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Hydrologic implications of the isotopic kinetic fractionation of open-water evaporation

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Science China Earth Sciences 2018年第10期61卷 1523-1532页

作者： Wei XIAO Yufei QIAN Xuhui LEE Wei WANG Mi ZHANG Xuefa WEN Shoudong LIU yongbo hu Chengyu XIE Zhen ZHANG Xuesong ZHANG Xiaoyan ZHAO Fucun ZHANG Yale-NUIST Center on Atmospheric Environment & Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment Technology(CICAEET) Nanjing University of Information Science & Technology School of Forestry and Environmental Studies Yale University Jiangsu Key Laboratory of Agricultural Meteorology Nanjing University of Information Science & Technology Key Laboratory of Ecosystem Network Observation and Modeling Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of Sciences

The kinetic fractionation of open-water evaporation against the stable water isotope H_2 ^(18)O is an important mechanism underlying many hydrologic studies that use ^(18)O as an isotopic tracer. A recent in-situ measurement of the isotopic water vapor flux over a lake indicates that the kinetic effect is much weaker(kinetic factor 6.2‰) than assumed previously(kinetic factor14.2‰) by lake isotopic budget studies. This study investigates the implications of the weak kinetic effect for studies of deuterium excess-humidity relationships, regional moisture recycling, and global evapotranspiration partitioning. The results indicate that the low kinetic factor is consistent with the deuterium excess-humidity relationships observed over open *** moisture recycling rate in the Great Lakes region derived from the isotopic tracer method with the low kinetic factor is a much better agreement with those from atmospheric modeling studies than if the default kinetic factor of 14.2‰ is used. The ratio of transpiration to evapotranspiration at global scale decreases from 84±9%(with the default kinetic factor) to 76±19%(with the low kinetic factor), the latter of which is in slightly better agreement with other non-isotopic partitioning results.

关键词： Kinetic fractionation factor Craig-Gordon model Moisture recycling Evapotranspiration partitioning Deuteriumexcess

Structural covariance network of the hippocampus–amygdala complex in medication-nale patients with first-episode major depressive disorder

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Psychoradiology 2022年第4期2卷 190-198页

作者： Lianqing Zhang Xinyue hu yongbo hu Mengyue Tang hui Qiu Ziyu Zhu Yingxue Gao Hailong Li Weihong Kuang Weidong Ji Functional and molecular imaging Key Laboratory of Sichuan Province West China HospitalSichuan UniversityChengdu 610041PR China Department of Radiology West China Hospital of Sichuan UniversityChengdu 610041PR China Department of Psychiatry West China Hospital of Sichuan UniversityChengdu 610041PR China Shanghai Key Laboratory of Mental Health and Psychological Crisis Intervention School of Psychology and Cognitive Science and Affiliated Mental Health CenterEast China Normal UniversityShanghai 200335China Child Psychiatry Shanghai Changning Mental Health CenterShanghai 200335China

Background The hippocampus and amygdala are densely interconnected structures that work together in multiple affective and cognitive processes that are important to the etiology of major depressive disorder(MDD).Each of these structures consists of several heterogeneous *** aim to explore the topologic properties of the volume-based intrinsic network within the hippocampus–amygdala complex in medication-nale patients with first-episode *** High-resolution T1-weighted magnetic resonance imaging scans were acquired from 123 first-episode,medication-nale,and noncomorbid MDD patients and 81 age-,sex-,and education level-matched healthy control participants(HCs).The structural covariance network(SCN)was constructed for each group using the volumes of the hippocampal subfields and amygdala subregions;the weights of the edges were defined by the partial correlation coefficients between each pair of subfields/subregions,controlled for age,sex,education level,and intracranial *** global and nodal graphmetrics were calculated and compared between *** Compared with HCs,the SCN within the hippocampus–amygdala complex in patients with MDD showed a shortened mean characteristic path length,reduced modularity,and reduced small-worldness *** the nodal level,the left hippocampal tail showed increased measures of centrality,segregation,and integration,while nodes in the left amygdala showed decreased measures of centrality,segregation,and integration in patients with MDD compared with *** Our results provide the first evidence of atypical topologic characteristics within the hippocampus–amygdala complex in patients with MDD using structure network *** provides more delineate mechanism of those two structures that underlying neuropathologic process in MDD.

关键词： Major depressive disorder hippocampus-amygdala complex structural covariance network global network metrics local network metrics

Critical role of ROCK1 in AD pathogenesis via controlling lysosomal biogenesis and acidification

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Translational Neurodegeneration 2024年第1期13卷 259-280页

作者： Chenghuan Song Wanying huang Pingao Zhang Jiyun Shi Ting Yu Jing Wang yongbo hu Lanxue Zhao Rui Zhang Gang Wang Yongfang Zhang Hongzhuan Chen Hao Wang Department of Pharmacology and Chemical Biology Shanghai Jiao Tong University School of MedicineShanghai 200025China Academy of Integrative Medicine Shanghai University of Traditional Chinese MedicineShanghai 201203China Department of Neurology Chang-Hai HospitalThe Second Military Medical UniversityShanghai 200433China Department of Neurology and Neuroscience Institute Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Shuguang Lab of Future Health Shanghai Frontiers Science Center of TCM Chemical BiologyShuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 201203China

Background Lysosomal homeostasis and functions are essential for the survival of neural *** lysosomal biogenesis and acidification in Alzheimer’s disease(AD)pathogenesis leads to proteolytic dysfunction and ***,the key regulatory factors and mechanisms of lysosomal homeostasis in AD remain poorly *** ROCK1 expression and its co-localization with LAMP1 and SQSTM1/p62 were detected in post-mortem brains of healthy controls and AD ***-related fluorescence probe staining,transmission electron microscopy and immunoblotting were performed to evaluate the role of ROCK1 in lysosomal biogenesis and acidification in various neural cell *** interaction between ROCK1 and TFEB was confirmed by surface plasmon resonance and in situ proximity ligation assay(PLA).Moreover,we performed AAV-mediated ROCK1 downregulation followed by immunofluorescence,enzyme-linked immunosorbent assay(ELISA)and behavioral tests to unveil the effects of the ROCK1-TFEB axis on lysosomes in APP/PS1 transgenic *** ROCK1 level was significantly increased in the brains of AD individuals,and was positively correlated with lysosomal markers and Aβ.Lysosomal proteolysis was largely impaired by the high abundance of ROCK1,while ROCK1 knockdown mitigated the lysosomal dysfunction in neurons and ***,we verified ROCK1 as a previously unknown upstream kinase of TFEB independent of m-TOR or GSK-3β.ROCK1 elevation resulted in abundant extracellular Aβdeposition which in turn bound to Aβreceptors and activated RhoA/ROCK1,thus forming a vicious circle of AD *** downregulating ROCK1 lowered its interference with TFEB,promoted TFEB nuclear distribution,lysosomal biogenesis and lysosome-mediated Aβclearance,and eventually prevented pathological traits and cognitive deficits in APP/PS1 *** In summary,our results provide a mechanistic insight into the critical role of ROCK1 in lysosomal regulation and

关键词： ROCK1 Lysosomal biogenesis Lysosomal acidification TFEB Alzheimer’s disease

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利用扁铲侧胀试验确定粗粒砂土的超固结比

地质与勘探 2020年第4期56卷 862-869页

作者：胡永波陕西铁道工程勘察有限公司陕西西安710000

本文利用扁铲侧胀试验对超固结砂土的土力学参数进行测试,目的是获取砂土的超固结比OCR和静止土压力系数k 0。经过一系列室内试验箱砂土物理模型试验的精确测试,分别得到在加载和卸载阶段的P 0压力值和P 1压力值,并换算成各项扁铲侧胀... 详细信息

本文利用扁铲侧胀试验对超固结砂土的土力学参数进行测试,目的是获取砂土的超固结比OCR和静止土压力系数k 0。经过一系列室内试验箱砂土物理模型试验的精确测试,分别得到在加载和卸载阶段的P 0压力值和P 1压力值,并换算成各项扁铲侧胀试验指标。试验结果表明,在扁铲侧胀试验指标中,侧胀水平应力指数K D更能反映粗颗粒砂土的超固结比,因此,可用相对密实度D r和侧胀水平应力指数K D建立超固结比OCR的表达式;由于K D/k 0和E D/σ′m之间有共同的因子,即状态参数ψ,因此可建立两者的关系式来计算静止土压力系数k 0。

关键词：扁铲侧胀试验静止土压力系数超固结比粗颗粒砂土

Stress-Induced Precipitation of Fineγ'-Phase and Thermodynamics Analysis

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Journal of Materials Science & Technology 2001年第2期17卷 257-259页

作者： Sugui TIAN Department of Materials Science and Engineering, Shenyang Polytechnic University, Shenyang 110023, China Jinghua ZHANG, yongbo XU and Zhuangqi hu State Key Laboratory for Fatigue and Fracture of Materials, Institute of Metal Research, Chinese Shenyang Polytech Univ Dept Mat Sci & Engn Shenyang 110023 Peoples R China Chinese Acad Sci Inst Met Res State Key Lab Fatigue & Fracture Mat Shenyang 110015 Peoples R China Northeastern Univ Shenyang 110006 Peoples R China

The microstructures of a single crystal Ni-base superalloy with [001] orientation were observed by means of TEM. Results showed that the fine γ' particles were precipitated in the γ matrix channels during the tensile deformation of the alloy. Thermodynamics analysis indicated that the solubility of elements M(Al,Ta) within the γ matrix may be changed when the alloy was deformed by the external applied stress. The tensile stress reduced the solubility of elements Al and Ta so as to occur the over-saturation and agglomeration of them, which promoted the precipitation of fine γ'-phase in the γ matrix.

关键词： In Phase and Thermodynamics Analysis Stress-Induced Precipitation of Fine Ta

The China Alzheimer Report 2022

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General Psychiatry 2022年第1期35卷 1-19页

作者： Rujing Ren Jinlei Qi Shaohui Lin Xinya Liu Peng Yin Zhihui Wang Ran Tang Jintao Wang Qiang huang Jianping Li Xinyi Xie yongbo hu Shishuang Cui Yuan Zhu Xiaoping Yu Pengfei Wang Yikang Zhu Yiran Wang Yanyan huang Yisong hu Ying Wang Chunbo Li Maigeng Zhou Gang Wang Department of Neurology and Institute of Neurology Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina National Center for Chronic and Noncommunicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina School of Public Health Fudan UniversityShanghaiChina NHC Key Laboratory of Health Technology Assessment Fudan UniversityShanghaiChina Department of Geriatrics Huashan HospitalFudan UniversityShanghaiChina National Survey Research Center Renmin University of ChinaBeijingChina

China’s population has rapidly aged over the recent decades of social and economic development as neurodegenerative disorders have proliferated,especially Alzheimer’s disease(AD)and related dementias(ADRD).AD’s incidence rate,morbidity,and mortality have steadily increased to make it presently the fifth leading cause of death among urban and rural residents in China and magnify the resulting financial burdens on individuals,families and ***‘Healthy China Action’plan of 2019-2030 promotes the transition from disease treatment to health maintenance for this expanding population with *** report describes related epidemiological trends,evaluates the economic burden of the disease,outlines current clinical diagnosis and treatment status and delineates existing available public health *** specifically,it examines the public health impact of ADRD,including prevalence,mortality,costs,usage of care,and the overall effect on caregivers and *** addition,this special report presents technical guidance and supports for the prevention and treatment of AD,provides expertise to guide relevant governmental healthcare policy development and suggests an information platform for international exchange and cooperation.

关键词： Alzheimer mortality prevention

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关于市政桥梁的预应力施工技术分析

中外建筑 2018年第6期 206-208页

作者：胡勇波湖南地生项目管理有限公司

随着我国工程建设行业的迅速发展,市政交通基础设施建设水平,尤其是代表建筑施工领域最高技术水准的桥梁工程建设水平,已经走在了世界的前列。为了满足城市立体交通发展需要,桥梁工程施工正向着大跨径、轻量化方向发展,桥梁工程施工对... 详细信息

随着我国工程建设行业的迅速发展,市政交通基础设施建设水平,尤其是代表建筑施工领域最高技术水准的桥梁工程建设水平,已经走在了世界的前列。为了满足城市立体交通发展需要,桥梁工程施工正向着大跨径、轻量化方向发展,桥梁工程施工对预应力施工技术的依赖性也日益增加。和发达国家相比,我国的预应力施工技术起步较晚,但发展迅速,经过几十年的发展,我国的预应力施工技术及工程可靠性得到显著提升,但在部分施工细节方面还存在不少问题,这些问题严重影响了预应力桥梁结构的承载性能。因此,本文以预应力施工过程中的若干关键流程为研究切入点,就预应力桥梁施工技术细节进行详细分析,以期为今后的大跨径预应力桥梁施工提供参考和借鉴。

关键词：市政桥梁预应力施工技术分析

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R404A/R744复叠制冷机组设计探讨

上海化工 2013年第5期38卷 17-19页

作者：胡泳波上海美乐柯制冷设备有限公司上海200083

通过对R404A/R744复叠制冷机组的设计匹配计算,探讨了复叠制冷系统中CO2作为低温级制冷剂的应用问题。

关键词： R404A R744 复叠式设计

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3D打印技术在岩石力学试验中的应用与展望

土木工程学报 2023年第11期56卷 137-154页

作者：王乐华胡永搏付寅韬李建林许晓亮三峡大学三峡库区地质灾害教育部重点实验室湖北宜昌443000

非连续、非均质性岩石试样加工和复杂岩体物理模型成型技术一定程度上影响着岩石力学试验的发展,3D打印技术具备几何适应性好、可个性化定制、天然模型还原度高、离散性小、高效便捷等优势,能克服传统制样方法的诸多不足。通过介绍目前... 详细信息

非连续、非均质性岩石试样加工和复杂岩体物理模型成型技术一定程度上影响着岩石力学试验的发展,3D打印技术具备几何适应性好、可个性化定制、天然模型还原度高、离散性小、高效便捷等优势,能克服传统制样方法的诸多不足。通过介绍目前岩石力学试验中常用的3D打印技术和打印原料,从岩石裂纹扩展和破裂机制、岩体剪切和渗流特性、岩体物理模型试验及岩土交叉学科研究等方面较为系统地阐述了3D打印技术在岩石力学试验中的发展现状,重点分析了当下3D打印技术的局限性及亟待解决的问题,认为3D打印技术在模型尺度、打印精度、成型速度之间的协调性还需进一步提升,多出料口多材料协同连续打印技术亟待突破,打印模型还原度和相似度定量评价问题尚待解决,打印模型的后处理和养护有待标准化和规范化。最后,着眼于复杂岩体物理模型试验、岩石尺寸效应、各向异性和岩土交叉学科等岩石力学研究的热点和难点问题,对3D打印技术在岩石力学领域的应用进行了展望。

关键词： 3D打印岩石力学试验不连续面离散性交叉学科各向异性

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