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N6-methyladenosine methylation regulates the tumor microenvironment of Epstein-Barr virus-associated gastric cancer

World Journal of Gastrointestinal Oncology 2024年第6期16卷 2555-2570页

作者： Yu Zhang Fang Zhou Ming-Yu Zhang li-na Feng jia-Lun Guan Ruo-nan Dong Yu-Jie huang Su-Hong Xia jia-Zhi liao Kai Zhao Department of Gastroenterology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina Institute of liver and Gastrointestinal Diseases Hubei Key Laboratory of Hepato-Pancreato-Biliary DiseasesTongji Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina Department of Pharmacy Wuhan Fourth HospitalWuhan 430030Hubei ProvinceChina

BACKGROUND N6-methyladenosine(m6A)methylation modification exists in Epstein-Barr virus(EBV)primary infection,latency,and lytic *** also modifies EBV latent genes and lytic ***-associated gastric cancer(EBVaGC)is a distinctive molecular subtype of *** hypothesized EBV and m6A methylation regulators interact with each other in EBVaGC to differentiate it from other types of *** To investigate the mechanisms of m6A methylation regulators in EBVaGC to determine the differentiating factors from other types of *** First,The Cancer Gene Atlas and Gene Expression Omnibus databases were used to analyze the expression pattern of m6A methylation regulators between EBVaGC and EBV-negative GC(EBVnGC).Second,we identified Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)functional enrichment of m6A-related differentially expressed *** quantified the relative abundance of immune cells and inflammatory factors in the tumor microenvironment(TME).Finally,cell counting kit-8 cell proliferation test,transwell test,and flow cytometry were used to verify the effect of insulin-like growth factor binding protein 1(IGFBP1)in EBVaGC cell *** m6A methylation regulators were involved in the occurrence and development of *** with EBVnGC,the expression levels of m6A methylation regulators Wilms tumor 1-associated protein,Rna binding motif protein 15B,CBL proto-oncogene like 1,leucine rich pentatricopeptide repeat containing,heterogeneous nuclear ribonucleoprotein A2B1,IGFBP1,and insulin-like growth factor 2 binding protein 1 were significantly downregulated in EBVaGC(Pnal enrichment analyses showed that the immunity pathways were significantly activated and rich in immune cell infiltration in *** with EBVnGC,the infiltration of activated CD4+T cells,activated CD8+T cel

关键词： N6-methyladenosine methylation Tumor microenvironment Epstein-Barr virus Gastric cancer Insulin-like growth factor binding protein 1

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Enhanced preparation of dendritic metallic vanadium in recyclable naCl-KCl-VCl_(2) molten salt by V_(2)CO electrolysis

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Rare Metals 2024年第8期43卷 3961-3973页

作者： jia-liang An Ming-yong Wang yong-Zheng jia Jin-Tao Zhang Bao-Yan Feng Shu-Qiang jiao State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China College of Material Science and Engineering Hebei Province Laboratory of Inorganic Nonmetallic MaterialsNorth China University of Science and TechnologyTangshan 063210China

A promising method for the preparation of pure metallic vanadium via V_(2)CO anode electrolysis was proposed and *** simple and controllable synthesis of a molten chloride salt containing VCl_(2) by an insitu reaction between VCl_(3) and metallic vanadium was verified through thermodynamic analysis and ***-KCl-VCl_(2) molten salt exhibited excellent recycling performance and could be repetitively used to prepare metallic vanadium by V_(2)CO *** V^(2+) ions remained in the molten salt after *** electrolysis conditions,such as the cathode diameter,current density,V^(2+) ion concentration,and temperature,were optimised to maximise the current *** was also simulated to reveal the regulatory *** highest current efficiency was 85%.The purity of metallic vanadium was up to 99.8%.In this study,an easy and efficient preparation of pure metallic vanadium was achieved.

关键词： V_(2)CO Metallic vanadium Current efficiency Molten salt electrolysis

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Carbon felt electrode coated with WS2 enables a high-performance polysulfide/ferricyanide flow battery

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Rare Metals 2024年第10期43卷 5039-5047页

作者： liang-Yu li Su Yan Ying-jia huang Fang-Fang Zhong Jin-Chao Cao Mei Ding Chuan-Kun jia College of Materials Science and Engineering Changsha University of Science and Technology Institute of Energy Storage Technology College of Energy and Power EngineeringChangsha University of Science and Technology Binzhou Institute of Technology Weiqiao-UCAS Science and Technology Park

Polysulfide/ferricyanide flow batteries （S/Fe RFBs）,with the advantages of abundant earth reservation low cost,high safety,and environmental friendliness,have attracted significant interest and demonstrated noteworthy potential for practical ***,the battery performance,including the energy efficiency （EE）,voltage efficiency （VE）,and power density of the S/Fe RFBs remains low owing to the slow redox kinetics of polysulfide *** address these concerns,WS2was selected as the booster and deposited on a commercial carbon felt electrode （WS2–CF） to stimulate the redox reactions of polysulfide *** better hydrophilicity and smaller charge-transfer resistance,WS2–CF exhibits enhanced electrochemical activity toward polysulfide redox ***,the battery performance of S/Fe RFB with WS2–CF as the anode has been improved,with EE of 84%,VE of 84%,and a peak power density of 175.7 mW·cm-2,which are all higher than the cell only with the bare carbon felt （CF） as electrodes (76%,77% and 155.8 mW·cm-2,respectively).Furthermore,the cycling life of the S/Fe RFB with WS2–CF has been prolonged to 2200 cycles with a capacity retention of 96% a 40 mA·cm-2because of the good stability of WS2–CF as the ***,under the same conditions,the S/Fe RFB without WS2–CF terminated after 1500 cycles with a fast capacity *** successful utilization of WS2as a booster on an electrode provides an efficient strategy for obtaining advanced S/Fe RFBs for practical applications.

关键词： Carbon felt Energy storage Polysulfide/ferricyanide flow battery Tungsten disulfide

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Barrier Option Pricing in Regime Switching Models with Rebates

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Acta Mathematicae Applicatae Sinica 2024年第3期40卷 849-861页

作者： Yue-xu ZHAO jia-yong BAO School of Economics Hangzhou Dianzi UniversityHangzhou 310018China School of Sciences Hangzhou Dianzi UniversityHangzhou 310018China

This paper is concerned with the valuation of single and double barrier knock-out call options in a Markovian regime switching model with specific *** integral formulas of the rebates are derived via matrix Wiener-Hopf factorizations and Fourier transform techniques,also,the integral representations of the option prices are ***,the first-passage time density functions in two-state regime model are *** applications,several numerical algorithms and numerical examples are presented.

关键词： option pricing Markovian regime switching Wiener-Hopf factorization Fourier transform

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Toxicity of the disinfectant benzalkonium chloride(C_(14))towards cyanobacterium Microcystis results from its impact on the photosynthetic apparatus and cell metabolism

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Journal of Environmental Sciences 2024年第1期135卷 198-209页

作者： Yunlu jia Yi huang Jin Ma Shangwei Zhang Jin liu Tianli li lirong Song Institute of Hydrobiology Chinese Academy of SciencesWuhan 430072China School of Environmental Studies China University of GeosciencesWuhan 430074China Advanced Interdisciplinary Institute of Environment and Ecology Beijing Normal UniversityZhuhai 519087China

Quaternary ammonium compounds(QACs)are commonly used in a variety of consumer and commercial products,typically as a component of *** the COVID-19 pandemic,QACs became one of the primary agents utilized to inactivate the SARS CoV-2 virus on ***,the ecotoxicological effects of QACs upon aquatic organisms have not been fully *** this study,we examined the effects of a widely used QAC(benzalkonium chloride-C_(14),BAC-14)on two toxigenic Microcystis strains and one non-toxigenic freshwater Microcystis strain and carried out an analysis focused on primary,adaptive and compensatory stress responses at apical(growth and photosynthesis)and metabolic *** analysis revealed that the two toxic Microcystis strains were more tolerant than the non-toxic strain,with 96 hr-EC_(50)values of 0.70,0.76,and 0.38 mg/L BAC-14 for toxigenic *** FACHB-905,toxigenic *** FACHB-469,and non-toxigenic *** FACHB-908,*** photosynthetic activities of the Microcystis,assessed via F_(v)/F_(m) values,were significantly suppressed under 0.4 mg/L ***,this analysis revealed that BAC-14 altered 14,12,and 8 metabolic pathways in *** FACHB-905,*** FACHB-469,and *** FACHB-908,*** is noteworthy that BAC-14 enhanced the level of extracellular microcystin production in the toxigenic Microcystis strains,although cell growth was not significantly ***,these data show that BAC-14 disrupted the physiological and metabolic status of Microcystis cells and stimulated the production and release of microcystin,which could result in damage to aquatic systems.

关键词： Disinfectants Quaternary ammonium compounds Microcystis Cyanotoxin Metabolomics Chlorophyll fluorescence

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High efficiency removal of NO using waste calcium carbide slag by facile KOH modification

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Journal of Environmental Sciences 2024年第5期139卷 182-192页

作者： Fang Wang Hui li Jiyun Gao na Geng Enzhu jiang Futing Xia Mingwu Xiang lijuan jia Ping Ning School of Chemistry and Environment Yunnan Minzu UniversityKunming 650504China Faculty of Environmental Science and Engineering Kunming University of Science and TechnologyKunming 650500China

Waste calcium carbide slags(CS),which are widely applied to desulfurisation,are not typically used in ***,to well achieve waste control by waste,a facile and highefficiency denitration strategy is developed using KOH to modify the calcium carbide slags(KCS).Various KCS samples were investigated using a series of physical and chemical *** performance test results showed that the KOH concentration and reaction temperature are the main factors affecting the denitration efficiency of KCS,and CS modified with 1.5 mol/L KOH(KCS-1.5)can achieve 100% denitration efficiency at 300℃.Such excellent removal efficiency is due to the catalytic oxidation of the oxygen-containing functional groups derived from the *** studies showed that KOH treatment significantly increased the concentration of oxygen vacancies,nitro compounds,and basic sites of *** study provides a novel strategy for the resource utilisation of waste CS in the future.

关键词： Waste Carbide slag KOH Effective denitration

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Simultaneous Bulk-and Surface-initiated living Polymerization Studied with a Heterogeneous Stochastic Reaction Model

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Chinese Journal of Polymer Science 2024年第3期42卷 364-372,I0008页

作者： jia-Shu Ma Zhi-Ning huang jia-Hao li Bang-Ping jiang Yan-Da liao Shi-Chen Ji Xing-Can Shen State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources(Ministry of Education of China)School of Chemistry and Pharmaceutical SciencesGuangxi Normal UniversityGuilin 541004China School of Computer Science and Engineering&School of Software Guangxi Normal UniversityGuilin 541004China

To better characterize the properties of surface-initiated polymers, simultaneous bulk-and surface-initiated polymerizations are usually carried out by assuming that the properties of the surface-initiated polymers resemble those of the bulk-initiated polymers. Through a Monte Carlo simulation using a heterogeneous stochastic reaction model, it was discovered that the bulk-initiated polymers exhibit a higher molecular weight and a lower dispersity than the corresponding surface-initiated polymers, which indicates that the equivalent assumption is invalid. Furthermore, the molecular weight distributions of the two types of polymers are also different, suggesting different polymerization mechanisms. The results can be simply explained by the heterogeneous distributions of reactants in the system. This study is helpful to better understand surface-initiated polymerization.

关键词： Surface-initiated polymerization Polymer brush Stochastic reaction model Heterogeneous polymerization Simultaneous polymerization

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Converting intercalation-type cathode in spent lithium-ion batteries into conversion-type cathode

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nano Research 2024年第5期17卷 4602-4609页

作者： Dingding Zhu yong Su Jingzhao Chen Xiangze Ou Xuedong Zhang Wen Xie Yuyan Zhou Yunna Guo Qiushi Dai Peng jia Jitong Yan lin Geng Baiyu Guo liqiang Zhang yongfu Tang Qiao huang jianyu huang School of Materials Science and Engineering Xiangtan UniversityXiangtan 411105China Clean nano Energy Center State Key Laboratory of Metastable Materials Science and TechnologyYanshan UniversityQinhuangdao 066000China

The widespread applications of lithium-ion batteries(liBs)generate tons of spent ***,recycling liBs is of paramount importance in protecting the environment and saving the *** commercialized liBs mostly adopt layered oxides such as liCoO_(2)(LCO)or lini_(x)Co_(y)Mn_(1-x-y)O_(2)(NMC)as the cathode *** the intercalation-type spent oxides into conversion-type cathodes(such as metal fluorides(MFs))offers a valid recycling strategy and provides substantially improved energy densities for ***,two typical Co-based cathodes,LCO and lini_(0.6)Co_(0.2)Mn_(0.2)O_(2)(NMC622),in spent liBs were successfully converted to CoF_(2) and(Ni_(x)Co_(y)Mn_(z))F_(2) cathodes by a reduction and fluorination *** as converted CoF_(2) and(Ni_(x)Co_(y)Mn_(z))F_(2) delivered cell energy densities of 650 and 700 Wh/kg,*** atomic-level electron microscopy revealed that the used LCO and NMC622 were converted to highly phase pure Co metal and Ni_(0.6)Co_(0.2)Mn_(0.2) alloys in the used graphite-assisted reduction roasting,simultaneously producing the important product of li_(2)CO_(3) using only environment friendly *** study provided a versatile strategy to convert the intercalation-type Co-based cathode in the spent liBs into conversion-type MFs cathodes,which offers a new avenue to recycle the spent liBs and substantially increase the energy densities of next generation liBs.

关键词： spent lithium-ion batteries recycling energy densities conversion-type cathode

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Deep learning methods for roping defect analysis in aluminum alloy sheets: prediction and grading

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Advances in Manufacturing 2024年第3期12卷 576-590页

作者： Yuan-Zhe Hu Ru-Xue liu jia-Peng He Guo-Wei Zhou Da-yong li State Key Laboratory of Mechanical Systems and Vibration Shanghai Jiao Tong UniversityShanghai200240People’s Republic of China School of naval Architecture Ocean and Civil EngineeringShanghai Jiao Tong UniversityShanghai200240People’s Republic of China

Roping is a severe band-like surface defect that occurs in deformed aluminum alloy *** roping prediction and rating are essential for industrial ***,the authors introduced an artificial neural network(ANN)model to efficiently forecast roping behavior across the thickness of large regions with texture *** this study,the previously proposed ANN model for roping prediction is briefly reviewed,and a few-shot learning(FSL)-based method is developed for roping grading with limited *** consider the directionality of the roping patterns,the roping dataset constructed from experimental observations is transformed into the frequency domain for more compact characterization.A transfer-based FSL method is further presented for grade roping with manifold mixup regularization and the Sinkhorn mapping algorithm.A new component-focused representation is also implemented for data-processing,exploiting the close correlation between roping and power distribution in the frequency *** ultimate FSL method achieved an optimal accuracy of 95.65%in roping classification with only five training samples per class,outperforming four typical FSL *** FSL approach can be applied to grade the roping morphologies predicted by the ANN ***,the combination of prediction and grading using deep learning provides a new paradigm for roping analysis and control.

关键词： Roping Artificial neural network(ANN) Aluminum alloys Few-shot classification Surface morphology

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Variation in the permafrost active layer over the Tibetan Plateau during 1980–2020

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Atmospheric and Oceanic Science Letters 2024年第5期17卷 34-39页

作者： Jinglong huang Chaofan li Binghao jia Chujie Gao Ruichao li College of Oceanography Hohai UniversityNanjingChina Center for Monsoon System Research Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijingChina

The active layer,acting as an intermediary of water and heat exchange between permafrost and atmosphere,greatly influences biogeochemical cycles in permafrost areas and is notably sensitive to climate *** the Chinese Meteorological Forcing Dataset to drive the Community Land Model,version 5.0,this study simulates the spatial and temporal characteristics of active layer thickness(ALT)on the Tibetan Plateau(TP)from 1980 to *** show that the ALT,primarily observed in the central and western parts of the TP where there are insufficient station observations,exhibits significant interdecadal changes after *** average thickness on the TP decreases from 2.54 m during 1980–1999 to 2.28 m during 2000–*** change is mainly observed in the western permafrost region,displaying a sharp regional inconsistency compared to the eastern region.A persistent increasing trend of ALT is found in the eastern permafrost region,rather than an interdecadal *** aforementioned changes in ALT are closely tied to the variations in the surrounding atmospheric environment,particularly air ***,the area of the active layer on the TP displays a profound interdecadal change around 2000,arising from the permafrost thawing and *** consistently decreases before 2000 but barely changes after *** regional variation in the permafrost active layer over the TP revealed in this study indicates a complex response of the contemporary climate under global warming.

关键词： Active layer thickness Permafrost Tibetan plateau Climatological characteristics

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