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Ultrathin polyamide nanofiltration membrane prepared by triazine-based porous organic polymer as interlayer for dye removal

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Chinese Journal of Chemical Engineering 2023年第5期57卷 193-201页

作者： yongbo liu Zhihao Si Cong Ren Hanzhu Wu Peng Zhan Yuqing Peng Peiyong Qin National Energy R&D Center for Biorefinery Beijing University of Chemical TechnologyBeijing 100029China College of Life Science and Technology Beijing University of Chemical TechnologyBeijing 100029China Beijing Key Laboratory of Membrane Science and Technology College of ChemicalEngineeringBeijing University of Chemical TechnologyBeijing 100029China

Separation membrane with high flux is generally encouraged in industrial application,because of the tremendous needs for decreasing membrane areas,usage costs and space requirements.The most effective and direct method for obtaining the high flux is to decrease membrane thickness.Polyamide(PA)nanofiltration membrane is conventionally prepared by the direct interfacial polymerization(IP)on substrate surface,and results in a thick PA layer.In this work,we proposed a strategy that constructing triazine-based porous organic polymer(TRZ-POP)as the interlayer to prepare the ultrathin PA nanofiltration membranes.TRZ-POP is firstly deposited on the polyethersulfone substrate,and then the formed TRZ-POP provides more adhesion sites towards PA based on its high specific surface areas.The chemical bonding between terminal amine group of TRZ-POP and the amide group of PA further improves the binding force,and strengthens the stability of PA layer.More importantly,the high porosity of TRZPOP layer causes the higher polymerization of initial PA owning to the stored sufficient amino monomer;and H-bonding interaction between amine groups of TRZ-POP and piperazine(PIP)can astrict the release of PIP.Thus,IP process is controlled,and the thinnest thickness of prepared PA layer is only<15 nm.As expected,PA/TRZ-POP membrane shows a more excellent water flux of 1414 L·m^(-2)·h^(-1)·MPa^(-1)than that of the state-of-the-art nanofiltration membranes,and without sacrificing dye rejection.The build of TRZPOP interlayer develops a new method for obtaining a high-flux nanofiltration membrane.

关键词： Polyamide Nanofiltration Interfacial polymerization Triazine-based porous organic polymer

PROTAC mediated FKBP12 degradation enhances Hepcidin expression via BMP signaling without immunosuppression activity

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Signal Transduction and Targeted Therapy 2022年第6期7卷 1891-1894页

作者： Tianbai Zhong Xiuyun Sun Li Yu yongbo liu Xin Lin Yu Rao Wei Wu MOE Key Laboratory of Protein Sciences Beijing Advanced Innovation Center for Structural BiologySchool of Life SciencesTsinghua UniversityBeijing 100084P.R.China MOE Key Laboratory of Protein Sciences School of Pharmaceutical SciencesMOE Key Laboratory of Bioorganic Phosphorus Chemistry&Chemical BiologyTsinghua UniversityBeijing 100084China Institute for Immunology and School of Medicine Tsinghua UniversityBeijing 100084China

Dear Editor,Hepcidin is a 25-amino acid peptide acting as a pivotal negative regulator in iron homeostasis,which can bind to an iron exporter,ferroportin 1,and induce its internalization and degradation.1 Hepcidin is produced in hepatocytes mainly under the control of BMP signaling.BMP2/6,secreted by liver endothelial cells in response to iron level,binds to BMP type I and type II receptors and triggers the phosphorylation of Smad1/5/8 which directly promotes hepcidin expression.1 The immunophilin family protein FKBP12 is associated with BMP type I receptors to prevent uncontrolled receptor activation.

关键词： Hepcidin FKBP12 BMP

PROTACs:great opportunities for academia and industry (an update from 2020 to 2021)

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Signal Transduction and Targeted Therapy 2022年第7期7卷 2181-2244页

作者： Ming He Chaoguo Cao Zhihao Ni yongbo liu Peilu Song Shuang Hao Yuna He Xiuyun Sun Yu Rao Ministry of Education(MOE)Key Laboratory of Protein Sciences School of Pharmaceutical SciencesMOE Key Laboratory of Bioorganic Phosphorus Chemistry&Chemical BiologyTsinghua University100084 BeijingP.R.China Tsinghua-Peking Center for Life Sciences 100084 BeijingP.R.China School of Pharmaceutical Sciences Zhengzhou University450001 ZhengzhouChina

PROteolysis TArgeting Chimeras(PROTACs)technology is a new protein-degradation strategy that has emerged in recent years.It uses bifunctional small molecules to induce the ubiquitination and degradation of target proteins through the ubiquitin–proteasome system.PROTACs can not only be used as potential clinical treatments for diseases such as cancer,immune disorders,viral infections,and neurodegenerative diseases,but also provide unique chemical knockdown tools for biological research in a catalytic,reversible,and rapid manner.In 2019,our group published a review article“PROTACs:great opportunities for academia and industry”in the journal,summarizing the representative compounds of PROTACs reported before the end of 2019.In the past 2 years,the entire field of protein degradation has experienced rapid development,including not only a large increase in the number of research papers on protein-degradation technology but also a rapid increase in the number of small-molecule degraders that have entered the clinical and will enter the clinical stage.In addition to PROTAC and molecular glue technology,other new degradation technologies are also developing rapidly.In this article,we mainly summarize and review the representative PROTACs of related targets published in 2020–2021 to present to researchers the exciting developments in the field of protein degradation.The problems that need to be solved in this field will also be briefly introduced.

关键词： diseases clinical journal

Electromagnetohydrodynamic flows and mass transport in curved rectangular microchannels

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Applied Mathematics and Mechanics(English Edition) 2020年第9期41卷 1431-1446页

作者： yongbo liu Yongjun JIAN School of Mathematical Science Inner Mongolia UniversityHohhot 010021China

Curved microchannels are often encountered in lab-on-chip systems because the effective axial channel lengths of such channels are often larger than those of straight microchannels for a given per unit chip length.In this paper,the effective diffusivity of a neutral solute in an oscillating electromagnetohydrodynamic(EMHD)flow through a curved rectangular microchannel is investigated theoretically.The flow is assumed as a creeping flow due to the extremely low Reynolds number in such microflow systems.Through the theoretical analysis,we find that the effective diffusivity primarily depends on five dimensionless parameters,i.e.,the curvature ratio of the curved channel,the Schmidt number,the tidal displacement,the angular Reynolds number,and the dimensionless electric field strength parameter.Based on the obtained results,we can precisely control the mass transfer characteristics of the EMHD flow in a curved rectangular microchannel by appropriately altering the corresponding parameter values.

关键词： electromagnetohydrodynamic(EMHD)flow curved rectangular microchannel mass transfer characteristic effective diffusivity

Genome Assembly and Population Resequencing Reveal the Geographical Divergence of Shanmei(Rubus corchorifolius)

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Genomics, Proteomics & Bioinformatics 2022年第6期20卷 1106-1118页

作者： Yinqing Yang Kang Zhang Ya Xiao Lingkui Zhang Yile Huang Xing Li Shumin Chen Yansong Peng Shuhua Yang yongbo liu Feng Cheng Institute of Vegetables and Flowers Chinese Academy of Agricultural SciencesKey Laboratory of Biology and Genetic Improvement of Horticultural CropsMinistry of Agriculture and Rural AffairsSino-Dutch Joint Laboratory of Horticultural GenomicsBeijing 100081China Biotechnology Research Center Xiangxi Academy of Agricultural SciencesJishou 416000China Lushan Botanical Garden Chinese Academy of SciencesJiujiang 332900China State Environmental Protection Key Laboratory of Regional Eco-process and Function Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China

Rubus corchorifolius(Shanmei or mountain berry,2n=14)is widely distributed in China,and its fruits possess high nutritional and medicinal values.Here,we reported a highquality chromosome-scale genome assembly of Shanmei,with contig size of 215.69 Mb and 26,696 genes.Genome comparison among Rosaceae species showed that Shanmei and Fupenzi(Rubus chingii Hu)were most closely related,followed by blackberry(Rubus occidentalis),and that environmental adaptation-related genes were expanded in the Shanmei genome.Further resequencing of 101 samples of Shanmei collected from four regions in the provinces of Yunnan,Hunan,Jiangxi,and Sichuan in China revealed that among these samples,the Hunan population of Shanmei possessed the highest diversity and represented the more ancestral population.Moreover,the Yunnan population underwent strong selection based on the nucleotide diversity,linkage disequilibrium,and historical effective population size analyses.Furthermore,genes from candidate genomic regions that showed strong divergence were significantly enriched in the flavonoid biosynthesis and plant hormone signal transduction pathways,indicating the genetic basis of adaptation of Shanmei to the local environment.The high-quality assembled genome and the variome dataset of Shanmei provide valuable resources for breeding applications and for elucidating the genome evolution and ecological adaptation of Rubus species.

关键词： Rubus corchorifolius Genome assembly Resequencing Divergence Genome evolution

Rotating electroosmotic flows in soft parallel plate microchannels

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Applied Mathematics and Mechanics(English Edition) 2019年第7期40卷 1017-1028页

作者： yongbo liu Yongjun JIAN School of Mathematical Science Inner Mongolia University

We present a theoretical investigation of rotating electroosmotic flows(EOFs) in soft parallel plate microchannels. The soft microchannel, also called as the polyelectrolyte-grafted microchannel, is denoted as a rigid microchannel coated with a polyelectrolyte layer(PEL) on its surface. We compare the velocity in a soft microchannel with that in a rigid one for different rotating frequencies and find that the PEL has a trend to lower the velocities in both directions for a larger equivalent electrical double layer(EDL) thickness λFCL(λFCL = 0.3) and a smaller rotating frequency ω(ω < 5).However, for a larger rotating frequency ω(ω = 5), the main stream velocity u far away from the channel walls in a soft microchannel exceeds that in a rigid one. Inspired by the above results, we can control the EOF velocity in micro rotating systems by imparting PELs on the microchannel walls, which may be an interesting application in biomedical separation and chemical reaction.

关键词： rotating electroosmotic flow (EOF) soft microchannel polyelectrolyte layer (PEL) thickness

Electroviscous effect on electromagnetohydrodynamic flows of Maxwell fluids in parallel plate microchannels

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Applied Mathematics and Mechanics(English Edition) 2019年第10期40卷 1457-1470页

作者： yongbo liu Yongjun JIAN School of Mathematical Science Inner Mongolia University

Considering the influence of the streaming potential and electroviscous effects, the analytical solutions for electromagnetohydrodynamic (EMHD) flows in parallel plate microchannels are obtained. The electrolyte solutions in the microchannels are taken as generalized Maxwell fluids, and slip boundary conditions are adopted. To accurately analyze the EMHD flow characteristics, the variation trends of the electroviscous effects with the corresponding parameters must be understood. The results show that the electroviscous effects increase with the increase in the relaxation time De, the slip coefficient , and the wall zeta potential 0. However, the increase in the inverse of the electrical double-layer (EDL) thickness K, the electrical oscillating Reynolds number Re, and the ionic P'eclet number Pe can decrease the electroviscous effects. We also demonstrate that the electroviscous effect on the EMHD flows of generalized Maxwell fluids is larger than that of Newtonian fluids. This work will be useful in designing EMHD flows in parallel plate microchannels.

关键词： electroviscous e ect electromagnetohydrodynamic (EMHD) ow generalized Maxwell uid

Porch Design Based on Family Health Needs

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Journal of Architectural Research and Development 2022年第1期6卷 45-50页

作者： yongbo liu Suan Sunandha Rajabhat University BangkokThailand

Physical health is the basic need for survival.There are many factors affecting health,and pathogenic bacteria and viruses are the main reasons.A healthy lifestyle can effectively reduce the risk of disease,and family living space is the main place of life,so improving family health awareness and living habits is an effective measure to maintain health.Indoor living space and outdoor space are relatively independent.The porch is the entrance of the family and the buffer space connecting indoor and outdoor.Therefore,optimizing the sanitary design of the porch is not only conducive to blocking the spread of viruses and bacteria,but also to form a good health awareness and maintain healthy living habits.

关键词： Health needs Porch design Functionality Health awareness

Association between Metabolic Dysfunction-associated Fatty Liver Disease and Cognitive Impairment

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Journal of Clinical and Translational Hepatology 2022年第6期10卷 1034-1041页

作者： Qiang Yu Ruixin He Haowen Jiang Ji Wu Zhifeng Xi Kang He yongbo liu Tao Zhou Mingxuan Feng Ping Wan Hexin Yan Qiang Xia Department of Liver Surgery Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Depart-ment of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic DiseasesRuijin HospitalShang-hai Jiaotong University School of MedicineShanghaiChina Shanghai National Clinical Research Center for Metabolic Diseases Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR ChinaShang-hai National Center for Translational MedicineRuijin HospitalShanghai Jiaotong University School of MedicineShang-haiChina State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghaiChina Department of Anesthesiology and Critical Care Medicine Renji HospitalSchool of MedicineShanghai Jiaotong UniversityShanghaiChina.

Background and Aims:Metabolic dysfunction-associated fatty liver disease(MAFLD)is a newly proposed term based on modified criteria.Although nonalcoholic fatty liver disease(NAFLD)has been well-documented as a multisystem dis-ease,research on the correlation of MAFLD and extra-hepatic diseases is limited.This study aimed to clarify the association of MAFLD,as well as NAFLD status with cognitive function.Methods:A total of 5,662 participants 20-59 years of age who underwent cognitive tests and liver ultrasonography in the Third National Health and Nutrition Examination Survey were included in the analysis.Cognitive function was evalu-ated using three computer-administered tests,the serial dig-it learning test(SDLT),the simple reaction time test(SRTT)and the symbol digit substitution test(SDST).Results:Par-ticipants with MAFLD had significantly poorer performance on the SRTT[odds ratio(OR)1.47,95%confidence interval(CI):1.14-1.89)].MAFLD with moderate-severe liver stea-tosis was associated with higher risks of scoring low in the SDLT(OR 1.37,95%CI:1.04-1.82)and SRTT(OR 1.55,95%CI:1.19-2.02).NAFLD combined with metabolic dys-function,instead of NAFLD without metabolic disorders,was associated an increased risk of a low SRTT score(OR 1.44,95%CI:1.10-1.82).MAFLD patients had a high probability of fibrosis,prediabetes,and diabetes and were also signifi-cantly associated with increased risks based on the SDST or SRTT score.Conclusions:MAFLD was significantly associ-ated with increased risk of cognitive impairment,especially among MAFLD patients with a high degree of liver fibrosis,moderate-severe steatosis,or hyperglycemia.

关键词： NHANES Metabolic dysfunction-associated fatty liver disease Nonalcoholic fatty liver disease Cognitive dysfunction