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Androgen downregulation of miR-760 promotes prostate cancer cell growth by regulating IL6

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Asian Journal of Andrology 2021年第1期23卷 85-90页

作者： Shuo Wang yong yang Yu-Dong Cao Xing-Xing Tang peng Du Department of Urology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing)Peking University Cancer Hospital and InstituteBeijing 100142China

Prostate cancer(PCa)is one of the most common malignancies in Western *** have shown that androgen contributes to the progression of PCa,but how androgen promotes PCa remains largely ***,we demonstrated that androgen suppressed the expression of miR-760 depending on the interaction between androgen and androgen receptor(AR).miR-760 was downregulated in prostate cancer tissues compared with normal *** experiments showed that miR-760 downregulation promoted the proliferation and growth of LNCaP and 22rv1 *** contrast,miR-760 ectopic expression inhibited the proliferation of LNCaP and 22 rv1 *** synthesis was suppressed by ***,miR-760 bound to the 3 fUTR of interleukin 6(IL6).A mutation in the binding site disrupted their *** addition,silencing of IL6 suppressed the proliferation of LNCaP and 22 rv1 ***6 was upregulated in PCa *** study reveals that androgen downregulates miR-760 to promote the growth of PCa cells by regulating IL6.

关键词： androgen interleukin 6 miR-760 prostate cancer

A Novel Movement Behavior Control Method for Carp Robot through the Stimulation of Medial Longitudinal Fasciculus Nucleus of Midbrain

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Journal of Bionic Engineering 2022年第5期19卷 1302-1313页

作者： yang Zhao yong peng Yudong Wen Lingjun Han Hui Zhang Zheng Zhao Xiaoyue Liu School of Electrical Engineering Yanshan UniversityQinhuangdao 066004China Key Laboratory of National Defense of Mechanical Structure and Material Science Under Extreme Conditions Yanshan UniversityQinhuangdao 066004China Institute of Marine Science and Engineering Yanshan UniversityQinhuangdao 066004China

Biological robot is a kind of creature controlled by human beings by applying intervention signals through control technology to regulate biological *** present,the research on bio-robot mainly focuses on terrestrial mammals and insects,while the research on aquatic animal robot is *** studies have shown that the medial longitudinal fasciculus nucleus(NFLM)of carp midbrain was related to tail wagging,but the research has not been applied to the navigation control of the carp *** purpose of this study is to realize the quantitative control of the forward and steering behavior of the carp robot by NFLM electrical *** the condition of no craniotomy,brain electrode was implanted into the NFLM of the carp midbrain,and the underwater control experiment was carried out by applying different electrical stimulation *** the ImageJ software and self-programmed,the forward motion speed and steering angle of steering motion of the carp robot before and after being stimulated were *** experimental results showed for the carp robot that was induced the steering motion,the left and right steering motion of 30°to 150°could be achieved by adjusting the stimulation parameters,for the carp robot that was induced the forward motion,the speed of forward motion could be controlled to reach 100 cm/*** research lays a foundation for the accurate control of the forward and steering motion of the aquatic animal robot.

关键词： Carp robot Midbrain Medial longitudinal fasciculus nucleus Electrical stimulation Steering motion control Forward motion control

Adaptation analysis and fusion correction method of CMIP6 precipitation simulation data on the Qinghai-Tibetan Plateau

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Journal of Mountain Science 2024年第2期21卷 555-573页

作者： peng Hao QIN Dahui WANG Zegen ZHANG Menghan yang Yanmei yong Zhiwei School of Civil Engineering and Geomatics Southwest Petroleum UniversityChengdu 610500China School of Geoscience and Technology Southwest Petroleum UniversityChengdu 610500China

In order to obtain more accurate precipitation data and better simulate the precipitation on the Tibetan Plateau,the simulation capability of 14 Coupled Model Intercomparison Project Phase 6(CMIP6)models of historical precipitation(1982-2014)on the Qinghai-Tibetan Plateau was evaluated in this *** indicate that all models exhibit an overestimation of precipitation through the analysis of the Taylor index,temporal and spatial statistical *** correct the overestimation,a fusion correction method combining the Backpropagation Neural Network Correction(BP)and Quantum Mapping(QM)correction,named BQ method,was *** this method,the historical precipitation of each model was corrected in space and time,*** correction results were then analyzed in time,space,and analysis of variance(ANOVA)with those corrected by the BP and QM methods,***,the fusion correction method results for each model were compared with the Climatic Research Unit(CRU)data for significance analysis to obtain the trends of precipitation increase and decrease for each *** results show that the IPSL-CM6A-LR model is relatively good in simulating historical precipitation on the Qinghai-Tibetan Plateau(R=0.7,RSME=0.15)among the uncorrected *** terms of time,the total precipitation corrected by the fusion method has the same interannual trend and the closest precipitation values to the CRU data;In terms of space,the annual average precipitation corrected by the fusion method has the smallest difference with the CRU data,and the total historical annual average precipitation is not significantly different from the CRU data,which is better than BP and ***,the correction effect of the fusion method on the historical precipitation of each model is better than that of the QM and BP *** precipitation in the central and northeastern parts of the plateau shows a significant increasing *** correlation coefficients between monthly

关键词： GCM CMIP6 Precipitation correction BP-QM fusion correction Spatio-temporal characteristics

Root stoichiometric dynamics and homeostasis of invasive species Phyllostachys edulis and native species Cunninghamia lanceolata in a subtropical forest in China

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Journal of Forestry Research 2021年第5期32卷 2001-2010页

作者： Chao peng Jia Tu Ming yang yong Meng Meiqun Li Wensheng Ai Institute of Bamboo Research Hunan Academy of ForestryChangsha 410004Hunan ProvinceP.R.China

The community species abundance and diversity declined with bamboo invasion had been widely reported ***,the physiological strategies used during root competition between native species and invasive bamboo are poorly *** clarify the mechanisms underlying such strategies,the stoichiometric dynamics and homeostasis of nitrogen,phosphorus,organic carbon in root orders of Phyllostachys edulis(I du[=Ⅰ-Pe,years 1 and 2];Ⅱdu[=Ⅱ-Pe,years 3 and 4]),Cunninghamia lanceolata in transition and pure forests were *** increasing intensity of bamboo invasion,N,P,and C content of *** root orders declined,N and P content in *** rhizome orders declined,while C increased,the stoichiometric ratios in mixed forest interface mainly increased,and the stoichiometric differences within native and invasive species root orders ***,the stoichiometric homeostasis index(H)of elements in the same root order and even the same elements in different root orders were not consistent.H of most root orders(except some HP)was greater than 4,the H ranked order wasⅠ-Pe>Cl>Ⅱ-Pe in mixed interfaces,and the N:P ratio of most species root orders was greater than 16,despite being affected by *** research concluded that the bamboo invasion narrows stoichiometric differences within root orders,and the juvenile bamboo rhizome has a stronger capacity for homeostatic regulation than in adult bamboo and ***,which is a key determinant of bamboo invasion success.

关键词： Bamboo invasion Root orders Nutrient dynamics Homeostatic regulation coefficient

Shale Gas Reservoir Evaluation by Geophysical Measurements:A Case Study of the Upper Ordovician–Lower Silurian in the Fenggang Block,Northern Guizhou Province

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Acta Geologica Sinica(English Edition) 2021年第4期95卷 1310-1321页

作者： XIA peng FU yong GUO Chuan yang Zhen HUANG Jinqiang MOU Yuliang Resource and Environmental Engineering College Guizhou UniversityGuiyang 550025China Key Laboratory of Geological Resources and the Environment Guizhou UniversityGuivang 550025China College of Eco-Environmental Engineering Guizhou Minzu UniversityGuiyang 550025China

With the aid of geophysical measurements,including seventeen two-dimensional(2 D)seismic lines and the well logging curves of well FGY1,the structure and reservoir characteristics of the Upper Ordovician–Lower Silurian strata in the Fenggang block,northern Guizhou Province,were analyzed thoroughly to identify desert areas and favorable *** results show that Longmaxi-Wufeng is the most prospect-rich formation,consisting of a thick succession of overmature black shale,this formation remaining partially in the Suiyang,Fenggang and Jianchaxi *** Longmaxi-Wufeng shale,especially the lower member,was deposited in a reducing low-energy environment with relatively high U content and a low Th/U *** this shale,the organic matter type(sapropelic and humic-sapropelic),total organic carbon(TOC)content,gas content,gas adsorption capacity,vitrinite reflectance and brittle mineral content are profitable for shale gas preservation and *** fractures of this shale were closed because of its high overburden *** gas adsorption capacity of this shale increases with increasing TOC content and *** the Longmaxi-Wufeng Formation at well FGY1,the most favorable intervals are in the depth ranges of 2312.4–2325.1 m and 2325.8–2331.1 m.

关键词： shale gas reservoir property geophysics Longmaxi-Wufeng Guizhou

Quantitative feedback controller design and test for an electro-hydraulic position control system in a large-scale reflecting telescope

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Frontiers of Information Technology & Electronic Engineering 2017年第10期18卷 1624-1634页

作者： Xiong-bin peng Guo-fang GONG Hua-yong yang Hai-yang LOU Wei-qiang WU Tong LIU State Key Laboratory of Fluid Power Transmission and Control Zhejiang University College of Engineering Shantou University

For the primary mirror of a large-scale telescope, an electro-hydraulic position control system(EHPCS) is used in the primary mirror support system. The EHPCS helps the telescope improve imaging quality and requires a micron-level position control capability with a high convergence rate, high tracking accuracy, and stability over a wide mirror cell rotation region. In addition, the EHPCS parameters vary across different working conditions, thus rendering the system nonlinear. In this paper, we propose a robust closed-loop design for the position control system in a primary hydraulic support system. The control system is synthesized based on quantitative feedback theory. The parameter bounds are defined by system modeling and identified using the frequency response method. The proposed controller design achieves robust stability and a reference tracking performance by loop shaping in the frequency domain. Experiment results are included from the test rig for the primary mirror support system, showing the effectiveness of the proposed control design.

关键词： Large-scale reflecting telescope Quantitative feedback theory Electro-hydraulic position control system Micron-level position control capability System identification Robust stability

Wet air oxidation treatment of H-acid wastewater

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Journal of Environmental Sciences 1998年第4期10卷 2-10页

作者： Jiang Zhan-peng Liu yong yang Zhi-hua Zhu Wan-peng Wang yong-yi Department of Environmental Engineering Tsinghua UniversityBeijing 100084China

This paper presents the effect of reaction factors on wet air oxidation(WAO) of H acid wastewater. Higher COD Cr removal were observed at low initial pH, high reaction temperature and no addition of Na 2SO 4. Initial oxygen pressure P O 2 should be consistent with the initial H acid concentration. The changes of some indexes were also studied. A significant initial (about 10 min) rapid reduction in COD Cr was observed at 200℃ and 250℃. The decline of pH and the increase of SO 2- 4 concentration were found in all the experiments. Some formic acid and large amount of acetic acid were detected in the treated solution in this study. The analysis of off gas indicated undetectable amount of SO 2 and nitrogen oxides. The biodegradability of H acid solution was greatly improved after WAO treatment. The ratio of BOD 5/COD Cr increased from initial 3 4% to 33 3% after one hour reaction at 160℃ and 3 MPa initial oxygen pressure(initial H acid concentration:10 g/L, mixing speed:300 r/min). The result of WAO of H acid production wastewater was similar to that of WAO of H acid pure compound in distilled water.

关键词： wet air oxidation(WAO) H acid biodegradability off gas BOD 5/COD Cr .

Transforming waste particles into valuable adsorbents via amyloid-mediated molecular engineering

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Science China Chemistry 2025年第1期 317-328页

作者： Qingmin yang Jian Zhao Yujia Zhang Xingyu Zhou Hao Ren Bowen Hu Zhongli Lei Lixin Chen peng yang School of Material and Chemical Engineering Bengbu University Anhui Provincial Engineering Laboratory of Silicon-Based Materials School of Chemistry and Chemical Engineering Northwestern Polytechnical University Key Laboratory of Applied Surface and Colloid Chemistry Ministry of Education School of Chemistry and Chemical EngineeringShaanxi Normal University Xi'an Key Laboratory of Polymeric Soft Matter School of Chemistry and Chemical Engineering Shaanxi Normal University International Joint Research Center on Functional Fiber and Soft Smart Textile School of Chemistry and Chemical EngineeringShaanxi Normal University

The high-value utilization of industrial solid waste using a facile and eco-friendly process is of great interest and significance in reducing environmental pollution and developing a green circular economy. Herein, we propose an amyloid-mediated molecular engineering strategy to transform particulate waste into valuable adsorbents for metal ions. Our method has the advantage of aqueous solution fabrication under mild conditions without the use of high-temperature hydrothermal methods and toxic chemical reagents. Amyloid-mediated molecular engineering manipulates the phase transition of bovine serum albumin(BSA)on particulate waste surfaces, resulting in a remarkable ～3.1 times improvement in the adsorption capacity of fly ash, a typical industrial solid waste for gold ions after modification with the phase-transitioned BSA(PTB). The resultant adsorption ability was 69–1,980 times higher than those of conventional and emerging adsorbent materials such as ion exchange resins, activated carbon(AC), covalent organic frameworks(COFs), and metal-organic frameworks(MOFs). We further demonstrated the application of our PTB-modified materials in the recovery of precious metals from low-grade gold ore and electronic waste leachates. Consequently, this strategy could increase the value of waste materials nearly 27 times. In addition, this method is generally extendable to other conventional industrial adsorbents such as resin, clay, and Al2O3, and enhances their adsorption capabilities at least twofold. Overall, this work provides a simple and green approach for improving the adsorption performance of solid particles, and is expected to develop into a universal strategy for transforming waste particles into high-value-added products.

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Memetic algorithms-based neural network learning for basic oxygen furnace endpoint prediction

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第11期11卷 841-848页

作者： peng CHEN yong-zai LU Department of Automation Shanghai Jiao Tong University Shanghai 200240 China Department of Automation Zhejiang University Hangzhou 310027 China

Based on the critical position of the endpoint quality prediction for basic oxygen furnaces （BOFs） in steelmaking, and the latest results in computational intelligence （C1）, this paper deals with the development of a novel memetic algorithm （MA） for neural network （NN） lcarnmg. Included in this is the integration of extremal optimization （EO） and Levenberg-Marquardt （LM） pradicnt search, and its application in BOF endpoint quality prediction. The fundamental analysis reveals that the proposed EO-LM algorithm may provide superior performance in generalization, computation efficiency, and avoid local minima, compared to traditional NN learning methods. Experimental results with production-scale BOF data show that the proposed method can effectively improve the NN model for BOF endpoint quality prediction.

关键词： Memetic algorithm (MA) Neural network (NN) learning Back propagation (BP) Extremal optimization (EO) gevenberg-Marquardt (LM) gradient search Basic oxygen furnace (BOF)