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A Novel Recommendation Algorithm Integrates Resource Allocation and Resource Transfer in Weighted Bipartite Network

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Big Data Mining and Analytics 2024年第2期7卷 357-370页

作者： Qiang Sun Leilei shi Lu Liu Zixuan Han Liang Jiang Yan wu Yeling Zhao School of Computer Science and Communication Engineering Jiangsu UniversityZhenjiang 212013China School of Computing and Mathematical Sciences University of LeicesterLeicesterLE17RHUK School of Ocean College Jiangsu University of Science and TechnologyZhenjiang 212003China School of Finance and Economics Jiangsu UniversityZhenjiang 212013China

Grid-based recommendation algorithms view users and items as abstract nodes,and the information utilised by the algorithm is hidden in the selection relationships between users and *** these relationships can be easily handled,much useful information is overlooked,resulting in a less accurate recommendation *** aim of this paper is to propose improvements on the standard substance diffusion algorithm,taking into account the influence of the user’s rating on the recommended item,adding a moderating factor,and optimising the initial resource allocation vector and resource transfer matrix in the recommendation *** average ranking score evaluation index is introduced to quantify user satisfaction with the recommendation *** are conducted on the MovieLens training dataset,and the experimental results show that the proposed algorithm outperforms classical collaborative filtering systems and network structure based recommendation systems in terms of recommendation accuracy and hit rate.

关键词： cloud computing link prediction bipartite graph network recommendation algorithm cold start problem

Correction of a CADASIL point mutation using adenine base editors in hiPsCsandbloodvessel organoids

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Journal of Genetics and Genomics 2024年第2期51卷 197-207页

作者： Jingwen Wang Lei Zhang Guanglan wu Jinni wu Xinyao Zhou Xiaolin Chen yongxia Niu Yiren Jiao Qianyi Liu Puping Liang Guang shi Xueqing wu Junjiu Huang MOE Key Laboratory of Gene Function and Regulation State Key Laboratory of BiocontrolSchool of Life SciencesSun Yat-sen UniversityGuangzhouGuangdong 510275China Key Laboratory of Reproductive Medicine of Guangdong Province The First Affiliated Hospital and School of Life SciencesSun Yat-sen UniversityGuangzhouGuangdong 510275China Center of Reproductive Medicine Children's Hospital of Shanxi and Women Health Center of ShanxiTaiyuanShanxi 030013China

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a monogenic small vessel disease caused by mutations in the NOTCH3 gene. However, the pathogenesis of CADASIL remains unclear, and patients have limited treatment options. Here, we use human induced pluripotent stem cells (hiPSCs) generated from the peripheral blood mononuclear cells of a patient with CADASIL carrying a heterozygous NOTCH3 mutation (c.1261C>T, p.R421C) to develop a disease model. The correction efficiency of different adenine base editors (ABEs) is tested using the HEK293T-NOTCH3 reporter cell line. ABEmax is selected based on its higher efficiency and minimization of predicted off-target effects. Vascular smooth muscle cells (VSMCs) differentiated from CADASIL hiPSCs show NOTCH3 deposition and abnormal actin cytoskeleton structure, and the abnormalities are recovered in corrected hiPSC-derived VSMCs. Furthermore, CADASIL blood vessel organoids generated for in vivo modeling show altered expression of genes related to disease phenotypes, including the downregulation of cell adhesion, extracellular matrix organization, and vessel development. The dual adeno-associated virus (AAV) split-ABEmax system is applied to the genome editing of vascular organoids with an average editing efficiency of 8.82%. Collectively, we present potential genetic therapeutic strategies for patients with CADASIL using blood vessel organoids and the dual AAV split-ABEmax system.

关键词： CADASIL Induced pluripotent stem cells Adenine base editors AAV Blood vessel Organoid

GLUL stabilizes N-Cadherin by antagonizing β-Catenin to inhibit the progresses of gastric cancer

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Acta Pharmaceutica Sinica B 2024年第2期14卷 698-711页

作者： Qiwei Jiang yong Li Songwang Cai Xingyuan shi Yang Yang Zihao Xing Zhenjie He Shengte Wang Yubin Su Meiwan Chen Zhesheng Chen Zhi shi Department of Cell Biology&Institute of Biomedicine National Engineering Research Center of Genetic MedicineState Key Laboratory of Bioactive Molecules and Druggability AssessmentMOE Key Laboratory of Tumor Molecular BiologyGuangdong Provincial Key Laboratory of Bioengineering MedicineCollege of Life Science and TechnologyJinan UniversityGuangzhou 510632China Department of Gastrointestinal Surgery&General Surgery the Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Department of Thoracic Surgery The First Affiliated Hospital of Jinan UniversityGuangzhou 510632China Department of Radiation Oncology The Fifth Hospital of Guangzhou Medical UniversityGuangzhou 510150China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao 519000China Department of Pharmaceutical Sciences College of Pharmacy and Health SciencesSt.John’s UniversityQueensNY 11439USA

Glutamate-ammonia ligase(GLUL, also known as glutamine synthetase) is a crucial enzyme that catalyzes ammonium and glutamate into glutamine in the ATP-dependent condensation. Although GLUL plays a critical role in multiple cancers, the expression and function of GLUL in gastric cancer remain unclear. In the present study, we have found that the expression level of GLUL was significantly lower in gastric cancer tissues compared with adjacent normal tissues, and correlated with N stage and TNM stage, and low GLUL expression predicted poor survival for gastric cancer patients. Knockdown of GLUL promoted the growth, migration, invasion and metastasis of gastric cancer cells in vitro and in vivo, and vice versa, which was independent of its enzyme activity. Mechanistically, GLUL competed with β-Catenin to bind to N-Cadherin, increased the stability of N-Cadherin and decreased the stability of β-Catenin by alerting their ubiquitination. Furthermore, there were lower N-Cadherin and higher β-Catenin expression levels in gastric cancer tissues compared with adjacent normal tissues. GLUL protein expression was correlated with that of N-Cadherin, and could be the independent prognostic factor in gastric cancer. Our findings reveal that GLUL stabilizes N-Cadherin by antagonizing β-Catenin to inhibit the progress of gastric cancer.

关键词： Gastric cancer GLUL N-Cadherin β-Catenin Enzyme

Observation of maximal intrinsic chirality empowered by dual quasi-bound states in the continuum in a planar metasurface

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Photonics Research 2024年第2期12卷 244-252页

作者： XIN QI JIAJU wu FENG wu SONG ZHAO CHAO wu YUEYANG MIN MINA REN YUFEI WANG HAITAO JIANG YUNHUI LI ZHIWEI GUO YAPING YANG WANHUA ZHENG HONG CHEN yong SUN MOE Key Laboratory of Advanced Micro-Structured Materials School of Physics Science and EngineeringTongji UniversityShanghai 200092China School of Optoelectronic Engineering Guangdong Polytechnic Normal UniversityGuangzhou 510665China l3 Shanghai Key Laboratory of Special Artificial Microstructure Materials and Technology School of Physics Science and EngineeringTongji UniversityShanghai 200092China Department of Electrical Engineering Tongji UniversityShanghai 201804China State Key Laboratory on Integrated Optoelectronics Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China

Metasurfaces with spin-selective transmission play an increasingly critical role in realizing optical chiral responses,especially for strong intrinsic chirality,which is limited to complex three-dimensional *** this paper,we propose a planar metasurface capable of generating maximal intrinsic chirality and achieving dual-band spinselective transmission utilizing dual quasi-bound states in the continuum(quasi-BICs)caused by the structural symmetry ***,the value of circular dichroism(CD)and the transmittance of two kinds of circular polarization states can be arbitrarily controlled by tuning the asymmetry *** CD approaching unity with the maximum transmittance up to 0.95 is experimentally achieved in the dual ***,assisted by chiral BICs,the application in polarization multiplexed near-field image display is also *** work provides a new avenue to flexibly control intrinsic chirality in planar structure and offers an alternative strategy to develop chiral sensing,multiband spin-selective transmission,and high-performance circularly polarized wave *** basic principle and design method of our experiments in the microwave regime can be extended to other bands,such as the terahertz and infrared wavelengths.

关键词： planar intrinsic quasi

Enhanced UAV Pursuit-Evasion Using Boids Modelling: A Synergistic Integration of Bird Swarm Intelligence and DRL

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Computers, Materials and Continua 2024年第3期80卷 3523-3553页

作者： Jin, Weiqiang Tian, Xingwu shi, Bohang Zhao, Biao Duan, Haibin wu, Hao School of Information and Communications Engineering Faculty of Electronic and Information Engineering Xi’an Jiaotong University Xi’an 710049 China China Academy of Electronics and Information Technology China Electronics Technology Group Corporation (CETC) Beijing 100041 China Department of Automatic Control School of Automation Science and Electrical Engineering Beihang University Beijing 100191 China

The UAV pursuit-evasion problem focuses on the efficient tracking and capture of evading targets using unmanned aerial vehicles (UAVs), which is pivotal in public safety applications, particularly in scenarios involving intrusion monitoring and interception. To address the challenges of data acquisition, real-world deployment, and the limited intelligence of existing algorithms in UAV pursuit-evasion tasks, we propose an innovative swarm intelligence-based UAV pursuit-evasion control framework, namely "Boids Model-based DRL Approach for Pursuit and Escape" (Boids-PE), which synergizes the strengths of swarm intelligence from bio-inspired algorithms and deep reinforcement learning (DRL). The Boids model, which simulates collective behavior through three fundamental rules, separation, alignment, and cohesion, is adopted in our work. By integrating Boids model with the Apollonian Circles algorithm, significant improvements are achieved in capturing UAVs against simple evasion strategies. To further enhance decision-making precision, we incorporate a DRL algorithm to facilitate more accurate strategic planning. We also leverage self-play training to continuously optimize the performance of pursuit UAVs. During experimental evaluation, we meticulously designed both one-on-one and multi-to-one pursuit-evasion scenarios, customizing the state space, action space, and reward function models for each scenario. Extensive simulations, supported by the PyBullet physics engine, validate the effectiveness of our proposed method. The overall results demonstrate that Boids-PE significantly enhance the efficiency and reliability of UAV pursuit-evasion tasks, providing a practical and robust solution for the real-world application of UAV pursuit-evasion missions. Copyright © 2024 The Authors. Published by Tech Science Press.

关键词： Swarm intelligence

Development and validation of a nomogram model for predicting the risk of gallstone recurrence after gallbladder-preserving surgery

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 288-292页

作者： Peng Liu yong-Wei Chen Che Liu Yin-Tao wu Wen-Chao Zhao Jian-yong Zhu Yang An Nian-Xin Xia Faculty of Hepato-Pancreato-Biliary Surgery the First Medical CenterChinese PLA General HospitalBeijing 100853China Institute of Hepatobiliary Surgery of Chinese PLA Beijing 100853China Key Laboratory of Digital Hepetobiliary Surgery of Chinese PLA Beijing 100853China

Background:The high incidence of gallstone recurrence was a major concern for laparoscopic gallbladderpreserving *** study aimed to investigate the risk factors for gallstone recurrence after gallbladder-preserving surgery and to establish an individualized nomogram model to predict the risk of gallstone ***:The clinicopathological and follow-up data of 183 patients who were initially diagnosed with gallstones and treated with gallbladder-preserving surgery at our hospital from January 2012 to January 2019 were retrospectively *** independent predictive factors for gallstone recurrence following gallbladder-preserving surgery were identified by multivariate logistic regression analysis.A nomogram model for the prediction of gallstone recurrence was constructed based on the selected *** C-index,receiver operating characteristic(ROC)curve and calibration curve were used to evaluate the predictive power of the nomogram model for gallstone ***:During the follow-up period,a total of 65 patients experienced gallstone recurrence,and the recurrence rate was 35.5%.Multivariate logistic regression analysis revealed that the course of gallstones>2 years[odds ratio(OR)=2.567,95%confidence interval(CI):1.270-5.187,P=0.009],symptomatic gallstones(OR=2.589,95%CI:1.059-6.329,P=0.037),multiple gallstones(OR=2.436,95%CI:1.133-5.237,P=0.023),history of acute cholecystitis(OR=2.778,95%CI:1.178-6.549,P=0.020)and a greasy diet(OR=2.319,95%CI:1.186-4.535,P=0.014)were independent risk factors for gallstone recurrence after gallbladder-preserving surgery.A nomogram model for predicting the recurrence of gallstones was established based on the above five *** results showed that the C-index of the nomogram model was 0.692,suggesting it was valuable to predict gallstone ***,the calibration curve showed good consistency between the predicted probability and actual ***:The nomogram model for

关键词： Gallstone Gallbladder-preserving surgery Recurrence Risk factors Nomogram

Relationship between the unique microstructures and behaviors of high-entropy alloys

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International Journal of Minerals,Metallurgy and Materials 2024年第6期31卷 1350-1363页

作者： Yaqi wu Peter KLiaw Ruixuan Li Weiran Zhang Guihong Geng Xuehui Yan Guiqun Liu yong Zhang State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China Department of Materials Science and Engineering The University of TennesseeKnoxvilleTN 37996USA Xi’an Rare Metal Materials Institute Co.Ltd. Xi’an 710016China School of Materials Science and Engineering North Minzu UniversityYinchuan 750030China GRIMAT Engineering Institute Co. Ltd.Beijing 101407China

High-entropy alloys(HEAs),which were introduced as a pioneering concept in 2004,have captured the keen interest of nu-merous ***,in this context,can be perceived as representing disorder and *** contrast,elemental composi-tions within alloy systems occupy specific structural sites in space,a concept referred to as *** accordance with Shannon entropy,structure is analogous to ***,the arrangement of atoms within a material,termed its structure,plays a pivotal role in dictating its *** addition to expanding the array of options for alloy composites,HEAs afford ample opportunities for diverse structural *** profound influence of distinct structural features on the exceptional behaviors of alloys is underscored by numer-ous *** features include remarkably high fracture strength with excellent ductility,antiballistic capability,exceptional radi-ation resistance,and corrosion *** this paper,we delve into various unique material structures and properties while elucidating the intricate relationship between structure and performance.

关键词： high-entropy alloys unique microstructure special properties alloy design

High performance 2T0C DRAM cells based on atomic-layer-deposited InAlZnO FETs

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Science China(Information Sciences) 2024年第09期67卷 344-345页

作者： Wen XIONG Binbin LUO Wei MENG Bao ZHU Xiaohan wu shi-Jin DING School of Microelectronics Fudan University

Recently, the oxide semiconductor-based 2T0C dynamic random-access memory(DRAM) has shown great potential in monolithic three-dimensional(M3D)-integrated memory,owing to some unique advantages of oxide semiconductors,such as high electron mobility, wide band gap, and compatibility with back-end-of-line(BEOL) processes [1, 2].

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Rapid fabrication of modular 3D paper-based microfluidic chips using projection-based 3D printing

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BIO-DESIGN AND MANUFACTURING 2024年第5期7卷 611-623页

作者： Xie, Mingjun Fu, Zexin Lu, Chunfei wu, Sufan Pan, Lei He, yong Sun, Yi Wang, Ji Hangzhou Med Coll Zhejiang Prov Peoples Hosp Affiliated Peoples Hosp Plast & Reconstruct Surg CtrDept Plast & Reconstr Hangzhou 310014 Peoples R China Zhejiang Univ Sch Mech Engn State Key Lab Fluid Power & Mechatron Syst Hangzhou 310058 Peoples R China Zhengzhou Univ Key Lab Mat Proc & Mold Zhengzhou 450002 Peoples R China Zhejiang Univ Coll Mech Engn Key Lab 3D Printing Proc & Equipment Zhejiang Prov Hangzhou 310058 Peoples R China Zhejiang Univ Canc Ctr Hangzhou 310058 Peoples R China

Paper-based microchips have different advantages, such as better biocompatibility, simple production, and easy handling, making them promising candidates for clinical diagnosis and other fields. This study describes a method developed to fabricate modular three-dimensional (3D) paper-based microfluidic chips based on projection-based 3D printing (PBP) technology. A series of two-dimensional (2D) paper-based microfluidic modules was designed and fabricated. After evaluating the effect of exposure time on the accuracy of the flow channel, the resolution of this channel was experimentally analyzed. Furthermore, several 3D paper-based microfluidic chips were assembled based on the 2D ones using different methods, with good channel connectivity. Scaffold-based 2D and hydrogel-based 3D cell culture systems based on 3D paper-based microfluidic chips were verified to be feasible. Furthermore, by combining extrusion 3D bioprinting technology and the proposed 3D paper-based microfluidic chips, multiorgan microfluidic chips were established by directly printing 3D hydrogel structures on 3D paper-based microfluidic chips, confirming that the prepared modular 3D paper-based microfluidic chip is potentially applicable in various biomedical applications. [GRAPHICS] .

关键词： Paper-based microfluidic chip Projection-based 3D printing (PBP) Modularization Cell culture LOW-COST DEVICES WAX