and Nanosciences of Education Ministry Department of Physics Tsinghua University Beijing 100084China

Optical clearing improves the penetration depth of optical measurements in turbid tissues.Polarization imaging has been demonstrated as a potentially promising tool for detecting cancers in superficial tissues,but its limited depth of detection is a major obstacle to the effective application in clinical diagnosis.In the present paper,detection depths of two polarization imaging methods,i.e.,rotating linear polarization imaging(RLPI)and degree of polarization imaging(DOPI),are examined quantitatively using both experiments and Monte Carlo simulations.The results show that the contrast curves of RLPI and DOPI are different.The characteristic depth of DOPI scales with transport mean free path length,and that of RLPI increases slightly with g.Both characteristic depths of RLPI and DOPI are on the order of transport mean free path length and the former is almost twice as large as the latter.It is expected that they should have different response to optical clearing process in tissues.

关键词： Polarization imaging penetration depth optical scattering

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Improved oral bioavailability of Cajaninstilbene acid using metabolism-inhibitory self-miroemulsion

Improved oral bioavailability of Cajaninstilbene acid using ...

引用

2018年第十二届中国药物制剂大会

作者：姬赐玉 FeiFei Yang RuiLe Pan Qi Chang YuBin Ji Yonghong Liao Institute of Medicinal Plant Development （IMPLAD） Chinese Academy of Medical Sciences ＆ Peking Union Medical College Life Sciences and Environmental Sciences Center Harbin University of Commerce

Cajaninstilbene acid（CSA）, a natural phenolic compound with extensive phar-macological activities, exhibits limited oral bioavailability due to intestinal udp-glucu-ronictransferase（UGT）-mediated metabolism. Therefore, we hypothesized that involving UGT inhibitors in formulation is an effective way to improve the oral bioavailability of CSA. The purpose of this study was to the bioavailability of CSA using UGT-enzyme inhibitors containing self-microemulsion（SME）. we set out to prepare SME-1 with UGT inhibitory pharmaceutical excipients（SME prepared from excipients without inhibitory activities named SME-2）, and compared pharmacokinetics of CSA and CSA-G（metabolite of CSA） after oral administration of SME-1, SME-2 and free drug. Higher CSA（Fig.A） level, reduced CSA-G（Fig.B） level and increased systemic bioavailability were observed post SME-1 administration compared with SME-2 and free drug. In vivo results demonstrated that the molar ratios of CSA-G/CSA were 133.18±21.74 and 87.52±4.56 for free drug and SME-2, respectively. It decreased to 45.31±8.42 in SME-1 group. Remarkably, production of CSA-G reduced 29.70% and 47.9% in SME-1 relative to SME-2 and free drug. Pharmacokinetic study confirmed the potential of UGT inhibitory excipients containing SME in increasing bioavailability of CSA through inhibiting glucuronidation. In conclusion, involving of UGT inhibitory excipients in SME formulation is an approach to improve oral bioavailability of those undergoing UGT-mediated intestinal metabolism.

关键词： Cajaninstilbene acid self-microemulsion udp-glucuronictransferase

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

超声在重力锤型鼻肠管置入中的应用价值

引用

中国超声医学杂志 2023年第4期39卷 425-428页

作者：熊盛廖甜肖勇洪长沙市中医医院(长沙市第八医院)超声影像科长沙市中医医院(长沙市第八医院)肾病风湿免疫科

目的探讨超声在重力锤型鼻肠管置入中的应用价值。方法回顾性分析40例经超声引导的重力锤型鼻肠管置入术，总结超声引导重力锤型鼻肠管通过幽门的操作要点，并归纳超声评估十二指肠内鼻肠管位置的应用经验。结果 (1)超声引导重力锤型... 详细信息

目的探讨超声在重力锤型鼻肠管置入中的应用价值。方法回顾性分析40例经超声引导的重力锤型鼻肠管置入术，总结超声引导重力锤型鼻肠管通过幽门的操作要点，并归纳超声评估十二指肠内鼻肠管位置的应用经验。结果 (1)超声引导重力锤型鼻肠管置入术40例，术后经腹部X线摄影证实鼻肠管均成功置入小肠。(2)术中经超声证实39例鼻肠管成功置入患者十二指肠内，1例因肠腔胀气超声无法识别小肠内鼻肠管。结论超声引导下置入重力锤型鼻肠管并评估小肠内鼻肠管位置是安全、成功率高且价廉的方法，是重力锤型鼻肠管置入术的首选手段，但胃肠胀气严重则可能影响操作及评估，应及时选用其他方案。

关键词：超声引导鼻肠管置入术重力锤型鼻肠管肠内营养幽门十二指肠

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：