检索结果-南通市图书馆

Current Medical Science 2021年第3期41卷 491-497页

作者： Lin-wei XU yong-zhong su Hong-fang TAO Department of Hematologyf the First Affiliated Hospital of Shantou University Medical College Shantou 515041China

All-trans retinoic acid(ATRA)and pre-upfront arsenic trioxide(ATO)have revolutionized the therapy of acute promyelocytic leukemia(APL).However,internal tandem duplication of FMS-like tyrosine kinase 3(FLT3-ITD)mutations is associated with increased risk of *** aim of this study was to analyze the prognostic impact of FLT3-ITD on APL patients who received remission induction with ATRA,idarubicin(IDA)and/or ATO,followed by ATRA plus ATO along with anthracycline,as consolidation therapy.A total of 72 patients newly diagnosed with APL were included in this study.83.3%of the patients achieved complete remission(CR)after induction ***3-ITD mutations were detected in 16(22.2%)patients and closely related to bcr-3 PML-RARa transcript(Psurvival(OS)rate was 100%in both FLT3-ITDposltlve and FLT3-ITD^(negatlve)groups,and there was no significant difference in 5-year event-free survival(EFS)between the two groups(78.3%vs.83.3%,P=0.85).ATRA plus ATO and anthracycline-based chemotherapy achieved great outcome in newly diagnosed APL regardless of the FLT3-ITD mutation status.

关键词： all-trans retinoic acid acute promyelocytic leukemia arsenic trioxide anthracycline internal tandem duplication of FMS-like tyrosine kinase 3

Turner syndrome with primary myelofibrosis,cirrhosis and ovarian cystic mass:A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2022年第9期10卷 2931-2937页

作者： Lin-Wei Xu yong-zhong su Hong-Fang Tao Department of Hematology The First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

BACKGROUND Turner syndrome(TS)with leukemia is a complicated clinical *** clinical course and outcome of these patients are poor,so the treatment and prognosis of TS with hematological malignancies deserve our *** suMMARY Here,we report a case of a 20-year-old woman diagnosed with TS,primary myelofibrosis(PMF),cirrhosis,and an ovarian cystic *** is the first report on the coexistence of TS and PMF with the MPL and SH2B3 *** patient was diagnosed with cirrhosis of unknown cause,splenomegaly and severe gastroesophageal ***,an ovarian cystic mass caused the patient to appear *** patient was treated with the JAK2 inhibitor-ruxolitinib according to peripheral blood cells,although myelofibrosis was improved,the splenomegaly did not ***,hematemesis and melena occasionally *** Ruxolitinib may clearly reduce *** myelofibrosis was improved,cirrhosis and splenomegaly in this case continued to *** treatment should be discussed.

关键词： Turner syndrome Primary myelofibrosis Cirrhosis Ovarian cystic mass Ruxolitinib Case report

Microsegregation and Improved Methods of Squeeze Casting 2024 Aluminium Alloy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2003年第5期19卷 413-416页

作者： yong zhong, Guoyue su and Ke YANGThe National Engineering Research Center, the Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China Natl. Eng. Res. Ctr. Inst. of Metal Res. Chinese Acad. of Sci. Shenyang 110016 China

The squeeze casting of a 2024 Al alloy was carried out to investigate the effect on microsegregation in the alloy of the application of pressure followed by diffusion annealing. The experimental results indicate that an optimum applied pressure followed by an optimum diffusion annealing process can markedly reduce the degree of microsegregation and improve the mechanical properties to a degree that can approach the level of forged 2024 Al alloy.

关键词： 2024 Al alloy Squeeze casting Microsegregation Diffusion annealing

维普期刊数据库

A Time-Domain Numerical Simulation for Free Motion Responses of Two Ships Advancing in Head Waves

在线全文

学校读者我要写书评

暂无评论

China Ocean Engineering 2024年第3期38卷 519-530页

作者： PAN su-yong CHENG yong School of Naval Architecture and Ocean Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China

The constant panel method within the framework of potential flow theory in the time domain is developed for solving the hydrodynamic interactions between two parallel ships with forward *** solving problems within a time domain framework,the free water surface needs to simultaneously satisfy both the kinematic and dynamic boundary conditions of the free water *** provides conditions for adding artificial damping *** the Runge−Kutta method to solve equations related to *** upwind differential scheme is used in the present method to deal with the convection terms on the free surface to prevent waves *** the comparison with the available experimental data and other numerical methods,the present method is proved to have good mesh convergence,and satisfactory results can be *** constant panel method is applied to calculate the hydrodynamic interaction responses of two parallel ships advancing in head *** simulations are conducted on the effects of forward speed,different longitudinal and lateral distances on the motion response of two modified Wigley ships in head *** further investigations are conducted on the effects of different ship types on the motion response.

关键词： ship motions time domain simulation forward speed different distances wave loads

维普期刊数据库

Miniaturized power detection module operating in millimeter wave band

在线全文

学校读者我要写书评

暂无评论

Journal of Electronic Science and Technology 2024年第2期22卷 69-76页

作者： Xiang Zhou Zhi-yong zhong School of Electronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu611731China

The miniaturized broadband detection module can be embedded into the microwave application system such as the front end of the transmitter to detect the power or other parameters in real *** is highly prospective in military and scientific *** this paper,a broadband power detection module operating at 26.5 GHz-40.0 GHz is designed by using low-barrier Schottky diode as the detector and a comparator for threshold *** module can dynamically detect the power range between-10 dBm and 10 dBm with the detection accuracy of 0.1 ***,the temperature compensation circuit is also applied to improve the measurement *** a result,the resulted error low to±1 dB in the temperature range of -55℃ to +85℃ is *** designed module is encapsulated by a Kovar alloy with a small volume of 9 mm×6 mm×3 *** endows the designed module the advantages of small size,easy integration,and low cost,and even it is applicable to high-reliability environments such as satellites.

关键词： Diode Miniaturization Power detection Temperature compensation

A Geometric Based Connection between Fractional Calculus and Fractal Functions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Mathematica Sinica,English Series 2024年第2期40卷 537-567页

作者： yong Shun LIANG Wei Yi su School of Mathematics and Statistic Nanjing University of Science and TechnologyNanjing 210094P.R.China Department of Mathematics Nanjing UniversityNanjing 210023P.R.China

Establishing the accurate relationship between fractional calculus and fractals is an important research content of fractional calculus *** the present paper,we investigate the relationship between fractional calculus and fractal functions,based only on fractal dimension *** dimension of the Riemann-Liouville fractional integral of continuous functions seems no more than fractal dimension of functions *** fractal dimension of the Riemann-Liouville fractional differential of continuous functions seems no less than fractal dimension of functions themselves when they *** further discussion,fractal dimension of the Riemann-Liouville fractional integral is at least linearly decreasing and fractal dimension of the Riemann-Liouville fractional differential is at most linearly increasing for the Holder continuous *** about other fractional calculus,such as the Weyl-Marchaud fractional derivative and the Weyl fractional integral has also been given *** work is helpful to reveal the mechanism of fractional calculus on continuous *** the same time,it provides some theoretical basis for the rationality of the definition of fractional *** is also helpful to reveal and explain the internal relationship between fractional calculus and fractals from the perspective of geometry.

关键词： Fractional calculus fractal functions fractal dimension fractional calculus equation relationship

维普期刊数据库

Water–solid contact electrification and catalysis adjusted by surface functional groups

在线全文

学校读者我要写书评

暂无评论

Nano Research 2024年第4期17卷 3344-3351页

作者： Yusen su Andy Berbille zhong Lin Wang Wei Tang CAS Center for Excellence in Nanoscience Beijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing100083China School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing100049China Georgia Institute of Technology AtlantaGA 30332-0245USA

Chemical functional groups on solid surfaces greatly influence contact electrification(CE)at water–solid *** studies of their effects mainly swapped materials or bonded related molecules to a substrate,introducing other factors of *** work aims at unambiguously demonstrating the role of functional groups in water-polymer *** study the contribution of functional groups,by using ion coupled plasma etching to modify a high-density polyethylene(HDPE)film,a polymer with a naturally quasi-null charge transfer ***(HDPE–F)and hydroxyl(HDPE–OH)functional groups are generated and endowed HDPE with charge withdrawing ***–F withdraws 2.5–2.7 times more charges than HDPE–***,the surface charges accumulated generate electrostatic forces,altering the droplets *** phenomenon provides another approach to study CE,helping to evaluate the contribution of electrons to solid–liquid ***,employing HDPE–F to perform contact-electro-catalysis shows its activity is 2.4 times higher than that of commercial fluorinated films.

关键词： contact-electro-catalysis charge transfer solid–liquid interfaces contact electrification

Structures and ion transport mechanisms of plant high-affinity potassium transporters

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular Plant 2024年第3期17卷 409-422页

作者： Jiangqin Wang Yanping Luo Fan Ye zhong Jie Ding Shao Jian Zheng Shuai Qiao yong Wang Jiangtao Guo Wei Yang Nannan su international Institutes of Medicine the Fourth Affiliated HospitalZhejang University School of MedicineYiwuZhejiang 322000China Department of Biophysics and Department of Neurology of the Fourth Affiliated Hospital Zhejiang University School of MedicineHangzhouZhejang 310058China State Key Laboratory of Plant Environmental Resilience College of Life SciencesZhejang UniversityHangzhouZhejang 310058China College of Life Sciences Zhejiang UniversityHangzhouZhejiang 310058China NHC and CAMS Key Laboratory of Medical Neurobiology MOE Frontier Science Center for Brain Science and Brain-machine IntegrationSchool of Brain Science and Brain MedicineZhejiang UniversityHangzhouZhejiang 310058China Nanhu Brain-computer Interface Institute Hangzhou.Zheiang 311100.China

Plant high-affinity K^(+) transporters(HKTs)mediate Na^(+) and K^(+) uptake,maintain Na^(+)/K^(+) homeostasis,and therefore play crucial roles in plant salt *** this study,we present cryoelectron microscopy structures of HKTs from two classes,classI HKT1;1 from Arabidopsis thaliana(AtHKT1;1)and class II HKT2;1 from Triticum aestivum(TaHKT2;1),in both Na^(+) -and K^(+) -bound states at 2.6-to 3.0-A ***1;1and TaHKT2;1function *** HKT subunit consists of four tan-dem domain units(D1-D4)with a repeated K^(+) -channel-like M-P-M *** each subunit,D1-D4 assemble into an ion conduction pore with a pseudo-four-fold *** both TaHKT2;1and AtHKT1;1 have only one putative Na^(+) ion bound in the selectivity filter with a similar coordination pattern,the two HKTs display different K^(+) binding modes in the ***2;1 has three K^(+) ions bound in the selec-tivity filter,but AtHKT1;1 has only two K^(+) ions bound in the filter,which has a narrowed external entrance due to the presence of a Ser residue in the first filter *** structures,along with compu-tational,mutational,and electrophysiological analyses,enable us to pinpoint key residues that are critical for the ion selectivity of *** findings provide new insights into the ion selectivity and ion transport mechanisms of plant HKTs and improve our understanding about how HKTs mediate plant salt tolerance and enhance crop growth.

关键词： HKTs structure ion selectivity mechanism salt tolerance

Adjuvant Therapy for Hepatocellular Carcinoma After Curative Treatment:Several Unanswered Questions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Clinical and Translational Hepatology 2024年第5期12卷 525-533页

作者： Le Li Zhen-Zhen Li Li-Xin Pan Jia-yong su Shan Huang Liang Ma Jian-Hong zhong Hepatobiliary surgery Department Guangxi Medical University Cancer HospitalNanningGuangxiChina Guangxi Academy of Medical Sciences Emergency DepartmentThe People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxiChina Pathology Department Guangxi Medical University Cancer HospitalNanningGuangxiChina Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor(Guangxi Medical University) Ministry of EducationNanningGuangxiChina Guangxi Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor NanningGuangxiChina

Most patients with hepatocellular carcinoma(HCC)have a poor *** and local ablation are the main curative treatments for ***,the recurrence rate after hepatectomy or ablation is up to 70%,which seriously affects patient *** adjuvant therapies have been explored to reduce postoperative ***,although a variety of adjuvant therapies have been shown to reduce the recurrence rate and improve overall survival,a standard consensus of national HCC guidelines for adjuvant treatment is ***,there are significant differences in the recommendations for adjuvant therapy for HCC between the Eastern and Western guidelines.A variety of adjuvant treatment methods,such as antiviral therapy,transarterial chemoembolization or traditional Chinese medicine,are recommended by the Chinese HCC ***,Western guidelines make few recommendations other than antiviral *** immune checkpoint inhibitors are recommended only in the recently updated American Association for the Study of Liver Diseases *** review summarized the existing adjuvant therapy options after curative hepatectomy or ablation and discusses several important dilemmas of adjuvant treatments.

关键词： Hepatocellular carcinoma Adjuvant therapy Curative hepatectomy Recurrence Overall survival Immune checkpoint inhibitor

Energy consumption optimization for edge computing-supported cellular networks based on optimal transport theory

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2024年第2期67卷 201-218页

作者： Xiangyu LV Xiaohu GE Yi zhong Qiang LI yong XIAO School of Electronic Information and Communications Huazhong University of Science and Technology

With advancements in mobile communication technologies, there have been multiple user device(UD) connections to cellular networks. Because of changes in the spatial distribution of UDs and application requirements, the traditional offloading mechanism based on the nearest distance will result in heavy loads for some base stations(BSs). Because there is a high-order relationship between the energy consumption of the BS processing tasks and the number of computing tasks, the traditional offloading mechanism will result in high energy consumption, and UD’s offloading decision must be dynamically adjusted. The offloading decision of UDs is optimized based on detailed information about various parameters associated with a network from the standpoint of distribution. This information includes details regarding the spatial distribution of UDs,application requirements, and the offloading period of computing tasks. Based on optimal transport theory,an energy consumption optimization algorithm is suggested to lower the total amount of energy consumed by the offloading process of UDs’ computing tasks by reasonably planning the offloading BSs of the UDs in the networks. The simulation results show that the proposed offloading mechanism based on energy consumption optimization reduces the total energy consumption of the offloading process by 28.09% when compared to the traditional offloading mechanism, and the traffic managed by each BS is balanced.

关键词： optimal transport theory edge computing energy consumption reduction dynamic voltage frequency scaling