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Stabilizing semi-transparent perovskite solar cells with a polymer composite hole transport layer

Nano Research 2024年第3期17卷 1500-1507页

作者： yongbin Jin Huiping Feng Zheng Fang Liu Yang Kaikai Liu Bingru Deng Jingfu chen Xueling chen Yawen Zhong Jinxin Yang chengbo Tian Liqiang Xie Zhanhua Wei Xiamen Key Laboratory of Optoelectronic Materials and Advanced Manufacturing Institute of Luminescent Materials and Information DisplaysCollege of Materials Science and EngineeringHuaqiao UniversityXiamen 361021China

Semi-transparent perovskite solar cells(ST-PSCs)have broad applications in building integrated photovoltaics.However,the stability of ST-PSCs needs to be improved,especially in n-i-p ST-PSCs since the doped 2,2',7,7'-tetrakis(N,N-di-p-methoxyphenyl-amine)-9,9'-spirobifluorene(Spiro-OMeTAD)is unstable at elevated temperatures and high humidity.In this work,aπ-conjugated polymer poly[(2,6-(4,8-bis(5-(2-ethylhexyl)thiophene-2-yl)-benzo[1,2-b:4,5-b']dithiophene))-alt-(5,5-(1',3'-di-2-thienyl-5',7'-bis(2-ethylhexyl)benzo[1',2'-c:4',5'-c']dithiophene-4,8-dione)](PBDB-T)is selected to form a polymer composite hole transport layer(HTL)with Spiro-OMeTAD.The sulfur atom of the thiophene unit and the carbonyl group of the polymer interact with the undercoordinated Pb2+at the perovskite surface,which stabilizes the perovskite/HTL interface and passivates the interfacial defects.The incorporation of the polymer also increases the glass transition temperature and the moisture resistance of Spiro-OMeTAD.As a result,we obtain ST-PSCs with a champion efficiency of 13.71%and an average visible light transmittance of 36.04%.Therefore,a high light utilization efficiency of 4.94%can be obtained.Moreover,the encapsulated device can maintain 84%of the initial efficiency after 751 h under continuous one-sun illumination(at 30%relative humidity)at the open circuit and the unencapsulated device can maintain 80%of the initial efficiency after maximum power tracking for more than 1250 h under continuous one-sun illumination.

关键词： semi-transparent solar cells π-conjugated polymer composite hole transport layer building integrated photovoltaics

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Genome-wide association study of seedling nitrogen-use efficiency-associated traits in common wheat(Triticum aestivum L.)

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The Crop Journal 2024年第1期12卷 222-231页

作者： Huawei Shi Weichong Wang Lifeng Gao Jirong Wu chengmei Hu Huishu Yan Yugang Shi Ning Li Youzhi Ma yongbin Zhou Zhaoshi Xu Jun chen Wensi Tang Kai chen Daizhen Sun Yuxiang Wu Ming chen College of Agriculture Shanxi Agricultural UniversityJinzhong 030801ShanxiChina National Key Facility for Crop Gene Resources and Genetic Improvement Key Laboratory of Biology and Genetic Improvement of Triticeae CropsMinistry of AgricultureInstitute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China

Nitrogen(N)fertilizer application is essential for crop-plant growth and development.Identifying genetic loci associated with N-use efficiency(NUE)could increase wheat yields and reduce environmental pollution caused by overfertilization.We subjected a panel of 389 wheat accessions to N and chlorate(a nitrate analog)treatments to identify quantitative trait loci(QTL)controlling NUE-associated traits at the wheat seedling stage.Genotyping the panel with a 660K single-nucleotide polymorphism(SNP)array,we identified 397 SNPs associated with N-sensitivity index and chlorate inhibition rate.These SNPs were merged into 49 QTL,of which eight were multi-environment stable QTL and 27 were located near previously reported QTL.A set of 135 candidate genes near the 49 QTL included TaBOX(F-box family protein)and TaERF(ethylene-responsive transcription factor).A Tabox mutant was more sensitive to low-N stress than the wild-type plant.We developed two functional markers for Hap 1,the favorable allele of TaBOX.

关键词： Wheat NUE Genome-wide association study Nitrogen sensitive index Chlorate inhibition rate

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RIOX1-demethylated cGAS regulates ionizing radiation-elicited DNA repair

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Bone Research 2022年第2期10卷 367-377页

作者： Yanxuan Xiao Jingyi Li Xiaoyu Liao Yumin He Tao He Cuiping Yang Lu Jiang So Mi Jeon Jong-Ho Lee yongbin chen Rui Liu Qianming chen State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesChinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and ManagementWest China Hospital of StomatologySichuan UniversityChengduSichuan 610041China The Second Affiliated Hospital of chengdu Medical College China National Nuclear Corporation 416 HospitalChengduSichuan 610051China School of Biological Sciences and Technology Chengdu Medical CollegeChengdu 610599China Department of Cardio-thoracic Surgery the Second Affiliated Hospital of Chengdu Medical CollegeChina National Nuclear Corporation 416 HospitalChengduSichuan 610051China Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences Yunnan Province Kunming Institute of ZoologyKunmingYunnan 650223China Department of Health Sciences The Graduate School of Dong-A UniversityBusan 49315Republic of Korea Department of Biological Sciences Dong-A UniversityBusan 49315Republic of Korea Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunmingYunnan 650223China

Exposure to radiation causes DNA damage;hence, continuous surveillance and timely DNA repair are important for genome stability. Epigenetic modifications alter the chromatin architecture, thereby affecting the efficiency of DNA repair. However, how epigenetic modifiers coordinate with the DNA repair machinery to modulate cellular radiosensitivity is relatively unknown. Here, we report that loss of the demethylase ribosomal oxygenase 1(RIOX1) restores cell proliferation and reduces cell death after exposure to ionizing radiation. Furthermore, RIOX1 depletion enhances homologous recombination(HR) repair but not nonhomologous endjoining(NHEJ) repair in irradiated bone marrow cells and oral mucosal epithelial cells. Mechanistic study demonstrates that RIOX1 removes monomethylation at K491 of cyclic GMP-AMP synthase(c GAS) to release c GAS from its interaction with the methyl-lysine reader protein SAGA complex-associated factor 29(SGF29), which subsequently enables c GAS to interact with poly(ADP-ribosyl)ated poly(ADP-ribose) polymerase 1(PARP1) at DNA break sites, thereby blocking PARP1-mediated recruitment of Timeless. High expression of RIOX1 maintains c GAS K491 me at a low level, which impedes HR repair and reduces cellular tolerance to ionizing radiation. This study highlights a novel RIOX1-dependent mechanism involved in the non-immune function of c GAS that is essential for the regulation of ionizing radiation-elicited HR repair.

关键词： thereby repair remove

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First-line camrelizumab(a PD-1 inhibitor)plus apatinib(an VEGFR-2 inhibitor)and chemotherapy for advanced gastric cancer(SPACE):a phase 1 study

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1760-1767页

作者： Xiaofeng chen Hao Xu Xiaobing chen Tongpeng Xu Yitong Tian Deqiang Wang Fen Guo Kangxin Wang Guangfu Jin Xiao Li Rong Wang Fengyuan Li yongbin Ding Jie Tang Yueyu Fang Jing Zhao Liang Liu Ling Ma Lijuan Meng Zhiguo Hou Rongrong Zheng Yang Liu Ni Guan Bei Zhang Shuang Tong Shiqing chen Xing Li Yongqian Shu Department of Oncology The First Affiliated Hospital with Nanjing Medical UniversityNanjingChina Gusu School Nanjing medical UniversitySuzhouChina Jiangsu Key Lab of Cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Cancer Personalized MedicineNanjing Medical UniversityNanjingChina Department of General surgery The First Affiliated Hospital with Nanjing Medical UniversityNanjingChina Department of Oncology Henan Cancer Hospital Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhouChina Henan Engineering Research Center of Precision Therapy of Gastrointestinal Cancer&Zhengzhou Key Laboratory for Precision Therapy of Gastrointestinal Cancer ZhengzhouChina Department of Oncology Digestive Disease Institute&Cancer Institute of Jiangsu UniversityAffiliated Hospital of Jiangsu UniversityZhenjiangChina Department of Oncology Suzhou Hospital of Nanjing Medical UniversitySuzhouChina Department of Oncology Nanjing PuKou People’s HospitalNanjingChina Department of Epidemiology School of Public HealthNanjing Medical UniversityNanjingChina Department of Pathology The First Affiliated Hospital with Nanjing Medical UniversityNanjingChina Department of general surgery Jurong Branch hospital of Jiangsu Province People HospitalJurongChina Department of Medical Oncology Liyang People’s HospitalLiyangChina Department of radiology Nanjing PuKou People’s HospitalNanjingChina Jiangsu Hengrui Pharmaceuticals ShanghaiChina Department of Medical Affairs 3D Medicines Inc.ShanghaiChina Shanghai OrigiMed Co. Ltd.ShanghaiChina

Patients with advanced gastric cancer typically face a grim prognosis.This phase 1a(dose escalation)and phase 1b(dose expansion)study investigated safety and efficacy of first-line camrelizumab plus apatinib and chemotherapyfor advanced gastric or gastroesophageal junction adenocarcinoma.The primary endpoints included maximum tolerated dose(MTD)in phase 1a and objective response rate(ORR)across phase 1a and 1b.Phase 1a tested three dose regimens of camrelizumab,apatinib,oxaliplatin,and S-1.Dose regimen 1:camrelizumab 200 mg on day 1,apatinib 250 mg every other day,oxaliplatin 100 mg/m^(2) on day 1,and S-140 mg twice a day on days 1-14.Dose regimen 2:same as dose regimen 1,but oxaliplatin 130mg/m.Dose regimen3:same as dose regimen 2,but apatinib 250 mg daily.Thirty-four patients were included(9 in phase 1a,25 in phase 1b).No dose-limiting toxicities occurred so no MTD was identified.Dose 3 was set for the recommended phase 2 doses and administered in phase 1b.The confrmed ORR was 76.5%(95%CI 58.8-89.3).The median progression-free survival was 8.4 months(95%CI 5.9-not evaluable[NE]),and the median overall survival(OS)was not mature(11.6-NE).Ten patients underwent surgery after treatment and the multidisciplinary team evaluation.Among 24 patients without surgery,the median OS was 19.6 months(7.8-NE).Eighteen patients(52.9%)developed grade≥3 treatment-emergent adverse events.Camrelizumab plus apatinib and chemotherapy showed favorable clinical outcomes and manageable safety for untreated advanced gastric cancer(ChiCTR2000034109).

关键词： regimen cancer doses

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MrgprF acts as a tumor suppressor in cutaneous melanoma by restraining PI3K/Akt signaling

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Signal Transduction and Targeted Therapy 2022年第6期7卷 2027-2040页

作者： Qiushuo Shen Yanfei Han Kai Wu Yaomei He Xiulin Jiang Peishen Liu Cuifeng Xia Qiuxia Xiong Rui Liu Qianming chen Yong Zhang Song Zhao Cuiping Yang yongbin chen Department of Thoracic Surgery the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences&Yunnan Province Kunming Institute of ZoologyKunmingYunnan 650223China Kunming Medical University KunmingYunnan 650118China State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesChinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and ManagementWest China Hospital of StomatologySichuan UniversityChengduSichuanChina Department of Pathology Cancer Hospital of China Medical UniversityShenyangLiaoning 110042China The International Peace Maternity and Child Health Hospital School of MedicineShanghai Jiao Tong UniversityShanghai 200030China Shanghai Key Laboratory of Embryo Original Diseases Shanghai 200030China

The incidence of cutaneous melanoma(CM)has been increasing annually worldwide.In this study,we identify that MrgprF,a MAS related GPR family member,is decreased in cutaneous melanoma tissues and cell lines due to hypermethylation of its promoter region,and show that patients with CM expressing high levels of MrgprF exhibit an improved clinical outcome.We demonstrate that MrgprF forced expression inhibits tumor cell proliferation,migration,xenograft tumor growth,and metastasis.On the contrary,MrgprF knockdown promotes tumor cell proliferation and transformation of immortalized human keratinocyte-HaCaT cells,supporting the inhibitory role of MrgprF during tumor progression.Mechanistic studies reveal that MrgprF reduces the phosphoinositol‑3‑kinase(PI3K)complex formation between p101 and p110γsubunits,the critical step for phosphatidylinositol-(3,4)-P2(PIP2)conversion to phosphatidylinositol-(3,4,5)-P3(PIP3),and then reduces the activation of PI3K/Akt signaling.This effect can be reversed by Akt specific agonist SC79.In addition,AMG 706,a previously documented inhibitor for endothelial cell proliferation,is identified as a potential agonist for MrgprF,and can impede tumor growth both in vitro and in vivo.Taken together,our findings suggest that MrgprF,a novel tumor suppressor in cutaneous melanoma,may be useful as a therapeutic target in the future.

关键词： PI3K/Akt melanoma suppressor

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多尺寸注意力的命名实体识别方法

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计算机科学与探索 2024年第2期18卷 506-515页

作者：唐瑞雪秦永彬陈艳平贵州财经大学信息学院贵阳550025 贵州大学计算机科学与技术学院贵阳550025 公共大数据国家重点实验室贵阳550025

命名实体识别(NER)任务的准确性将促进自然语言领域中诸多下游任务的研究。由于文本中存在大量嵌套语义,导致命名实体识别困难,成为自然语言处理中的难点。以往研究提取特征尺度单一,边界信息利用不够充分,忽略了不同尺度下的许多细节信... 详细信息

命名实体识别(NER)任务的准确性将促进自然语言领域中诸多下游任务的研究。由于文本中存在大量嵌套语义,导致命名实体识别困难,成为自然语言处理中的难点。以往研究提取特征尺度单一,边界信息利用不够充分,忽略了不同尺度下的许多细节信息,从而造成实体识别错误或遗漏的情况。针对上述问题,提出一种多尺度注意力的命名实体识别方法(MSA-NER)。首先,利用BERT模型得到包含上下文信息的表示向量,并通过BiLSTM网络加强文本的上下文表示。其次,将表示向量进行枚举拼接形成跨度信息矩阵,并融合方向信息获得更丰富的交互信息。然后,利用多头注意力构建多个子空间,通过二维卷积在每个子空间下可选地聚合不同尺度的文本信息,在每个注意力层同时进行多尺度的特征融合。最后,将融合的矩阵进行跨度分类以识别命名实体。实验表明,该方法在GENIA和ACE2005英文数据集上F1分别达到81.7%和86.8%,与现有主流模型相比有更好的识别效果。

关键词：命名实体识别(NER) 嵌套语义多尺度注意力卷积神经网络子空间

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氧化物协同改性对有机硅树脂抗烧蚀性能的影响

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塑料 2024年第2期53卷 41-44,51页

作者：王彬丁振礼陈永彬山东航空学院机电工程学院山东滨州256600 滨州渤海活塞有限公司山东滨州256606

为改善树脂基热防护材料的抗烧蚀性能,采用氧化硼和氧化钛作为填料,对环氧改性有机硅树脂进行协同改性,制备了改性复合材料。分析了氧化硼和氧化钛协同改性对复合材料抗烧蚀性能、力学性能和热稳定性的影响。结果表明,添加氧化硼和氧化... 详细信息

为改善树脂基热防护材料的抗烧蚀性能,采用氧化硼和氧化钛作为填料,对环氧改性有机硅树脂进行协同改性,制备了改性复合材料。分析了氧化硼和氧化钛协同改性对复合材料抗烧蚀性能、力学性能和热稳定性的影响。结果表明,添加氧化硼和氧化钛后,复合材料的拉伸强度、密度和硬度大幅提高,热解失重显著减小,复合材料的马弗炉静态烧蚀和氧-乙炔烧蚀性能有效提升。在高温氧-乙炔烧蚀条件下,氧化硼和氧化钛的复合添加,能够在复合材料表面形成颗粒状与羽毛状的协同改善多孔结构,显著提升了复合材料的抗烧蚀性能,其线烧蚀率低至0.12 mm/s,与改性前相比,降幅超过75%。

关键词：环氧改性有机硅协同改性烧蚀性能氧化硼氧化钛

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The role of m6A modification in the biological functions and diseases

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Signal Transduction and Targeted Therapy 2021年第3期6卷 763-778页

作者： Xiulin Jiang Baiyang Liu Zhi Nie Lincan Duan Qiuxia Xiong Zhixian Jin Cuiping Yang yongbin chen Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences&Yunnan Province Kunming Institute of Zoology650223 KunmingYunnanChina Kunming College of Life Science University of Chinese Academy of Sciences100049 BeijingChina Kunming Medical University 650500 KunmingChina Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences650223 KunmingYunnanChina

N6-methyladenosine(m6A)is the most prevalent,abundant and conserved internal cotranscriptional modification in eukaryotic RNAs,especially within higher eukaryotic cells.m6A modification is modified by the m6A methyltransferases,or writers,such as METTL3/14/16,RBM15/15B,ZC3H3,VIRMA,CBLL1,WTAP,and KIAA1429,and,removed by the demethylases,or erasers,including FTO and ALKBH5.It is recognized by m6A-binding proteins YTHDF1/2/3,YTHDC1/2 IGF2BP1/2/3 and HNRNPA2B1,also known as"readers".Recent studies have shown that m6A RNA modification plays essential role in both physiological and pathological conditions,especially in the initiation and progression of different types of human cancers.In this review,we discuss how m6A RNA methylation influences both the physiological and pathological progressions of hematopoietic,central nervous and reproductive systems.We will mainly focus on recent progress in identifying the biological functions and the underlying molecular mechanisms of m6A RNA methylation,its regulators and downstream target genes,during cancer progression in above systems.We propose that m6A RNA methylation process offer potential targets for cancer therapy in the future.

关键词： m6A diseases removed

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A novel preparation of nanosized hexagonal Mg（OH）2 as a flame retardant

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Particuology 2016年第1期14卷 177-182页

作者： yongbin chen Tao Zhou Huaxiong Fang Simin Li Yuting Yao Bailin Fan Jian Wang Key Laboratory of Resources Chemistry of Nonferrous Metals College of Chemistry and Chemical Engineering Central South UniversityChangsha 410083 China

Nanosized dispersive hexagonal magnesium hydroxide （Mg（OH）2） has been prepared using an ammonia- hydrothermal method. Citric acid and monoethanolamine （MEA） were added to the reaction system during the ammonia precipitation and hydrothermal processes, respectively, to improve the crystallinity and dispersion of the （Mg（OH）2） particles. The resulting Mg（OH）2 samples obtained under the opti- mum preparation conditions were characterized by scanning electron microscopy, X-ray diffraction and thermal gravity analysis, which showed that this newly developed procedure afforded well-dispersed hexagonal nanoolates of Mg（OH）2 with a mean diameter of 246 nm.

关键词： Nanosized Mg（OH）2 Hydrothermal process Dispersion

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湖北随州叶家山墓地M126出土铜器科学分析

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文博 2024年第1期 106-112页

作者：郁永彬陈丽新陈建立陈坤龙国家文物局考古研究中心北京100013 湖北省文物考古研究院湖北武汉430077 北京大学考古文博学院北京100871 北京科技大学科技史与文化遗产研究院北京100083

本文通过科技检测手段对叶家山M126出土铜器进行了分析。结果表明,经分析的10件器物中,有7件为铅锡青铜制成,包括6件容器和1件兵器,有3件锡青铜,全部为容器。这批铜器制作采用块范铸造工艺。祖己爵M126:16为一件商代器物。其他器物分属... 详细信息

本文通过科技检测手段对叶家山M126出土铜器进行了分析。结果表明,经分析的10件器物中,有7件为铅锡青铜制成,包括6件容器和1件兵器,有3件锡青铜,全部为容器。这批铜器制作采用块范铸造工艺。祖己爵M126:16为一件商代器物。其他器物分属A类和C类普通铅的范畴。其他族属铭文铜器中,一部分器物使用了与曾国铜器相同或相似的矿料,另一部分器物与曾国铜器使用的矿料不同,体现了西周早中期青铜物料流通信息,部分以器物组的形式流通。

关键词：冶金考古叶家山墓地西周铜器铅同位素比值

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