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Predictability of polygenic risk score for progression to dementia and its interaction with APOEε4 in mild cognitive impairment

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Translational neurodegeneration 2021年第3期10卷 412-420页

作者： j.ng‑Min Pyun Young Ho Park Keon‑joo Lee SangYun Kim Andrew j.Saykin Kwangsik nho Department of neurology Uijeongbu Eulji Medical CenterEulji UniversityUijeongbuRepublic of Korea Department of neurology Seoul National University Bundang Hospital and Seoul National University College of Medi‑cineSeongnamRepublic of Korea Department of Radiology and Imaging Sciences and the Indiana Alzheimer Disease CenterIndiana University School of MedicineIndianapolisINUSA Department of Medical and Molecular Genetics Indiana University School of MedicineIndianapolisINUSA Center for Computational Biology and Bioinformatics Indiana University School of MedicineIndianapolisINUSA.

Background:The combinatorial efect of multiple genetic factors calculated as a polygenic risk score(PRS)has been studied to predict disease progression to Alzheimer’s disease(AD)from mild cognitive impairment(MCI).Previous studies have investigated the performance of PRS in the prediction of disease progression to AD by including and excluding single nucleotide polymorphisms within the region surrounding the APOE *** studies may have missed the APOE genotype-specifc predictability of PRS for disease progression to ***:We analyzed 732 MCI from the Alzheimer’s Disease neuroimaging Initiative cohort,including those who progressed to AD within 5 years post-baseline(n=270)and remained stable as MCI(n=462).The predictability of PRS including and excluding the APOE region(PRS_(+APOE) and PRS_(−APOE))on the conversion to AD and its interaction with the APOEε4 carrier status were assessed using Cox regression ***:PRS_(+APOE)(hazard ratio[HR]1.468,95%CI 1.335-1.615)and PRS_(−APOE)(HR 1.293,95%CI 1.157-1.445)were both associated with a signifcantly increased risk of MCI progression to *** interaction between PRS_(+APOE) and APOEε4 carrier status was signifcant with a P-value of *** association of PRSs with the progression risk was stronger in APOEε4 non-carriers(PRS_(+APOE):HR 1.710,95%CI 1.244-2.351;PRS_(−APOE):HR 1.429,95%CI 1.182-1.728)than in APOEε4 carriers(PRS_(+APOE):HR 1.167,95%CI 1.005-1.355;PRS_(−APOE):HR 1.172,95%CI 1.020-1.346).Conclusions:PRS could predict the conversion of MCI to dementia with a stronger association in APOEε4 noncarriers than APOEε4 *** indicates PRS as a potential genetic predictor particularly for MCI with no APOEε4 alleles.

关键词： Polygenic risk score Mild cognitive impairment Alzheimer’s disease Disease progression APOEε4

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非标异型紧固件ML08Al钢铆钉开裂原因分析和工艺改进

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特殊钢 2021年第3期42卷 39-41页

作者：赵满堂陶群南陈永峰陆继欢芜湖新兴铸管有限责任公司研究院芜湖241002

分析表明非标异型紧固件ML08A1钢铆钉开裂由于材料原始屈服强度偏高、材料塑性差是造成铆钉翻边开裂的主要原因。通过优化成分控制在0.04%0.06%C、≤0.05%Si、0.30%0.35%Mn,Ti含量由0.021%降至0.001%,冶炼过程[n]控制小于30×10-6,使屈... 详细信息

分析表明非标异型紧固件ML08A1钢铆钉开裂由于材料原始屈服强度偏高、材料塑性差是造成铆钉翻边开裂的主要原因。通过优化成分控制在0.04%0.06%C、≤0.05%Si、0.30%0.35%Mn,Ti含量由0.021%降至0.001%,冶炼过程[n]控制小于30×10-6,使屈服强度由260264 MPa降至219226 MPa,降低材料加工硬化率,获得更高的塑性应变能力,保证铆钉深加工质量要求,百吨铆钉开裂率由原来的8%降低至0.33%左右。

关键词： ML08Al钢非标异型紧固件铆钉开裂力学性能材料塑性

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Thermal Properties of Some Turkish Peloids and Clay Minerals for Their Use in Pelotherapy

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Geomaterials 2016年第4期6卷 79-90页

作者： M. Çelik Karakaya n. Karakaya H. Cingilli Vural Selcuk üniversitesi Mühendislik Fak. jeoloji Mühendisligi Bolümü Konya Turkey Faculty of Medicine Necmettin Erbakan University Konya Turkey

The thermal properties such as specific heat capacity and heat dissipation of peloids play an important role in therapeutic applications. Therefore, these properties were determined on the peloids samples taken from spas where peloid applications are used in Turkey. In addition, some pure clay minerals were investigated to determine their suitability as possible constituents of therapeutic peloids and to make recommendations for preparing the most usable peloids for thermal therapy. For this aim, the mineralogical and thermal properties of samples were investigated using X-ray diffraction (XRD) and Differential Scanning Calorimeter (DSC). The mineralogical compositions of the peloid samples are not homogenous, and their clay mineral content is approximately 60%, and the most abundant clay mineral is calcium montmorillonite. The cooling time of peloids are between 20 and 25 minutes, which is suitable for therapy and thus these peloids are suitable for using in health problems requiring heat treatment. The samples have favorable heat dissipation capacity and partially cooling kinetics. Specific heat capacity of the peloid samples is partially appropriate for heat therapy and these values range from 0.60 to 1.41 j/g·°C, and partially high in peloids with high smectite content. The pure sepiolite samples have higher heat dissipation properties than those of other clay minerals especially illites and kaolinites. Ca-montmorillonite and kaolinite have the lowest specific heat values while sepiolite samples have higher values. Sepiolite and partly na-Ca-montmorillonite are more appropriate than the other studied clay minerals as a peloid constituent especially for therapy of musculoskeletal pain.

关键词： Clay Minerals Health Heat Dissipation Peloid Pelotherapy Specific Heat

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Magnetic bioassembly platforms towards the generation of extracellular vesicles from human salivary gland functional organoids for epithelial repair

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Bioactive Materials 2022年第12期7卷 151-163页

作者： Ajjima Chansaenroj Christabella Adine Sawanya Charoenlappanit Sittiruk Roytrakul Ladawan Sariya Thanaphum Osathanon Sasitorn Rungarunlert Ganokon Urkasemsin Risa Chaisuparat Supansa Yodmuang Glauco R.Souza joao n.Ferreira Avatar Biotechnologies for Oral Health and Healthy Longevity Research Unit Faculty of DentistryChulalongkorn UniversityBangkok10330Thailand Faculty of Dentistry National University of Singapore119077SingaporeSingapore Department of Biomedical Engineering Faculty of EngineeringNational University of Singapore119077SingaporeSingapore Functional Ingredients and Food Innovation Research Group National Center for Genetic Engineering and BiotechnologyNational Science and Technology Development AgencyPathum Thani12120Thailand The Monitoring and Surveillance Center for Zoonotic Diseases in Wildlife and Exotic Animals Faculty of Veterinary ScienceMahidol UniversityNakhon Pathom73170Thailand Department of Anatomy Faculty of DentistryChulalongkorn UniversityBangkok10330Thailand Department of Preclinical and Applied Animal Science Faculty of Veterinary ScienceMahidol UniversityNakhon Pathom73170Thailand Research Affairs Faculty of MedicineChulalongkorn UniversityBangkok10330Thailand University of Texas Health Sciences Center at Houston HoustonTX77030USA nano3D Biosciences Inc. HoustonTX77030USA Greiner Bio-One north America Inc MonroeNC28110USA

Salivary glands(SG)are exocrine organs with secretory units commonly injured by ***-engineered organoids and extracellular vesicles(EV)are currently under investigation as potential strategies for SG ***,three-dimensional(3D)cultures of SG functional organoids(SGo)and human dental pulp stem cells(hDPSC)were generated by magnetic 3D bioassembly(M3DB)*** growth factor 10(FGF10)was used to enrich the SGo in secretory epithelial *** 11 culture days via M3DB,SGo displayed SG-specific acinar epithelial units with functional properties upon *** consistently develop 3D hDPSC in vitro,3 culture days were sufficient to maintain hDPSC undifferentiated genotype and phenotype for EV *** isolation was performed via sequential centrifugation of the conditioned media of hDPSC and SGo *** were characterized by nanoparticle tracking analysis,electron microscopy and *** were in the exosome range for hDPSC(diameter:88.03±15.60 nm)and for SGo(123.15±63.06 nm).Upon ex vivo administration,exosomes derived from SGo significantly stimulated epithelial growth(up to 60%),mitosis,epithelial progenitors and neuronal growth in injured SG;however,such biological effects were less distinctive with the ones derived from ***,these exosome biological effects were investigated by proteomic *** spectrometry profiling of SGo exosomes predicted that cellular growth,development and signaling was due to known and undocumented molecular targets downstream of *** were identified as one of the novel targets requiring further ***,M3DB platforms can generate exosomes with potential to ameliorate SG epithelial damage.

关键词： Salivary gland Hyposalivation Human dental pulp stem cells Magnetic bioassembly Organoids Exosome

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Effect of Rotation Rate on Microstructure and Mechanical Properties of Friction Stir Spot Welded DP780 Steel

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journal of Materials Science & Technology 2016年第4期32卷 326-332页

作者： G.M.Xie H.B.Cui Z.A.Luo W.Yu j.Ma G.D.Wang State Key Laboratory of Rolling and Automation Northeastern University

DP780 steel sheets consisting of ferrite and martensite were successfully friction stir spot welded （FSSW） at the rotation rates of 500 to 1500 r/min using a W-Re alloy tool, The effect of rotation rate on micro- structure and mechanical properties of the FSSW DP780 was investigated. The peak temperatures in the welds at various rotation rates were identified to be above A3 temperature. FSSW caused the dynamic recrystallization in the stir zone （SZ）, thereby producing the fine equiaxed grain structures. At the higher rotation rates of≥1000 r/min, a full martensitic structure was observed throughout the SZs, whereas at the lower rotation rate of 500 r/min, the SZ consisted of a fine dual phase structure of ferrite and mar- tensite due to the action of deformation induced ferrite transformation. The maximum average failure load as high as 18.2 kn was obtained at the rotation rate of 1000 r/min and the fracture occurred at the thinned upper sheet.

关键词： Friction stir spot weldingDual phase steelMicrostructureDeformation induced ferritetransformationMechanical property

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A near infrared spectroscopy calibration for the prediction of fresh grass quality on Irish pastures

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Information Processing in Agriculture 2022年第2期9卷 243-253页

作者： Darren j.Murphy Bernadette O’Brien Michael O’Donovan Tomas Condon Michael D.Murphy Teagasc Animal&Grassland Research and Innovation CentreMooreparkFermoyCo.CorkIreland Department of Process Energy and Transport EngineeringMunster Technological UniversityCorkIreland

The aim of this study was to develop near infrared spectroscopy(nIRS)calibrations to predict quality parameters,dry matter(DM,g kg1)and crude protein(CP,g kg1 DM),in fresh un-dried *** of these parameters would enable more precise allocation of quality herbage to grazing *** ryegrass samples(n=1615)were collected over the 2017 and 2018 grazing seasons at Teagasc Moorepark to develop a nIRS calibration *** samples were collected for an independent validation dataset(n=197)during the 2019 grazing *** were scanned using a FOSS 6500 spectrometer at 2 nm intervals in the range of 1100~2500 nm and absorption was recorded as log 1/Reflec*** wet chemistry analysis was carried out for both parameters and the resultant data were calibrated against spectral data by means of modified partial least squares regression.A range of mathematical spectral treatments were examined for each calibration,which were ranked in order of standard error of prediction(SEP)and ratio of percent deviation(RPD).Best performing calibrations achieved high predictive precision for DM(R2=0.86 SEP=9.46 g kg1,RPD=2.60)and moderate precision for CP(R2=0.84 SEP=20.38 g kg1 DM,RPD=2.37).These calibrations will aid the optimisation of grassland management and the development of precision agricultural technologies.

关键词： near infrared spectroscopy Fresh grass analysis Grassland management Grass quality Precision agriculture

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Does epigenetics have a role in age related macular degeneration and diabetic retinopathy?

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Genes & Diseases 2021年第3期8卷 279-286页

作者： S.Mohana Devi I.Mahalaxmi j.Kaavya V.Chinnkulandhai V.Balachandar Sn OnGC Department of Genetics and Molecular Biology Vision Research FoundationSankara Nethralaya41/18College RoadChennai600006India Department of Zoology Avinashilingam Institute for Home Science and Higher Education for WomenAvinashilingam University for WomenCoimbatoreTamil Nadu641046India Department of Biochemistry Dr.N.G.P Arts and Science CollegeCoimbatoreTami lNadu641046India Human Molecular Genetics and Stem Cells Laboratory Department of Human Genetics and Molecular BiologyBharathiar UniversityCoimbatoreTamil Nadu641046India

Epigenetic mechanisms play an important part in the regulation of gene expression and these alterations may induce long-term changes in gene function and *** have received extensive attention in bridging the gap between environmental exposures and disease development via their influence on gene *** methylation is the earliest discovered epigenetic *** this review,we try to examine the role of DnA methylation and histone modification in Age related macular degeneration(AMD)and Diabetic Retinopathy(DR),its vascular complications and recent *** the complex nature of AMD and DR,it is crucial to improve therapeutics which will greatly enhance the quality of life and reduce the burden for millions of patients living with these potentially blinding conditions.

关键词： Age-related macular degeneration(AMD) Diabetic Retinopathy(DR) Epigenetics Gene expression

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文化、不平等性与卫生服务提供

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中国卫生政策研究 2016年第3期9卷 74-80,F0003页

作者： napier A D Ancarno C Butler B Calabrese j Chater A Chatterjee H Guesnet F Horne R jacyna S jadhav S Macdonald A neuendorf U Parkhurst A Reynolds R Scambler G Shamdasani S Smith S Z Stougaard-nielsen j Thomson L Tyler n Volkmann A M Walker T Watson j Williams A C Willott C Wilson j Woolf K 伦敦大学学院英国伦敦WC1E6BT 伦敦国王学院英国伦敦WC2R2LS 贝德福特大学英国贝德福特LV13JV 国际长寿中心英国伦敦SW1P3QB

1动态不平等性对基层医疗卫生人力的影响政治、社会、文化、专业群体皆建立在一致且常规的人类行为之上。当遭受巨大变革和内外压力时,这些群体会变得十分脆弱。尤其在动荡时期,这些群体往往更关注社会和文化的差异性,而非二者的一致性... 详细信息

1动态不平等性对基层医疗卫生人力的影响政治、社会、文化、专业群体皆建立在一致且常规的人类行为之上。当遭受巨大变革和内外压力时,这些群体会变得十分脆弱。尤其在动荡时期,这些群体往往更关注社会和文化的差异性,而非二者的一致性。尽管社会中的个体思维和行为会呈现较大的差异,但对健康的感知具有统一性,并在更广范围人群内尤为突出,这主要归因于文化价值观的作用。广义的文化心态会随着时间和地理位置的不同而不同,就像健康的社会决定因素也会因文化类型的不同而产生差异。

关键词：卫生服务不平等性专业群体基层医疗卫生结构暴力个体思维文化类型价值观体系文化心态卫生人员

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A Synopsis of Pterostemon (Iteaceae), a Group Endemic to Mexico

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American journal of Plant Sciences 2013年第12期4卷 1-9页

作者： judith Márquez Guzmán Martha Martínez Gordillo Ramiro Cruz Durán jaime jiménez Ramírez María Cristina Pérez-Amador Departamento de Biología Comparada Facultad de Ciencias Universidad Nacional Autónoma de México México D.F. México Laboratorio de Desarrollo en Plantas Facultad de Ciencias Universidad Nacional Autónoma de México México D. F. México Laboratorio de Química Facultad de Ciencias Universidad Nacional Autónoma de México México D. F. México

The genus Pterostemon Schauer (Iteaceae), is a group of three species restricted in distribution to Mexico. It includes: Pterostemon mexicanus Schauer, P. rotundifolius Ramírez, and P. bravoanus j. jiménez-Ram. & Martínez Gordillo. On the basis of field observations and herbarium specimens, we review the morphology (vegetative and reproductive), and distribution to give an updated taxonomic treatment for the genus. Additionally the utility of morphological characters is evaluated for taxomic use, and detailed taxonomic descriptions and ecological associations are given for each species.

关键词： Endemic Mexico Pterostemon Iteaceae

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Isolation and Identification of Secondary Metabolites from Albizia cortex and There Inhibitory Effect on hACAT-1 and hACAT-2

Isolation and Identification of Secondary Metabolites from A...

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13th Asian Chemical Congress

作者： BAEK M.Y. CHO j.G jEOnG T.S LEE j.W. LEE Y.H. LEE M.K. SHRESTHA S AHn E.M BAEK n.I Graduate School of Biotechnology Kyung Hee University Institute of Bioscience and Biotechnology Daejeon 305-333Korea Daegu Haany University

＜正＞Albiziajulibrissin Durazz（Leguminosae,silk flower）is deciduous tree,growing abundantly in Korea. Authors’ experiment revealed that the alcohol extracts improved some skin troubles caused by atopy. So this study was carried out to isolate the principal compound from the bark of *** to manifest the *** stem bark of *** was extracted with 70%aqueous EtOH,and the

关键词： Albizia julibrissin Albizia cortext Triterpenoid Lignan hACAT-1 hACAT-2

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