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Process analytical technologies and self-optimization algorithms in automated pharmaceutical continuous manufacturing

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Chinese Chemical Letters 2024年第3期35卷 87-95页

作者： Peiwen liu Hui Jin Yan Chen Derong Wang Haohui Yan Mingzhao Wu Fang Zhao Weiping Zhu State Key Laboratory of Bioreactor Engineering Shanghai Key Laboratory of Chemical BiologySchool of PharmacyEast China University of Science and TechnologyShanghai 200237China State Key Laboratory of Chemical Engineering School of Chemical EngineeringEast China University of Science and TechnologyShanghai 200237China Engineering Research Center of Pharmaceutical Process Chemistry Ministry of EducationSchool of PharmacyEast China University of Science and TechnologyShanghai 200237China

The pharmaceutical industry is now paying increased attention to continuous *** the revolution to continuous and automated manufacturing is deepening in most of the top pharma companies in the world,the advancement of automated pharmaceutical continuous manufacturing in China is relatively slow due to some key challenges including the lack of knowledge on the related technologies and shortage of qualified *** this review,emphasis is given to two of the crucial technologies in automated pharmaceutical continuous manufacturing,i.e.,process analytical technology(PAT)and self-optimizing *** work published in recent 5 years employing advanced PAT tools and self-optimization algorithms is introduced,which represents the great progress that has been made in automated pharmaceutical continuous manufacturing.

关键词： Pharmaceutical continuous manufacturing Automation Process analytical technology Self-optimization algorithm

Method of extracting disturbed position in φ-OTDR based on signal relevance evaluation

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Optoelectronics Letters 2024年第9期20卷 513-517页

作者： LI Chengzhi YAng Yang liu Lijun GAO Fei DU Xuan LIAng Hu Kunlun Digital Technology Co. Ltd.Beijing 102206China Tianjin Navigation Instruments Research Institute Tianjin 300131China

A theoretical analysis was conducted on the intrinsic bond between multi-point responses caused by the same single vibration in phase sensitive optical time-domain reflectometer(OTDR). Temporal similarity of signals collected from adjacent sample locations were investigated. Referring to correlation coefficient as well as the relative energy level, a method of extracting disturbed position in φ-OTDR based on signal relevance evaluation is proposed to perform fast screening of massive φ-OTDR raw data to pinpoint those signals with significance.

关键词： OTDR signal disturbed

Prevent effects of soybean meal peptides in acute alcoholic liver injury based on gut microbiota and metabolome alteration

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Food Science and Human Wellness 2024年

作者： Jingbo liu Shengrao Li Qi Yang Siwen Lü Xuanting liu Zhiyang Du Xiaomin Shang Ting Zhang Jilin Provincial Key Laboratory of Nutrition and Functional Food， College of Food Science and Engineering， Jilin University

This study investigated the preventive effects of soybean meal peptides (SPs) and their purification peptides (GTYW) on acute alcoholic liver injury. We combined the gut microbiota， metabolites， liver inflammation， and oxidative stress indicators to explore the prevention mechanism of SPs and GTYW. Results showed that SPs， GTYW effectively improved the hepatic oxidative stress and inflammatory. Additionally， SPs and GTYW reversed the effects of alcohol on the gut microbiota， which were evident in the increased abundance of Alloprevotella， Parasutterella in the GTYW group and norank-f-Muribaculaceae in the SPs group. Non-targeted metabolomic analysis showed that SPs ameliorated metabolic disorders by regulating phenylalanine， tyrosine and tryptophan biosynthesis， while GTYW regulated metabolites through α-linolenic acid metabolism and phenylalanine metabolism. Furthermore， significant correlations were observed between gut microbiota， metabolites and liver indicators. These findings confirmed that SPs and GTYW can prevent acute alcoholic liver injury.

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非结式消元7R双环球面机构运动学位移分析

机械工程学报 2024年第7期60卷 45-53页

作者：刘伟刘宏昭西安工程大学机电工程学院西安710048 西安理工大学机械与精密仪器工程学院西安710048

提出一种7R双环球面机构运动学位移分析的方法。将球面4R机构连杆的方向矢量作为中间变量,建立关于其线性方程组,不进行结式消元,直接得到输入与输出一对一的运动学位移方程,位移分析结果与现有文献中数据一致。该方法的优点是不需将中... 详细信息

提出一种7R双环球面机构运动学位移分析的方法。将球面4R机构连杆的方向矢量作为中间变量,建立关于其线性方程组,不进行结式消元,直接得到输入与输出一对一的运动学位移方程,位移分析结果与现有文献中数据一致。该方法的优点是不需将中间关节变量引入运动学位移方程,使得机构位移分析过程简化。使用该方法对一种多模式7R双环球面机构运动学位移进行分析,通过对运动学方程进行因式分解,确定了机构具有的两种运动模式和其共同位型,分析机构的转动工作空间。结果表明该7R双环球面机构具有一维转动位移子群与一维转动位移流形两种运动模式。提出的运动学位移分析方法,在分析结构参数对7R双环球面机构运动模式的影响方面具有一定的理论应用价值。

关键词： 7R 双环球面机构运动模式

Development of the second version of Global Prediction System for Epidemiological Pandemic

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Fundamental Research 2024年第3期4卷 516-526页

作者： Jianping Huang Li Zhang Bin Chen Xiaoyue liu Wei Yan Yingjie Zhao Siyu Chen Xinbo Lian Chuwei liu Rui Wang Shuoyuan Gao Danfeng Wang Collaborative Innovation Center for Western Ecological Safety Lanzhou UniversityLanzhou 730000China College of Atmospheric Sciences Lanzhou UniversityLanzhou 730000China

Coronavirus disease 2019(COvID-19)is a severe global public health emergency that has caused a major cri-sis in the safety of human life,health,global economy,and social ***,CovID-19 poses significant challenges to healthcare systems *** prediction and early warning of infectious diseases on a global scale are the premise and basis for countries to jointly fight ***,because of the complexity of epidemics,predicting infectious diseases on a global scale faces significant *** this study,we developed the second version of Global Prediction System for Epidemiological Pandemic(GPEP-2),which combines statis-tical methods with a modified epidemiological *** GPEP-2 introduces various parameterization schemes for both impacts of natural factors(seasonal variations in weather and environmental impacts)and human so-cial behaviors(government control and isolation,personnel gathered,indoor propagation,virus mutation,and vaccination).The GPEP-2 successfully predicted the COVID-19 pandemic in over 180 countries with an average accuracy rate of 82.7%.It also provided prediction and decision-making bases for several regional-scale CovID-19 pandemic outbreaks in China,with an average accuracy rate of 89.3%.Results showed that both anthropogenic and natural factors can affect virus spread and control measures in the early stages of an epidemic can effectively control the *** predicted results could serve as a reference for public health planning and policymaking.

关键词： COVID-19 Epidemiological model Prediction GPEP SEIR Statistical-dynamic

The Nano Research Young Innovators Awards in bio-inspired nanomaterials

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Nano Research 2024年第2期17卷 417-425页

作者： Jun Chen Shuotao Wang Department of Bioengineering University of CaliforniaLos AngelesLos AngelesCA 90095USA Key Laboratory of Bio-inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China

Nano Research Young Innovators(NR45)Awards are designed to acknowledge and celebrate the achievements of young researchers under 45 years of *** individuals have made significant contributions to the field of nanoscience and *** the inaugural NR45 Awards in 2018,the journal's editorial board has recognized over a hundred innovators specializing in nanobiotechnology,nano energy,two-dimensional materials,and *** focus of the 2023 NR45 Awards is on bioinspired nanomaterials,acknowledging thirty-three outstanding young innovators for their extraordinary contributions in developing these materials with applications spanning clean energy,human healthcare,monitoring,and disease treatments,as shown in *** extend our heartfelt congratulations to all the 33 NR45 Awardees in 2023!

关键词： journal materials contributions

Climate-growth relationships of Pinus tabuliformis along an altitudinal gradient on Baiyunshan Mountain,Central China

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Journal of Forestry Research 2024年第1期35卷 202-212页

作者： Xiaoxu Wei Jianfeng Peng Jinbao Li Jinkuan Li Meng Peng Xuan Li Yameng liu Jiaxin Li College of Geography and Environmental Science Henan UniversityKaifeng 475004People’s Republic of China Key Laboratory of Earth System Observation and Simulation of He’nan Province Kaifeng 475004People’s Republic of China Department of Geography University of Hong KongPokfulamHong Kong SARPeople’s Republic of China HKU Shenzhen Institute of Research and Innovation Shenzhen 518057People’s Republic of China

A set of standard chronologies for tree-ring width(TRW),earlywood width(EWW)and latewood width(LWW)in Pinus tabuliformis *** an altitudi-nal gradient(1450,1400,and 1350 m a.s.l.)on Baiyunshan Mountain,Central China to analyze the effect of varying temperature and precipitation on growth along the *** analyses showed that at all three altitudes and the TRW and EWW chronologies generally had signifi-cant negative correlations with mean and maximum tem-peratures in the current April and May and with minimum temperatures in the prior July and August,but significant positive correlations with precipitation in the current *** were generally significantly negative between LWW chronologies and all temperatures in the prior July and August,indicating that the prior summer temperature had a strong lag effect on the growth of *** that increased with *** correlation with the standard-ized precipitation evapotranspiration index(SPEI)confirmed that wet conditions in the current May promoted growth of TR and EW at all *** altitudinal differences were also found;at 1400 m,there were significant positive correlations between EWW chronologies and SPEI in the current April and significant negative correlations between LWW chronologies and SPEI in the current September,but these correlations were not significant at 1450 *** 1350 m,there were also significant negative correlations between the TRW and the EWW chronologies and SPEI in the prior October and the current July and between LWW chronology and SPEI in the current August,but these cor-relations were not significant at 1400 *** correlation results showed a stable response of EWW in relation to the SPEI in the current May at all three altitudes and of LWW to maximum temperature in the prior July-August at 1400 m from 2002 to *** EWW chronology at 1400 m and the LWW chronology at 1450 m were identified as more suitable for climate reconstruction.T

关键词： Tree rings Climate response Altitudinal gradient Baiyunshan Mountain Pinus tabuliformis Carr

Pectin Oligosaccharides Glycosylation Modification Reduced the Sensitization of Shrimp Tropomyosin by Regulating Cytokines Expression and Th1/Th2 Immune Balance

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Food Science and Human Wellness 2024年

作者： Mengya Zhao Chunyu Wu Jing liu Xinian Li Zhenpeng Gao Xin Yang Di liu Fangyu Long College of Food Science and Engineering， Northwest A&F University Institute of Animal Husbandry and Veterinary Medicine， Guizhou Academy of Agricultural Sciences College of Animal Science and Technology， Northwest A&F University

Tropomyosin (TM) is the predominant allergenic protein in shrimp， which has induced IgE-mediated food allergy reactions. In this study， Lit v 1 was purified from Penaeus vannamei muscles， which were glycosylated by pectic oligosaccharides. The results showed that Di-Galacturonic acid (DGA) and galacturonic acid (GA) induced the unfolding of the primary protein structure of TM， and changed alpha-helical structure， and IgE binding capacity. In addition， compared with TM-sensitized BALB/c mice， galacturonic acid-modified TM (GA-TM) and Di-Galacturonic acid-modified TM (DGA-TM) were insufficient to stimulate sensitization， and significantly reduced the hypersecretion of IgE， IgG1， HIS， and IL-4， up-regulated IgG2a and IFN-γ levels to improve imbalanced Th1/Th2， Treg/Th17 immunity， and promoted mRNA expression of tight junction proteins. Together， this study confirmed that glycosylation modification alleviated sensitization by altering TM structure， reducing IgE binding allergic inflammatory response， and regulating cytokine immune balance. Overall， these results indicated that glycosylation modification was a promising method for decreasing the allergenic reactivity of allergic proteins.

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Heterologous expression facilitates the discovery and characterization of marine microbial natural products

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Engineering Microbiology 2024年第2期4卷 77-90页

作者： Shuang Zhao Ruiying Feng Yuan Gu Liyuan Han Xiaomei Cong Yang liu Shuo liu Qiyao Shen liujie Huo Fu Yan State Key Laboratory of Microbial Technology Shandong UniversityQingdao 266237China Helmholtz-Institute for Pharmaceutical Research Saarland Saarland University Campus66123SaarbrückenGermany

Microbial natural products and their derivatives have been developed as a considerable part of clinical drugs and agricultural *** microbial natural products exhibit diverse chemical structures and bioactivities with substantial potential for the development of novel ***,discovering compounds with new skeletons from marine microbes remains *** recent decades,multiple approaches have been de-veloped to discover novel marine microbial natural products,among which heterologous expression has proven to be an effective *** by large DNA cloning and comparative metabolomic technologies,a few novel bioactive natural products from marine microorganisms have been identified by the expression of their biosynthetic gene clusters(BGCs)in heterologous *** expression is advantageous for character-izing gene functions and elucidating the biosynthetic mechanisms of natural *** review provides an overview of recent progress in heterologous expression-guided discovery,biosynthetic mechanism elucidation,and yield optimization of natural products from marine microorganisms and discusses the future directions of the heterologous expression strategy in facilitating novel natural product exploitation.

关键词： Marine natural products Heterologous expression Biosynthetic gene clusters Biosynthetic mechanism