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Synchronous gastric cancer complicated with chronic myeloid leukemia (multiple primary cancers):A case report

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World Journal of Clinical Cases 2022年第30期10卷 11146-11154页

作者： yong-xun zhao Ze Yang Li-Bin Ma Jia-Yao Dang Hui-Ying Wang The Seventh Department of General Surgery The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina The First Clinical Medical School The First Clinical Medical School of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina

BACKGROUND With the advancement of medical technology and improvement in living standards,the incidence of multiple primary cancers has gradually *** particular,tumors of the digestive system account for a large proportion of multiple primary *** diagnosis and treatment of chronic myeloid leukemia,particularly with synchronous gastric cancer,at the first consultation is relatively *** SUMMARY Herein,we present the case of a middle-aged man who was referred to the Department of Hematology owing to an elevated white blood cell *** the examination,he was diagnosed with chronic myeloid leukemia and was administered *** months after the initial diagnosis,he visited our hospital again for abdominal pain,and further examination revealed gastric *** discussion with a multidisciplinary team,S-1(Tegafur,Gimeracil,and Oteracil Potassium Capsules) combined with oxaliplatin—SOX regimen—was ***,the patient’s condition rapidly *** developed colonic obstruction and underwent an ostomy;however,he died less than 6 months after the initial *** Multiple primary cancers are influenced by environmental and genetic factors;a standardized multidisciplinary discussion plays a key role in treatment.

关键词： Multiple primary cancers Gastric cancer Leukemia Leukemia inhibitory factor Case report

Cancerous inhibitor of protein phosphatase 2A enhances chemoresistance of gastric cancer cells to oxaliplatin

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World Journal of Gastrointestinal Oncology 2023年第2期15卷 286-302页

作者： yong-xun zhao Li-Bin Ma Ze Yang Fang Wang Hui-Ying Wang Jia-Yao Dang The Seventh Department of General Surgery The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Pathology The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina The First Clinical Medical School Lanzhou UniversityLanzhou 730000Gansu ProvinceChina

BACKGROUND Cancerous inhibitor of protein phosphatase 2A(CIP2A)is a newly discovered *** is an active cell proliferation regulatory factor that inhibits tumor apoptosis in gastric cancer(GC)***2A is functionally related to chemoresistance in various types of tumors according to recent *** underlying mechanism,however,is ***,the primary treatment regimen for GC is oxaliplatin-based ***,it often fails due to chemoresistance of GC cells to *** The goal of this study was to examine CIP2A expression and its association with oxaliplatin resistance in human GC *** Immunohistochemistry was used to examine CIP2A expression in GC tissues and adjacent normal ***2A expression in GC cell lines was reduced using small interfering *** confirming the silencing efficiency,3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide tetrazolium and flow cytometry assays were used to evaluate cell proliferation and apoptosis caused by oxaliplatin ***,the key genes and protein changes were verified using realtime quantitative reverse transcription PCR and Western blotting,respectively,before and after *** bioinformatics analysis,we used the R software and Bioconductor *** statistical analysis,we used GraphPad Prism 6.0 and the Statistical Package for the Social Sciences software version 20.0(IBM,Armonk,United States).RESULTS A high level of CIP2A expression was associated with tumor size,T stage,lymph node metastasis,Tumor Node Metastasis stage,and a poor ***,CIP2A expression was higher in GC cells than in normal human gastric epithelial *** small interfering RNA against CIP2A,we discovered that CIP2A knockdown inhibited cell proliferation and significantly increased GC cell sensitivity to ***,CIP2A knockdown enhanced oxaliplatin-induced apoptosis in GC ***,high CIP2A levels in GC may be a factor in chemoresistance

关键词： Cancerous inhibitor of protein phosphatase 2A Gastric cancer Oxaliplatin Chemoresistance Akt

Helicobacter pylori promotes invasion and metastasis of gastric cancer by enhancing heparanase expression

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World Journal of Gastroenterology 2018年第40期24卷 4565-4577页

作者： Li-Ping Liu Xi-Ping Sheng Tian-Kui Shuai yong-xun zhao Bin Li Yu-Min Li The Second Clinical Medical School of Lanzhou University Lanzhou 730000Gansu ProvinceChina Department of Critical Care Medicine The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Critical Care Medicine The Donggang District of First Hospital of Lanzhou UniversityLanzhou 730030Gansu ProvinceChina Institute of Epidemiology and Health Statistics School of Public HealthLanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Surgical Oncology The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Key Laboratory of Digestive System Tumors of Gansu Province The Second Clinical Medical School of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina

AIM To detect the mechanisms of Helicobacter pylori(H. pylori) infection in the invasion and metastasis of gastric cancer(GC).METHODS Specimens from 99 patients with GC were collected. The correlation among H. pylori infection, heparanase(HPA) and mitogen-activated protein kinase(MAPK) expression, which was determined by immunohistochemistry, and the clinical features of GC was analysed using SPSS 22.0. Overall survival(OS) and relapse-free survival(RFS) of GC patients were estimated by the KaplanMeier method. Independent and multiple factors of HPA and MAPK with prognosis were determined with COX proportional hazards models. HPA and MAPK expression in MKN-45 cells infected with H. pylori was analysed using Western blot. RESULTS H. pylori infection was observed in 70 of 99 patients with GC(70.7%), which was significantly higher than that in healthy controls. H. pylori infection was related to lymph metastasis and expression of HPA and MAPK(P < 0.05); HPA expression was relevant to MAPK expression(P = 0.024). HPA and MAPK expression in MKN-45 cells was significantly upregulated following H. pylori infection and peaked at 24 h and 60 min, before decreasing(P < 0.05). SB203580, an inhibitor of MAPK, significantly decreased HPA expression. HPA was related to lymph metastasis and invasive depth. HPA positive GC cases and H. pylori positive GC cases showed poorer prognosis than HPA negative cases(P < 0.05). COX models showed that the prognosis of GC was connected with HPA expression, lymph metastasis, tissue differentiation, and invasive depth. CONCLUSION H. pylori may promote the invasion and metastasis of GC by increasing HPA expression that may associate with MAPK activation, thus causing a poorer prognosis of GC.

关键词： Gastric cancer Helicobacter pylori Heparanase Mitogen-activated protein kinase Overall survival Relapse-free survival

Helicobacter pylori promotes invasion and metastasis of gastric cancer by enhancing heparanase expression

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World Journal of Gastroenterology 2021年第22期27卷 3138-3141页

作者： Li-Ping Liu Xi-Ping Sheng Tian-Kui Shuai yong-xun zhao Bin Li Yu-Min Li The Second Clinical Medical School of Lanzhou University Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Critical Care Medicine The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Critical Care Medicine The Donggang District of First Hospital of Lanzhou UniversityLanzhou 730030Gansu ProvinceChina Institute of Epidemiology and Health Statistics School of Public HealthLanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Surgical Oncology The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Key Laboratory of Digestive System Tumors of Gansu Province The Second Clinical Medical School of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina

Correction to"Liu LP,Sheng XP,Shuai TK,zhao YX,Li B,Li *** pylori promotes invasion and metastasis of gastric cancer by enhancing heparanase *** J Gastroenterol 2018;24:4565-4577[PMID:30386106 DOI:10.3748/wjg.v24.i40.4565]."In this article,we have identified some of the images in Figure 2A,C,E,G,and I are identical to the images in Figures 1B,2A,3B,3E,and 3G of another paper entitled"Liu L,zhao Y,Fan G,Shuai T,Li B,Li *** pylori infection enhances heparanase leading to cell proliferation via mitogenactivated protein kinase signalling in human gastric cancer cells.",which was published by us in the Molecular Medicine Reports in December,2018[PMID:30320396 DOI:10.3892/mmr.2018.9558].The reason why we asked to replace the pictures was that when we were simultaneously preparing to submit our two different articles to the World Journal of Gastroenterology(WJG)and Molecular Medicine Reports,we uploaded the wrong pictures to the WJG,which were same as those submitted to the Molecular Medicine *** apologize for this negligence and any inconvenience that this may *** would be grateful if you could replace the wrong pictures with the correct ones attached.

关键词： Correction Replace the wrong pictures Gastric cancer Helicobacter pylori

Exploring the vital role of microglial membrane receptors in Alzheimer’s disease pathogenesis: a comprehensive review

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BIOCELL 2024年第7期48卷 1011-1022页

作者： JUN-FENG zhao YI-RAN JIANG TIAN-LIN GUO yong-QING JIAO xun WANG Department of Neurointervention Center Dalian No.3 People’s HospitalDalian Medical UniversityDalianChina Department of Clinical Medicine China Medical UniversityShenyangChina

Neurodegenerative diseases constitute a broad category of diseases caused by the degeneration of the *** are mainly manifested by the gradual loss of neuron structure and function and eventually can cause death or loss of *** the global population ages rapidly,increased people are being diagnosed with neurodegenerative *** has been established that the onset of Alzheimer’s disease(AD)is closely linked with increasing age and its major pathological features include amyloid-beta plaques(Aβ),Tau hyperphosphorylation,Neuroﬁbrillary tangles(NFTs),neuronal death as well as synaptic *** involvement of microglia is crucial in the pathogenesis and progression of AD and exhibits a dual *** instance,in the early stage of AD,microglia surface membrane proteins or receptors can participate in immunophagocytosis,and anti-inﬂammatory functions and act as a physical barrier after recognizing various ligands such as Aβand ***,in the later stage of the disease,membrane receptors on the surface of microglia can cause its activation to release a substantial quantity of pro-inﬂammatory *** can amplify the neuroinﬂammatory *** rapid decline of normal immune phagocytosis can result in the continuous accumulation of abnormal proteins,leading to neuronal dysfunction and destruction of the formed physical barrier as well as the neurovascular *** can also increase the transformation of microglia from anti-inﬂammatory phenotype M2 to pro-inﬂammatory phenotype M1,induce severe neuronal injury or apoptosis,and aggravate the progression of *** to few articles have focused on the AD-related membrane protein receptors on microglia,thus in this paper,we have reviewed several representative microglial membrane proteins or receptors about their speciﬁc roles and functions implicated in AD,and expect that there will be more in-depth research and scientiﬁc research results in the treatment of AD by targeted regulation of mi

关键词： Neurodegeneration Glial cell Receptor Alzheimer’s disease

Modified electronic structure and enhanced hydroxyl adsorption make quaternary Pt-based nanosheets efficient anode electrocatalysts for formic acid-/alcohol-air fuel cells

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Journal of Energy Chemistry 2024年第5期92卷 142-150页

作者： Fengling zhao Qiang Yuan Siyang Nie Liang Wu xun Wang State-Local Joint Laboratory for Comprehensive Utilization of Biomass Center for R&D of Fine ChemicalsCollege of Chemistry and Chemical EngineeringGuizhou UniversityGuiyang 550025GuizhouChina Key Lab of Organic Optoelectronics&Molecular Engineering Tsinghua UniversityBeijing 100084China School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240China

Surface/interface engineering of a multimetallic nanostructure with diverse electrocatalytic properties for direct liquid fuel cells is desirable yet ***,using visible light,a class of quaternary Pt_(1)Ag_(0.1)Bi_(0.16)Te_(0.29)ultrathin nanosheets is fabricated and used as high-performance anode electrocatalysts for formic acid-/alcohol-air fuel *** modified electronic structure of Pt,enhanced hydroxyl adsorption,and abundant exterior defects afford Pt_(1)Ag_(0.1)Bi_(0.16)Te_(0.29)/C high intrinsic anodic electrocatalytic activity to boost the power densities of direct formic acid-/methanol-/ethanol-/ethylene glycol-/glycerol-air fuel cells,and the corresponding peak power density of Pt_(1)Ag_(0.1)Bi_(0.16)Te_(0.29)/C is respectively 129.7,142.3,105.4,124.3,and 128.0 mW cm^(-2),considerably outperforming Pt/*** in situ Fourier transform infrared reflection spectroscopy reveals that formic acid oxidation on Pt_(1)Ag_(0.1)Bi_(0.16)Te_(0.29)/C occurs via a CO_(2)-free direct *** functional theory calculations show that the presence of Ag,Bi,and Te in Pt_(1)Ag_(0.1)Bi_(0.16)Te_(0.29)suppresses CO^(*)formation while optimizing dehydrogenation steps and synergistic effect and modified Pt effectively enhance H_(2)O dissociation to improve electrocatalytic *** synthesis strategy can be extended to 43 other types of ultrathin multimetallic nanosheets(from ternary to octonary nanosheets),and efficiently capture precious metals(i.e.,Pd,Pt,Rh,Ru,Au,and Ag)from different water sources.

关键词： Pt-based nanosheets Modifiedelectronic structure Enhanced hydroxyl adsorption Formicacidand alcohol oxidation Direct liquid fuel cells

Homological Transfer between Additive Categories and Higher Differential Additive Categories

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Acta Mathematica Sinica,English Series 2024年第5期40卷 1325-1344页

作者： Xi TANG zhao yong HUANG School of Science Guilin University of Aerospace TechnologyGuilin 541004P.R.China Department of Mathematics Nanjing UniversityNanjing 210093P.R.China

Given an additive category C and an integer n≥*** higher differential additive category consists of objects X in C equipped with an endomorphism ϵ_(X)satisfying ϵ_(X)^(n).Let R be a,finite-dimensional basic algebra over an algebraically closed field and T the augmenting functor from the category of finitely generated left R-modules to that of finitely generated left R/(t^(n))-*** is proved that a finitely generated left R-module M isτ-rigid(respectively,(support)τ-tilting,almost completeτ-tilting)if and only if so is T(M)as a left R[t]/(t^(n))-***,R isτm-selfinjective if and only if so is R[t]/(t^(n)).

关键词： Higher differential objects Wakamatsu tilting subcategories G_(ω)-projective modules sup-portτ-tilting modules τ_(m)-selfinjective algebras precluster tilting subcategories

Thymoquinone affects hypoxia-inducible factor-1αexpression in pancreatic cancer cells via HSP90 and PI3K/AKT/mTOR pathways

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World Journal of Gastroenterology 2024年第21期30卷 2793-2816页

作者： Zhan-Xue zhao Shuai Li Lin-xun Liu Department of General Surgery Qinghai Provincial People's HospitalXining 810007Qinghai ProvinceChina Department of Clinical Pharmacy The Affiliated Hospital of Qinghai UniversityXining 810001Qinghai ProvinceChina

BACKGROUND Pancreatic cancer(PC)is associated with some of the worst prognoses of all major ***(TQ)has a long history in traditional medical practice and is known for its anti-cancer,anti-inflammatory,anti-fibrosis and antioxidant pharmacological *** studies on hypoxia-inducible factor-1α(HIF-1α)and PC have shown that HIF-1αaffects the occurrence and development of PC in many *** addition,TQ could inhibit the development of renal cancer by decreasing the expression of HIF-1α.Therefore,we speculate whether TQ affects HIF-1αexpression in PC cells and explore the *** To elucidate the effect of TQ in PC cells and the regulatory mechanism of HIF-1α*** Cell counting kit-8 assay,Transwell assay and flow cytometry were performed to detect the effects of TQ on the proliferative activity,migration and invasion ability and apoptosis of PANC-1 cells and normal pancreatic duct epithelial(hTERTHPNE)*** real-time polymerase chain reaction and western blot assay were performed to detect the expression of HIF-1αmRNA and protein in PC *** effects of TQ on the HIF-1αprotein initial expression pathway and ubiquitination degradation in PANC-1 cells were examined by western blot assay and *** TQ significantly inhibited proliferative activity,migration,and invasion ability and promoted apoptosis of PANC-1 cells;however,no significant effects on hTERT-HPNE cells were *** significantly reduced the mRNA and protein expression levels of HIF-1αin PANC-1,AsPC-1,and BxPC-3 *** significantly inhibited the expression of the HIF-1αinitial expression pathway(PI3K/AKT/mTOR)related proteins,and promoted the ubiquitination degradation of the HIF-1αprotein in PANC-1 *** had no effect on the hydroxylation and von Hippel Lindau protein mediated ubiquitination degradation of the HIF-1αprotein but affected the stability of the HIF-1αprotein by inhibiting the interaction between HI

关键词： Thymoquinone Pancreatic cancer Hypoxia-inducible factor-1α PI3K/AKT/mTOR HSP90

A calibration and compensation method for an industrial robot with high accuracy harmonic reducers

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Science China(Technological Sciences) 2024年第3期67卷 725-739页

作者： zhao YiYang LIU xun CAO JiaBin LIU JinYu XU Yan YAN WeiXin School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China College of Computer and Control Engineering Northeast Forestry UniversityHarbin 150040China

Industrial serial robots need high stiffness to keep absolute pose accuracy and meet the requirements in practical applications. However, the weak stiffness feature of robot joints and the payloads affected on robot end-effector, which will also increase the pose error of robot. Especially, the existing calibration methods often consider under no-payload condition without discussing the payload state. In this paper, we report a new industrial serial robot composed by a new harmonic reducer: Model-Y, based on high accuracy and high stiffness, and a kinematic parameter calibration algorithm which is based on a harmonic reducer forcedeformation model. To decrease the accuracy effects of payload, an iterative calibration method for kinematic parameters with payload situation was proposed. Simulation and experiments are conducted to verify the effectiveness of the proposed calibration method using the self-developed industrial serial robot. The results show a remarkably improved accuracy in absolute position and orientation with the robot's payload range. The position mean error has 70% decreased to 0.1 mm and the orientation mean error diminished to less than 0.01° after calibration with compensation. Additionally, online linear and circular tests are carried out to evaluate the position error of the robot during large-scale spatial and low-speed continuous movement. The accuracy is consistent with the previous calibration results, indicating the effectiveness and advantages of the proposed strategy in this article.

关键词： industrial serial robot Model-Y harmonic calibration stiffness model online compensation