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Nomogram to predict severe retinopathy of prematurity in Southeast China

International Journal of Ophthalmology(English edition) 2024年第2期17卷 282-288页

作者： Dan Liu Xing-yong Li Hong-Wu He Ka-Lu Jin Ling-Xia Zhang Yang Zhou Zhi-Min Zhu Chen-Chen jiang Hai-jian Wu Sui-Lian Zheng Department of Ophthalmology the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Eye Hospital and School of Ophthalmology and Optometry Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Taizhou Optometry Hospital Taizhou 318001Zhejiang ProvinceChina Department of Ophthalmology Jiaxing Maternity and Child Health Care HospitalJiaxing 314009Zhejiang ProvinceChina Department of Ophthalmology Taizhou Women and Children’s Hospital of Wenzhou Medical UniversityTaizhou 318001Zhejiang ProvinceChina Clinical Medical Research Center the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Department of Ophthalmology Taizhou Municipal HospitalTaizhou 318099Zhejiang ProvinceChina

AIM:To define the predictive factors of severe retinopathy of prematurity(ROP)and develop a nomogram for predicting severe ROP in southeast ***:Totally 554 infants diagnosed with ROP hospitalized in the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University and hospitalized in Taizhou Women and Children’s Hospital were *** data and 43 candidate predictive factors of ROP infants were collected *** regression model was used to identify predictive factors of severe ROP and to propose a nomogram for individual risk prediction,which was compared with WINROP model and Digirop-Birth ***:Infants from the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University(n=478)were randomly allocated into training(n=402)and internal validation group(n=76).Infants from Taizhou Women and Children’s Hospital were set as external validation group(n=76).Severe ROP were found in 52 of 402 infants,12 of 76 infants,and 7 of 76 infants in training group,internal validation group,and external validation group,*** weight[odds ratio(OR),0.997;95%confidence interval(CI),0.996-0.999;Phan that of WINROP model and Digirop-Birth model(80.2 versus 51.1 and 63.4).The decision curve analysis of the nomogram demonstrated better clinical efficacy than that of WINROP model and Digirop-Birth *** calibration curves demonst

关键词： retinopathy of prematurity nomogram predictive factor birth weight multiple births non-invasive ventilation

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组合式轧辊轧制过程的稳定性分析

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中南大学学报（自然科学版） 2009年第1期40卷 164-168页

作者：向勇杨建军刘建华中南大学机电工程学院湖南长沙410083 涟源钢铁有限公司湖南娄底417009

采用MAC软件计算组合式轧辊辊芯与辊套温度场,建立相应的传热方程与热应力分析模型及其边界条件。研究结果表明:与轧件接触的轧辊表面的温度在开始轧制时迅速上升,随着轧制过程的进行,温度趋于呈稳定周期性变化,温度达到稳定的时间大约... 详细信息

采用MAC软件计算组合式轧辊辊芯与辊套温度场,建立相应的传热方程与热应力分析模型及其边界条件。研究结果表明:与轧件接触的轧辊表面的温度在开始轧制时迅速上升,随着轧制过程的进行,温度趋于呈稳定周期性变化,温度达到稳定的时间大约为2h;当轧辊旋转到与轧件接触处,温度达到最高,最高温度约为300℃,此时辊套轧辊结构稳定,据此生产的组合式轧辊在轧制过程中性能优越。

关键词：温度场有限元轧辊辊套

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一种在线微机械微波功率传感器的研究

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中国机械工程 2005年第Z1期16卷 135-137页

作者：韩磊廖小平朱健东南大学南京210096 南京电子器件研究所南京210016

介绍了一种在线微机械微波功率传感器的结构,该传感器用来连续监测来自于MMIC放大器或多级微波放大器各级之间的微波功率,它由功率取用、功率放大和功率测量三部分构成,分别用微带线定向耦合器、微波功率放大器和间接加热终端式微机械... 详细信息

介绍了一种在线微机械微波功率传感器的结构,该传感器用来连续监测来自于MMIC放大器或多级微波放大器各级之间的微波功率,它由功率取用、功率放大和功率测量三部分构成,分别用微带线定向耦合器、微波功率放大器和间接加热终端式微机械微波功率传感器实现.微波功率传感器通过嵌入到微波和毫米波单片集成电路中,实现微波功率的在线监测.

关键词：微波功率微机械功率传感器在线监测

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机械产品设计的过程建模

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北京航空航天大学学报 2000年第5期26卷 604-607页

作者：韩晓建邓家褆北京航空航天大学机械工程与自动化学院

产品设计是一种复杂的人类创造性思维活动 .在分析产品设计及其过程的基础上 ,利用集合与映射的理论与方法 ,依此建立了产品设计、产品设计过程、产品概念设计过程的模型 ,给出了产品概念设计过程的网络算法框图 ,并且详细定义了后者的... 详细信息

产品设计是一种复杂的人类创造性思维活动 .在分析产品设计及其过程的基础上 ,利用集合与映射的理论与方法 ,依此建立了产品设计、产品设计过程、产品概念设计过程的模型 ,给出了产品概念设计过程的网络算法框图 ,并且详细定义了后者的分解与综合的流程 ,为产品设计过程的模型化、规律化打下了良好的基础 ,同时也为产品全生命周期设计过程计算机软件支持工具的开发作出了有益的探索 .

关键词：机械产品产品设计过程建模网络算法框图

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LWB指定验证者签名方案证明的改进

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浙江大学学报（工学版） 2008年第3期42卷 434-436,501页

作者：廖永建陈抗生浙江大学信息与电子工程学系浙江杭州310027

针对不可授权的指定验证者签名LWB方案,由于其区分器构造的不合理,在不可伪造性证明过程中,导致其证明不正确的问题,在随机预言机模型下,重新构造了区分器,通过用统计测试的方法计算证明了四元组是Diffie-Hellman四元组的概率和随机四... 详细信息

针对不可授权的指定验证者签名LWB方案,由于其区分器构造的不合理,在不可伪造性证明过程中,导致其证明不正确的问题,在随机预言机模型下,重新构造了区分器,通过用统计测试的方法计算证明了四元组是Diffie-Hellman四元组的概率和随机四元组的概率,从而达到该区分器的预期目的,并证明在假设DDH问题为难问题的条件下,该方案在选择消息攻击情况下是不可伪造的,从而对LWB指定验证者签名方案的证明进行了改进,确保了该方案是安全可证明的.

关键词：指定验证者签名签名权授权随机预言机不可程序化

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Syndrome Differentiation of Chinese Medicine in Mars 500 Long-Term Closed Environment

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Chinese Journal of Integrative Medicine 2020年第6期26卷 428-433页

作者： SHI Hong-zhi FAN Quan-chun BAI Gui-e GAO jian-yi LIU Jun-lian MI Tao ZHAO Shuang LIU Yu GUO Li-guo XU Dong LI yong-zhi CHEN Kai-xian State Key Laboratory of Space Medicine Fundam entals and Application China Astronaut Research and Training CenterBeijing(100094)China Shanghai University of Traditional Chinese Medicine Shanghai(201203)China

Objective:To summarize and elucidate the characteristics and evolvement of Chinese medicine(CM)patterns reflecting the physical and mental conditions of participants in the Mars 500 long-term closed ***:The DS01-T Digital TCM Four-Diagnostic Instrument and CM Inquiring Diagnostic Questionnaire were used to collect information from 6 participants in the Mars 500 International Joint Research Project,through diagnostic methods of observation,palpation and inquiry according to CM *** the 520 days of the experiment,data collection was performed 37 times;a total of over 400 digital images of tongues and facial complexion and over 20,000 data were *** data were then analyzed by a team of experts in CM,statistics,and data ***:The CM pattern evolvement of participants in the long-term closed environment followed some common *** deficiency was the main CM pattern observed,with individual features depending on constitutional differences[manifested in varying degrees of accompanying patterns of Gan(Liver)qi stagnation,Pi(Spleen)deficiency,dampness encumbering,or yin deficiency].Conclusion:The research has verified the effectiveness of CM syndrome differentiation based on the four diagnostic methods,which should serve as a solid foundation for observation,monitoring,and intervention in regard to the health conditions of astronauts in long-term space flights in the future.

关键词： Mars 500 long-term closed environment health condition syndrome differentiation Chinese medicine

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美国再工业化对中国制造业国际竞争力的影响

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国际经贸探索 2016年第4期32卷 51-62页

作者：韩永彩中南财经政法大学工商管理学院湖北武汉430073 Wuzhou University

在经济全球化、生产任务化纵向深入的背景下,比较优势理论对美国再工业化战略后的政策效果和影响解释力不足。再工业化促使美国经济快速复苏,保持国际竞争力,是竞争力理论的新应用。基于波特钻石模型,采用中国制造业产业层面数据,结合... 详细信息

在经济全球化、生产任务化纵向深入的背景下,比较优势理论对美国再工业化战略后的政策效果和影响解释力不足。再工业化促使美国经济快速复苏,保持国际竞争力,是竞争力理论的新应用。基于波特钻石模型,采用中国制造业产业层面数据,结合基于附加值的RCA指标,将外资和中美进出口作为外在机遇,以跨时面板数据检验美国再工业化政策实施前后中国不同层级制造业国际竞争力的表现。结果显示,美国再工业化后,中国制造业国际竞争力受到外在冲击的影响呈明显的产业特征。政府加大劳动密集型产业研发投入,鼓励技术创新和应用,提高FDI质量,扩大从美国进口高技术中间品都是减少美国再工业化不利影响的有效途径。

关键词：再工业化国际竞争力制造业

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Therapeutic effects of the extract of Sancao Formula, a Chinese herbal compound, on imiquimod-induced psoriasis via cysteine-rich protein 61

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Journal of Integrative Medicine 2022年第4期20卷 376-384页

作者： Wan-jun Guo Yi Wang Yu Deng Lin-yan Cheng Xin Liu Ruo-fan Xi Sheng-jie Zhu Xin-yi Feng Liang Hua Kan Ze jian-yong Zhu Dong-jie Guo Fu-lun Li Department of Dermatology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China School of Medicine Chengdu UniversityChengdu 610106Sichuan ProvinceChina Institute of Cancer Biology and Drug Discovery Chengdu UniversityChengdu 610106Sichuan ProvinceChina Clinical Laboratory Medicine Center Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China

Objective: Psoriasis is a common chronic inflammatory skin disease that is prone to recurrence, and the proinflammatory factor, cysteine-rich protein 61(Cyr61), is important in its pathophysiology. Long-term clinical practice has shown that Sancao Formula(SC), a Chinese herbal compound, is effective in the treatment of psoriasis, but the precise mechanism remains unknown. In this study, we investigate the mechanism by which SC extract alleviates imiquimod(IMQ)-induced ***: The expression of Cyr61 in psoriatic lesions and normal healthy skin was detected using immunohistochemical analysis to investigate the biological role of Cyr61 in models of psoriatic inflammation. A psoriatic mouse model was established by topical application of IMQ, and the effect of topical application of SC extract was evaluated using the psoriasis area and severity index(PASI) score,hematoxylin-eosin staining, and histopathological features of the skin. Next, a HaCaT cell inflammation model was established using interferon-γ(IFN-γ), and the effect of SC extract on the mRNA and protein levels of Cyr61 and intercellular cell adhesion molecule-1(ICAM-1) was confirmed using Western blot and quantitative real-time polymerase chain reaction ***: Immunohistochemical staining showed that the expression of Cyr61 in psoriatic lesions was higher than that in normal skin samples(78.26% vs 41.18%, P han in normal skin(18.66 ± 2.51 vs4.33 ± 1.52, P < 0.05). Treatment in mice with IMQ-induced psoriasis showed that SC extract could significantly improve the inflammatory phenotype, PASI score(10.875 ± 0.744 vs 3.875 ± 0.582, P < 0.05),and pathological features compared with those in IMQ model group;SC treatment was also associated with decreased levels of Cyr61 and ICAM-1. In the IFN-γ-induced inflammatory cell model, the mRNA and protein levels of Cyr61 and ICAM-1 were upregulated, w

关键词： Traditional Chinese medicine Sancao Formula Psoriasis Plant extracts Cysteine-rich protein 61 Intercellular cell adhesion molecule-1

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The reproductive toxicity of saponins isolated from Cortex Albiziae in female mice

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Chinese Journal of Natural Medicines 2015年第2期13卷 119-126页

作者： SHU Yang CAO Mei YIN Zhong-Qiong LI Ping LI Tai-Qiang LONG Xing-Fa ZHU Lian-Fa JIA Ren-yong DAI Shu-Jun ZHAO jian College of Veterinary Medicine Sichuan Agricultural University Core Laboratory Sichuan Provincial People's Hospital Ganzi Prefecture Institute of Animal Science College of Life Sciences Sichuan University

Saponin frsom Cortex Albiziae(SCA) are extensively used in the clinical treatment of tumor and depression. However, SCA may cause several adverse effects, including reproductive toxicity. The present study was designed to assess the mechanism by which SCA cause reproductive toxicity in female mice. The general reproductive toxicity testing was accomplished in female Kunming mice. The animals were divided into four groups: three groups that were treated by oral gavage with 135, 270, and 540 mg·kg-1·d-1 of SCA prepared in physiological saline, respectively, and one vehicle control group that was treated with physiological saline only. The gestational toxicity tests were conducted at 540 mg·kg-1·d-1. The general reproductive toxicity results showed that the pregnancy rate of the SCA-treated group decreased with the pregnancy rate being decreased by 70% at 540 mg·kg-1·d-1. SCA elicited maternal toxicity in the ovary and the uterus, but no fetal toxicity or teratogenicity was observed. The rates of implantation in the early, middle, and late pregnancy were all decreased, with stillbirths and maternal deaths being observed. Histopathological changes showed that SCA adversely affected the ovary and the uterus. In conclusion, SCA-induced reproductive toxicity in female mice is most likely caused by its damage to the ovary and the uterus.

关键词： Saponin Cortex Albiziae Female mice Reproductive toxicity

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洞庭湖大桥承台大体积混凝土温控试验研究

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桥梁建设 2016年第4期46卷 45-50页

作者：张永健李鸥湖南省高速公路管理局湖南长沙410003 中铁大桥科学研究院有限公司湖北武汉430034

大岳高速洞庭湖大桥为(460+1 480+491)m钢桁梁悬索桥,其桥塔承台为哑铃形结构,每个塔柱的承台为长方形,平面尺寸23.5m(顺桥向)×30m(横桥向)×8m(厚度),混凝土用量5 597m3,为大体积混凝土。为避免施工过程中混凝土温升导致主拉应力过大... 详细信息

大岳高速洞庭湖大桥为(460+1 480+491)m钢桁梁悬索桥,其桥塔承台为哑铃形结构,每个塔柱的承台为长方形,平面尺寸23.5m(顺桥向)×30m(横桥向)×8m(厚度),混凝土用量5 597m3,为大体积混凝土。为避免施工过程中混凝土温升导致主拉应力过大,对大体积混凝土进行温控试验研究。在3个副孔承台采用不同的水泥,对其混凝土温度进行监测,采用有限元软件MIDAS计算桥塔承台混凝土温度和应力,并在承台内布置温度测点,对混凝土温度进行全程监测。结果表明:与普通硅酸盐水泥混凝土相比,低热水泥混凝土的温升值和平均升温速率均降低很多;在升温阶段和降温阶段,承台混凝土的主拉应力均小于容许应力;实测温度场的变化趋势与计算结果吻合较好。

关键词：承台大体积混凝土温度控制低热水泥主拉应力有限元法

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