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Protein neddylation and its role in health and diseases

Signal Transduction and Targeted Therapy 2024年第5期9卷 1869-1904页

作者： Shizhen zhang Qing Yu zhijian Li yongchao z.ao Yi Sun Department of Breast Surgery the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310029China Cancer Institute(Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education)the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310029China Institute of Translational Medicine Zhejiang University School of MedicineHangzhou 310029China Department of Thyroid Surgery Zhejiang Cancer HospitalInstitute of Basic Medicine and Cancer(IBMC)Chinese Academy of SciencesHangzhou 310022China Key Laboratory of Head&Neck Cancer Translational Research of zhejiang Province Hangzhou 310022China Department of Hepatobiliary and Pancreatic Surgery Zhejiang University School of MedicineHangzhou 310029China zhejiang Provincial Key Laboratory of Pancreatic Disease The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310029China zhejiang University Cancer Center Hangzhou 310029China Leading Innovative and Entrepreneur Team Introduction Program of zhejiang Hangzhou 310024China Research Center for Life Science and Human Health Binjiang Institute of Zhejiang UniversityHangzhou 310053China

NEDD8(Neural precursor cell expressed developmentally downregulated protein 8)is an ubiquitin-like protein that is covalently attached to a lysine residue of a protein substrate through a process known as neddylation,catalyzed by the enzyme cascade,namely NEDD8 activating enzyme(E1),NEDD8 conjugating enzyme(E2),and NEDD8 ligase(E3).The substrates of neddylation are categorized into cullins and non-cullin *** of cullins activates CRLs(cullin RING ligases),the largest family of E3 ligases,whereas neddylation of non-cullin substrates alters their stability and activity,as well as subcellular ***,the neddylation pathway and/or many neddylation substrates are abnormally activated or over-expressed in various human diseases,such as metabolic disorders,liver dysfunction,neurodegenerative disorders,and cancers,among ***,targeting neddylation becomes an attractive strategy for the treatment of these *** this review,we first provide a general introduction on the neddylation cascade,its biochemical process and regulation,and the crystal structures of neddylation enzymes in complex with cullin substrates;then discuss how neddylation governs various key biological processes via the modification of cullins and non-cullin *** further review the literature data on dysregulated neddylation in several human diseases,particularly cancer,followed by an outline of current efforts in the discovery of small molecule inhibitors of neddylation as a promising therapeutic ***,few perspectives were proposed for extensive future investigations.

关键词： NEDD8 attached attractive

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阿替普酶修复急性缺血性脑卒中后T淋巴细胞介导的脑组织免疫炎症损伤的成效研究

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中国免疫学杂志 2024年第7期40卷 1484-1489页

作者：王建宇张莉王勇朝魏琰衡水市人民医院衡水053000

目的:研究阿替普酶修复急性缺血性脑卒中(AIS)后T淋巴细胞介导的脑组织免疫炎症损伤。方法:选取2022年6月至2023年6月衡水市人民医院收治的AIS患者100例,分为常规组、阿替普酶组,每组50例,入组后常规组行常规措施干预治疗,阿替普酶组加... 详细信息

目的:研究阿替普酶修复急性缺血性脑卒中(AIS)后T淋巴细胞介导的脑组织免疫炎症损伤。方法:选取2022年6月至2023年6月衡水市人民医院收治的AIS患者100例,分为常规组、阿替普酶组,每组50例,入组后常规组行常规措施干预治疗,阿替普酶组加用阿替普酶溶栓治疗。比较两组患者神经功能、脑血管储备功能、脑部血流动力学、T淋巴细胞介导脑组织免疫炎症损伤指标CD4^(+)T细胞亚群[促炎细胞(Th1、Th17)、抗炎细胞(Th2、Treg细胞)]及其相关细胞因子水平变化,评价临床疗效及预后转归情况。结果:治疗后阿替普酶组神经功能NIHSS评分低于常规组[(6.57±0.79)分vs (9.34±1.23)分,t=13.400,P<0.05]。阿替普酶组脑血管储备功能CVR、BHI高于常规组[(34.54±4.35)%vs (29.89±2.31)%、1.00±0.23 vs 0.92±0.08,t=6.676、2.323,P<0.05],PI低于常规组(0.60±0.07 vs 0.72±0.08,t=7.982,P<0.05)。阿替普酶组脑部血流动力学CBF高于常规组[(49.89±9.76) ml/(100 g/min) vs (40.34±7.86) ml/(100 g/min),t=5.389,P<0.05],MTT、TTP短于常规组[(6.45±0.78) s vs(9.78±1.02) s、(24.45±2.16) s vs (26.78±3.25) s,t=18.340、4.222,P<0.05]。阿替普酶组Th1、Th17细胞比例及相关细胞因子IFN-γ、IL-17水平低于常规组[(3.27±0.59)%vs (5.64±0.52)%、(2.34±0.25)%vs (4.35±0.38)%、(3.24±0.45) pg/ml vs (4.90±0.65) pg/ml、(10.23±1.43) pg/ml vs (14.35±2.14) pg/ml,t=21.310、31.250、14.850、11.320,P<0.05],Th2、Treg细胞比例及相关细胞因子IL-4、TGF-β水平高于常规组[(8.75±0.54)%vs (7.02±0.37)%、(7.24±2.13)%vs (5.88±1.67)%、(13.24±2.16) pg/ml vs(10.26±1.29) pg/ml、(90.32±9.02) pg/ml vs (81.45±8.97) pg/ml,t=18.690、3.553、8.375、4.930,P<0.05]。阿替普酶组总有效率、预后良好率高于常规组(94.00%vs 80.00%、80.00%vs 62.00%,χ^(2)=4.332、3.934,P<0.05)。结论:阿替普酶在AIS治疗中具有修复T淋巴细胞介导的脑组织免疫炎症损伤的作用,可减轻脑损伤,改善脑血管储备功能和神经功能,预后转归良好。

关键词：阿替普酶急性缺血性脑卒中 T淋巴细胞免疫炎症损伤

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A Curious Identity on Multiple Sums over Fields with Applications

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Algebra Colloquium 2021年第2期28卷 295-308页

作者： yongchao Xu Shaofang Hong Mathematical College Sichuan UniversityChengdu 610064China

Let F be a field,and let e,k be integers such that 1≤e≤|F\{0}|and k≥*** show that for any subset{a1,……,ae}■F\{0},the curious identity∑(i1+……ie)∈z^(e)≥0,i1+……+ie=k a_(1)^(i1)…a_(e)^(ie)=∑i=1 e a_(i)^(k+e-1)/∏i≠j=1 e(a_(i)-a_(j))holds with z≥0 being the set of nonnegative *** an application,we prove that for any subset{a_(1)…,a_(e)}■F_(q)\{0}with F_(q)being the finite field of q elements and e,l being integers such that 2≤e≤q-1 and 0≤l≤e-2,∑(i_(1),…,i_(e))∈z^(e)≥0,i_(1)+…i_(e)=q-e+l a_(1)^(i1)…a_(e)^(ie)=0 Using this identity and providing an extension of the principle of cross-classification that slightly generalizes the one obtained by Hong in 1996,we show that if r is an integer with 1≤r≤q-2,then for any subset{a_(1),…a_(r)}■F_(q)^(*)we have x^(q-1)-1/∏i=1 r(x-a_(i))-∑i=1 q-1-r(∑i_(1)+…+i_(r)=q-1-r-i^(a_(1)^(i1)…a_(r)^(ir)))x^(i).This implies#{x∈Fq*|∑i=0 q-1-4(∑_(i1)+…+ir=q-1-r-i^(a_(1)^(i1)…a_(r)^(ir)))x^(i)=0}=q-1-r.

关键词： identity homogeneous polynomial zero polynomial field finite field decomposition generalized principle of cross-classification

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AgCl/Ag/g-C_3N_4 Hybrid Composites: Preparation,Visible Light-Driven Photocatalytic Activity and Mechanism

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Nano-Micro Letters 2016年第2期8卷 182-192页

作者： yongchao Bao Kezheng Chen Lab of Functional and Biomedical Nanomaterials Qingdao University of Science and Technology College of Environment and Safety Engineering Qingdao University of Science and Technology College of Materials Science and Engineering Qingdao University of Science and Technology

The ternary plasmonic Ag Cl/Ag/g-C_3N_4 photocatalysts were successfully fabricated by a modified deposition–precipitation method, through which Ag/Ag Cl nanoparticles(5–15 nm in size) were evenly dispersed on the surface of g-C_3N_4. The Ag Cl/Ag/g-C_3N_4 composites exhibited higher photocatalytic activity than Ag/Ag Cl and g-C_3N_4. The enhanced photocatalytic performance could be attributed to an efficient separation of electron–hole pairs through a z-scheme mechanism, in which Ag nanoparticles acted as charge separation centers.

关键词： AgCl/Ag/g-C3N4 Hybrid Photocatalytic activity

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Co-Channel Interference Suppression Techniques for Full Duplex Cellular System

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China Communications 2015年第S1期12卷 18-27页

作者： XIN yongchao MA Meng z.ao zijun JIao Bingli School of Electronics Engineering and Computer Science Peking University

Co-frequency and co-time full duplex(CCFD) is a promising technique for improving spectral efficiency in next generation wireless communication systems. However, for the applications of CCFD in a cellular network, severe co-channel interference is an essential problem. Specifically, there are two significant interferences, i.e., inter-terminal interference(ITI) and inter-cell interference(ICI), which lead to an obvious performance degradation. In this paper, two techniques are proposed for suppressing the ITI and ICI in a CCFD cellular system, respectively. The first technique is obtained by modeling the three-node CCFD system as the z-channel. After deriving the sum-capacity of the z-channel, a sum-capacity-achieving scheme based on successive interference cancellation(SIC) is proposed. The second technique is designed by combining the fractional frequency reuse scheme with CCFD. The performance gains of the proposed two techniques in terms of signalto-interference plus noise ratio(SINR) and sumcapacity are analyzed. Simulation results show that the proposed scheme can achieve significant interference suppression performance and higher system capacity, especially for cell edge users.

关键词： co-frequency and co-time full duplex(CCFD) fractional frequency reuse(FFR) successive interference cancellation(SIC) z-channel

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多源数据驱动的主控式创新框架

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浙江大学学报(工学版) 2024年第10期58卷 2084-2095+2118页

作者：石庆林张凯瑞侯亮郭小暄张文博连晓振陈永超穆瑞厦门大学机电工程系厦门大学航空航天学院厦门大学萨本栋微米纳米科学技术研究院厦门盈趣科技股份有限公司

为了解决设计知识和单源数据驱动的传统需求挖掘方法过于依赖设计经验、需求挖掘不全面、缺乏需求预测等问题，提出新的主控式创新框架.以非结构化文本数据为对象，从用户角度对需求进行特征提取及分类；以产品运行大数据为对象，从产... 详细信息

为了解决设计知识和单源数据驱动的传统需求挖掘方法过于依赖设计经验、需求挖掘不全面、缺乏需求预测等问题，提出新的主控式创新框架.以非结构化文本数据为对象，从用户角度对需求进行特征提取及分类；以产品运行大数据为对象，从产品角度挖掘用户需求；运用需求预测理论对未来产品隐性需求进行预测，构建数据驱动的主控式创新矩阵.相较于知识驱动为主的传统市场调研和单源数据的需求挖掘方法，所提框架显性需求挖掘更为客观全面，兼顾未来隐性需求挖掘.以某智能制造企业的迷你打印机为案例，验证了所提框架的有效性.

关键词：多源数据主控式创新在线评论运行大数据创新矩阵需求预测

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铅锌尾矿/电石渣基加气混凝土的组成及结构

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材料导报 2024年第14期38卷 144-150页

作者：梁宝瑞王长龙平浩岩刘治兵马锦涛郑永超荆牮霖齐洋翟玉新刘枫北京科技大学天津学院天津301830 河北工程大学土木工程学院河北邯郸056038 北京建筑材料科学研究总院有限公司固废资源化利用与节能建材国家重点实验室北京100041 中铁建设集团有限公司北京100040 中铁建设集团建筑发展有限公司北京100070

为了综合利用固体废弃物,以铅锌尾矿和电石渣为原料制备加气混凝土(AAC)。综合应用宏观与微观的分析方法,研究了铅锌尾矿的细度和掺量对加气混凝土性能的影响,以及不同养护阶段加气混凝土的物相组成、微观结构和蒸压反应机理。结果表明... 详细信息

为了综合利用固体废弃物,以铅锌尾矿和电石渣为原料制备加气混凝土(AAC)。综合应用宏观与微观的分析方法,研究了铅锌尾矿的细度和掺量对加气混凝土性能的影响,以及不同养护阶段加气混凝土的物相组成、微观结构和蒸压反应机理。结果表明:随着铅锌尾矿细度减小,料浆的流动性提高,水化反应速度加快。但细度过小,易导致料浆过稠,影响加气混凝土良好气孔结构形成和性能;铅锌尾矿掺量过大,体系内未反应的铅锌尾矿残余颗粒堆积增多,颗粒间缝隙减小,影响了水化产物的生长和结晶,导致加气混凝土制品性能下降;当铅锌尾矿比表面积为420 m^(2)/kg、掺量为63%(质量分数)时,加气混凝土的绝干密度和抗压强度分别为590 kg/m^(3)、4.98 MPa,达到了《蒸压加气混凝土砌块》(GB/T 11968-2020)规定的A3.5、B06级加气混凝土合格品的要求。静停养护前加气混凝土坯体内水化产物为C-S-H凝胶和钙矾石(AFt),经静停和蒸压养护后AFt分解,主要水化产物为C-S-H凝胶和托贝莫来石。

关键词：铅锌尾矿电石渣加气混凝土静停养护托贝莫来石

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纳米碳-钛夹联合标记法在SiewertⅡ型食管胃结合部腺癌手术中的应用价值

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中华胃肠外科杂志 2024年第3期27卷 274-277页

作者：方永超王源钊吴伟航林楠杨劲卢维北罗子强王瑜联勤保障部队第九〇〇医院普通外科福州350001 厦门大学附属东方医院普通外科厦门361000 福建医科大学福州总临床医学院(第九〇〇医院)普通外科福州350001

目的探讨纳米碳-钛夹联合标记法确定SiewertⅡ型食管胃结合部腺癌(AEG)手术近端切缘的可行性。方法本研究采用回顾性队列研究方法,收集2017年2月至2020年12月在联勤保障部队第九〇〇医院胃肠外科经同一治疗组确诊并治疗的63例SiewertⅡ... 详细信息

目的探讨纳米碳-钛夹联合标记法确定SiewertⅡ型食管胃结合部腺癌(AEG)手术近端切缘的可行性。方法本研究采用回顾性队列研究方法,收集2017年2月至2020年12月在联勤保障部队第九〇〇医院胃肠外科经同一治疗组确诊并治疗的63例SiewertⅡ型AEG患者的临床病理资料,其中2019年2月至2020年12月期间手术的30例患者,均在术前采用纳米碳-钛夹联合标记肿瘤(纳米碳-钛夹联合标记组);2017年2月至2018年12月期间手术的33例患者术前未行肿瘤标记(未标记组)。比较两组患者的术中及术后情况。结果与未标记组比较,纳米碳-钛夹联合标记组探查确定近端切缘时间和手术时间均较短,术中出血量较少,离体前近端切缘长度、离体后近端切缘长度以及固定后近端切缘长度均更长,差异均有统计学意义(均P0.05)。两组患者术后排气时间、术后首次流质饮食时间、术后住院时间以及术后并发症情况比较,差异均无统计学意义(均P>0.05)。结论纳米碳-钛夹联合标记法在SiewertⅡ型AEG手术中可以辅助术者快速客观定位,实现精准快速切除。

关键词：食管胃结合部腺癌纳米碳钛夹近端切缘

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Studies on the Specific Degranulation of Mast Cell Sensitized by Several Allergens in vitro

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Cellular & Molecular Immunology 2009年第2期6卷 149-153页

作者： yongchao Guo zhenxing Li Hong Lin Haider Samee Jamil Khalid Food safety laboratory Ocean University of China Qingdao 266003. Shandong China Pakistan Council for Scientific and Industrial Research Laboratories Complex Karachi Pakistan

Food allergy is a major health issue worldwide. Mast cells play a very important role in the immediate hypersensitivity for which mast cell degranulation needs to be studied extensively. In this study, an approach was taken to study the characteristics of sensitized mast cell degranulation in vitro, which associated with the study of mast cells and animal models. BALB/c mice were immunized respectively by several food allergens, then blood and peritoneal mast cells were collected at different time points. A dynamic determination was carried out between mast cells and serumal IgE. Comparative analysis on sequential time points showed that there was a close coincidence between mast cell degranulation and IgE antibody titers in sensitized BALB/c mice. Furthermore, it is interesting that sensitized mast cells could implement specific degranulation against the challenges in vitro, but the closely tropomyosins induced mast cell degranulation displayed cross reactions. This is very similar to IgE resisting the allergens in vivo. The study disclosed some characteristics on mast cells, coming from sensitized BALB/c mice, degranulation in vitro.

关键词： food allergy allergen mast cell degranulation

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Homogenous metallic deposition regulated by abundant lithiophilic sites in nickel/cobalt oxides nanoneedle arrays for lithium metal batteries

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Journal of Energy Chemistry 2023年第2期77卷 11-18,I0001页

作者： Fenqiang Luo Dawei Xu yongchao Liao Minghao Chen Shuirong Li Dechao Wang zhifeng zheng Fujian Provincial Industry Technologies Development Base for New Energy Fujian Provincial Engineering and Research Center of Clean and High-valued Technologies for BiomassXiamen Key Laboratory for High-valued Conversion Technology of Agricultural BiomassCollege of EnergyXiamen UniversityXiamen 361102FujianChina China Fujian Innovation Laboratory of Energy Materials Science and Technology(Tan Kah Kee Innovation Laboratory) Xiamen 361102FujianChina

Although lithium(Li)metal delivers the highest theoretical capacity as a battery anode,its high reactivity can generate Li dendrites and"dead"Li during cycling,resulting in poor reversibility and low Li *** uniform Li plating/stripping is the core of solving these ***,we design a highly lithiophilic carbon film with an outer sheath of the nanoneedle arrays to induce homogeneous Li plating/*** excellent conductivity and 3D framework of the carbon film not only offer fast charge transport across the entire electrode but also mitigate the volume change of Li metal during *** abundant lithiophilic sites ensure stable Li plating/stripping,thereby inhibiting the Li dendritic growth and"dead"Li *** resulting composite anode allows for stable Li stripping/plating under 0.5 mA cm^(-2) with a capacity of 0.5 mA h cm^(-2) for 4000 h and 3 mA cm^(-2) with a capacity of3 mA h cm^(-2) for 1000 *** Ex-SEM analysis reveals that lithiophilic property is different at the bottom,top,or channel in the structu re,which can regulate a bottom-up uniform Li deposition *** cells paired with LFP show a stable capacity of 155 mA h g^(-1) under a current density of *** pouch cell can keep powering light-emitting diode even under 180°bending,suggesting its good flexibility and great practical applications.

关键词： Nickel/cobalt oxides Nanoneedle arrays Lithiophilic sites Lithium metal batteries

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