检索结果-南通市图书馆

Boron-Stereogenic Compounds:Synthetic Developments and Opportunities

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2024年第19期42卷 2401-2411页

作者： yonghong guo Bing Zu Cadmus Du Chen Chuan He Key laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education Key Laboratory of Chemical Biology of Hebei ProvinceCollege of Chemistry and Materials ScienceHebei UniversityBaodingHebei 071002China Shenzhen Grubbs Institute and Department of Chemistry Guangdong Provincial Key Laboratory of CatalysisSouthern University of Science and TechnologyShenzhenGuangdong 518055China

Comprehensive Summary The 21st century has witnessed a continuous evolution in the development of boron-stereogenic *** the 1990s,various innovations for the synthesis of tetracoordinate boron-stereogenic compounds,which exhibited great potential applications,have been demonstrated by synthetic *** paper reviews the significant progress and recent advances towards the assembly of enantioenriched boron-stereogenic compounds,and hopes to shed light on new perspectives and inspire further research in this emerging field.

关键词： Chiral organoboron Boron-stereogenic compounds Chiral resolution Asymmetric synthesis Asymmetric catalysis Chirality Heterocycles Chelates

Sialyltransferase ST3GAL6 silencing reduces α2,3-sialylated glycans to regulate autophagy by decreasing HSPB8-BAG3 in the brain with hepatic encephalopathy

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第6期25卷 485-498页

作者： Xiaocheng LI Yaqing XIAO Pengfei LI Yayun ZHU yonghong guo Huijie BIAN Zheng LI Laboratory for Functional Glycomics College of Life SciencesNorthwest UniversityXi’an 710069China National Translational Science Center for Molecular Medicine Department of Cell BiologyFourth Military Medical UniversityXi’an 710032China Medical Experiment Center Shaanxi University of Chinese MedicineXianyang 712046China The Infectious Disease Department Gongli HospitalPudong New AreaShanghai 200135China

End-stage liver diseases,such as cirrhosis and liver cancer caused by hepatitis B,are often combined with hepatic encephalopathy(HE);ammonia poisoning is posited as one of its main pathogenesis *** is closely related to autophagy,but the molecular mechanism of ammonia’s regulatory effect on autophagy in HE remains *** is an essential form of *** the nervous system,abnormal sialylation affects various physiological processes,such as neural development and synapse ***3 β-galactoside α2,3-sialyltransferase 6(ST3GAL6)is one of the significant glycosyltransferases responsible for addingα2,3-linked sialic acid to substrates and generating glycan *** found that the expression of ST3GAL6 was upregulated in the brains of mice with HE and in astrocytes after ammonia induction,and the expression levels of α2,3-sialylated glycans and autophagy-related proteins microtubule-associated protein light chain 3(LC3)and Beclin-1 were upregulated in ammonia-induced *** findings suggest that ST3GAL6 is related to autophagy in ***,we aimed to determine the regulatory relationship between ST3GAL6 and *** found that silencing ST3GAL6 and blocking or degrading α2,3-sialylated glycans by way of Maackia amurensis lectin-II(MAL-II)and neuraminidase can inhibit *** addition,silencing the expression of ST3GAL6 can downregulate the expression of heat shock proteinβ8(HSPB8)and Bcl2-associated athanogene 3(BAG3).Notably,the overexpression of HSPB8 partially restored the reduced autophagy levels caused by silencing ST3GAL6 *** results indicate that ST3GAL6 regulates autophagy through the HSPB8-BAG3 complex.

关键词： Hepatic encephalopathy Hyperammonemia Autophagy ST3β-galactosideα2,3-sialyltransferase 6(ST3GAL6) Heat shock proteinβ8(HSPB8)

Stability mechanism and control of the pumpable supports in longwall recovery room

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Mining Science and Technology 2024年第7期34卷 957-974页

作者： Dong Zhang Jianbiao Bai Zhijun Tian Zizheng Zhang yonghong guo Rui Wang Ying Xu Hao Fu Shuai Yan Min Deng Shuaigang Liu State Key Laboratory of Coal Resources and Safe Mining China University of Mining and TechnologyXuzhou 221116China Key Laboratory of Xinjiang Coal Resources Green Mining Xinjiang Key Laboratory of Coal-bearing Resources Exploration and ExploitationXinjiang Engineering Research Center of Green Intelligent Coal MiningXinjiang Institute of EngineeringUrumqi 830023China Work Safety Key Laboratory on Prevention and Control of Gas and Roof Disasters for Southern Goal Mines Hunan Provincial Key Laboratory of Safe Mining Techniques of Coal MinesHunan University of Science and TechnologyXiangtan 411201China School of Mines China University of Mining and TechnologyXuzhou 221116China

The load-bearing performance(LBP)of pumpable supports(PPS)is crucial for the stability of longwall pre-driven recovery room(PRR)surrounding ***,the unbalanced bearing coefficient(UBC)of the PPS(undertaking unequal load along the mining direction)has not been investigated.A mechanical model of the PRR was established,considering the main roof cantilever beam structure,to derive an assessment formula for the load,the failure criteria,and the UBC of the ***,the generation mechanisms,and influencing factors of the UBC were *** sensitivity analysis shows that the main roof hanging length(l_(2))and the spacing between the PPS(r)significantly impact the UBC.A novel design of the PPS and the coupling control technology were proposed and applied to reduce the UBC of the PPS in the adjacent longwall *** results showed no failure of the PPS at the test site,with the UBC(ζ)reduced to 1.1 consistent with the design value(1.15)basically,fully utilizing the collaborative LBP of the ***,the maximum roof-to-floor convergence of the PRR was 234 mm,effectively controlling the stability of the surrounding rock of the PRR and ensuring the mining equipment recovery.

关键词： Pre-driven recovery room Pumpable supports Unbalanced bearing coefficient Hydraulic fracture Stability analysis Surrounding rock control

维普期刊数据库

Interferon-α enhanced CD100/Plexin-B1/B2 Interactions Regulate Natural Killer Cell Functions during Infection with Chronic Hepatitis C Virus

在线全文

学校读者我要写书评

暂无评论

Interferon-α enhanced CD100/Plexin-B1/B2 Interactions Regul...

Interferon-α enhanced CD100/Plexin-B1/B2 Interactions Regulate Natural Killer Cell Functions during Infection with Chronic Hepatitis C Virus

中华医学会第四届全国病毒性肝炎慢性化、重症化基础与临床研究进展学术会议

作者： Yu He yonghong guo Ying Zhang Zhansheng Jia Department of Infectious Diseases and Center of Liver Diseases Tangdu Hospitalthe Fourth Military Medical University

Background & Aims CD100,also known as Sema4 D,is an immune semaphorin constitutively expressed on natural killer(NK) cells and T *** an adhesion molecule,CD100 has important immunoregulatory e

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Interferon-α enhanced CD100/Plexin-B1/B2 Interactions Regul...

第四届全国病毒性肝炎慢性化、重症化基础与临床研究进展学术会议

作者： Yu He yonghong guo Ying Zhang Zhansheng Jia Department of Infectious Diseases and Center of Liver Diseases Tangdu Hospitalthe Fourth Military Medical University

Background&Aims CD100,also known as Sema4D,is an immune semaphorin constitutively expressed on natural killer(NK)cells and T *** an adhesion molecule,CD100 has important immunoregulatory effects on NK functions by enhancing the adhesion between NK cells and target *** aim of this work was to investigate whether hepatitis C virus infection affect CD100 expression,and subsequently interferon-αtreatment enhance NK killing activity and facili-

关键词： HCV Interferon enhanced CD100/Plexin-B1/B2 Interactions Regulate Natural Killer Cell Functions during Infection with Chronic Hepatitis C Virus

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

基于卷积和注意力机制的小样本目标检测

兵工学报 2023年第11期44卷 3508-3515页

作者：郭永红牛海涛史超郭铖中国兵器工业计算机应用技术研究所北京100089 北京理工大学机械与车辆学院北京100081

小样本目标检测(FSOD)旨在使检测器只用少量的训练样本就能适应未见的类别。典型的FSOD方法使用Faster R-CNN作为基本检测框架,利用卷积神经网络提取图像特征,而卷积神经网络中采用的旨在捕获尽可能多的图像信息的池化操作将不可避免地... 详细信息

小样本目标检测(FSOD)旨在使检测器只用少量的训练样本就能适应未见的类别。典型的FSOD方法使用Faster R-CNN作为基本检测框架,利用卷积神经网络提取图像特征,而卷积神经网络中采用的旨在捕获尽可能多的图像信息的池化操作将不可避免地导致图像信息的丢失。在主干网络中引入混合扩张卷积,以确保更大的感受野并最大限度地减少图像信息的损失。在k-shot设置中,为充分利用给定的支持数据,提出支持特征动态融合模块,以每个支持特征和查询特征之间的相关性为权重,自适应地融合支持特征,以获得更强大的支持线索。实验结果表明,新方法在公共Pascal VOC和MS-COCO数据集上实现了较好的FSOD性能。

关键词：小样本目标检测混合扩张卷积支持特征动态融合

维普期刊数据库博看期刊

同方期刊数据库

Biomimetic Syntheses of Callistrilones A-E via an Oxidative [3 + 2] Cycloaddition

在线全文

学校读者我要写书评

暂无评论

Biomimetic Syntheses of Callistrilones A-E via an Oxidative ...

STUDIES ON THE CHARACTERISTICS OF THE HONEY-BEE SPIROPLASMA IN CHINA

中国化学会·第十五届全国有机合成化学学术研讨会

作者： yonghong guo Yuhan Zhang Mingxing Xiao 谢志翔 State Key Laboratory of Applied Organic Chemistry & College of Chemistry and Chemical Engineering Lanzhou University 兰州大学

Callistrilones A(2) and B(3) were isolated from Callistemon rigidus(Myrtaceae). Bioactivity research showed that 2 has moderate activity against Gram-positive bacteria, including multiresistant *** unprecedented pentacyclic ring system, and the biosynthetic pathways feature have inspired us to engage in total syntheses of these two *** recently, Li and co-workers isolated callistrilones C-E, which are closely related to callistrilones A and B in structure, and accomplished the elegant catalytic asymmetric total syntheses of callistrilones A, C, D and E. Almost at the same time, callistrilones A, B, and D were biomimetically synthesized via catalytic Friedel-Crafts alkylation and palladium-catalyzed Wacker-type oxidative cyclization by Dethe. Following our syntheses of callistrilones A and B, callistrilones C-E were also synthesized by us with the same ***, we report these new biomimetic syntheses of callistrilones A-E. The synthetic strategy, which was primarily inspired by the biogenetic hypothesis, was enabled by an oxidative [3 + 2] cycloaddition of 7 and 8, followed by a Michael addition and an intramolecular nucleophilic addition to construct the target ***, Viminalin I(12) was also synthesized with its absolute configuration being unambiguously confirmed.

关键词： callistrilones biomimetic synthesis oxidative [3 + 2] cycloaddition

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Science in China,Ser.B 1988年第9期31卷 1073-1079页

作者：陈永萱薛宝娣郭永红 Department of Plant Protection Nanjing Agricultural University

Spiroplasma has been successfully isolated from the honey bee （Apis mellifera） and cultivated in R-2 medium in China. The isolate, CH-1 is obtained through triple cloning. CH-1 shows a helical morphology and a contractile movement. It is 0.17 μm in diameter and its length varies considerably with different growth periods. CH-1 forms granular-type and/or fried-egg-shaped colonies, 75—210 μm in diameter, on R-2 medium. It grows normally at temperatures ranging 25—35℃ （the optimum being 28—32℃）. The optimal pH for growth is 7.0. The best growth occurs in medium containing 0.25 mol/L of sucrose. Under the optimal condition, its growth reaches the stationary phase 48 h after subculture. CH-1 cannot grow in serum-free medium and its growth is inhibited by digitonin. CH-1 can metabolize glucose, fructose, maltose, and trehalose. It can dehydrate arginine, CH-1 does not have an ability to utilize urea, nor dehydrate gelatin, nor reduce methylence blue. The taxonomic position of CH-1 has also been discuss

关键词： honey-bee spiroplasma mophology and cultural properties growth eharacteristrcs.

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

回撤通道围岩稳定与主被动联控技术研究

采矿与安全工程学报 2023年第4期40卷 774-785页

作者：闫帅张栋柏建彪郭永红中国矿业大学深部煤炭资源开采教育部重点实验室矿业工程学院江苏徐州221116 中国矿业大学煤炭资源与安全开采国家重点实验室江苏徐州221116 新疆工程学院矿业工程与地质学院新疆乌鲁木齐830091 国能蒙西煤化工股份有限公司内蒙古乌海016062

为解决综采工作面预掘回撤通道贯通及设备回撤期间大变形失稳问题,建立渐变煤柱承载力模型,引入Weibull分布函数对煤柱上方增量载荷进行高度拟合,并基于修正的SMP准则理论计算得出渐变煤柱临界失稳宽度为10.5 m。基于基本顶断裂位置与... 详细信息

为解决综采工作面预掘回撤通道贯通及设备回撤期间大变形失稳问题,建立渐变煤柱承载力模型,引入Weibull分布函数对煤柱上方增量载荷进行高度拟合,并基于修正的SMP准则理论计算得出渐变煤柱临界失稳宽度为10.5 m。基于基本顶断裂位置与回撤通道围岩稳定相互关系,确定基本顶合理跨度,分析揭示回撤通道围岩的失稳机理,并利用UDEC数值计算模型对回撤通道围岩响应特征进行模拟验证,结果具有一致性。提出“水力压裂主控切顶+高水材料墩柱让压支护”主被动联控技术成功应用于棋盘井矿I030901工作面回撤通道围岩控制。监测结果表明:工作面贯通时,墩柱最大工作阻力为9382 kN,巷道顶板最大下沉量为198 mm,支架工作阻力整面最大平均值为4278 kN,保证了综采设备安全高效回撤。

关键词：回撤通道失稳机理渐变煤柱墩柱支护水力压裂

维普期刊数据库