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pan-cancer immunogenic death analysis identifies key roles of CXCR3 and CCL18 in hepatocellular carcinoma

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Genes & Diseases 2024年第2期11卷 568-570页

作者： Jia Guo xin Sun Guowei pan Ce Li xin He Xiaofang Che Zan Teng Xiujuan Qu Yunpeng Liu Bowen Yang Department of Medical Oncology Provincial Key Laboratory of Anticancer Drugs and Biotherapy of Liaoning ProvinceLiaoning Provincial Clinical Research Center for CancerClinical Cancer Research Center of ShenyangThe First Hospital of China Medical UniversityShenyangLiaoning 110001China Research Center for Universal Health School of Public HealthChina Medical UniversityShenyangLiaoning 110122China

Immunogenic death is a form of programmed cell death that is common in the development and progression of ***,its impact on tumor progression differs depending on the location of the ***,it also plays an important role in antitumor immunity because the process of immunogenic death can release substances that activate immunity.1 Therefore,in this study,the key mechanism of mediating immunogenic death in hepatocellular carcinoma(HCC)was found from the excavation of the immunogenic death characteristics of pan-cancer and the in-depth investigation of its effects on different tumor types(Fig.1A).

关键词： death CXCR3 immunity

Real-Time Intelligent Diagnosis of Co-frequency Vibration Faults in Rotating Machinery Based on Lightweight-Convolutional Neural Networks

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Chinese Journal of Mechanical Engineering 2024年第2期37卷 264-282页

作者： xin pan Xiancheng Zhang Zhinong Jiang Guangfu Bin Beijing Key Laboratory of Health Monitoring and Self-recovery for High-End Mechanical Equipment College of Mechanical and Electrical EngineeringBeijing University of Chemical TechnologyBeijing 100029China Key Laboratory of Engine Health Monitoring-Control and Networking(Ministry of Education) College of Mechanical and Electrical EngineeringBeijing University of Chemical TechnologyBeijing 100029China College of Mechanical Engineering Hunan University of Science and TechnologyXiangtan 411201China

The co-frequency vibration fault is one of the common faults in the operation of rotating equipment,and realizing the real-time diagnosis of the co-frequency vibration fault is of great significance for monitoring the health state and carrying out vibration suppression of the *** engineering scenarios,co-frequency vibration faults are highlighted by rotational frequency and are difficult to identify,and existing intelligent methods require more hardware conditions and are exclusively ***,Lightweight-convolutional neural networks(LW-CNN)algorithm is proposed in this paper to achieve real-time fault *** critical parameters are discussed and verified by simulated and experimental signals for the sliding window data augmentation *** on LW-CNN and data augmentation,the real-time intelligent diagnosis of co-frequency is ***,a real-time detection method of fault diagnosis algorithm is proposed for data acquisition to fault *** is verified by experiments that the LW-CNN and sliding window methods are used with high accuracy and real-time performance.

关键词： Co-frequency vibration Real-time diagnosis LW-CNN Data augmentation

Flow Field Simulation and Parameter Analysis of Hydraulic Unbalanced Bionic Self-recovery Actuator for Rotary Equipment

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Journal of Bionic Engineering 2024年第1期21卷 325-343页

作者： Wei Li xin pan Dehong Ge Jinji Gao Key Laboratory of Engine Health Monitoring-Control and Networking of Ministry of Education Beijing University of Chemical TechnologyBeijing 100029China Beijing Key Laboratory of High-End Mechanical Equipment Health Monitoring and Self-Recovery Beijing University of Chemical TechnologyBeijing 100029China

The rotor is the most important component of rotating machinery,and the vibration produced by its mass unbalance has a serious influence on the secure and steady operation of the machine,so an effective online suppression technology is urgently needed.A new hydraulic unbalanced bionic self-recovery system is introduced,imitating the way of manually repairing faulty *** accomplish the effect of actuator mass redistribution,the technology employs pressurized air to drive the quantitative transfer of liquid in the reservoir cavity at opposite *** can complete the online adjustment of the equipment's balancing state and suppress the unbalanced vibration of equipment in real time,which gives the equipment the ability to maintain an autonomous health state and improve equipment *** composition and working principle of the system are introduced in detail,and the key performance parameters,such as the minimum running speed and the balancing liquid transfer speed,are analyzed *** fluid-solid coupling model of the actuator was established,and the two-phase flow from inside the hydraulic unbalanced bionic self-recovery actuator was simulated under multiple working conditions and the performance parameters were quantitatively analyzed.A balancing simulation test bed was built,and its effectiveness was verified by performance parameter tests and unbalanced bionic self-recovery *** experimental results show that the mass distribution adjustment of the balancing disk can be achieved using different viscosity balancing liquid,and the response of liquid viscosity 10 cSt is faster than that of liquid viscosity 100 cSt in the process of balancing liquid transfer,and the time is reduced by more than 75%;the system can reduce the simulated rotor amplitude from 18.3μm to 10.6μm online in real time,which provides technical support for the subsequent development of a new generation of bionic intelligent equipment.

关键词： Engineering self-recovery-Bionics Simulation analysis Self-recovery regulation

A review on current development of thermophotovoltaic technology in heat recovery

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International Journal of Extreme Manufacturing 2024年第2期6卷 297-323页

作者： Shuni Chen Yanming Guo Qinghui pan yong Shuai Ministry of Industry and Information Technology Key Laboratory of Aerospace Thermophysics School of Energy Science and EngineeringHarbin Institute of TechnologyHarbin 150001People’s Republic of China

The burning of fossil fuels in industry results in significant carbon emissions,and the heat generated is often not fully *** high-temperature industries,thermophotovoltaics(TPVs)is an effective method for waste heat *** review covers two aspects of high-efficiency TPV systems and industrial waste heat *** the system level,representative results of TPV complete the systems,while selective emitters and photovoltaic cells in the last decade are *** key points of components to improve the energy conversion efficiency are further analyzed,and the related micro/nano-fabrication methods are *** the application level,the feasibility of TPV applications in high-temperature industries is shown from the world waste heat utilization *** potential of TPV in waste heat recovery and carbon neutrality is illustrated with the steel industry as an example.

关键词： thermophotovoltaic waste heat recovery micro/nano-fabrication carbon neutrality

Intelligent Diagnosis Method for Typical Co-frequency Vibration Faults of Rotating Machinery Based on SAE and Ensembled ResNet-SVM

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Chinese Journal of Mechanical Engineering 2024年第4期37卷 215-230页

作者： Xiancheng Zhang xin pan Hao Zeng Haofu Zhou Beijing Key Laboratoryof Health Monitoring and Self-recovery for High-end Mechanical Equipment Beijing University of Chemical TechnologyBeijing 100029China Engineering Research Center of Chemical Safety(Ministry of Education) Beijing University of Chemical TechnologyBeijing 100029China Engineering Management Department of China Three Gorges New Energy(Group)Co. Ltd.Beijing 101199China

Intelligent fault diagnosis is an important method in rotating machinery fault diagnosis and equipment health *** deal with co-frequency vibration faults,a type of typical fault in rotating machinery,this paper proposes a fault diagnosis method based on the stacked autoencoder(SAE)and ensembled ***,the time-and frequency-domain features of several co-frequency vibration faults are summarized based on the mechanism analysis and calculated using actual vibration *** realize and validate the high-precision diagnosis method of rotating equipment with co-frequency faults proposed in this study,the following three criteria are required:First,to improve the effectiveness and robustness of the ensembled model and the sliding window using data augmentation,adding noise,autoencoder(AE)and SAE methods are analyzed in terms of principle and practical ***,ResNet is used as the feature extractor for the ensembled ResNet-SVM *** extraction is carried out twice,and the extracted co-frequency fault features are more ***,the data augmentation method and ensemble ResNet-SVM are combined for fault diagnosis and compared with other *** experimental results show that the accuracy of the proposed method can exceed 99.9%.

关键词： Co-frequency vribation Data argumentation Ensembeled ResNet-SVM High precision fault diagnosis

TuBG1 promotes hepatocellular carcinoma via ATR/P53-apoptosis and cycling pathways

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Hepatobiliary & pancreatic Diseases International 2024年第2期23卷 195-209页

作者： Yan Zhang Zhen-Zhen Wang An-Qi Han Ming-Ya Yang Li-xin Zhu Fa-Ming pan yong Wang Department of General Surgery The Second Hospital of Anhui Medical UniversityHefei 230601China Department of General Surgery The First Affiliated Hospital of Anhui Medical UniversityHefei 230022China Department of Epidemiology and Biostatistics School of Public HealthAnhui Medical UniversityHefei 230032China The Key Laboratory of Major Autoimmune Diseases Anhui Medical UniversityHefei 230032China

Background:As reported,γ-tubulin(TuBG1)is related to the occurrence and development of various types of malignant ***,its role in hepatocellular cancer(HCC)is not *** present study was to investigate the relationship between TuBG1 and clinical parameters and survival in HCC ***:The correlation between TuBG1 and clinical parameters and survival in HCC patients was ex-plored by bioinformatics *** was used for the *** molecular function of TuBG1 was measured using colony formation,scratch assay,trans-well assay and flow *** set enrichment analysis(GSEA)was used to pick up the enriched pathways,followed by investigating the target pathways using Western *** tumor-immune system interactions and drug bank database(TISIDB)was used to evaluate TuBG1 and *** on the TuBG1-related immune genes,a prognostic model was constructed and was further validated internally and ***:The bioinformatic analysis found high expressed TuBG1 in HCC tissue,which was confirmed us-ing immunohistochemistry and Western *** silencing the TuBG1 in HCC cell lines,more G1 arrested cells were found,cell proliferation and invasion were inhibited,and apoptosis was ***,the silence of TuBG1 increased the expressions of Ataxia-Telangiectasia and Rad-3(ATR),phospho-P38 mitogen-activated protein kinase(P-P38MAPK),phospho-P53(P-P53),B-cell lymphoma-2 associated X protein(Bax),cleaved caspase 3 and P21;decreased the expressions of B-cell lymphoma-2(Bcl-2),cyclin D1,cyclin E2,cyclin-dependent kinase 2(CDK2)and *** correlation analysis of immunohistochemistry and clinical parameters and survival data revealed that TuBG1 was negatively corre-lated with the overall *** constructed immune prognosis model could effectively evaluate the ***:The increased expression of TuBG1 in HCC is associated with poor prognosis,which might be involved in the oc

关键词： TuBG1 Hepatocellular carcinoma Apoptosis Cell cycling Immunomodulators

Wear behavior of copper material removal during fluid jet polishing:A comparative study between experiment and simulation

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Friction 2024年第8期12卷 1680-1695页

作者： Wenjing ZHANG xin ZHANG Tiancheng AI Dan GUO Guoshun pan State Key Laboratory of Tribology in Advanced Equipment Tsinghua UniversityBeijing 100084China Guangdong Provincial Key Laboratory of Optomechatronics Shenzhen 518057China

As a crucial part in micro-electromechanical manufacture,local ultra-precision processing of highly ductile copper is expected to be realized by fluid jet polishing(FJP),which widely utilized in optical *** copper exhibits different wear behavior from stiff and brittle material,there is currently no abrasive wear prediction model applicable for copper to investigate the polishing *** research reveals that the copper material removal is dominated by deformation wear rather than cutting wear through abrasive jet impact experiments and localized wear scars analysis.A three-dimensional gas-liquid-particle triphasic wear model for copper in FJP is developed by considering impact energy and wear mechanism ***,validation assessments at various working pressures and impingement angles achieve the goodness-of-fit up to 0.92–0.97 in quantitative comparison between simulations and experimental measurements,which demonstrate the wear prediction ability of the proposed *** investigation facilitates a better understanding of copper wear mechanism and provides theoretical guidance for FJP process optimization.

关键词： fluid jet polishing(FJP) wear mechanism computational fluid mechanics wear model material removal

Aerodynamic/control integrated optimization method for unpowered high-speed vehicle configuration design

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Chinese Journal of Aeronautics 2024年第7期37卷 153-167页

作者： xin pan Linlin WANG Li LI Lulu JIANG Gang CHEN State Key Laboratory for Strength and Vibration of Mechanical Structures School of Aerospace EngineeringXi’an Jiaotong UniversityXi’an 710049China Shannxi Key Laboratory for Environment and Control of Flight Vehicle School of Aerospace EngineeringXi’an Jiaotong UniversityXi’an 710049China Beijing Institute of Space Long March Vehicle Beijing 100076China AVIC Xi’an Aeronautics Computing Technique Research Institute Xi’an 710068China

The unpowered high-speed vehicle experiences a significant coupling between the disciplines of aerodynamics and control due to its characteristics of high flight speed and extensive maneuverability within large *** conventional aircraft conceptual design process follows a sequential design approach,and there is an artificial separation between the disciplines of aerodynamics and control,neglecting the coupling effects arising from their *** a result,this design process often requires extensive iterations over long periods when applied to high-speed vehicles,and may not be able to effectively achieve the desired design *** enhance the overall performance and design efficiency of high-speed vehicles,this study integrates the concept of Active Control Technology(ACT)from modern aircraft into the philosophy of aerodynamic/control integrated *** integrated optimization strategies,with differences in coupling granularity,have been ***,these strategies are put into action on a biconical vehicle that operates at Mach *** results reveal that the comprehensive performance of the synthesis optimal model derived from the aerodynamic/control integrated optimization strategy is improved by 31.76%and 28.29%respectively compared to the base model under high-speed conditions,demonstrating the feasibility and effectiveness of the method and optimization strategies ***,in comparison to the single-stage strategy,the multi-stage strategy takes into deeper consideration the impact of control *** a result,the control performance of the synthesis opti-mal model derived from the multi-stage strategy improves by 13.99%,whereas the single-stage strategy only achieves a 5.79%*** method enables a fruitful interaction between aerodynamic configuration design and control system design,leading to enhanced overall performance and design ***,it improves the controllability of high-sp

关键词： Aerodynamic/Control Integrated Optimization MDO High-speed vehicle Shape Optimization Controllability

Limits of Uneven Battery Power in Modular Multilevel Converter-based Battery Energy Storage Systems

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 686-695页

作者： Yao pan Xiaofeng Sun Wei Zhao xin Li Yao Cai Institute of Electrical Engineering Yanshan UniversityQinhuangdao 066004China

For modular multilevel converter-based battery energy storage systems (MMC-BESS), uneven power among batteries of SMs will be deduced by battery aging, battery fault, etc., which will degrade performance and even lead to system failure. For maintaining the balance of capacitor voltage, this paper analyzes the limits of the uneven power of batteries, which are presented as the current limits in this paper. According to analysis, an analytical method is proposed that only the dc and fundamental frequency components of the arm current are used to calculate current limits. With the current limits it is able to evaluate the reasonability of power distribution among batteries. Meanwhile, increase of fundamental frequency component will enhance the current limits, and the dc component determines the size relationship between the absolute values of the upper and lower current limits. Finally, simulation model and experiment prototype are built for verifying the theoretical analysis and current limits calculation method, and satisfactory results are provided.

关键词： Arm current balance of capacitor voltage current limits MMC-BESS uneven power