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Disruption of PABPN1 phase separation by SNRPD2 drives colorectal cancer cell proliferation and migration through promoting alternative polyadenylation of CTNNBIP1

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Science China(Life Sciences) 2024年第6期67卷 1212-1225页

作者： Zhijie Hu Mengxia Li Yufeng Chen Liutao Chen Yuting Han Chengyong Chen Xin Lu Nan You Yawen Lou Yingye Huang Zhanfeng Huo Chao Liu Cheng Liang Susu Liu Ke Deng Liangfu Chen Shangwu Chen Guohui Wan Xiaojian Wu yonggui fu Anlong Xu State Key Laboratory of Biocontrol Guangdong Province Key Laboratory of Pharmaceutical Functional GenesDepartment of BiochemistrySchool of Life SciencesSun Yat-sen UniversityGuangzhou 510275China Department of General Surgery(Colorectal Surgery)&Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases&Biomedical Innovation Center The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655China National-Local Joint Engineering Laboratory of Druggability and New Drug Evaluation National Engineering Research Center for New Drug and Druggability(cultivation)Guangdong Province Key Laboratory of New Drug Design and EvaluationSchool of Pharmaceutical SciencesSun Yat-sen UniversityGuangzhou 510006China School of Life Sciences Beijing University of Chinese MedicineBeijing 100029China

Generally shortened 3′UTR due to alternative polyadenylation(APA)is widely observed in cancer,but its regulation mechanisms for cancer are not well ***,with profiling of APA in colorectal cancer tissues and poly(A)signal editing,we firstly identified that the shortened 3′UTR of CTNNIBP1 in colorectal cancer promotes cell proliferation and *** found that liquid-liquid phase separation(LLPS)of PABPN1 is reduced albeit with higher expression in cancer,and the reduction of LLPS leads to the shortened 3′UTR of CTNNBIP1and promotes cell proliferation and ***,the splicing factor SNRPD2 upregulated in colorectal cancer,can interact with glutamic-proline(EP)domain of PABPN1,and then disrupt LLPS of PABPN1,which attenuates the repression effect of PABPN1 on the proximal poly(A)*** results firstly reveal a new regulation mechanism of APA by disruption of LLPS of PABPN1,suggesting that regulation of APA by interfering LLPS of 3′end processing factor may have the potential as a new way for the treatment of cancer.

关键词： alternative polyadenylation colorectal cancer CTNNBIP1 PABPN1 liquid-liquid phase separation SNRPD2

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Global First Suezmax LNG Dual-fueled Tanker Delivered

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船舶经济贸易 2022年第7期 65-67页

作者： Wang Jin Kuang Zhanting Peng yonggui fu Zhiguan Zhong Wei 不详

The first ship of 158,000 DWT LNG dual-fueled tankers GREENWAY,designed by MARIC,the CSSC No.708 Research Institute and built by Guangzhou Shipbuilding International(GSI),was officially delivered on June *** ship is not only the largest LNG dual-fuel green ship built in South China,but also the world's first Suezmax LNG dual-fueled tanker.

关键词： Dual official Guangzhou

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U1 snRNP proteins promote proximal alternative polyadenylation sites by directly interacting with 3'end processing core factors

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Journal of Molecular Cell Biology 2022年第8期14卷 29-42页

作者： Zhijie Hu Mengxia Li Zhanfeng Huo Liutao Chen Susu Liu Ke Deng Xin Lu Shangwu Chen yonggui fu Anlong Xu State Key Laboratory of Biocontrol Guangdong Province Key Laboratory of Pharmaceutical Functional GenesDepartment of BiochemistrySchool of Life SciencesSun Yat-sen UniversityHigher Education Mega CenterGuangzhou 510006China School of Life Sciences Beĳing University of Chinese MedicineBeĳing 100029China

In eukaryotic cells,both alternative splicing and alternative polyadenylation(APA)play essential roles in the gene regulation network.U1 small ribonucleoprotein particle(U1 snRNP)is a major component of spliceosome,and U1 snRNP complex can suppress proximal APA sites through crosstalking with 3end processing ***,here we show that both knockdown and overexpression of SNRPA,SNRPC,SNRNP70,and SNRPD2,the U1 snRNP proteins,promote the usage of proximal APA sites at the transcriptome ***70 can drive the phase transition of PABPN1 from droplet to aggregate,which may reduce the repressive effects of PABPN1 on the proximal APA ***,SNRNP70 can also promote the proximal APA sites by recruiting CPSF6,suggesting that the function of CPSF6 on APA is related with other RNA-binding proteins and cell ***,these results reveal that,on the contrary to U1 snRNP complex,the free proteins of U1 snRNP complex can promote proximal APA sites through the interaction with 3end processing machinery.

关键词： U1 snRNP 3'end processing factors alternative polyadenylation phase separation

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A Tutorial on Quantized Feedback Control

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IEEE/CAA Journal of Automatica Sinica 2024年第1期11卷 5-17页

作者： Minyue fu IEEE the School of System Design and Intelligent Manufacturing Shenzhen Key Laboratory of Control Theory and Intelligent Systems and Centre for Control Science and TechnologySouthern University of Science and TechnologyShenzhen 518055China

In this tutorial paper, we explore the field of quantized feedback control, which has gained significant attention due to the growing prevalence of networked control systems. These systems require the transmission of feedback information, such as measurements and control signals, over digital networks, presenting novel challenges in estimation and control design. Our examination encompasses various topics, including the minimal information needed for effective feedback control, the design of quantizers, strategies for quantized control design and estimation,achieving consensus control with quantized data, and the pursuit of high-precision tracking using quantized measurements.

关键词： Consensus control high-precision control networked control quantized estimation quantized feedback control robust control

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Coupling Coordination Analysis of Cropland Intensification and Agroecosystem Services:Evidence from Loess Plateau in Shaanxi Province,China

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Chinese Geographical Science 2024年第3期34卷 401-419页

作者： fu Shaowu fu Mengyu QIU Menglong Center for Land Resource Research in Northwest China Shaanxi Normal UniversityXi’an 710119China

One of the greatest challenges in the agroecosystem is to improve cropland intensification while preserving agroecosystem *** many studies have investigated the effect of cropland intensification on agroecosystem service,the interactive coupling and coordination among these factors remain largely *** view of this,this study performed a case study of the Loess Plateau in Shaanxi Province,China and constructed comprehensive evaluation models to quantify the cropland intensification and agroecosystem service in this *** analysis and the coupling coordination degree model were used to evaluate the interactive relationship between cropland intensification and agroecosystem service,and statistical analysis and spatial autocorrelation were used to analyze the spatial characteristics and potential mechanism of the coupling *** show that both the cropland intensification and agroecosystem service in the study area were relatively low yet gradually increased from 2000 to *** service lag was identified as the dominant unbalanced development *** the supply capacity of agroecosystem services plays a key role in the balanced development of cropland in the Loess *** coupling coordination degree between cropland intensification and agroecosystem service ranges from basic coordination to serious ***,cropland intensification practices in the area should be optimized to enhance this coordination *** upward trend was also observed in the coupling coordination degree from2000 to *** withdrawal of marginal cropland in the Grain for Green program is one of the most important reasons for this trend,especially for the northern *** 83.6%of the high-high clusters are concentrated in the southern region of the Loess Plateau,whereas 70.5%of the low-low clusters are distributed in the northern *** clustering characteristics are mainly attributed to the environmental

关键词： cropland intensification agroecosystem services balance analysis coupling coordination degree Loess Plateau,China

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Dynamics of 2×2 matrix non-Hermitian quantum systems on Bloch sphere

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Communications in Theoretical Physics 2024年第4期76卷 66-71页

作者： Libin fu Graduate School of China Academy of Engineering Physics Beijing 100193China

By casting evolution to the Bloch sphere, the dynamics of 2 × 2 matrix non-Hermitian systems are investigated in detail. This investigation reveals that there are four kinds of dynamical modes for such systems. The different modes are classified by different kinds of fixed points, namely,the elliptic point, spiral point, critical node, and degenerate point. The Hermitian systems and the unbroken PT non-Hermitian cases belong to the category with elliptic points. The degenerate point just corresponds to the systems with exceptional point(EP). The topological properties of the fixed point are also discussed. It is interesting that the topological charge for the degenerate point is two, while the others are one.

关键词： non-Hermitian quantum system two-level system dynamics on the Bloch sphere PT-symmetry fixed points

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基于区块链的农村电商监管档案

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图书情报导刊 2023年第6期8卷 54-59页

作者：付永贵山西财经大学信息学院山西太原030006

针对农村电商业务复杂、信任问题突出,而现有的监管措施在实施时具有局限性的现实情况,提出将区块链应用于农村电商监管,构建基于区块链的农村电商监管档案的构想。研究了基于区块链的农村电商监管档案记录方法、监管信息生成原理以及... 详细信息

针对农村电商业务复杂、信任问题突出,而现有的监管措施在实施时具有局限性的现实情况,提出将区块链应用于农村电商监管,构建基于区块链的农村电商监管档案的构想。研究了基于区块链的农村电商监管档案记录方法、监管信息生成原理以及监管体系拓扑结构,并以顾客监管下农产品培育、生长为例分析了区块链技术下信息生成、记录方式及监管档案的内容结构,对农村电商监管档案管理的原则进行了说明。本研究对区块链在农村电商领域的应用具有很强的指导意义。

关键词：区块链农村电商监管档案

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New speckle pattern interferometry for precise in situ deformation measurements

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Chinese Optics Letters 2024年第1期22卷 34-40页

作者：章如月 Yu fu 缪泓 CAS Key Laboratory of Mechanical Behavior and Design of Materials Department of Modern MechanicsUniversity of Science and Technology of ChinaHefei 230027China Shenzhen Key Laboratory of Intelligent Optical Measurement and Detection College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 518060China

A new electronic speckle pattern interferometry method is proposed to realize in situ deformation *** feature of the method is the combination of a high-speed camera and multiple laser Doppler vibrometers(LDVs)for synchronous *** high-speed camera is used to record and select effective interferograms,while the LDVs are used to measure the rigid body displacement caused by vibrations.A series of effective interferograms with known shifted phase values are obtained to calculate the deformation *** experimental results show that the method performs well in measuring static and dynamic deformations with high accuracy in vibrating environments.

关键词： speckle pattern interferometry laser Doppler vibrometers in situ deformation measurements

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Small Cycles Property of Some Cremer Rational Maps and Polynomials

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Chinese Annals of Mathematics,Series B 2024年第1期45卷 123-136页

作者： Rong fu Ji ZHOU Faculty of Science Yibin UniversityYibin 644000SichuanChina Department of Mathematical Sciences Sichuan Normal UniversityChengdu 610066China

This paper concerns the linearization problem on rational maps of degree d≥2 and polynomials of degree d>2 from the perspective of *** authors introduce a set l_(∞) of irrational numbers and show that if α∈l_(∞),then any rational map is not linearizable and has infinitely many cycles in every neighborhood of the fixed point with multiplier λ=e^(2πiα),Adding more constraints to cubic polynomials,they discuss the above problems by polynomial-like *** the family of polynomials,with the help of Yoccoz's method,they obtain its maximum dimension of the set in which the polynomials are non-linearizable.

关键词： Irrationally indifferent fixed point Linearization problem Small cycles property

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A stochastic gradient-based two-step sparse identification algorithm for multivariate ARX systems

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Control Theory and Technology 2024年第2期22卷 213-221页

作者： Yanxin fu Wenxiao Zhao Key Laboratory of Systems and Control Academy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing100190China School of Mathematical Sciences University of Chinese Academy of SciencesBeijing100049China

We consider the sparse identification of multivariate ARX systems, i.e., to recover the zero elements of the unknown parameter matrix. We propose a two-step algorithm, where in the first step the stochastic gradient (SG) algorithm is applied to obtain initial estimates of the unknown parameter matrix and in the second step an optimization criterion is introduced for the sparse identification of multivariate ARX systems. Under mild conditions, we prove that by minimizing the criterion function, the zero elements of the unknown parameter matrix can be recovered with a finite number of observations. The performance of the algorithm is testified through a simulation example.

关键词： ARX system Stochastic gradient algorithm Sparse identification Support recovery Parameter estimation Strong consistency

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