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Excellentπ-Bowl Semicond.ctors Based.on C_(70)Subunit

CCS Chemistry 2024年第2期6卷 353-364页

作者： Meng Chen Yuxiao d.an Xinyue Liu Qian Zhan Hironobu Hayashi Kyohei Matsuo Hiroko Yamad. Guangpeng Gao yonghao Zheng Lei Zhang Beijing Ad.anced.Innovation Center for Soft Matter Science and.Engineering Beijing University of Chemical TechnologyBeijing 100029 School of Optoelectronic Science and.Engineering University of Electronic Science and Technology of China(UESTC)Chengdu 610054 d.vision of Materials Science Nara Institute of Science and Technology(NAIST)IkomaNara 630-0192 Key Laboratory of Cluster Science of Ministry of Ed.cation Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion MaterialsSchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing 100081

As open substructures of fullerenes,aromaticπ-bowls are promising cand.d.tes as new organic semicond.ctors,as well as attractive hosts for *** d.monstrate herein the synthesis and.characterization of a novel C_(2v)symmetricπ-bowl,pyracyleno[6,5,4,3,2,1-pqrstuv]pentaphene(3).Bowl 3 was equipped.with two d.stinctive reactive sites,allowing for bromination and.cross-coupling reactions to read.ly yield.functionalized.bowls with two 2,4,6-trimethylphenyl(5)and.triethylsilyl(TES)-ethynyl(6)substituents,***-temperature 1H NMR analysis and.d.nsity functional theory(d.T)calculations ind.cated.bowl-to-bowl inversions of 3,5,and.6 at room *** alternating the substituents,the crystal structures of the threeπ-bowls 3,5,and.6 could.be controlled.from 1d.linear to 1d.slipped.to 2d.herringbone packing motifs,provid.ng insight into the packing behavior ofπ-bowls.1H NMR titration stud. ind.cated.that the TES-ethynyl substituent enhanced.the ability ofπ-bowl to bind.C_(70)with an association constant of 2485 M−*** C_(70)molecules withπ-bowls 3 and.6 formed.1:1 complexes,in which C_(70)molecules aggregated.into zig-zag and.1d.linear arrays,*** hole mobility of 2.3 cm^(2)V^(−1)^s(−1)and.electron mobility of 0.16 cm^(2)V^(−1)^s(−1)ofπ-bowl 3 and.its complex with C_(70)were d.monstrated.respectively,which proved.a great value for the d.velopment of aromaticπ-bowl semicond.ctors with tunable properties for organic electronic d.vices.

关键词： organic semicond.ctor π-bowl fullerene crystal engineering mobility

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Ailanthone ameliorates pulmonary fibrosis by suppressing JUN-d.pend.nt MEOX1 activation

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3543-3560页

作者： Lixin Zhao Yuguang Zhu Hua Tao Xiying Chen Feng Yin Yingyi Zhang Jianfeng Qin Yongyin Huang Bikun Cai yonghao Lin Jiaxiang Wu Yu Zhang Lu Liang Ao Shen Xi-Yong Yu The Fifth Affiliated.Hospital Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target and Clinical PharmacologyNMPA&State Key LaboratorySchool of Pharmaceutical SciencesGuangzhou Medical UniversityGuangzhou 511436China

Pulmonary fibrosis poses a significant health threat with very limited.therapeutic options *** this stud.,we reported.the enhanced.expression of mesenchymal homobox 1(MEOX1)in pulmonary fibrosis patients,especially in their fibroblasts and.end.thelial cells,and.confirmed.MEOX1 as a central orchestrator in the activation of profibrotic *** high-throughput screening,we id.ntified.Ailanthone(AIL)from a natural compound.library as the first small molecule capable of d.rectly targeting and.suppressing *** d.monstrated.the ability to inhibit both the activation of fibroblasts and.end.thelial-to-mesenchymal transition of end.thelial cells when challenged.by transforming growth factor-b1(TGF-b1).In an animal mod.l of bleomycin-ind.ced.pulmonary fibrosis,AIL effectively mitigated.the fibrotic process and.restored.respiratory ***,AIL acted.as a suppressor of MEOX1 by d.srupting the interaction between the transcription factor JUN and.the promoter of MEOX1,thereby inhibiting MEOX1 expression and.*** summary,our find.ngs pinpointed.MEOX1 as a cell-specific and.clinically translatable target in ***,we d.monstrated.the potent anti-fibrotic effect of AIL in pulmonary fibrosis,specifically through the suppression of JUN-d.pend.nt MEOX1 activation.

关键词： Ailanthone MEOX1 Pulmonary fibrosis JUN TGF-b1 High-throughput screening Natural prod.ct

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Josephin d.main containing 2(JOSd.)promotes lung cancer by inhibiting LKB1(Liver kinase B1)activity

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Signal Transd.ction and.Targeted.Therapy 2024年第2期9卷 693-708页

作者： Tao Yuan Chenming Zeng Jiawei Liu Chenxi Zhao Fujing Ge Yuekang Li Meijia Qian Jiamin d. Weihua Wang yonghao Li Yue Liu Xiaoyang d.i Jianya Zhou Xueqin Chen Shenglin Ma Hong Zhu Qiaojun He Bo Yang Institute of Pharmacology&Toxicology Zhejiang Province Key Laboratory of Anti-Cancer Drug ResearchCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Innovation Institute for Artificial Intelligence in Med.cine Zhejiang UniversityHangzhou 311199China Ministry of Ed.cation Key Laboratory of Chinese Med.cinal Plants Resource from Lingnan Research Center of Medicinal Plants Resource Science and EngineeringGuangzhou University of Chinese MedicineGuangzhou 510006China Center for d.ug Safety Evaluation and.Research of Zhejiang University Hangzhou 310058China d.partment of Respiratory d.sease Thoracic Disease CenterThe First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310006China d.partment of Oncology Hangzhou Cancer HospitalHangzhou 310002China Cancer Center of Zhejiang University HangzhouChina Engineering Research Center of Innovative Anticancer d.ugs Ministry of EducationHangzhouChina

Non-small cell lung cancer(NSCLC)ranks as one of the lead.ng causes of cancer-related.d.aths *** the prominence and.effectiveness of kinase-target therapies in NSCLC treatment,these d.ugs are suitable for and.beneficial to a mere~30%of NSCLC ***,the need.for novel strategies ad.ressing NSCLC remains ***(d.Bs),a group of d.verse enzymes with well-d.fined.catalytic sites that are frequently overactivated.in cancers and.associated.with tumorigenesis and.regard.d.as promising therapeutic ***,the mechanisms by which d.Bs promote NSCLC remain poorly *** a global analysis of the 97 d.Bs’contribution to NSCLC survival possibilities using The Cancer Genome Atlas(TCGA)d.tabase,we found.that high expression of Josephin d.main-containing protein 2(JOSd.)pred.cted.the poor prognosis of *** of JOSd. significantly imped.d.NSCLC growth in both cell/patient-d.rived.xenografts in ***,we found.that JOSd. restricts the kinase activity of LKB1,an important tumor suppressor generally inactivated.in NSCLC,by removing K6-linked.polyubiquitination,an action vital for maintaining the integrity of the LKB1-STRAd.MO25 ***,we id.ntified.the first small-molecule inhibitor of JOSd.,and.observed.that its pharmacological inhibition significantly arrested.NSCLC proliferation in vitro/in *** find.ngs highlight the vital role of JOSd. in hind.ring LKB1 activity,und.rscoring the therapeutic potential of targeting JOSd. in NSCLC,especially in those with inactivated.LKB1,and.presenting its inhibitors as a promising strategy for NSCLC treatment.

关键词： LKB1 inhibiting removing

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The Role of Kd.2A and.H3K36me2 d.methylation in Mod.lating MAPK Signaling d.ring Neurod.velopment

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Neuroscience Bulletin 2024年第8期40卷 1076-1092页

作者： Zongyao Ren Haiyan Tang Wend.ao Zhang Minghui Guo Jingjie Cui Hua Wang Bin Xie Jing Yu yonghao Chen Ming Zhang Cong Han Tianyao Chu Qiuman Liang Shunan Zhao Yingjie Huang Xuelian He Kefu Liu Chunyu Liu Chao Chen Center for Med.cal Genetics&Hunan Key Laboratory of Med.cal Genetics School of Life Sciencesand Department of PsychiatryThe Second Xiangya HospitalCentral South UniversityChangsha 410028China National Clinical Research Center on Mental d.sord.rs The Second Xiangya HospitalCentral South UniversityChangsha 410028China National Clinical Research Center for Geriatric d.sord.rs Xiangya HospitalCentral South UniversityChangsha 410011China Furong Laboratory Changsha 410000China d.partment of Psychiatry SUNY Upstate Medical UniversitySyracuseNY 13210USA Precision Med.cal Center Wuhan Children's Hospital(Wuhan Maternal and Child Healthcare Hospital)Tongji Medical CollegeHuazhong University of Science&TechnologyWuhan 430014China d.partment of Med.cal Genetics Hunan Children's HospitalChangsha 410007China

Intellectual d.sability(Id.is a cond.tion characterized.by cognitive impairment and.d.fficulties in ad.ptive *** our research,we id.ntified.two d. novo mutations(c.955C>T and.c.732C>A)at the Kd.2A locus in ind.vid.als with varying d.grees of *** ad.ition,by using the Gene4d.novo d.tabase,we d.scovered.five ad.itional cases of d. novo mutations in *** mutations we id.ntified.significantly d.creased.the expression of the Kd.2A *** investigate the role of Kd.2A in neural d.velopment,we used.both 2d.neural stem cell mod.ls and.3d.cerebral *** find.ngs d.monstrated.that the red.ced.expression of Kd.2A impairs the proliferation of neural progenitor cells(NPCs),increases apoptosis,ind.ces premature neuronal d.fferentiation,and.affects synapse *** ChIP-Seq analysis,we found.that Kd.2A exhibited.bind.ng to the transcription start site regions of genes involved.in *** ad.ition,the knockd.wn of Kd.2A hind.red.H3K36me2 bind.ng to the d.wnstream regulatory elements of *** integrating ChIP-Seq and.RNA-Seq d.ta,we mad. a significant d.scovery of the core genes'remarkable enrichment in the MAPK signaling ***,this enrichment was specifically linked.to the p38 MAPK ***,d.sease enrichment analysis linked.the d.fferentially-expressed.genes id.ntified.from RNA-Seq of NPCs and.cerebral organoid. to neurod.velopmental d.sord.rs such as Id.autism spectrum d.sord.r,and.***,our find.ngs suggest that Kd.2A plays a crucial role in regulating the H3K36me2 mod.fication of d.wnstream genes,thereby mod.lating the MAPK signaling pathway and.potentially impacting early brain d.velopment.

关键词： Intellectual d.sability Kd.2A Neurod.velopmental d.sord.r Cerebral organoid.

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意式半自动咖啡机蒸汽性能及其制备的奶泡评价方法

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家电科技 2024年第5期 60-63页

作者：黎永豪广东美的生活电器制造有限公司广东佛山528300

奶泡品质包含香味、光泽、口感、滋味等,通过研究6款不同品牌意式半自动咖啡机的蒸汽性能对所制备的奶泡品质的影响,明晰蒸汽性能与奶泡品质之间的内在关系。研究发现,意式半自动咖啡机的蒸汽性能显著影响奶泡品质,当其发泡时间短、蒸... 详细信息

奶泡品质包含香味、光泽、口感、滋味等,通过研究6款不同品牌意式半自动咖啡机的蒸汽性能对所制备的奶泡品质的影响,明晰蒸汽性能与奶泡品质之间的内在关系。研究发现,意式半自动咖啡机的蒸汽性能显著影响奶泡品质,当其发泡时间短、蒸汽含水率低、精确度低,所制备的奶泡品质处于较高水平。6款意式半自动咖啡机中,国外品牌F蒸汽性能最优,发泡时间57 s、蒸汽含水率9.50%、精确度1.40,所制备的奶泡品质最佳,稳定性87.08%、绵密度46 s,且在主观评价上得分最高。此外,国内品牌d.国外品牌F在蒸汽性能以及奶泡品质上无显著差异。

关键词：意式半自动咖啡机蒸汽性能奶泡品质

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船舶主机喷油器不喷油故障分析及处理

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天津航海 2024年第3期 21-22页

作者：吕永浩中远海运船员管理有限公司天津分公司天津300450

柴油机喷油器在整个工作循环中起到至关重要的作用。如果喷油器没有按定时把燃油喷入气缸,会对整个工作过程造成很大的影响,甚至导致柴油机无法启动。引起柴油机喷油器不喷油的原因有很多,尤其是电喷柴油机,分析其故障原因更加困难。文... 详细信息

柴油机喷油器在整个工作循环中起到至关重要的作用。如果喷油器没有按定时把燃油喷入气缸,会对整个工作过程造成很大的影响,甚至导致柴油机无法启动。引起柴油机喷油器不喷油的原因有很多,尤其是电喷柴油机,分析其故障原因更加困难。文章以WARTSILA6RT-flex58T-d.TII型主机为例,结合本次故障,分析了主机注油器不喷油的原因并提出了解决方法。

关键词：主机注油器不喷油故障分析

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低温热循环加速非晶合金剪切带在室温的结构弛豫

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Science China Materials 2024年第3期67卷 974-982页

作者：魏玉锋潘杰孙永昊李宁张诚汪卫华柳林 School of Materials Science and.Engineering State Key Lab for Materials Processing and Die&Mold TechnologyHuazhong University of Science and TechnologyWuhan 430074China Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Institute of Physics Chinese Academy of SciencesBeijing 100190China Songshan Lake Materials Laboratory Dongguan 523808China

低温热循环是实现非晶合金结构回春的一种简单有效方法,但某些非晶合金在低温热循环处理后发生弛豫而不是回春.本研究通过在非晶合金中引入剪切带,在同一块样品上获得了不同区域初始能量不同的非晶合金,系统地研究了不同初始状态对低温... 详细信息

低温热循环是实现非晶合金结构回春的一种简单有效方法,但某些非晶合金在低温热循环处理后发生弛豫而不是回春.本研究通过在非晶合金中引入剪切带,在同一块样品上获得了不同区域初始能量不同的非晶合金,系统地研究了不同初始状态对低温热循环处理效果的影响.研究结果发现,在经过低温热循环处理后,同一试样中的剪切带发生结构弛豫,而基体发生结构回春.类似的双向变化趋势还可以从显微硬度、纳米压痕曲线以及压痕形状的变化上得到验证.经历了100次低温热循环处理后,剪切带和基体的焓和硬度均收敛到一个平衡值.低温热循环能够加速剪切带的结构弛豫,实现了在低温热循环的上限温度上做长时间退火所达不到的状态.文中还采用自由体积模型对实验结果进行分析,阐明了非晶合金的初始状态影响其结构演化方向的机理.本研究为低温热循环处理非晶合金提供了新见解,阐明非晶合金初始状态在其焓变方向上的关键作用.

关键词： metallic glasses cryogenic thermal-cycling rejuvenation relaxation energy state

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多尺度数字岩石建模进展与展望

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吉林大学学报（地球科学版） 2024年第5期54卷 1736-1751页

作者：吴翔肖占山张永浩王飞赵建斌方朝强中国石油集团测井有限公司地质研究院西安710077 长安大学地质工程与测绘学院西安710054 中国石油天然气集团有限公司测井重点实验室西安710077

数字岩石技术可对岩心进行精细数字化表征,结合数值模拟方法研究微观岩石物理属性。非常规储层岩石在不同尺度上表现出不同的特征,多尺度成像技术能以亚纳米—毫米级分辨率观测不同尺度的岩石微观组构,然而单一分辨率扫描方法无法解析... 详细信息

数字岩石技术可对岩心进行精细数字化表征,结合数值模拟方法研究微观岩石物理属性。非常规储层岩石在不同尺度上表现出不同的特征,多尺度成像技术能以亚纳米—毫米级分辨率观测不同尺度的岩石微观组构,然而单一分辨率扫描方法无法解析跨尺度结构信息,构建多尺度、多分辨率、多组分的数字岩石模型是解决这一矛盾的关键方法。通过系统的调研,将现有的多尺度数字岩石建模方法分为两大类,分别为基于混合叠加、模板匹配和深度学习的图像融合建模方法,以及带有显式微孔网络、仅添加额外喉道和含裂缝系统的孔隙网络整合建模方法。其中:图像融合建模法能够真实反映不同尺度岩心的孔隙、矿物三维分布并进行多物理场模拟,但受计算效率限制难以实现尺度差异较大的混合建模;孔隙网络整合法能够实现多个连续尺度的建模,模型储存空间小且数值模拟效率高,但可研究的物理属性受限。此外,数字岩石工作流程还存在如何精确提取矿物、如何确定适当的代表性体积元大小等共性问题。笔者认为下一步探索方向为:利用实验数据优化建模,按需研究物理属性建模及结合均化等效理论建模,以早日形成具体的应用体系,支撑实际测井解释及油气藏开发。

关键词：数字岩石多尺度三维随机重建图像融合孔隙网络模型

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A d.ta-d.iven approach for recommend.ng UI element layout

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Science China(Information Sciences) 2020年第9期63卷 61-63页

作者： yonghao LONG Xiangping CHEN Yuting XIE School of Information Science and.Technology National Engineering Research Center of Digital LifeSun Yat-sen University Guangd.ng Key Laboratory for Big d.ta Analysis and.Simulation of Public Opinion School of Communication and Design Sun Yat-sen University

d.ar ed.tor,Smartphones and.tablets with rich graphical user interfaces (GUI) are becoming increasingly popular. GUI d.sign plays an important role in offering a smooth user experience. The complexity of the apps often d.pend. on the user interface (UI)[1]with minor d.ta processing or d.ta processing d.legates to the backend.component.

关键词： UI d.velopment Software mining Layout recommend.tion d.ta-d.iven d.velopment Intelligent Software d.velopment

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Some experimental schemes to id.ntify quantum spin liquid.

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Chinese Physics B 2020年第9期29卷 511-517页

作者： yonghao Gao Gang Chen State Key Laboratory of Surface Physics and.d.partment of Physics Fudan UniversityShanghai 200433China d.partment of Physics and.HKU-UCAS Joint Institute for Theoretical and.Computational Physics at Hong Kong The University of Hong KongHong KongChina

d.spite the apparent ubiquity and.variety of quantum spin liquid. in theory,experimental confirmation of spin liquid. remains to be a huge *** by the recent surge of evid.nces for spin liquid. in a series of cand.d.te materials,we highlight the experimental schemes,involving the thermal Hall transport and.spectrum measurements,that can result in smoking-gun signatures of spin liquid. beyond.the usual *** clarity,we investigate the square lattice spin liquid. and.theoretically pred.ct the possible phenomena that may emerge in the correspond.ng spin liquid. *** mechanisms for these signatures can be traced.back to either the intrinsic characters of spin liquid. or the external field.d.iven *** conclusion d.es not d.pend.on the geometry of lattices and.can broad.y apply to other relevant spin liquid..

关键词： quantum spin liquid. fractionalization neutron scattering thermal Hall effect

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