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Classifying Chinese Medicine Constitution Using Multimodal Deep-Learning Model

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Chinese Journal of Integrative Medicine 2024年第2期30卷 163-170页

作者： gu Tian-yu YAN Zhuang-zhi JIANG jie-hui School of Communication&Information Engineering Shanghai UniversityShanghai(200444)China School of Life Science Shanghai UniversityShanghai(200444)China

Objective:To develop a multimodal deep-learning model for classifying Chinese medicine constitution,i.e.,the balanced and unbalanced constitutions,based on inspection of tongue and face images,pulse waves from palpation,and health information from a total of 540 ***:This study data consisted of tongue and face images,pulse waves obtained by palpation,and health information,including personal information,life habits,medical history,and current symptoms,from 540 subjects(202 males and 338 females).Convolutional neural networks,recurrent neural networks,and fully connected neural networks were used to extract deep features from the *** fusion and decision fusion models were constructed for the multimodal ***:The optimal models for tongue and face images,pulse waves and health information were ResNet18,Gate Recurrent Unit,and entity embedding,*** fusion was superior to decision *** multimodal analysis revealed that multimodal data compensated for the loss of information from a single mode,resulting in improved classification ***:Multimodal data fusion can supplement single model information and improve classification *** research underscores the effectiveness of multimodal deep learning technology to identify body constitution for modernizing and improving the intelligent application of Chinese medicine.

关键词： Chinese medicine constitution classification multimodal deep learning tongue image face image pulsewave health information

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GRK2-YAP signaling is implicated in pulmonary arterial hypertension development

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Chinese Medical Journal 2024年第7期137卷 846-858页

作者： Peng Ye Yunfei Deng Yue gu Pengfei Liu jie Luo Jiangqin Pu Jingyu Chen Yu Huang Nanping Wang yong Ji Shaoliang Chen Division of Cardiovascular Molecular Laboratory Third Clinical CollegeNanjing Medical UniversityNanjingJiangsu 210006China Division of Cardiovascular Laboratory Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu 210006China Division of Cardiology Shanghai General HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200080China Division of Pulmonary Surgery Wuxi People’s HospitalNanjing Medical UniversityWuxiJiangsu 300247China Institute of Vascular Medicine The Chinese University of Hong KongHongkong 999077China Health Science Center East China Normal UniversityShanghai 200241China School of Pharmacy Nanjing Medical UniversityNanjingJiangsu 210004China Division of Cardiology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu 210006China

Background:Pulmonary arterial hypertension(PAH)is characterized by excessive proliferation of small pulmonary arterial vascular smooth muscle cells(PASMCs),endothelial dysfunction,and extracellular matrix remodeling.G protein-coupled receptor kinase 2(GRK2)plays an important role in the maintenance of vascular tone and blood ***,the role of GRK2 in the pathogenesis of PAH is ***:GRK2 levels were detected in lung tissues from healthy people and PAH patients.C57BL/6 mice,vascular smooth muscle cell-specific Grk2-knockout mice(Grk2^(∆SM22)),and littermate controls(Grk2^(flox/flox))were grouped into control and hypoxia mice(n=8).Pulmonary hypertension(PH)was induced by exposure to chronic hypoxia(10%)combined with injection of the SU5416(cHx/SU).The expression levels of GRK2 and Yes-associated protein(YAP)in pulmonary arteries and PASMCs were detected by Western blotting and immunofluorescence *** mRNA expression levels of Grk2 and Yes-associated protein(YAP)in PASMCs were quantified with real-time polymerase chain reaction(RT-PCR).Wound-healing assay,3-(4,5)-dimethylthiahiazo(-z-y1)-3,5-di-phenytetrazoliumromide(MTT)assay,and 5-Ethynyl-2′-deoxyuridine(EdU)staining were performed to evaluate the proliferation and migration of ***,the interaction among proteins was detected by immunoprecipitation ***:The expression levels of GRK2 were upregulated in the pulmonary arteries of patients with PAH and the lungs of PH ***,cHx/SU-induced PH was attenuated in Grk2^(∆SM22) mice compared with littermate *** amelioration of PH in Grk2^(∆SM22) mice was accompanied by reduced pulmonary vascular *** vitro study further confirmed that GRK2 knock-down significantly altered hypoxia-induced PASMCs proliferation and migration,whereas this effect was severely intensified by overexpression of *** also identified that GRK2 promoted YAP expression and nuclear translocation in PASMCs,resulting in excessive PA

关键词： Pulmonary arterial hypertension GRK2 YAP Pulmonary artery smooth muscle cell Hypoxia

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Identification of TNFRSF1A as a novel regulator of carfilzomib resistance in multiple myeloma

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Oncology Research 2024年第2期32卷 325-337页

作者： jie ZHAO XUANTAO YANG HAIXI ZHANG XUEZHONG gu Department of Hematology The First People’s Hospital of Yunnan ProvinceYunnan Province Clinical Research Center for Hematologic DiseaseYunnan Province Clinical Center for Hematologic DiseaseKunming650032China Department of Pathology The First People’s Hospital of Yunnan ProvinceKunming650032China

Multiple myeloma(MM)is a hematological tumor with high mortality and recurrence *** is a new-generation proteasome inhibitor that is used as the first-line therapy for ***,the development of drug resistance is a pervasive obstacle to treating ***,elucidating the drug resistance mechanisms is conducive to the formulation of novel therapeutic *** elucidate the mechanisms of carfilzomib resistance,we retrieved the GSE78069 microarray dataset containing carfilzomib-resistant LP-1 MM cells and parental MM *** gene expression analyses revealed major alterations in the major histocompatibility complex(MHC)and cell adhesion *** upregulation of the tumor necrosis factor(TNF)receptor superfamily member 1A(TNFRSF1A)gene was accompanied by the downregulation of MHC genes and cell adhesion ***,to investigate the roles of these genes,we established a carfilzomib-resistant cell model and observed that carfilzomib resistance induced TNFRSF1A overexpression and TNFRSF1A silencing reversed carfilzomib resistance and reactivated the expression of cell adhesion ***,TNFRSF1A silencing suppressed the tumorigenesis of MM cells in immunocompetent mice,indicating that TNFRSF1A may lead to carfilzomib resistance by dampening antitumor ***,our results indicated that TNFRSF1A overexpression conferred carfilzomib resistance in MM cells and suppressed the expression of MHC genes and cell adhesion *** suppression of MHC genes and cell adhesion molecules may impair the interaction between immune cells and cancer cells to impair antitumor *** studies are warranted to further investigate the signaling pathway underlying the regulatory role of TNFRSF1A in MM cells.

关键词： Multiple myeloma Carfilzomib Drug resistance Major histocompatibility complex TNFRSF1A

Asymmetric copolyimide membranes fabricated by nonsolvent-induced phase separation for He/CH_(4) and He/N_(2) separation

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Frontiers of Chemical Science and Engineering 2024年第4期18卷 97-106页

作者： Ying Li Lu Wang Junyan Xie yong Dai Xuehong gu Xuerui Wang State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing 211816China Quzhou Membrane Material Innovation Institute Quzhou 324000China

Membrane gas separation is considered an energy-saving technique to extract He from natural gas due to no phase change and room temperature ***,the membrane performance was strongly limited by the trade-off between permeance and ***,novel 4,4′-(hexafluoroisopropylidene)diphthalic anhydride(6FDA)-2,2′-bis(3-amino-4-hydroxyphenyl)hexafluoropropane(APAF)-5-amino-2-(4-aminobenzene)benzimidazole(BIA)asymmetric membranes with a thickness of 300 nm were successfully prepared by the non-solvent induced phase separation *** membrane performance was modulated by regulating dope solution compositions(e.g.,tetrahydrofuran and polymer concentration).The ideal He/CH_(4) selectivity was 124 and the optimized He permeance reached 87 GPU,beyond the current upper ***/CH_(4) selectivity was 75 and He permeance was 73 GPU for the binary mixture feed containing 0.2 mol%*** membrane showed good resistance to CO_(2) and C_(2)H_(6),which are the typical impurities in natural *** 6FDA-APAF-BIA membranes have good stability(>160 h),which can provide great potential in He extraction from natural gas.

关键词： He separation membrane natural gas copolyimide

The influence of stress-dependent overpotential on dendrite growth in all-solid-state battery with cracks

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Science China Technological Sciences 2024年第8期67卷 2493-2504页

作者： ZHANG ZhenHua ZHANG yong LIU Chang HOU Xu WANG jie Department of Engineering Mechanics School of Aeronautics and Astronautics Zhejiang University School of Aerospace Engineering and Applied Mechanics Tongji University Applied Mechanics and Structure Safety Key Laboratory of Sichuan Province School of Mechanics and Aerospace Engineering Southwest Jiaotong University Department of Industrial and Systems Engineering The Hong Kong Polytechnic University Zhejiang Laboratory Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province Zhejiang University

Dendrite growth is one of the main challenges in maintaining the service life of all-solid-state lithium-ion batteries. Mechanical stress has been reported to significantly affect dendrite growth. In this study, to explain the effect of mechanical stress on electrochemical reactions in all-solid-state batteries, a modified phase-field model for dendrite growth is proposed by considering the stress-dependent overpotential. Dendrite growth under different mechanical loadings in an all-solid-state battery is investigated using the proposed model. Consistent with previous experimental results, the current result shows that compressive stress inhibits dendrite growth. Considering the stress concentration at the tips of processing-induced microcracks, the effects of the number and distribution of microcracks on dendrite growth are investigated. The results show that the stress-concentration field induced at the tips of cracks or voids can change the morphology of dendrites and decrease their growth rates. This study provides a new perspective for explaining Li dendrite growth under mechanical stress and offers inspiration for prolonging the service life of all-solid-state batteries based on defect and stress regulation, which may be further realized in experiments by filling solid electrolytes with different types of nanofillers.

关键词： Butler–Volmer equation stress-dependent overpotential microcracks all-solid-state battery phase-field simulation

A single micro-LED manipulation system based on micro-gripper

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Nanotechnology and Precision Engineering 2024年第2期7卷 45-52页

作者： jie Bai Pingjuan Niu Erdan gu Jianming Li Clarence Augustine TH Tee School of Mechanical Engineering Tiangong University School of Electronic and Information Engineering Tiangong University Institute of Photonics University of Strathclyde Tianjin Key Laboratory of Micro Low Gravity Environment Simulation Technology Tianjin Aerospace Electromechanical Equipment Research Institute Department of Electrical and Information Engineering School of Physics and Electrical Information EngineeringZhejiang Normal University

Micro-LEDs(μLEDs) have advantages in terms of brightness, power consumption, and response speed. In addition, they can also be used as micro-sensors implanted in the body via flexible electronic skin. One of the key techniques involved in the fabrication of μLED-based devices is transfer printing. Although numerous methods have been proposed for transfer printing, improving the yield of μLED arrays is still a formidable task. In this paper, we propose a novel method for improving the yield of μLED arrays transferred by the stamping method, using an innovative design of piezoelectrically driven asymmetric micro-gripper. Traditional grippers are too large to manipulate μLEDs, and therefore two micro-sized cantilevers are added at the gripper tips. A μLED manipulation system is constructed based on the micro-gripper together with a three-dimensional positioning system. Experimental results using this system show that it can be used successfully to manipulate μLED arrays.

关键词： Manipulation Micro-gripper Micro-LED Transfer printing

The genome-wide meiotic recombination landscape in ciliates and its implications for crossover regulation and genome evolution

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Journal of Genetics and Genomics 2024年第3期51卷 302-312页

作者： Lu Fu Chen gu Kazufumi Mochizuki jie Xiong Wei Miao guangying Wang Key Laboratory of Aquatic Biodiversity and Conservation Institute of HydrobiologyChinese Academy of SciencesWuhanHubei 430072China University of Chinese Academy of Sciences Beijing 100049China Institute of Human Genetics(IGH) CNRSUniversity of Montpellier34396 MontpellierFrance Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture Chinese Academy of SciencesWuhanHubei 430072China Key Laboratory of Lake and Watershed Science for Water Security Chinese Academy of SciencesNanjingJiangsu 210008China

Meiotic recombination is essential for sexual reproduction and its regulation has been extensively studied in many ***,genome-wide recombination landscape has not been reported in ciliates and it remains unknown how it is affected by the unique features of ciliates:the synaptonemal complex(SC)-independent meiosis and the nuclear ***,we show the recombination landscape in the model ciliate Tetrahymena thermophila by analyzing single-nucleotide polymorphism datasets from 38 hybrid *** detect 1021 crossover(CO)events(35.8 per meiosis),corresponding to an overall CO rate of 9.9 cM/***,gene conversion by non-crossover is rare(1.03 per meiosis)and not biased towards G or C *** with the reported roles of SC in CO interference,we find no obvious sign of CO *** tends to occur within germ-soma common genomic regions and many of the 44 identified CO hotspots localize at the centromeric or subtelomeric *** ontology analyses show that CO hotspots are strongly associated with genes responding to environmental *** discuss these results with respect to how nuclear dimorphism has potentially driven the formation of the observed recombination landscape to facilitate environmental adaptation and the sharing of machinery among meiotic and somatic recombination.

关键词： Meiotic recombination Hotspot Crossover interference Adaptive evolution

Printable,flexible ceramic fiber paper based on electrospinning

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Rare Metals 2024年第6期43卷 2739-2746页

作者： yong-Shuai Xie Yuan Cheng Yang Lyu Rui Li jie-Cai Han National Key Laboratory of Science and Technology on Advanced Composites in Special Environments Harbin Institute of TechnologyHarbin 150001China State Key Laboratory of Intelligent Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhan 430074China

Based on the fact that it is challenging for the polymer flexible circuit substrates to meet the requirements of serving in high-temperature environments,this work proposed the idea of using printable ceramic fiber paper as a high-temperature flexible circuit substrate.A ceramic fiber paper with all ceramic components had been developed via electrospinning,solving the problems of low strength and severe strength drop at high temperatures of traditional ceramic fiber *** tensile strength of the prepared ceramic fiber paper is 2.63 MPa,and the reliable service temperature is 1200℃.Its bulk density is about 1.5 times that of traditional ceramic fiber *** can be printed with patterns by commercial inkjet printers like ordinary printing paper and has excellent *** feasibility of ceramic fiber paper as a flexible circuit substrate was verified by constructing a simple *** the fiber paper is significantly bent,the circuit still forms a complete path,which proves that it has a strong application potential for high-temperature flexible circuit substrate and is expected to promote the development of flexible electronic devices serving at extreme high-temperature environments.

关键词： Ceramic fiber paper High temperature Inkjet printing Flexible electronic

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A High-Accuracy Curve Boundary Recognition Method Based on the Lattice Boltzmann Method and Immersed Moving Boundary Method

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Computer Modeling in Engineering & Sciences 2024年第9期140卷 2533-2557页

作者： jie-Di Weng yong-Zheng Jiang Long-Chao Chen Xu Zhang guan-yong Zhang Hunan Provincial Key Laboratory of Health Maintenance for Mechanical Equipment Hunan University of Science and TechnologyXiangtan411201China School of Mechanical Engineering Hunan Chemical Vocational Technology CollegeZhuzhou412000China

Applying numerical simulation technology to investigate fluid-solid interaction involving complex curved bound-aries is vital in aircraft design,ocean,and construction ***,current methods such as Lattice Boltzmann(LBM)and the immersion boundary method based on solid ratio(IMB)have limitations in identifying custom curved ***,IBM based on velocity correction(IBM-VC)suffers from inaccuracies and numerical ***,this study introduces a high-accuracy curve boundary recognition method(IMB-CB),which identifies boundary nodes by moving the search box,and corrects the weighting function in LBM by calculating the solid ratio of the boundary nodes,achieving accurate recognition of custom curve *** addition,curve boundary image and dot methods are utilized to verify *** findings revealed that IMB-CB can accurately identify the boundary,showing an error of less than 1.8%with 500 ***,the flow in the custom curve boundary and aerodynamic characteristics of the NACA0012 airfoil are calculated and compared to *** showed that IMB-CB yields lower lift and drag coefficient errors than IBM-VC,with a 1.45%drag coefficient *** addition,the characteristic curve of IMB-CB is very stable,whereas that of IBM-VC is *** the moving boundary problem,LBM-IMB-CB with discrete element method(DEM)is capable of accurately simulating the physical phenomena of multi-moving particle flow in complex curved *** research proposes a new curve boundary recognition method,which can significantly promote the stability and accuracy of fluid-solid interaction simulations and thus has huge applications in engineering.

关键词： Fluid-solid interaction curve boundary recognition method Lattice Boltzmann method immersed moving boundary method