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Bioactive Materials 2021年第8期6卷 2546-2556页

作者： Zhongqiang Zhu Qiang Gao Ziyue Long Qiuyi Huo Yifan Ge Ntakirutimana Vianney Nishimwe Anodine Daliko yongchun meng Jia Qu Hao Chen Bailiang Wang School of Ophthalmology&Optometry Eye HospitalWenzhou Medical UniversityWenzhou325027China Central Laboratory Yantai Affiliated Hospital of Binzhou Medical University717 Jinbu StreetYantaiShandong264100China

Implanted biomaterials such as medical catheters are prone to be adhered by proteins,platelets and bacteria due to their surface hydrophobicity characteristics,and then induce related infections and ***,the development of a versatile strategy to endow surfaces with antibacterial and antifouling functions is particularly significant for blood-contacting *** this work,CuSO_(4)/H_(2)O_(2)was used to trigger polydopamine(PDA)and poly-(sulfobetaine methacrylate)(PSBMA)co-deposition process to endow polyurethane(PU)antibacterial and antifouling surface(PU/PDA(Cu)/PSBMA).The zwitterions contained in the PU/PDA(Cu)/PSBMA coating can significantly improve surface wettability to reduce protein adsorption,thereby improving its blood *** addition,the copper ions released from the metal-phenolic networks(MPNs)imparted them more than 90%antibacterial activity against *** and ***,PU/PDA(Cu)/PSBMA also exhibits excellent performance in vivo mouse catheter-related infections ***,the PU/PDA(Cu)/PSBMA has great application potential for developing multifunctional surface coatings for blood-contacting materials so as to improve antibacterial and anticoagulant properties.

关键词： Zwitterionic polymer Copper ions Surface modification Hemocompatibility Antibacterial

Corrigendum to“Polydopamine/poly(sulfobetaine methacrylate)Co-deposition coatings triggered by CuSO4/H2O2 on implants for improved surface hemocompatibility and antibacterial activity”[Bioactive materials 6(2021)2546-2556]

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Bioactive Materials 2022年第11期7卷 195-196页

作者： Zhongqiang Zhu Qiang Gao Ziyue Long Qiuyi Huo Yifan Ge Ntakirutimana Vianney Nishimwe Anodine Daliko yongchun meng Jia Qu Hao Chen Bailiang Wang School of Ophthalmology&Optometry Eye HospitalWenzhou Medical UniversityWenzhou325027China Central Laboratory Yantai Affliated Hospital of Binzhou Medical University717 Jinbu StreetYantaiShandong264100China

The authors regret to inform that Fig.3f is incorrect in the original article.A part of images of platelet adhesion on the PU and PU/PDA seemed to be duplicated with that on PU/PDA(Cu)/PSBMA *** authors had checked the original images and found the images were mistakenly taken from the same sample of PU/PDA(Cu)/PSBMA with continuous *** correction does not change any description,results or conclusions of the original paper.

关键词： compatibility checked correction

Potential role and therapeutic implications of glutathione peroxidase 4 in the treatment of Alzheimer's disease

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Neural Regeneration Research 2025年第3期20卷 613-631页

作者： Yanxin Shen Guimei Zhang Chunxiao Wei Panpan Zhao yongchun Wang Mingxi Li Li Sun Department of Neurology and Neuroscience Center The First Hospital of Jilin UniversityJilin UniversityChangchunJilin ProvinceChina Cognitive Impairment Center Department of NeurologyThe First Hospital of Jilin UniversityJilin UniversityChangchunJilin ProvinceChina

Alzheimer's disease is an age-related neurodegenerative disorder with a complex and incompletely understood pathogenesis. Despite extensive research, a cure for Alzheimer's disease has not yet been found. Oxidative stress mediates excessive oxidative responses, and its involvement in Alzheimer's disease pathogenesis as a primary or secondary pathological event is widely accepted. As a member of the selenium-containing antioxidant enzyme family, glutathione peroxidase 4 reduces esterified phospholipid hydroperoxides to maintain cellular redox homeostasis. With the discovery of ferroptosis, the central role of glutathione peroxidase 4 in anti-lipid peroxidation in several diseases, including Alzheimer's disease, has received widespread attention. Increasing evidence suggests that glutathione peroxidase 4 expression is inhibited in the Alzheimer's disease brain, resulting in oxidative stress, inflammation, ferroptosis, and apoptosis, which are closely associated with pathological damage in Alzheimer's disease. Several therapeutic approaches, such as small molecule drugs, natural plant products, and non-pharmacological treatments, ameliorate pathological damage and cognitive function in Alzheimer's disease by promoting glutathione peroxidase 4 expression and enhancing glutathione peroxidase 4 activity. Therefore, glutathione peroxidase 4 upregulation may be a promising strategy for the treatment of Alzheimer's disease. This review provides an overview of the gene structure, biological functions, and regulatory mechanisms of glutathione peroxidase 4, a discussion on the important role of glutathione peroxidase 4 in pathological events closely related to Alzheimer's disease, and a summary of the advances in small-molecule drugs, natural plant products, and non-pharmacological therapies targeting glutathione peroxidase 4 for the treatment of Alzheimer's disease. Most prior studies on this subject used animal models, and relevant clinical studies are lacking. Future clinica

关键词： apoptosis ferroptosis inflammation lipid peroxidation natural plant products neurodegenerative disorder neuroprotection oxidative stress small-molecule drugs

协调发展理念视域下农村教育发展面临的困境及破解策略

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河南科技学院学报（社会科学版） 2018年第4期38卷 18-22页

作者：敖永春陈猛重庆邮电大学马克思主义学院重庆400065

党的十九大明确指出要高度重视农村义务教育,推进教育公平。以协调发展理念为指导,促进农村教育发展,是促进教育公平、均衡教育资源、提升教育质量的必然举措。针对现今我国农村教育中存在的政府投资力度相对较少、教师结构不合理、设... 详细信息

党的十九大明确指出要高度重视农村义务教育,推进教育公平。以协调发展理念为指导,促进农村教育发展,是促进教育公平、均衡教育资源、提升教育质量的必然举措。针对现今我国农村教育中存在的政府投资力度相对较少、教师结构不合理、设备设施不完善、教学模式单一等问题,亟需在协调发展理念的指导下,加大政府投资力度,合理配置教师资源,完善设备设施,发展立体教学模式,进而提升农村教育协调发展水平。

关键词：协调发展理念农村教育教育公平

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碲化锡材料的制备及其特性研究

材料导报 2006年第F5期20卷 306-308页

作者：刘倩张方辉李亚利孟永春陕西科技大学电气与电子工程学院咸阳712081 陕西科技大学材料科学与工程学院咸阳712081 华南理工大学材料科学与工程学院广州510640

用Bridgman法合成SnTe晶体,并用X射线衍射仪测试其显微结构,发现其晶格常数比标准值略小。以制备的晶体为原料用真空蒸镀法制备了银灰色SnTe多晶薄膜,并对薄膜的显微结构、伏安特性及表面形貌进行了研究。结果发现,薄膜上晶粒的生长有... 详细信息

用Bridgman法合成SnTe晶体,并用X射线衍射仪测试其显微结构,发现其晶格常数比标准值略小。以制备的晶体为原料用真空蒸镀法制备了银灰色SnTe多晶薄膜,并对薄膜的显微结构、伏安特性及表面形貌进行了研究。结果发现,薄膜上晶粒的生长有一定择优取向,其伏安特性曲线有突变点,通电后薄膜表面的原子形成了团簇。

关键词： SnTe 晶体多晶薄膜显微结构伏安特性表面形貌

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生物可降解载药微球经巩膜向眼内给药的研究

中华眼视光学与视觉科学杂志 2017年第11期19卷 699-704页

作者：周诗宇韩寅孟永春程凌云温州医科大学眼视光学院眼科药物研究所 325027

由于眼部复杂的生理结构和诸多屏障，使得全身给药后药物到达眼后段的量有限，疗效甚微。眼局部药物使用方便，但药物难以传递到视网膜。玻璃体内给药侵袭性大，危险『生高。经巩膜给药有诸多优势，如巩膜表面积大，且位置表浅、操作简... 详细信息

由于眼部复杂的生理结构和诸多屏障，使得全身给药后药物到达眼后段的量有限，疗效甚微。眼局部药物使用方便，但药物难以传递到视网膜。玻璃体内给药侵袭性大，危险『生高。经巩膜给药有诸多优势，如巩膜表面积大，且位置表浅、操作简单，也不引起眼内屏障的损害。但要求药物在巩膜表面有适当的浓度，这个浓度过高会导致大量药物进入全身系统，引起全身不良反应；如果药物在巩膜表面浓度太低，通过巩膜进入脉络膜和视网膜所需的药物浓度梯度就难以建立。所以绝大部分药物溶液不适合经巩膜给药。为了满足巩膜表面合适药物浓度的要求，科研工作者尝试研发并使用生物材料药物微球或巩膜表面给药装置进行经巩膜给药。相比于巩膜表面给药装置，微球不需要手术植入，简单注射即可，使用较为方便。

关键词：结膜下注射眼球筋膜下注射药物微球经巩膜给药药物控释系统

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姜黄素缓释微球的制备及体外释放

中国组织工程研究 2022年第28期26卷 4489-4493页

作者：李希凯孟永春付丽刘卿王笑谷成旭黄飞滨州医学院基础医学院解剖学教研室山东省烟台市264000 滨州医学院康复医学院山东省烟台市264000

背景:姜黄素具有抑制炎症、促进轴突生长等作用,但存在半衰期短、清除速度快等问题。目的:制备姜黄素缓释微球,以达到缓慢持续释放姜黄素的效果。方法:以聚乳酸-羟基乙酸共聚物为原料,采用O/W乳化挥发法合成合成姜黄素缓释微球,预设载... 详细信息

背景:姜黄素具有抑制炎症、促进轴突生长等作用,但存在半衰期短、清除速度快等问题。目的:制备姜黄素缓释微球,以达到缓慢持续释放姜黄素的效果。方法:以聚乳酸-羟基乙酸共聚物为原料,采用O/W乳化挥发法合成合成姜黄素缓释微球,预设载药率分别为10%和20%,设为1、2号微球;以左旋聚乳酸-聚己内酯共聚物聚合物为原料,采用O/W乳化挥发法合成合成姜黄素缓释微球,预设载药率分别为10%和20%,设为3、4号微球,扫描电镜观察微球的表面形态特征,高效液相色谱检测微球的载药量和包封率。将4组微球浸泡在含有1%十二烷基硫酸钠的PBS释放外液中,模拟生理环境检测姜黄素微球的缓释情况。结果与结论:①扫描电镜显示,3、4号姜黄素微球的粒径、形态均优于1、2号姜黄素微球。②3号微球的包封率高于其他3组微球(P0.05)。③2、3、4号微球的载药率高于1号微球(P<0.01),2、4号微球的载药率高于3号微球(P<0.01)。④3号姜黄素缓释微球的体外释放可持续14 d,其余3种微球的体外释放可持续21 d,1、3号微球的药物累积释放率高于2、4号微球,3号微球的姜黄素释放浓度高于1号微球。⑤结果表明,以左旋聚乳酸-聚己内酯共聚物为原料合成的预设载药率10%的姜黄素缓释微球,缓释效果最接近零级释放要求。

关键词：姜黄素缓释微球聚乳酸羟基乙酸共聚物左旋聚乳酸聚己内酯体外释放

脂肪间充质干细胞外泌体可减轻过氧化氢诱导PC12细胞的凋亡

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中国组织工程研究 2024年第19期28卷 2988-2995页

作者：谷成旭张乃丽孟永春刘卿郭绮萱付丽张璐萍黄飞滨州医学院基础医学院人体解剖学教研室山东省烟台市264003 滨州医学院烟台附属医院山东省烟台市264100 山东大学齐鲁医学院基础医学院人体解剖学教研室山东省济南市250021 康复大学健康与生命科学学院山东省青岛市266071

背景:间充质干细胞外泌体在组织损伤修复中可能发挥关键作用,而miRNA是外泌体发挥治疗作用的重要成分,其中miR-29b-3p具有减少细胞凋亡、促进轴突再生和血管生成的作用。目的:研究脂肪间充质干细胞外泌体通过miR-29b-3p对过氧化氢诱导P... 详细信息

背景:间充质干细胞外泌体在组织损伤修复中可能发挥关键作用,而miRNA是外泌体发挥治疗作用的重要成分,其中miR-29b-3p具有减少细胞凋亡、促进轴突再生和血管生成的作用。目的:研究脂肪间充质干细胞外泌体通过miR-29b-3p对过氧化氢诱导PC12细胞损伤模型的保护作用,并探讨相关机制。方法:①首先采用胶原酶消化法提取大鼠脂肪间充质干细胞,通过miR-29b-3p模拟物及抑制物转染脂肪间充质干细胞,采用超速离心法从培养上清中提取外泌体并进行鉴定,从而构建高表达和敲低miR-29b-3p的脂肪间充质干细胞外泌体;②通过过氧化氢诱导PC12细胞模拟神经细胞损伤模型,研究脂肪间充质干细胞外泌体通过miR-29b-3p对神经元细胞损伤模型发挥保护作用的相关机制。结果与结论:①脂肪间充质干细胞外泌体具有典型的杯状形态,直径分布在50-140 nm范围内,表达外泌体表面特异性标志膜蛋白Alix、CD63及TSG101,并可被PC12细胞成功摄取;②脂肪间充质干细胞外泌体预处理可减轻过氧化氢诱导PC12细胞的凋亡,并且这种保护作用随着外泌体中miR-29b-3p表达的增加而增强,随着外泌体中miR-29b-3p表达的降低而减弱,其发挥作用的机制与脂肪间充质干细胞外泌体通过miR-29b-3p促进抗凋亡蛋白Bcl-2的表达及抑制凋亡蛋白Bax的表达相关。

关键词：脂肪间充质干细胞外泌体 miR-29b-3p PC12细胞凋亡 miRNA

Control System Design for an Unmanned Helicopter to Track a Ground Target

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Chinese Journal of Mechanical Engineering 2011年第3期24卷 420-427页

作者： XIN Zhekui FANG yongchun Beijing Aerospace Automatic Control Institute Beijing 100854 China Institute of Robotics andInformation Automatic System Nankai University Tianjin 300071 China

Due to potential wide applications,the problem of utilizing an unmanned helicopter to track a ground target has become one of the most active research directions in related ***,in most cases,it is possible for a dynamic target to implement evasive actions with strong maneuverability,such as a sudden turn during high-speed movement,to flee from the tracker,which then brings much difficulty for the design of tracking control ***,most research on this field focuses on utilizing a ground mobile robot to track a high-speed ***,it is very difficult to extend those developed methods to airborne applications due to much more complex dynamices of UAV-target relative *** study investiages thoroughly for the problem of using an unmanned helicopter to track a ground target,with particular emphasis on the avoidance of tracking failure caused by the evasive maneuvers of dynamic ***,a novel control scheme,which consists of an innovative target tracking controller and a classical flight controller,is proposed for the helicopter-target tracking ***,the tracking controller,whose design is the focus of the paper,aims to utilize the motion information of the helicopter and the dynamic target to construct a suitable trajectory for the helicopter,so that when it flies along this trajectory,the relative pose between the helicopter and the dynamic target will be kept *** designing the target tracking controller,a novel coordinate transformation is firstly introduced to convert the tracking system into a more compact form convenient for control law design,the desired velocities for the helicopter is then proposed with consideration of the dynamic *** stability of the closed-loop system is finally analyzed by Lyapunov *** on Matlab/Simulink environment,two groups of simulation are conducted for the helicopter-target tracking control system where the target moves along a linear path

关键词： unmanned helicopter trajectory plan target tracking