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Energy Consumption and Erosion Mechanism of Polyester Fiber Reinforced Cement Composite in Wind-blown Sand Environments

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Journal of Wuhan University of Technology(Materials Science) 2022年第4期37卷 666-676页

作者： HAO Yunhong liU Yanchen li yonggui GAO Feng School of Science Inner Mongolia University of TechnologyHohhot 010051China The Inner Mongolia Key Laboratory of Civil Engineering Structure and Mechanics Fuzhou 350108China The Inner Mongolia Autonomous Region Construction Inspection and Appraisal and Safety Assessment Engineering Technology Research Center Hohhot 010051China Fujian Key Laboratory of Novel Functional Textile Fibers and Materials Minjiang UniversityHohhot 010051China School of Civil Engineering Inner Mongolia University of TechnologyHohhot 010051China

Considering the economic and environmental benefits associated with the recycling of polyester(PET)fibres,it is vital to study the application of fibre-reinforced cement *** to the characteristics of the wind-blown sand environment in Inner Mongolia,the erosion resistance of the polyester fibre-reinforced cement composites(PETFRCC)with different PET fibre contents to various erosion angles,velocities and sand particle flows was investigated by the gas-blast *** on the actual conditions of sandstorms in Inner Mongolia,the sand erosion parameters required for testing were calculated by the similarity *** elastic-plastic model and rigid plastic model of PETFRCC and cement mortar were established,and the energy consumption mechanism of the model under particle impact was *** experimental results indicate that the microstructure of PETFRCC rafter hydration causes a spring-like buffering effect,and the deformation of PETFRCC under the same impact load is slightly smaller than that of cement mortar,and the damage mechanism of PETFRCC is mainly characterized by fiber deformation and slight brittle spalling of *** under the most unfavorable conditions of the erosion,the erosion rate of 0.5PETFRCC is about 57.69%lower than that of cement mortar,showing better erosion resistance.

关键词： wind-blown sand environment erosion resistance polyester fibre-reinforced cement composite energy consumption mechanism erosion mechanism

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Preliminary study on the safety and efficacy of a new polymyxin B-immoblized resin column in treatment of LPS-induced sepsis beagles

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Animal Models and Experimental Medicine 2022年第2期5卷 161-171页

作者： yonggui li Zhenggen Yang Jialiang Hu Zhennan lin Research and Development Center Guangzhou Koncen Bioscience Co.Ltd.GuangzhouPR China Guangdong Provincial Key Laboratory of Hemoadsorption Technology GuangzhouPR China

Background:This study aims to assess the safety and efficacy of direct hemoperfu-sion using a new polymyxin B-immobilized resin column(disposable endotoxin ad-sorber,KCEA)in an endotoxin/lipopolysaccharide(LPS)-induced sepsis ***:Eighteen beagles were randomized into 1 intervention group(KCEA group,n=6)and 2 control groups(sham group and model group,n=6 each).Sepsis was in-duced by continuous intravenous application of 0.5 mg/kg body weight of endotoxin for 60 *** extracorporeal hemoperfusion device made with KCEA for endotoxin adsorption was *** group beagles received standard treatment with fluids and vasoactive drugs,KCEA group beagles received standard treatment and direct hemoperfusion of KCEA for 2 h,and sham group beagles were treated with standard treatment and direct hemoperfusion of a sham column for 2 ***:Good blood compatibility of KCEA was confirmed by assessing clinical *** endotoxin peak levels in the KCEA group were significantly lower,resulting in a significant suppression of IL-6,TNF-αand procalcitonin,which improved mean arterial pressure and significantly lowered vasopressor demand,thereby pro-tecting organ function and improving survival time and *** the KCEA group,MAP was significantly higher over 6 h than those recorded both in the sham group and model *** 7-day survival rates of the KCEA,sham and model groups were 50%,0%and 0%,***:KCEA hemoadsorption was effective at detoxifying circulatory endotoxin and inflammatory mediators and contributed to the decreased mortality rate in the sepsis beagles.

关键词： endotoxin hemoadsorption polymyxin B sulfate resin sepsis

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Optimization on magnetic properties of Nd-doped Fe_(3)O_(4) nanoparticles for magnetic shielding fabrics

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Journal of Rare Earths 2024年第4期42卷 683-689页

作者： Xiaolei Song Congzhu Xu Yuyan Wang Huizhen Ke yonggui li Qufu Wei Xinqun Feng Faculty of Clothing and Design Minjiang UniversityFuzhou350108China Fujian Key Laboratory of Novel Functional Textile Fibers and Materials Minjiang UniversityFuzhou350108China College of Textile and Clothing Jiangnan UniversityWuxi214122China College of Fashion and Design Donghua UniversityShanghai201620China

High magnetic protective fabrics with rare earth Nd doped Fe_(3)O_(4) nanoparticles were fabricated via a grafting *** structure,crystal form,and elemental composition of nanoparticles were investigated by transmission electron microscopy,energy dispersive X-ray,X-ray powder diffraction,and X-ray photoelectron *** obtained NdFe_(2)O_(4) nanoparticles show spherical shape with fine dispersion and reasonable element ***,they demonstrate fine superparamagnetic properties with a magnetic saturation value of 29.25 A·m^(2)/g and low coercivity of 1.902 mT through the vibrating sample magnetometry technique,which can be well developed in magnetic shielding protective ***,the cotton fabrics with plain weave were finished by a proofing rapier loom as a *** NdFe_(2)O_(4) nanoparticles underwent some appropriate surface modification and then were grafted onto the cotton fabrics by a bridge agent of N,N’-dissuccinimidyl *** morphology,structure,dispersion effect,and electromagnetic protective properties of the fabrics were observed through scanning electron microscopy,Fourier infrared spectroscopy,thermogravimetric analysisdifferential scanning calorimetry(TG-DSC),and a vector network *** reliable fabrics with grafting reaction on the interface are expected to have potential applications in the field of electromagnetic protection and biomedicine fields.

关键词： Magnetic property Nd Fe_(3)O_(4)nanoparticles Magnetic shielding Fabrics Rare earths

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Characteristic roadmap of linker governs the rational design of PROTACs

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Acta Pharmaceutica Sinica B 2024年第10期14卷 4266-4295页

作者： Yawen Dong Tingting Ma Ting Xu Zhangyan Feng yonggui li lingling Song Xiaojun Yao Charles R.Ashby Jr Ge-Fei Hao School of Pharmaceutical Sciences Guizhou UniversityGuiyang 550025China State Key Laboratory of Green Pesticide Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationCenter for R&D of Fine ChemicalsGuizhou UniversityGuiyang 550025China Faculty of Applied Sciences Macao Polytechnic UniversityMacao 999078China Department of Pharmaceutical Sciences St.John’s UniversityNew YorkNY 11439USA

Proteolysis targeting chimera (PROTAC) technology represents a groundbreaking development in drug discovery, leveraging the ubiquitin‒proteasome system to specifically degrade proteins responsible for the disease. PROTAC is characterized by its unique heterobifunctional structure, which comprises two functional domains connected by a linker. The linker plays a pivotal role in determining PROTAC's biodegradative efficacy. Advanced and rationally designed functional linkers for PROTAC are under development. Nonetheless, the correlation between linker characteristics and PROTAC efficacy remains under-investigated. Consequently, this study will present a multidisciplinary analysis of PROTAC linkers and their impact on efficacy, thereby guiding the rational design of linkers. We will primarily discuss the structural types and characteristics of PROTAC linkers, and the optimization strategies used for their rational design. Furthermore, we will discuss how factors like linker length, group type, flexibility, and linkage site affect the biodegradation efficiency of PROTACs. We believe that this work will contribute towards the advancement of rational linker design in the PROTAC research area.

关键词： PROTAC PROTAC linker linker characteristics Rational design Biodegradation efficiency

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Compositional change in human enamel irradiated with MIR free electron laser

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Chinese Science Bulletin 2001年第23期46卷 2016-2018页

作者： liU Nianqing li yonggui ZHU Junbiao ZHANG liwen WANG Mingkai WU Gang YANG Xueping li Guangcheng Huang Yuying DONG Yanmei GAO Xuejun Institute of High Energy Physics Chinese Academy of SciencesBeijing 100039China Stomatological College Peking UniversityBeijing 100081China 不详

The purpose of this study was to investigate compositional changes in human enamel irradiated with the free electron laser (FEL). The exposure on dental enamel at the wavelength of 9.64 μm was observed with the Beijing free electron laser. The distribution of elements in the irradiated or non-irradiated enamel was measured by scanning electron microscope (SEM) with energy-dispersive spectroscopy and synchrotron radiation X-ray fluorescence (SRXRF) in Beijing Synchrotron Radiation Facility (BSRF). The results showed that the P/Ca ratio in the ablation region of enamel at the maximum wavelength of infrared absorption was obviously smaller than that at the non-maximum wavelength. In the ablation region the ratios of P/Ca and Ca/Sr were smaller than those in the non-ablation region. The distributions of P, Ca and Sr in the ablation region were heterogeneous due to the element change caused by FEL irradiation.

关键词： human enamel Beijing free electron laser synchrotron radiation X-ray fluorescence ablation element distribution.

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沉积Ag纳米层改善定型相变复合纤维膜的传热性能

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高分子材料科学与工程 2017年第4期33卷 81-86页

作者：柯惠珍李永贵闽江学院服装与艺术工程学院福建省高校纺织服装工程研究中心福建福州350108

以癸酸(CA)、月桂酸(LA)和肉豆蔻酸(MA)为原料制备了新型的脂肪酸三元低共熔物(CA-LA-MA),并将其作为固-液相变材料,以沉积2 h银(Ag)纳米颗粒的静电纺聚丙烯腈(PAN)纳米纤维膜为支撑材料,通过物理吸附法制备了新型的CA-LA-MA/PAN和CA-LA... 详细信息

以癸酸(CA)、月桂酸(LA)和肉豆蔻酸(MA)为原料制备了新型的脂肪酸三元低共熔物(CA-LA-MA),并将其作为固-液相变材料,以沉积2 h银(Ag)纳米颗粒的静电纺聚丙烯腈(PAN)纳米纤维膜为支撑材料,通过物理吸附法制备了新型的CA-LA-MA/PAN和CA-LA-MA/PAN/Ag定型相变复合纤维膜。研究了磁控溅射Ag纳米层对定型相变复合纤维传热性能的影响。结果表明,沉积Ag纳米层后定型相变复合纤维膜的储热和放热时间分别缩短了31%和25%。制备的CA-LA-MA/PAN/Ag定型相变复合纤维膜的融化温度和结晶温度分别为19.87℃和11.63℃,融化焓值和结晶焓值分别为123.1 kJ/kg和121.5 kJ/kg。

关键词：静电纺丝复合相变纤维脂肪酸三元低共熔物磁控溅射储热性能传热改善

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开洞高层建筑风能利用效能的试验研究

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太阳能学报 2015年第10期36卷 2505-2510页

作者：李永贵李秋胜湖南科技大学土木工程学院湘潭411201 湖南大学建筑安全与节能教育部重点试验室长沙410082 香港城市大学九龙999077

对开洞高层建筑模型进行风速测试的风洞试验，采用风速比来衡量开洞高层建筑的风能利用效能，根据试验结果分析一些因素对风速比的影响，研究洞口中心处风速的湍流度。结果表明：洞口对风速的放大效果存在额定风速比；单洞口情况下，上... 详细信息

对开洞高层建筑模型进行风速测试的风洞试验，采用风速比来衡量开洞高层建筑的风能利用效能，根据试验结果分析一些因素对风速比的影响，研究洞口中心处风速的湍流度。结果表明：洞口对风速的放大效果存在额定风速比；单洞口情况下，上洞口最大风速比为1.28～1.35，下洞口最大风速比为1.31～1.39；风向角较小时，洞口中心处的湍流度比来流湍流度小，有利于风机稳定地进行风能发电，风向角较大时，洞口中心处的湍流度迅速增大。最后结合工程实例给出提高风能利用效能的途径。

关键词：开洞高层建筑风能风速比风洞试验

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癸酸-棕榈酸-硬脂酸/聚丙烯腈/氮化硼复合相变纤维膜的传热性能

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纺织学报 2019年第3期40卷 26-31页

作者：柯惠珍李永贵闽江学院福建省新型功能性纺织纤维及材料重点实验室福建福州350108 闽江学院服装与艺术工程学院福建福州350108

为克服癸酸-棕榈酸-硬脂酸(CA-PA-SA)三元低共熔物液相渗漏和导热性能差的问题,以不同质量比的静电纺聚丙烯腈/氮化硼(PAN/BN)复合纳米纤维膜作为支撑材料,通过物理吸附法制备新型CA-PA-SA/PAN/BN复合相变纤维膜,并研究了BN导热纳米粒... 详细信息

为克服癸酸-棕榈酸-硬脂酸(CA-PA-SA)三元低共熔物液相渗漏和导热性能差的问题,以不同质量比的静电纺聚丙烯腈/氮化硼(PAN/BN)复合纳米纤维膜作为支撑材料,通过物理吸附法制备新型CA-PA-SA/PAN/BN复合相变纤维膜,并研究了BN导热纳米粒子对复合相变纤维膜的形貌结构、储热性能以及储热和放热速率的影响。结果表明:添加质量分数为10%的BN导热纳米粒子对制备的CA-PA-SA/PAN/BN复合相变纤维膜的形貌结构没有影响;复合相变纤维膜的融化温度和融化焓值分别为25℃和136.4～138.6 kJ/kg;通过添加具有高导热系数的BN纳米粒子,CA-PA-SA/PAN/BN复合相变纤维膜的整体传热性能增强,储热和放热时间分别缩短了38%和41%。

关键词：复合相变纤维膜氮化硼癸酸-棕榈酸-硬脂酸三元低共熔物储热性能传热性能

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转变经济发展方式的逻辑架构

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经济问题探索 2011年第2期 110-114页

作者：李永贵中国人民大学马克思主义学院北京100872

转变经济发展方式是以科学发展观为内核,以对经济发展方式的"为谁发展"、"靠谁发展"、"如何发展"等基本问题的新认识为出发点,以重视发挥政府、国有经济作用为特色,不断探索"为什么要转"、"转什么"、"如何转"等基本问题的理论和实践答... 详细信息

转变经济发展方式是以科学发展观为内核,以对经济发展方式的"为谁发展"、"靠谁发展"、"如何发展"等基本问题的新认识为出发点,以重视发挥政府、国有经济作用为特色,不断探索"为什么要转"、"转什么"、"如何转"等基本问题的理论和实践答案于一体的有机架构体系。转变经济发展方式理论就是当代中国经济发展理论。

关键词：经济发展转变经济发展方式逻辑架构

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高层建筑标准模型脉动风荷载阻塞效应试验研究

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建筑结构学报 2019年第7期40卷 70-78页

作者：李永贵李茂杰谭文俊李毅湖南科技大学结构抗风与振动控制湖南省重点实验室湖南湘潭411201 湖南科技大学土木工程学院湖南湘潭411201

在均匀低湍流度风场和均匀高湍流度风场中对阻塞比分别为1.7%、3.1%、4.5%、6.3%、8.6%和10.9%的高层建筑标准模型进行了多点同步测压试验,研究了不同风场下阻塞效应对高层建筑标准模型层脉动风力系数和基底脉动力矩系数的影响。结果表... 详细信息

在均匀低湍流度风场和均匀高湍流度风场中对阻塞比分别为1.7%、3.1%、4.5%、6.3%、8.6%和10.9%的高层建筑标准模型进行了多点同步测压试验,研究了不同风场下阻塞效应对高层建筑标准模型层脉动风力系数和基底脉动力矩系数的影响。结果表明:在均匀低湍流度风场中,当模型阻塞比不大于4.5%时,阻塞效应对高层建筑标准模型层脉动风力系数和基底脉动力矩系数的影响很小;当模型阻塞比大于4.5%时,随着阻塞比的增大,层脉动风力系数和基底脉动力矩系数均明显增大,横风向最为显著。在均匀高湍流度风场中,湍流度的增加增大了层脉动风力系数和基底脉动力矩系数,抑制了阻塞效应对层脉动阻力系数和顺风向基底脉动弯矩系数的影响,削弱了阻塞效应对层脉动升力、扭矩系数和横风向基底脉动弯矩系数、扭转向基底脉动扭矩系数的影响。基于试验结果,提出了高层建筑标准模型层脉动风力系数和基底脉动力矩系数的阻塞效应修正公式,可为相关试验结果的修正提供参考。

关键词：高层建筑标准模型阻塞效应风洞试验脉动风力修正方法

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