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Journal of Environmental Sciences 2024年第8期142卷 11-20页

作者： Guodong zhao Chong Tian Peidong Wu Xuguang Zhang Zhikang Wang Xiaoxiang Chen Zhuo Xiong yongchun zhao Junying Zhang State Key Laboratory of Coal Combustion School of Energy and Power EngineeringHuazhong University of Science and TechnologyWuhan 430074China School of Power and Mechanical Engineering Wuhan UniversityWuhan 430072China National Environmental Protection Engineering Technology Center for Trace Elements Pollution Control and Low Carbon Utilization of Coal Huazhong University of Science and TechnologyWuhan 430074China School of Environmental Engineering Wuhan Textile UniversityWuhan 430200China

Chromium released during municipal solid waste incineration(MSWI)is toxic and carcinogenic.The removal of chromium from simulated MSWI flue gas by four sorbents(CaO,bamboo charcoal(BC),powdered activated carbon(PAC),and Al_(2)O_(3))and the effects of four oxides(SiO_(2),Al_(2)O_(3),Fe_(2)O_(3),and CaO)on chromium speciation transformationwere investigated.The results showed that the removal rates of total Cr by the four sorbents were Al_(2)O_(3)

关键词： Cr(Ⅵ)reduction Cr(Ⅲ)oxidation Alkali oxides Acidic oxides Municipal solid waste incineration

Potential role and therapeutic implications of glutathione peroxidase 4 in the treatment of Alzheimer's disease

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Neural Regeneration Research 2025年第3期20卷 613-631页

作者： Yanxin Shen Guimei Zhang Chunxiao Wei Panpan zhao yongchun Wang Mingxi Li Li Sun Department of Neurology and Neuroscience Center The First Hospital of Jilin UniversityJilin UniversityChangchunJilin ProvinceChina Cognitive Impairment Center Department of NeurologyThe First Hospital of Jilin UniversityJilin UniversityChangchunJilin ProvinceChina

Alzheimer's disease is an age-related neurodegenerative disorder with a complex and incompletely understood pathogenesis. Despite extensive research, a cure for Alzheimer's disease has not yet been found. Oxidative stress mediates excessive oxidative responses, and its involvement in Alzheimer's disease pathogenesis as a primary or secondary pathological event is widely accepted. As a member of the selenium-containing antioxidant enzyme family, glutathione peroxidase 4 reduces esterified phospholipid hydroperoxides to maintain cellular redox homeostasis. With the discovery of ferroptosis, the central role of glutathione peroxidase 4 in anti-lipid peroxidation in several diseases, including Alzheimer's disease, has received widespread attention. Increasing evidence suggests that glutathione peroxidase 4 expression is inhibited in the Alzheimer's disease brain, resulting in oxidative stress, inflammation, ferroptosis, and apoptosis, which are closely associated with pathological damage in Alzheimer's disease. Several therapeutic approaches, such as small molecule drugs, natural plant products, and non-pharmacological treatments, ameliorate pathological damage and cognitive function in Alzheimer's disease by promoting glutathione peroxidase 4 expression and enhancing glutathione peroxidase 4 activity. Therefore, glutathione peroxidase 4 upregulation may be a promising strategy for the treatment of Alzheimer's disease. This review provides an overview of the gene structure, biological functions, and regulatory mechanisms of glutathione peroxidase 4, a discussion on the important role of glutathione peroxidase 4 in pathological events closely related to Alzheimer's disease, and a summary of the advances in small-molecule drugs, natural plant products, and non-pharmacological therapies targeting glutathione peroxidase 4 for the treatment of Alzheimer's disease. Most prior studies on this subject used animal models, and relevant clinical studies are lacking. Future clinical trials are required to validate the therapeuti

关键词： apoptosis ferroptosis inflammation lipid peroxidation natural plant products neurodegenerative disorder neuroprotection oxidative stress small-molecule drugs

A critical review on lead migration, transformation and emission control in Chinese coal-fired power plants

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Journal of Environmental Sciences 2023年第2期124卷 397-413页

作者： Yicheng Wang Hongyun Hu Xinye Wang Huimin Liu Lu Dong Guangqian Luo yongchun zhao Hong Yao State Key Laboratory of Coal Combustion School of Energy and Power EngineeringHuazhong University of Science and TechnologyWuhan 430074China Jiangsu Provincial Key Laboratory of Materials Cycling and Pollution Control School of Energy and Mechanical EngineeringNanjing Normal UniversityNanjing 210023China

Coal is widely utilized as an important energy source,but coal-fired power plant was considered to be an important anthropogenic lead emission source.In the present study,the distribution characteristics of lead in coal and combustion by-products are reviewed.Specifically,lead is mainly transferred to ash particles and the formation and migration mechanisms of particulate lead are summarized.Also,targeted measures are proposed to control the formation of fine particulate lead as well as to increase the removal efficiency during the low-temperature flue gas clean process.In detail,interactions between gaseous lead and some coal-bearing minerals or added adsorbents could obviously suppress the formation of fine particulate lead.On the other hand,some efforts(including promoting capture of fine particles,reducing resistivity of particles and strengthening the gas-liquid contact)could be made to improve the fine particulate lead removal capacity.Notably,the formation mechanism of fine particulate lead is still unclear due to the limitations of research methods.Some differences in the removal principles of fine particles and particulate lead make the lead emission precisely control a great challenge.Finally,the environmental potential risk of lead emission from flue gas and ash residues is addressed and further discussed.

关键词： Coal combustion Particulate lead Formation and migration Removal strengthen Environmental risk

Retention of trace elements in coal-fired flue gas by a novel heterogeneous agglomeration technology

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Journal of Environmental Sciences 2023年第3期125卷 234-243页

作者： Yushan Ji Xiangzheng Cui Jingchao Liu Tianle Zhang Shuzhou Wei Junfeng Zhang yongchun zhao Junying Zhang State Key Laboratory of Coal Combustion School of Energy and Power EngineeringHuazhong University of Science and TechnologyWuhan 430074China National Environmental Protection Engineering Technology Center for Trace Elements Pollution Control and Low Carbon Utilization of Coal Wuhan 430074China Sanhe Power Generation Co.Ltd Sanhe 065201China Hebei Coal-fired Power Station Pollution Control Technology Innovation Center Sanhe 065201China

Heterogeneous agglomeration (HA) is a very potential technology for coal-fired flue gas treatment.In this paper,the distribution and migration mechanisms of trace elements (TEs such as Se,As and Pb in CFPPs were studied on a 30,000 m^(3)/hr pilot-scale experimental plat form.The influences of HA on the removal efficiency of gaseous and particulate TEs were well analyzed.The results showed that Se,As and Pb were enriched in fly ash,and their sen sitivity to particle size is quite different.The content of Se was the highest in PM1,reaching193.04 mg/kg at the electrostatic precipitator (ESP) outlet.The average particle size of the total dust before ESP increased significantly from 21.686 to 62.612μm after injecting the heterogeneous agglomeration adsorbent,conducive to its further removal by ESP.In addi tion,the concentrations of gaseous Se,As and Pb in the flue gas decreased after adsorben spray,and accordingly,their contents in the hierarchical particles increased,indicating tha the adsorbent could effectively promote the adsorption of gaseous trace elements in fly ash and reduce the possibility of their escape to the atmosphere.Total concentrations of Se,As and Pb emitted by wet flue gas desulfurization (WFGD) are 0.223,0.668 and 0.076μg/m^(3)which decreased by 59.98%,47.69%and 90.71%,respectively.Finally,a possible HA mecha nism model was proposed,where chemical adsorption,physical condensation and collision agglomeration of gaseous TEs and fine particles with adsorbent droplets occurred to form larger agglomerates.

关键词： Heterogeneous agglomeration Hazardous trace elements Particulate matter Flue gas Pilot experiments

Integrated removal of NO and mercury from coal combustion flue gas using manganese oxides supported on TiO_2

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Journal of Environmental Sciences 2017年第3期29卷 141-150页

作者： Shibo Zhang yongchun zhao Zonghua Wang Junying Zhang Lulu Wang Chuguang Zheng State Key Laboratory of Coal Combustion School of Energy and Power EngineeringHuazhong University of Science and Technology Henan Institute of Metallurgy Co. Ltd. Research Center of Quality Inspection Analysis and Test of Henan Academy of Sciences

A catalyst composed of manganese oxides supported on titania （MnOx/TiO2） synthesized by a sol-gel method was selected to remove nitric oxide and mercury jointly at a relatively low temperature in simulated flue gas from coal-fired power plants. The physico-chemical characteristics of catalysts were investigated by X-ray fluorescence （XRF）, X-ray diffraction （XRD）, and X-ray photoelectron spectroscopy （XPS） analyses, etc. The effects of Mn loading, reaction temperature and individual flue gas components on denitration and Hg0 removal were examined. The results indicated that the optimal MrgTi molar ratio was 0.8 and the best working temperature was 240℃for NO conversion. 02 and a proper ratio of [NH3]/[NO] are essential for the denitration reaction. Both NO conversion and Hg0 removal efficiency could reach more than 80% when NO and Hg0 were removed simultaneously using Mn0.8Ti at 240℃. Hg0 removal efficiency slightly declined as the Mn content increased in the catalysts. The reaction temperature had no significant effect on Hg0 removal efficiency. 02 and HCI had a promotional effect on Hg0 removal. SO2 and NH3 were observed to weaken Hg0 removal because of competitive adsorption. NO first facilitated Hg0 removal and then had an inhibiting effect as NO concentration increased without 02, and it exhibited weak inhibition of Hg0 removal efficiency in the presence of 02. The oxidation of Hg0 on MnOx/ TiO= follows the Mars-Maessen and Langmuir-Hinshelwood mechanisms.

关键词： ManganeseTitaniaNitric oxideMercurySCR

表皮生长因子受体在胰腺腺鳞癌中的表达及临床意义

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中华肝胆外科杂志 2024年第1期30卷 38-43页

作者：付永纯赵昕吕少诚胡志朝贺强北京怀柔医院肝胆外科北京101400 首都医科大学附属北京朝阳医院肝胆外科北京100020

目的:探讨表皮生长因子受体(EGFR)在胰腺腺鳞癌(PASC)中的表达及临床意义。方法:收集2016年1月至2021年12月于首都医科大学附属北京朝阳医院接受手术治疗的60例胰腺癌组织标本和8例正常胰腺组织标本。回顾性分析这60例患者的临床病理资... 详细信息

目的:探讨表皮生长因子受体(EGFR)在胰腺腺鳞癌(PASC)中的表达及临床意义。方法:收集2016年1月至2021年12月于首都医科大学附属北京朝阳医院接受手术治疗的60例胰腺癌组织标本和8例正常胰腺组织标本。回顾性分析这60例患者的临床病理资料,包括男性23例,女性37例,年龄(62.7±10.2)岁,其中病理结果为PASC的20例,通过倾向性匹配同期胰腺导管腺癌(PDAC)40例。免疫组织化学染色(IHC)检测EGFR表达的积分光密度(IOD)值,荧光定量聚合酶链反应检测EGFR mRNA的表达差异,根据EGFR的IOD值中位数将20例PASC样本分为高、低表达两组,Kaplan-Meier生存分析比较EGFR表达对PASC患者预后的影响。结果:PASC组的癌组织IOD值为29.2(25.7,35.1),高于PDAC组的IOD值9.5(5.5,13.0),且均高于正常组织的2.4(1.7,3.1),差异均有统计学意义(均 P<0.001)。PASC组EGFR mRNA表达水平高于PDAC组[3.0(1.8,3.5)比1.2(0.8,1.2)],差异有统计学意义( P=0.0 079)。EGFR高表达组相较于低表达组生存时间更短( P=0.002)。PASC组血管侵犯率高于PDAC组[40.0%(8/20)比17.5%(7/40)],差异有统计学意义( P=0.002)。PASC组的中位生存时间为16.00(9.25,25.25)个月,低于PDAC组的21.50(11.25,40.75)个月,差异有统计学意义( P=0.033)。PASC组术后累积生存率低于PDAC组,差异有统计学意义( P<0.028)。结论:PASC组织中EGFR表达显著升高,且PASC患者预后不良。

关键词：胰腺肿瘤胰腺腺鳞癌表皮生长因子受体靶向治疗

基于大数据的汽轮机系统中变频技术与循环水泵优化研究

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电力系统装备 2024年第3期 89-91页

作者：赵永春江苏核电有限公司江苏连云港222042

随着工业领域的发展和汽轮机系统的广泛应用,提高系统运行效率和降低能耗成为重要课题。本研究基于大数据技术,针对汽轮机循环水泵进行改造与优化。通过分析变频技术的原理和优势,以及大数据技术在汽轮机系统中的应用,设计了基于大数据... 详细信息

随着工业领域的发展和汽轮机系统的广泛应用,提高系统运行效率和降低能耗成为重要课题。本研究基于大数据技术,针对汽轮机循环水泵进行改造与优化。通过分析变频技术的原理和优势,以及大数据技术在汽轮机系统中的应用,设计了基于大数据的汽轮机循环水泵变频改造方案。通过实施该方案,可充分利用大数据分析和变频技术,提高汽轮机系统的运行效率,提高系统的稳定性和可靠性。

关键词：大数据汽轮机循环水泵变频改造运行优化

维普期刊数据库博看期刊评论

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基于堆机协调的汽轮机停机顺控方案

今日自动化 2024年第1期 109-111页

作者：赵永春江苏核电有限公司江苏连云港222042

文章针对传统汽轮机停机顺控存在的问题,提出了基于堆机协调的汽轮机停机顺控方案.通过实施与应用,验证了该方案的有效性,并评估了其优势与局限.研究结果表明,基于堆机协调的汽轮机停机顺控方案能够实现高效的停机顺序调度,优化能源利用... 详细信息

文章针对传统汽轮机停机顺控存在的问题,提出了基于堆机协调的汽轮机停机顺控方案.通过实施与应用,验证了该方案的有效性,并评估了其优势与局限.研究结果表明,基于堆机协调的汽轮机停机顺控方案能够实现高效的停机顺序调度,优化能源利用,并提高停机操作的安全性和可靠性.

关键词：堆机协调汽轮机停机顺控

冻融作用下复合相变材料改良黄土力学特性研究及机理分析

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防灾减灾工程学报 2024年第3期44卷 715-724页

作者：朱怀太欧尔峰姜琪赵永春赵建沅兰州交通大学土木工程学院甘肃兰州730070 中国科学院西北生态环境资源研究院冻土工程国家重点实验室甘肃兰州730000 中国科学院大学北京100049

为降低冻融作用对黄土力学性能的劣化影响,基于相变材料的温度调控功能,提出了一种采用膨胀石墨-正十四烷复合相变材料(EG-C_(14))改良黄土的方法。以兰州黄土为研究对象,开展典型冻融循环后不同EG-C_(14)掺入比黄土试样的体积变形试验... 详细信息

为降低冻融作用对黄土力学性能的劣化影响,基于相变材料的温度调控功能,提出了一种采用膨胀石墨-正十四烷复合相变材料(EG-C_(14))改良黄土的方法。以兰州黄土为研究对象,开展典型冻融循环后不同EG-C_(14)掺入比黄土试样的体积变形试验、力学性能试验和微观结构试验,探究冻融作用下不同EG-C_(14)掺量对黄土力学性能的影响规律及改良机理。试验结果表明:EG-C_(14)减缓了冻融循环过程中土体内部的温度变化,进而有效抑制了土体的胀缩变形;同时,EG-C_(14)降低了冻融循环对土体微观结构的损伤,与素黄土相比,多次冻融循环后改良土体内部的支架孔隙明显减少,颗粒骨架也更为密实,进而增强了土体的力学性能;此外,EG-C_(14)改良黄土的力学性能随EG-C_(14)掺量的增加先增大然后逐渐趋于稳定,且掺量为4%时改良效果最佳。

关键词：冻融作用黄土复合相变材料力学特性机理分析

化学团聚耦合低温省煤器强化除尘协同脱硫废水零排放试验研究

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中国电机工程学报 2024年第6期44卷 2292-2300,I0017页

作者：王志康雍恒杨刚中熊卓赵永椿张军营煤燃烧国家重点实验室(华中科技大学) 湖北省武汉市430074

煤燃烧产生的细颗粒物和烟气脱硫产生的脱硫废水是燃煤电厂污染治理的难点。该文提出一种化学团聚耦合低温省煤器强化除尘协同脱硫废水零排放的处理工艺。将加入团聚剂的工艺水或脱硫废水通过双流体雾化喷入低温省煤器前烟道,细颗粒物... 详细信息

煤燃烧产生的细颗粒物和烟气脱硫产生的脱硫废水是燃煤电厂污染治理的难点。该文提出一种化学团聚耦合低温省煤器强化除尘协同脱硫废水零排放的处理工艺。将加入团聚剂的工艺水或脱硫废水通过双流体雾化喷入低温省煤器前烟道,细颗粒物在化学团聚剂液桥力的作用下发生团聚长大,沿程水分蒸发后,液桥力转化为固桥力形成大的团聚体,耦合低温省煤器促进静电除尘器对细颗粒物的脱除效率。示范试验结果表明,运行化学团聚可使粉尘排放浓度降低63.1%,168 h内平均粉尘排放浓度为2.66 mg/m^(3);基于运行数据优化了团聚剂喷量与低温省煤器循环水量;连续运行脱硫废水对强化除尘效果没有明显影响,实现了超低排放以及脱硫废水零排放。

关键词：化学团聚强化除尘低温省煤器脱硫废水燃煤电厂超低排放