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中华民族的文明内涵及其本质属性

世界民族 2024年第2期 14-26页

作者：都永浩黑龙江大学哈尔滨150001 中国民族理论学会

文明是文化发展的高级阶段,“是文化的根基”,是核心的精神价值和政治信仰,是人类公认、共享的精神成就以及推动人类进步的科学技术成就。因此,中华民族的文明内涵必然构成为中华民族的本质属性。内部性、共创性、共享性、凝聚性是中华... 详细信息

文明是文化发展的高级阶段,“是文化的根基”,是核心的精神价值和政治信仰,是人类公认、共享的精神成就以及推动人类进步的科学技术成就。因此,中华民族的文明内涵必然构成为中华民族的本质属性。内部性、共创性、共享性、凝聚性是中华古代文明形成的特点;中华古代文明的内涵主要包括包容性、协和性、转换性、一体性、正统性、一致性、进取性等。中华民族现代文明是人类文明新形态,主要包括主体性、共同性、人民性、本土性等内涵。在中华古代文明和中华民族现代文明内涵的影响下,中华民族体现出了内部辐射属性、内聚与内聚化属性、历史演化属性、“和生同不”属性。中华民族现代文明内涵中体现了中华民族固有的人民性、整体性、内部性、统一性、共同性、延续性等本质属性。

关键词：中华古代文明中华民族现代文明中华民族本质属性

Josephin domain containing 2(JOSD2)promotes lung cancer by inhibiting LKB1(Liver kinase B1)activity

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Signal Transduction and Targeted Therapy 2024年第2期9卷 693-708页

作者： Tao Yuan Chenming Zeng Jiawei Liu Chenxi Zhao Fujing Ge Yuekang Li Meijia Qian Jiamin du Weihua Wang yonghao Li Yue Liu Xiaoyang Dai Jianya Zhou Xueqin Chen Shenglin Ma Hong Zhu Qiaojun He Bo Yang Institute of Pharmacology&Toxicology Zhejiang Province Key Laboratory of Anti-Cancer Drug ResearchCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Innovation Institute for Artificial Intelligence in Medicine Zhejiang UniversityHangzhou 311199China Ministry of Education Key Laboratory of Chinese Medicinal Plants Resource from Lingnan Research Center of Medicinal Plants Resource Science and EngineeringGuangzhou University of Chinese MedicineGuangzhou 510006China Center for Drug Safety Evaluation and Research of Zhejiang University Hangzhou 310058China Department of Respiratory Disease Thoracic Disease CenterThe First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310006China Department of Oncology Hangzhou Cancer HospitalHangzhou 310002China Cancer Center of Zhejiang University HangzhouChina Engineering Research Center of Innovative Anticancer Drugs Ministry of EducationHangzhouChina

Non-small cell lung cancer(NSCLC)ranks as one of the leading causes of cancer-related deaths worldwide.Despite the prominence and effectiveness of kinase-target therapies in NSCLC treatment,these drugs are suitable for and beneficial to a mere~30%of NSCLC patients.Consequently,the need for novel strategies addressing NSCLC remains pressing.Deubiquitinases(duBs),a group of diverse enzymes with well-defined catalytic sites that are frequently overactivated in cancers and associated with tumorigenesis and regarded as promising therapeutic targets.Nevertheless,the mechanisms by which duBs promote NSCLC remain poorly understood.Through a global analysis of the 97 duBs’contribution to NSCLC survival possibilities using The Cancer Genome Atlas(TCGA)database,we found that high expression of Josephin Domain-containing protein 2(JOSD2)predicted the poor prognosis of patients.Depletion of JOSD2 significantly impeded NSCLC growth in both cell/patient-derived xenografts in vivo.Mechanically,we found that JOSD2 restricts the kinase activity of LKB1,an important tumor suppressor generally inactivated in NSCLC,by removing K6-linked polyubiquitination,an action vital for maintaining the integrity of the LKB1-STRAD-MO25 complex.Notably,we identified the first small-molecule inhibitor of JOSD2,and observed that its pharmacological inhibition significantly arrested NSCLC proliferation in vitro/in vivo.Our findings highlight the vital role of JOSD2 in hindering LKB1 activity,underscoring the therapeutic potential of targeting JOSD2 in NSCLC,especially in those with inactivated LKB1,and presenting its inhibitors as a promising strategy for NSCLC treatment.

关键词： LKB1 inhibiting removing

Satellite scheduling engine: The intelligent solver for future multi-satellite management

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Frontiers of Engineering Management 2022年第4期9卷 683-688页

作者： Yonghao Du Lining XING Yingguo CHEN College of Systems Engineering National University of Defense TechnologyChangsha 410073China School of Electronic Engineering Xidian UniversityXi’an 710075China

With the rapid development and popularization of worldwide aerospace industries over the recent decades,the optimization requirements of multi-satellite management have exploded significantly.The latest data show 4852 operational satellites orbiting the earth,of which the US,China,and Russia own 2944,499,and 169,respectively.Therefore,how to manage and schedule effectively hundreds of satellites to conform to the developing and popularizing aerospace tendency emerges as a worldwide problem.

关键词： hundreds satellite aerospace

Data-Driven Heuristic Assisted Memetic Algorithm for Efficient Inter-Satellite Link Scheduling in the BeiDou Navigation Satellite System

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IEEE/CAA Journal of Automatica Sinica 2021年第11期8卷 1800-1816页

作者： Yonghao Du Ling Wang Lining Xing Jungang Yan Mengsi Cai College of Systems Engineering National University of Defense TechnologyChangsha 410073China Leiden Institute of Advanced Computer Science Leiden UniversityLeiden 2332 CAThe Netherlands Department of Automation Tsinghua UniversityBeijing 100083China

Inter-satellite link(ISL)scheduling is required by the BeiDou Navigation Satellite System(BDS)to guarantee the system ranging and communication performance.In the BDS,a great number of ISL scheduling instances must be addressed every day,which will certainly spend a lot of time via normal metaheuristics and hardly meet the quick-response requirements that often occur in real-world applications.To address the dual requirements of normal and quick-response ISL schedulings,a data-driven heuristic assisted memetic algorithm(DHMA)is proposed in this paper,which includes a high-performance memetic algorithm(MA)and a data-driven heuristic.In normal situations,the high-performance MA that hybridizes parallelism,competition,and evolution strategies is performed for high-quality ISL scheduling solutions over time.When in quick-response situations,the data-driven heuristic is performed to quickly schedule high-probability ISLs according to a prediction model,which is trained from the high-quality MA solutions.The main idea of the DHMA is to address normal and quick-response schedulings separately,while high-quality normal scheduling data are trained for quick-response use.In addition,this paper also presents an easy-to-understand ISL scheduling model and its NP-completeness.A seven-day experimental study with 10080 one-minute ISL scheduling instances shows the efficient performance of the DHMA in addressing the ISL scheduling in normal(in 84 hours)and quick-response(in 0.62 hour)situations,which can well meet the dual scheduling requirements in real-world BDS applications.

关键词： BeiDou Navigation Satellite System(BDS) data-driven heuristic inter-satellite link(ISL)scheduling memetic algorithm metaheuristic quick-response

Research on cooling-temperature control strategy of fuel-cell engine test bench

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Clean Energy 2023年第1期7卷 42-52页

作者： Chang du Tiancai Ma Weikang Lin Kaihang Song yonghao Liang School of Automotive Studies Tongji UniversityShanghai201804PR China Institute of Carbon Neutrality Tongji UniversityShanghai200092PR China

As one of the important ways to utilize hydrogen energy,fuel cells are receiving more and more attention and research from countries and institutions.To meet the practical needs of testing the performance of high-power fuel-cell systems and simulate the actual application environment as much as possible,a fuel-cell system test bench is usually used to test the system performance,in which the cooling-temperature control of the test bench has a great impact on the results of the performance of the fuel-cell system.This paper studies the cooling-temperature control strategy of a 150-kW-class fuel-cell engine test platform,proposes a new test-bench cooling-system structure with a thermostat and heat exchanger as the main heat-dissipation components,and compares and analyzes the impact of coordinated thermostat and heat-exchanger control on the fuel-cell system test performance.The test results show that the control strategy of the coordinated operation of a thermostat and heat exchanger can maintain the steady-state error to within±0.3℃and maintain the temperature variation to within±1.5℃during the loading-condition test,so as to avoid the limitation of system output performance due to excessive cooling-temperature fluctuation and ensure that the fuel-cell engine performance-test process is carried out smoothly and efficiently.

关键词： fuel-cell engine test bench cooling-temperature control strategy thermostat heat exchanger

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“天下”内涵及与近现代中华民族的关系

中国边疆史地研究 2022年第4期32卷 1-11,213页

作者：都永浩中国民族理论学会吉林省延吉市133002

“天下”的“五方之民”以“中国”为中心,以中华文化的核心价值观为准则,向“天下”四方进行“教化”,最终于清朝实现了从文化、政治、民族、地域等维度的“大一统”国家的形成。“五方之民”是共存、共在的关系,即“华夷一体”,身份... 详细信息

“天下”的“五方之民”以“中国”为中心,以中华文化的核心价值观为准则,向“天下”四方进行“教化”,最终于清朝实现了从文化、政治、民族、地域等维度的“大一统”国家的形成。“五方之民”是共存、共在的关系,即“华夷一体”,身份以文化为标准可以互换(“夷变夏”“夏变夷”),同时“华夷之辨”“攻伐”成为“大一统”实践的辅助手段。西方的现代“nation”是一个建构性浓厚的概念,与公民、国家的现代属性存在密切的联系,因此将“nation”翻译成“人民共同体”,将“中华民族”理解为“中华人民”,可使“中华民族”概念既与历史渊源相联系,又能覆盖近现代国民或公民属性。

关键词： “天下” “华夷” 地理空间中华民族

磁流变液阻尼器分阶段建模与流道参数敏感性分析

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机械工程学报 2022年第11期58卷 143-155页

作者：李嘉豪张永浩杜新新卢军李星照廖昌荣重庆大学光电技术及系统教育部重点实验室重庆400040 中国核动力研究设计院二所成都610213

作为电流调节阻尼参数的器件,磁流变液阻尼器在车辆悬架减振和航空振动隔离等领域具有广泛的应用前景。针对磁流变液阻尼器非牛顿流体建模,其存在不能预测阻尼器速度特性中存在滞回效应的问题,以及目前缺乏流道参数对阻尼器调节范围影... 详细信息

作为电流调节阻尼参数的器件,磁流变液阻尼器在车辆悬架减振和航空振动隔离等领域具有广泛的应用前景。针对磁流变液阻尼器非牛顿流体建模,其存在不能预测阻尼器速度特性中存在滞回效应的问题,以及目前缺乏流道参数对阻尼器调节范围影响的研究。分析了环形流道混合工作模式下磁流变液的链化特征,采用了颗粒链化模型推导了预屈服阶段下的理论阻尼力表达式;利用Newton流体模型与Herschel-Bulkley模型分别描述无磁化区域与磁化区域磁流变液的本构关系,推导理论阻尼力表达式,在应用有限元方法对磁路仿真分析的基础上,建立了基于流道加权平均磁场叠加集成模型。根据研究的结果,设计并制作了磁流变液阻尼器,使用MTS试验机验证了预屈服阶段的颗粒链化模型与屈服阶段的准静态模型的有效性;利用预屈服链化模型与叠加集成模型分析了线圈匝数、活塞速度、阻尼流道间隙、阻尼流道长度等参数对磁流变液阻尼器调节范围的影响。研究表明,预屈服阶段的颗粒链条模型能够有效地预测速度特性的滞回效应,屈服阶段的叠加集成模型能够有效地预测其示功特性,线圈匝数与阻尼流道长度相对其他参数影响对阻尼器调节范围影响更为显著,为同类型设计提供有效参考。

关键词：磁流变液阻尼器滞回效应颗粒链化集成模型流道参数

边疆社会转型:近世中国西藏社会转型核心动因论

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西藏民族大学学报（哲学社会科学版） 2019年第4期40卷 103-110页

作者：杜永豪西藏民族大学管理学院

中外学人的社会转型动因研究聚焦于三,一是核心动因,二是动因源流,三是综合动因。离开人或将人置于从属地位,是大多数学人的通病和“核心遗漏”。人是目的性动物,其目的性源于自身需要。在人的一切需要中,生存独具决定意义。迄今,人类... 详细信息

中外学人的社会转型动因研究聚焦于三,一是核心动因,二是动因源流,三是综合动因。离开人或将人置于从属地位,是大多数学人的通病和“核心遗漏”。人是目的性动物,其目的性源于自身需要。在人的一切需要中,生存独具决定意义。迄今,人类史中上演的一切悲欢离合,都绕此而展开。基于生存,人们产生问题意识和提起求解,进而推动有关社会的转型。直言之,生存需要是导引一切社会转型的核心动因。近世我国西藏社会转型便是如此,英人入侵乃是外因,我们自身生存才是核心动因。当此强敌入侵,在既有文明和旧制度无力外御其侮、内营民生之时,一场社会大转型便是题中之意和必然选择。

关键词：社会转型核心遗漏人身依附

Impacts of laser pulse width and target thickness on laser micro-propulsion performance

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Plasma Science and Technology 2022年第10期24卷 113-126页

作者：王思博杜邦登杜宝盛郑永赞洪延姬叶继飞邢宝玉李承霖张永昊 State Key Laboratory of Laser Propulsion and Application Space Engineering UniversityBeijing 101416People's Republic of China Technical Institute of Physics and Chemistry Chinese Academy of SciencesBeijing 100190People's Republic of China

In order to optimize the laser ablation performance of a micro-thruster with 1U dimensions,which employs a micro semiconductor laser,the impacts of pulse width and glycidyl azide polymer(GAP)thickness on thrust performance were researched.The results showed that with a GAP thickness of 200μm,the single-pulse impulse(I)increased gradually with the increase in the laser pulse width from 50 to 800μs,while the specific impulse(I_(sp)),impulse coupling coefficient(Cm)and ablation efficiency(η)all reached optimal values with a 200μs pulse width.It is worth noting that the optimal pulse width is identical to the ignition delay time.Both Cmandηpeaked with a pulse width of 200μs,reaching 242.22μN W^(-1)and 35.4%,respectively.With the increase in GAP thickness,I and Cmincreased gradually.GAP of different thicknesses corresponded to different optimal laser pulse widths.Under a certain laser pulse width,the optimal GAP thickness should be the most vertical thickness of the ablation pit,and the various propulsion performance parameters at this time were also optimal.With the current laser parameters,the optimal GAP thickness was approximately 150μm,I_(sp)was approximately 322.22 s,andηwas approximately 34.94%.

关键词： laser micro-propulsion pulse width target thickness specific impulse ablation efficiency