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Research Advances in the Construction and Application of Intestinal Organoids

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Biomedical and Environmental Sciences 2025年第2期38卷 230-247页

作者： Qingxue Meng Hongyang Yi Peng Wang Shan Liu Weiquan Liang Cuishan Chi Chenyu Mao Weizheng Liang jun Xue Hongzhou lu Technology Department The First Affiliated Hospital of Hebei North UniversityZhangjiakou 075000HebeiChina Hebei Provincial Key Laboratory of Systems Biology and Gene Regulation Central LaboratoryThe First Affiliated Hospital of Hebei North UniversityZhangjiakou 075000HebeiChina National Clinical Research Centre for Infectious Diseases The Third People’s Hospital of Shenzhen and The Second Affiliated Hospital of Southern University of Science and TechnologyShenzhen 518112GuangdongChina Hebei North University Zhangjiakou 075000HebeiChina Bioimaging Core of Shenzhen Bay Laboratory Shenzhen 518132GuangdongChina FAW Jiefang Changchun 130011JilinChina Huigu School of High-tech Industrial Development Zone Changchun 130012JilinChina University of Pennsylvania PA 19104United States Hebei Provincial Key Laboratory of Systems Biology and Gene Regulation Department of SurgeryThe First Affiliated Hospital of Hebei North UniversityZhangjiakou 075000HebeiChina

The structure of intestinal tissue is *** vitro simulation of intestinal structure and function is important for studying intestinal development and ***,organoids have been successfully constructed and they have come to play an important role in biomedical *** are miniaturized three-dimensional(3D)organs,derived from stem cells,which mimic the structure,cell types,and physiological functions of an organ,making them robust models for biomedical *** organoids are 3D micro-organs derived from intestinal stem cells or pluripotent stem cells that can successfully simulate the complex structure and function of the intestine,thereby providing a valuable platform for intestinal development and disease *** this article,we review the latest progress in the construction and application of intestinal organoids.

关键词： 3D culture Colorectal cancer Disease model Intestinal organoids Organ transplantation Pluripotent stem cells Regenerative medicine Tumor organoids

Efficacy of water infusion combined with defoamers in colonoscopy

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World Journal of Gastrointestinal Surgery 2025年第3期17卷 190-197页

作者： Jian Li jun-Ping Chen Chun-Han Lai Lian Fu yong Ji Department of Gastroenterology Nanhai Family Practice Hospital(Nanhai Guicheng Hospital)Foshan 528000Guangdong ProvinceChina Department of Internal Medicine Nanhai Family Practice Hospital(Nanhai Guicheng Hospital)Foshan 528000Guangdong ProvinceChina Department of Gastrointestinal Surgery The First People's Hospital of FoshanFoshan 528000Guangdong ProvinceChina

BACKGROUND Currently,colonoscopy still needs continuous optimization and exploration of novel alternative approaches to enhance the experience of patients during *** To analyze the efficacy of water infusion combined with defoamers in *** This study included 97 patients undergoing colonoscopy from January 2024 to june *** participants were categorized into two groups,namely,the control group(n=47),who underwent conventional colonoscopy,and the experimental group(n=50),who received colonoscopy using water injection combined with defoamers.A comparative analysis was then conducted on the disease detection rate(colonic polyps,colonorrhagia,colonic ulcers,colonic mucosal lesions,and others),colonoscopy duration,abdominal pain[visual analog scale(VAS)],Boston bowel preparation scale(BBPS),self-rating anxiety scale(SAS),bowel preparation comfort,complications(intestinal perforation,bleeding,nausea and vomiting,abdominal pain,and abdominal distension),and patient *** The experimental group demonstrated a significantly higher total disease detection rate,BBPS scores,and patient satisfaction compared with the control ***,the research group exhibited shorter colonoscopy duration,lower VAS and SAS scores and total complication rate,and better patient comfort and *** These results indicate that the combination of water injection and defoamers exhibited an overall better therapeutic effect than conventional colonoscopy,mainly reflected in higher disease detection rate,faster examination ef-ficiency,lower abdominal pain,anxiety,and complication incidences,and significantly better bowel preparation,comfort,and patient satisfaction.

关键词： Water injection Defoamer Colonoscopy Curative effect Visual analog scale

Effect of Scanning Speed on Wear and Corrosion Resistance of Inconel 625 Coatings

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Surface Technology 2025年第3期54卷 130-141页

作者： Zou, Li Sun, Wenlei Zhang, Tuan lu, Yuer Li, yong Zhong, Huixuan Modern Industrial College of Intelligent Manufacturing School of Mechanical Engineering Xinjiang University Urumqi 830017 China

H13 steel (4Cr5MoSiV1) is a kind of widely used hot work tool steel. During operation, the tool steel is subject to prolonged high-temperature oxidation, high-intensity alternating stress, and thermal shock, which significantly shorten its effective service life. To enhance the wear and corrosion resistance of the H13 hot work tool steel surface and thereby extend its service life, this study employs laser cladding technology to prepare four sets of Inconel 625 coating samples on the H13 steel surface at scanning speed of 8 mm/s, 10 mm/s, 12 mm/s, and 14 mm/s, respectively. The research investigates the effect of scanning speed on the wear and corrosion resistance properties of the Inconel 625 coating. The microstructure and elemental distribution of the coatings were observed and analyzed with a scanning electron microscope (Zeiss Supra 55 V) which was equipped with an energy dispersive spectrometer (EDS). The phase composition of the coatings was measured and analyzed with a Bruker D8 ADVANCE X-ray diffractometer. Specific parameters for the X-ray diffractometer were: Cu target, scanning range 2θ (5°-90°), scanning speed 10°/min, operating current 30 mA, and acceleration voltage 40 kV. The microhardness of the coatings was measured with an HV-1000 A microhardness tester with the following settings: load 1.96 N load duration 10 s;measurement interval 0.1 mm;The average value of three measurements at the same level was taken as the experimental result. The friction coefficient of the coatings was tested with a reciprocating MFT-5000 Rtec wear tester, with a reciprocating speed of 0.02 m/s, wear time of 20 min, and a counter body of a Si3N4 ball with a diameter of 9 mm and a hardness value of 1 400HV-1 700HV. Electrochemical corrosion tests on the coatings were conducted at room temperature and atmospheric pressure with an electrochemical workstation (CHI760E). The working electrode (WE) was the specimen, the auxiliary electrode (CE) was platinu

关键词： Inconel 625 laser cladding scanning speed wear and corrosion resistance

Differentiation Impact of Urban Form on Heat Island Intensity Along Urban Development Gradients in Zhengzhou

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Huanjing Kexue/Environmental Science 2025年第3期46卷 1924-1936页

作者： Wang, Sen Zeng, Sui-Ping lu, jun-Mo Namaiti, Aihemaiti Zeng, Jian School of Architecture Tianjin University Tianjin300072 China School of Architecture Tianjin Chengjian University Tianjin300384 China

The impact mechanism of urban form on heat island intensity(HI)is a core issue of research attention. Existing achievements have mostly focused on the correlation between urban form and thermal environment. Research on the differences along urban development gradients,and research on marginal effects and optimization paths under gradient differences is relatively scarce. This study considered the central urban area of Zhengzhou as an example,based on multi-source data such as Landsat remote sensing images and NPP-VIIRS satellite night light remote sensing images,and introduced a gradient-enhanced regression tree model to improve the DEMATEL-ISM method,exploring the gradient differences and marginal effects of urban morphology on heat island intensity. The results showed that:① From 2006 to 2020,the HI decreased with the increase in urban development gradient,and the increasing trend slowed down annually. ② The gradient difference between urban form and HI was significant. The green space form index always had a strong impact on HI,among which,NDVI was the most significant variable within each gradient,and the impact intensity of the construction land pattern index increased significantly with the increase in gradient,whereas the role of building combination form index weakened accordingly. ③ According to the ISM model,a four story-three order structural model of urban form indicators was obtained. The construction land pattern indicator within the high intensity construction gradient was the root cause order,and the building combination form indicator within the low intensity construction gradient was the root cause order. ④ The differences in the marginal effect of urban form along the gradient were significant. As the value of the indicator increased,its impact intensity and direction would change. There were differences in the key indicators and threshold ranges that affected the intensity of HI within different gradients. The study proposes a marginal optimizati

关键词： Landsat

微纳米Mo_(2)C-C作为高性能微生物燃料电池的阳极电催化剂

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化学研究与应用 2025年第1期37卷 87-93页

作者：王俊侯勇中山职业技术学院广东中山528404

通过简单的溶液衍生前驱体和煅烧法成功制备了具有微纳米结构的Mo_(2)C-C复合材料,并用作微生物燃料电池(MFC)的高性能阳极电催化剂。形态和组成表征表明,制备的Mo_(2)C-C复合材料由Mo_(2)C和C组成,具有微/纳米颗粒结构。同时材料表面... 详细信息

通过简单的溶液衍生前驱体和煅烧法成功制备了具有微纳米结构的Mo_(2)C-C复合材料,并用作微生物燃料电池(MFC)的高性能阳极电催化剂。形态和组成表征表明,制备的Mo_(2)C-C复合材料由Mo_(2)C和C组成,具有微/纳米颗粒结构。同时材料表面含有丰富官能团,有助于提高微生物在阳极表面的附着。电化学测试结果表明,Mo_(2)C-C复合材料对阳极/微生物之间的电荷转移具有出色的电催化活性。装有微纳米Mo_(2)C-C/CF阳极的MFC的最大功率密度为1.61 W·m^(-2),明显优于商用碳毡阳极。这项工作为高性能、环保MFC阳极电催化剂提供新思路。

关键词： Mo_(2)C 微纳米材料阳极电催化微生物燃料电池

基于改进人工势场法的欠驱动无人船编队协同避碰避障

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控制与决策 2025年第1期40卷 252-260页

作者：李伟张永超宁君马昊冉刘陆彭周华大连海事大学航海学院辽宁大连116026 大连海事大学船舶电气工程学院辽宁大连116026

提出一种基于改进人工势场法且带有输入量化的欠驱动无人船编队协同避碰避障策略.借鉴导弹制导与控制机理,分层设计无人船运动学制导律与动力学控制律.首先,基于辅助变量法在无人船运动学子系统中设计分布式制导律,并引入改进人工势场... 详细信息

提出一种基于改进人工势场法且带有输入量化的欠驱动无人船编队协同避碰避障策略.借鉴导弹制导与控制机理,分层设计无人船运动学制导律与动力学控制律.首先,基于辅助变量法在无人船运动学子系统中设计分布式制导律,并引入改进人工势场法的斥力函数.通过重构制导律实现运动学层面的协同避碰避障以及欠驱动无人船期望轨迹的跟踪;其次,通过使用径向基神经网络对无人船动力学子系统中的外界干扰和系统未建模动态进行逼近,采用均匀量化器对输入变量进行量化并对量化过程进行线性描述,使得底层量化控制器无需预测关于量化参数的具体信息;在稳定性分析中,利用李雅普诺夫稳定性理论证明所设计USV编队跟踪控制系统的稳定性;最后,采用Matlab对理论策略进行仿真实验,仿真结果验证了所提出策略的有效性.

关键词：欠驱动无人船人工势场法分布式编队输入量化 RBF神经网络避障

决策者身份认同对ESG表现的影响研究——基于非正式制度视角

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软科学 2025年第1期39卷 130-137页

作者：叶勇刘泳君罗润梅西南交通大学经济管理学院成都3610031

以2012—2021年的A股主板上市公司为研究样本,基于非正式制度视角,实证考察了企业决策者身份认同对ESG表现的影响。结果表明:(1)本地决策者有助于提高企业ESG表现。在经过倾向得分匹配法、滞后一期回归和工具变量法等内生性检验和稳健... 详细信息

以2012—2021年的A股主板上市公司为研究样本,基于非正式制度视角,实证考察了企业决策者身份认同对ESG表现的影响。结果表明:(1)本地决策者有助于提高企业ESG表现。在经过倾向得分匹配法、滞后一期回归和工具变量法等内生性检验和稳健性检验后,主要结论仍然成立。(2)社会信任程度和宗族文化强度正向调节本地决策者与企业ESG表现的关系,在社会信任程度越高和宗族文化强度越高的地区,本地决策者对企业提升ESG表现的促进作用更明显。(3)进一步引入《上市公司治理准则》这一外生事件冲击,再次验证了本地决策者对企业ESG表现的积极影响。(4)异质性分析结果表明,在人口流动性和市场化程度较低的城市,本地决策者对企业提升ESG表现的促进作用更为明显。

关键词：本地决策者非正式制度身份认同企业ESG

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Prognostic model for esophagogastric variceal rebleeding after endoscopic treatment in liver cirrhosis: A Chinese multicenter study

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World Journal of Gastroenterology 2025年第2期31卷 85-101页

作者： jun-Yi Zhan Jie Chen Jin-Zhong Yu Fei-Peng Xu Fei-Fei Xing De-Xin Wang Ming-Yan Yang Feng Xing Jian Wang yong-Ping Mu Cell Biology Laboratory Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China Institute of Liver Diseases Shanghai Academy of Chinese MedicineShanghai 201203China Clinical Key Laboratory of Traditional Chinese Medicine of Shanghai Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China Key Laboratory of Liver and Kidney Disease of the Ministry of Education Shanghai University of Traditional Chinese MedicineShanghai 201203China Department of Gastroenterology and Hepatology Zhongshan Hospital Affiliated to Fudan UniversityShanghai 200032China Shanghai Institute of Liver Disease Fudan UniversityShanghai 200032China Evidence-Based Medicine Center Fudan UniversityShanghai 200032China Department of Gastrointestinal Endoscopy Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China Department of Hepatology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China

BACKGROUND Rebleeding after recovery from esophagogastric variceal bleeding(EGVB)is a severe complication that is associated with high rates of both incidence and *** its clinical importance,recognized prognostic models that can effectively predict esophagogastric variceal rebleeding in patients with liver cirrhosis are *** To construct and externally validate a reliable prognostic model for predicting the occurrence of esophagogastric variceal *** This study included 477 EGVB patients across 2 cohorts:The derivation cohort(n=322)and the validation cohort(n=155).The primary outcome was rebleeding events within 1 *** least absolute shrinkage and selection operator was applied for predictor selection,and multivariate Cox regression analysis was used to construct the prognostic *** validation was performed with bootstrap *** assessed the discrimination,calibration and accuracy of the model,and performed patient risk *** Six predictors,including albumin and aspartate aminotransferase concentrations,white blood cell count,and the presence of ascites,portal vein thrombosis,and bleeding signs,were selected for the rebleeding event prediction following endoscopic treatment(REPET)*** predicting rebleeding within 1 year,the REPET model ex-hibited a concordance index of 0.775 and a Brier score of 0.143 in the derivation cohort,alongside 0.862 and 0.127 in the validation ***,the REPET model revealed a significant difference in rebleeding rates(P<0.01)between low-risk patients and intermediate-to high-risk patients in both *** We constructed and validated a new prognostic model for variceal rebleeding with excellent predictive per-formance,which will improve the clinical management of rebleeding in EGVB patients.

关键词： Esophagogastric variceal bleeding Variceal rebleeding Liver cirrhosis Prognostic model Risk stratification Secondary prophylaxis

Predictive value of a constructed artificial neural network model for microvascular invasion in hepatocellular carcinoma:A retrospective study

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 88-100页

作者： Hai-Yang Nong yong-Yi Cen Shan-Jin lu Rui-Sui Huang Qiong Chen Li-Feng Huang Jian-Ning Huang Xue Wei Man-Rong Liu Lin Li Ke Ding Department of Radiology The Third Affiliated Hospital of Guangxi Medical UniversityNanning 530031Guangxi Zhuang Autonomous RegionChina Department of Radiology Affiliated Hospital of Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Guangxi Clinical Medical Research Center for Hepatobiliary Diseases Affiliated Hospital of Youiiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Ultrasound The Third Affiliated Hospital of Guangxi Medical UniversityNanning 530031Guangxi Zhuang Autonomous RegionChina Department of Hepatobiliary Surgery The Third Affiliated Hospital of Guangxi Medical UniversityNanning 530031Guangxi Zhuang Autonomous RegionChina

BACKGROUND Microvascular invasion(MVI)is a significant risk factor for recurrence and metastasis following hepatocellular carcinoma(HCC)***,there is a paucity of preoperative evaluation approaches for *** To investigate the predictive value of texture features and radiological signs based on multiparametric magnetic resonance imaging in the non-invasive preoperative prediction of MVI in *** Clinical data from 97 HCC patients were retrospectively collected from January 2019 to July 2022 at our *** were classified into two groups:MVI-positive(n=57)and MVI-negative(n=40),based on postoperative pathological *** correlation between relevant radiological signs and MVI status was ***4.6 software and the mutual information method were employed to identify the top 10 dominant texture features,which were combined with radiological signs to construct artificial neural network(ANN)models for MVI *** predictive performance of the ANN models was evaluated using area under the curve,sensitivity,and *** models with relatively high predictive performance were screened using the DeLong test,and the regression model of multilayer feedforward ANN with backpropagation and error backpropagation learning method was used to evaluate the models’*** The absence of a pseudocapsule,an incomplete pseudocapsule,and the presence of tumor blood vessels were identified as independent predictors of HCC *** ANN model constructed using the dominant features of the combined group(pseudocapsule status+tumor blood vessels+arterial phase+venous phase)demonstrated the best predictive performance for MVI status and was found to be automated,highly operable,and very *** The ANN model constructed using the dominant features of the combined group can be recommended as a noninvasive method for preoperative prediction of HCC MVI status.

关键词： Hepatocellular carcinoma Texture analysis Magnetic resonance imaging Microvascular invasion Pseudocapsule Tumor blood vessels