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Cationic liposome-mediated transfection of CD40 ligand gene inhibits hepatic tumor growth of hepatocellular carcinoma in mice

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第1期10卷 7-13页

作者： yong-fang jiang jing ma yan he yong-hong zhang yun xu guo-zhong gong Center for Liver Diseases the Second Xiangya Hospital Central South University Changsha 410011 China

Objective: To evaluate the efficacy of cationic liposome-mediated CD40 ligand (CD40L) gene therapy for hepato- cellular carcinoma. Methods: 1×106 of parental H22 cells or H22 cells transfected with the expression vector containing murine CD40L cDNA encoding the entire coding region (pcDNA3.1+-mCD40L) were inoculated subcutaneously into the left flanks of syngenic BALB/C mice. The tumor-bearing mice (tumor nodules 10 mm in maximal diameter) received the treatment of the intratumoral injection of pcDNA3.1+-mCD40L/Transfectam, pcDNA3.1+, or phosphate-buffered saline (PBS), or no treatment. The mice were monitored for tumor growth weekly. We examined mCD40L messenger ribonucleic acid (mRNA) expression by reverse transcription polymerase chain reaction (RT-PCR) and the histologic changes in tumors at two weeks after intratumoral injection using immunohistochemical staining of tumor tissues. Results: All mice inoculated with parental H22 cells developed a tumor subcutaneously, and the tumor size increased progressively within three weeks. However, the mice receiving H22-CD40L cells exhibited complete regression of the tumor two weeks after tumor cell inoculation. The tumor-bearing animals with the treatment of pcDNA3.1+ or PBS, or without treatment had progressive tumor growth, while those mice treated with pcDNA3.1+-mCD40L exhibited a significant inhibition of tumor growth. RT-PCR analysis showed that 783-bp fragments cor- responding to the mCD40L mRNA were amplified only from pcDNA3.1+-mCD40L treated tumors. The tumor samples from pcDNA3.1+-mCD40L-treated mice showed significant lymphocyte infiltration, apoptotic bodies, and confluent necrosis in the tumor tissues. Conclusion: The tumorigenicity of CD40L-expressing cells was abrogated when the cells were implanted subcu- taneously. In vivo gene therapy of established liver tumor nodules in mice by the intratumoral injection of pcDNA3.1+-mCD40L led to significant tumor inhibition. There was mCD40L mRNA expression in the

关键词： CD40 ligand gene hepatocellular carcinoma (HCC) Cationic liposome Transfection

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The Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST)

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Research in Astronomy and Astrophysics 2012年第9期12卷 1197-1242页

作者： Xiang-Qun Cui yong-heng Zhao Yao-Quan Chu guo-Ping Li Qi Li Li-Ping zhang hong-Jun Su Zheng-Qiu Yao Ya-Nan Wang Xiao-Zheng Xing Xin-Nan Li yong-Tian Zhu Gang Wang Bo-zhong Gu A-Li Luo Xin-Qi xu Zhen-Chao zhang Gen-Rong Liu Hao-Tong zhang De-Hua yang Shu-yun Cao Hai-Yuan Chen Jian-Jun Chen Kun-Xin Chen Ying Chen Jia-Ru Chu Lei Feng xue-Fei gong yong-Hui Hou hong-Zhuan Hu Ning-Sheng Hu zhong-Wen Hu Lei Jia fang-Hua jiang Xiang jiang Zi-Bo jiang Ge Jin Ai-Hua Li yan Li Ye-Ping Li Guan-QunLiu Zhi-Gang Liu Huo-Ming Shi Zheng-hong Tang Qing-Sheng Tao Xiang-yan Yuan Chao Zhai jing zhang yan-Xia zhang yong zhang Ming Zhao fang Zhou guo-Hua Zhou Jie Zhu Si-Cheng Zou National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China yzhao @ *** Nanjing Institute of Astronomical Optics and Technology National Astronomical ObservatoriesChinese Academy of Sciences Nanjing 210042 China University of Science and Tecfinologyof China Hefei 230026 China Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 China Institute of Architecture Design and Research Chinese Academy of Sciences Beijing 100190China

The Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST, also called the guo Shou jing Telescope) is a special reflecting Schmidt telescope. LAMOST’s special design allows both a large aperture (effective aperture of 3.6 m–4.9 m) and a wide field of view (FOV) (5°). It has an innovative active reflecting Schmidt configuration which continuously changes the mirror’s surface that adjusts during the observation process and combines thin deformable mirror active optics with segmented active optics. Its primary mirror (6.67m×6.05 m) and active Schmidt mirror (5.74m×4.40 m) are both segmented, and composed of 37 and 24 hexagonal sub-mirrors respectively. By using a parallel controllable fiber positioning technique, the focal surface of 1.75 m in diameter can accommodate 4000 optical fibers. Also, LAMOST has 16 spectrographs with 32 CCD cameras. LAMOST will be the telescope with the highest rate of spectral acquisition. As a national large scientific project, the LAMOST project was formally proposed in 1996, and approved by the Chinese government in 1997. The construction started in 2001, was completed in 2008 and passed the official acceptance in June 2009. The LAMOST pilot survey was started in October 2011 and the spectroscopic survey will launch in September 2012. Up to now, LAMOST has released more than 480 000 spectra of objects. LAMOST will make an important contribution to the study of the large-scale structure of the Universe, structure and evolution of the Galaxy, and cross-identification of multiwaveband properties in celestial objects.

关键词： techniques: wide field telescope - active optics - multi fiber - spectroscopy survey - data reduction

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Site-testing at Muztagh-ata site Ⅰ:ground meteorology and sky brightness

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Research in Astronomy and Astrophysics 2020年第6期20卷 162-174页

作者： jing xu Ali Esamdin Jin-Xin Hao Jin-Min Bai Ji yang xu Zhou yong-Qiang Yao Jin-Liang Hou Guang-Xin Pu guo-Jie Feng Chun-Hai Bai Peng Wei Shu-guo ma Abudusaimaitijiang Yisikandee Le-Tian Wang xuan zhang Liang Ming Lu ma Jin-zhong Liu Zi-Huang Cao yong-heng Zhao Lu Feng Jian-Rong Shi Hua-Lin Chen Chong Pei Xiao-Jun jiang Jian-Feng Wang Jian-Feng Tian yan-Jie xue jing-Yao Hu yun-Ying jiang Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China University of Chinese Academy of Sciences Beijing 100049China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China yunnan Observatories Chinese Academy of SciencesKunming 650000China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210008 China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Nanjing Institute of Astronomical Optics&Technology Chinese Academy of SciencesNanjing 210008China

Site-testing is crucial for achieving the goal of scientific research and analysis of meteorological and optical observing conditions,one of the associated basic *** one of three potential sites to host the 12-meter Large Optical/infrared Telescope(LOT),the Muztagh-ata site,which is located on the Pamir Plateau in Xinjiang,in west China,began its site-testing task in the spring of *** this paper,we firstly start with an introduction to the site and then present a statistical analysis of the ground-level meteorological properties such as air temperature,barometric pressure,relative humidity,and wind speed and direction,recorded by an automatic weather station with standard meteorological sensors for a two-year *** also show the monitoring results of sky brightness during this period.

关键词： site testing meteorological condition optical observing

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Site testing at Muztagh-ata site Ⅱ:seeing statistics

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Research in Astronomy and Astrophysics 2020年第6期20卷 175-184页

作者： jing xu Ali Esamdin Jin-Xin Hao Jin-Min Bai Ji yang xu Zhou yong-Qiang Yao Jin-Liang Hou Guang-Xin Pu guo-Jie Feng Chun-Hai Bai Peng Wei Shu-guo ma Abudusaimaitijiang Yisikandee Le-Tian Wang xuan zhang Liang Ming Lu ma Jin-zhong Liu Zi-Huang Cao yong-heng Zhao Lu Feng Jian-Rong Shi Hua-Lin Chen Chong Pei Xiao-Jun jiang Jian-Feng Wang Jian-Feng Tian yan-Jie xue jing-Yao Hu yun-Ying jiang Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China University of Chinese Academy of Sciences Beijing 100049China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China yun nan Observatories Chin ese Academy of Scie ncesKun ming 650000China Purple Mountain Observatory Chinese Academy of SciencesNanjing 21000&China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Nanjing Institute of Astronomical Optics&Technology Chinese Academy of SciencesNanjing 210008China

In this article,we present a detailed analysis of the statistical properties of seeing for the Muztaghata site which is a candidate site for hosting the future Chinese Large Optical/infrared Telescope(LOT)*** measurements were obtained with differential image motion monitors(DIMMs)from April2017 to November 2018 at different heights during different *** median seeings at 11 m and6 m are very close but significantly different from that on the *** mainly analyzed the seeing at11 m monthly and hourly,having found that the best season for observing was from late autumn to early winter and seeing tended to improve during the night only in *** analysis of the dependence on temperature inversion,wind speed and direction also was made and the best meteorological conditions for seeing are given.

关键词： site testing seeing

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Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China

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Biomedical and Environmental Sciences 2020年第12期33卷 893-905页

作者： ma yan ZHU Dong Shan CheN Ren Bo SHI Nan Nan LIU Si hong FAN Yi Pin WU Gui Hui yanG Pu Ye BAI jiang Feng CheN hong CheN Li Ying FENG Qiao guo Tuan mao HOU yong HU Gui Fen HU Xiao Mei HU yun hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun yan LI Min Qing LI Qun Tang LI Xian yong LIU hong De LIU Jin Ping LIU zhang ma Yu Ting maO Ya MO Liu Fen NA Hui WANG jing Wei SONG fang Li SUN Sheng WANG Dong Ting WANG Ming xuan WANG Xiao yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO yan Hua XIE Hai Jun xu hong Ming xu Shou fang xuE Rui Xia yanG Chun yanG Kai Jun YUAN Sheng Li zhang gong Qi zhang Jin Bo zhang Lin Song ZHAO Shu Sen ZHAO Wan Ying ZheNG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing zhang Hua Min WANG yan Ping WANG yong yan 无 Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China Centre for health management and Policy Research School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012ShandongChina Institute of Information on Traditional Chinese Medicine China Academy of Chinese Medical SciencesBeijing 100700China Department of Tuberculosis The Public Health Clinical Center of ChengduChengdu 610066SichuanChina Department of Infectious Disease Shaanxi Infectious Disease HospitalXi'an 610113ShaanxiChina Department of Infectious Disease Yulin Chinese Medicine HospitalYulin 719000ShaanxiChina President's Office The First Hospital of QiqiharQiqihar 161005HeilongjiangChina Department of Traditional Chinese Medicine Shangluo Central HospitalShangluo 726000ShaanxiChina Department of Traditional Chinese Medicine The People's Hospital of QitaiheQitaihe 154603HeilongjiangChina Department of Scientific Research Xianyang Central HospitalXianyang 712000ShaanxiChina Department of traditional Chinese medicine The First Affiliated Hospital of Anhui University of Traditional Chinese MedicineHefei 230012AnhuiChina Department of Infectious Disease Heping Hospital Affiliated to Changzhi Medical CollegeChangzhi 046000ShanxiChina Department of Traditional Chinese Medicine Langfang Hospital of Chinese MedicineLangfang 065000HeibeiChina Department of Traditional Chinese Medicine Xingtai Hospital of Chinese MedicineXingtai 054001HeibeiChina Department of Traditional Chinese Medicine The People's Hospital of Guangxi Zhuang Autonomous RegionNanning 168600GuangxiChina Department of Traditional Chinese Medicine The First People'sHospital of FangchenggangFangchenggang 538001GuangxiChina Department of Traditional Chinese Medicine Mianyang Hospital of Traditional Chinese MedicineMianyang 621000SichuanChina Department of Traditional Chinese Medicine Liuzhou People's HospitalLiuzhou 545006GansuChina Department of Traditional Chinese Medici

Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains *** A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of *** Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two *** Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes.

关键词： Comorbidities COVID-19 Severity Gender Age Treatment outcome

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Specific pupylation as IDEntity reporter(SPIDER)for the identification of protein-biomolecule interactions

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Science China(Life Sciences) 2023年第8期66卷 1869-1887页

作者： he-Wei jiang hong Chen yun-Xiao Zheng xue-Ning Wang Qingfeng Meng Jin Xie Jiong zhang ChangSheng zhang Zhao-Wei xu Zi-Qing Chen Lei Wang Wei-Sha Kong Kuan Zhou Ming-Liang ma Hai-Nan zhang Shu-Juan guo Jun-Biao xue jing-Li Hou Zhe-Yi Liu Wen-xue Niu fang-Jun Wang Tao Wang Wei Li Rui-Na Wang yong-Jun Dang Daniel MCzajkowsky JianFeng Pei Jia-Jia Dong Sheng-Ce Tao Shanghai Center for Systems Biomedicine Key Laboratory of Systems Biomedicine(Ministry of Education)Shanghai Jiao Tong UniversityShanghai 200240China Center for Quantitative Biology Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100871China Inflammation and Immune Mediated Diseases Laboratory of Anhui Province School of PharmacyAnhui Medical UniversityHefei 230032China Key Laboratory of Organofluorine Chemistry Center for Excellence in Molecular SynthesisShanghai Institute of Organic ChemistryUniversity of the Chinese Academy of SciencesChinese Academy of SciencesShanghai 200240China College of Chemistry and Molecular Engineering Peking UniversityBeijing 100871China Key Laboratory of Gastrointestinal Cancer(Fujian Medical University) Ministry of EducationFuzhou 350122China Department of Molecular Biology Princeton UniversityNew Jersey 08540USA Instrumental Analysis Center Shanghai Jiao Tong UniversityShanghai 200240China CAS Key Laboratory of Separation Sciences for Analytical Chemistry Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China Institute of Systems Biology Shenzhen Bay LaboratoryPeking University Shenzhen Graduate SchoolShenzhen 518055China Department of Medicinal Chemistry School of PharmacyChina Pharmaceutical UniversityNanjing 211198China Key Laboratory of Metabolism and Molecular Medicine the Ministry of EducationDepartment of Biochemistry and Molecular BiologySchool of Basic Medical SciencesFudan UniversityShanghai 200240China Center for Novel Target and Therapeutic Intervention Chongqing Medical UniversityChongqing 400016China School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai 200240China

Protein-biomolecule interactions play pivotal roles in almost all biological *** a biomolecule of interest,the identification of the interacting protein(s)is *** this need,although many assays are available,highly robust and reliable methods are always *** combining a substrate-based proximity labeling activity from the pupylation pathway of Mycobacterium tuberculosis and the streptavidin(SA)-biotin system,we developed the Specific Pupylation as IDEntity Reporter(SPIDER)method for identifying protein-biomolecule *** SPIDER,we validated the interactions between the known binding proteins of protein,DNA,RNA,and small *** successfully applied SPIDER to construct the global protein interactome for m^(6)A and m RNA,identified a variety of uncharacterized m^(6)A binding proteins,and validated SRSF7 as a potential m^(6)A *** globally identified the binding proteins for lenalidomide and Cob ***,we identified SARS-CoV-2-specific receptors on the cell ***,SPIDER is powerful and highly accessible for the study of proteinbiomolecule interactions.

关键词： proximity labeling protein-biomolecule interaction proteomics pupylation

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Efficacy and safety of Shenyankangfu Tablet,a Chinese patent medicine,for primary glomerulonephritis:A multicenter randomized controlled trial

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Journal of Integrative Medicine 2021年第2期19卷 111-119页

作者： Jie Wu Shu-wei Duan hong-tao yang Yue-yi Deng Wei Li Ya-ni he Zhao-hui Ni yong-li Zhan Shan Lin Zhi-yong guo Jun Zhu jing-ai fang xu-sheng Liu Li-hua Wang Rong Wang Nian-song Wang Xiao-hong Cheng Li-qun he Ping Luo Shi-ren Sun Ji-feng Sun Ai-ping Yin Geng-ru jiang hong-yu Chen Wen-hu Liu hong-li Lin Meng Liang Lu ma Ming Chen Li-qun Song Jian Chen Qing Zhu Chang-ying Xing yun Li Ji-ning Gao Rong-shan Li Ying Li Hao zhang Ying Lu Qiao-ling Zhou Jun-zhou Fu Qiang he Guang-yan Cai Xiang-mei Chen Department of Nephrology Chinese People’s Liberation Army General HospitalChinese People’s Liberation Army Institute of NephrologyState Key Laboratory of Kidney Diseases(2011DAV00088)National Clinical Research Center for Kidney DiseasesBeijing 100853China Department of Nephrology First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300192China Department of Nephrology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Department of Nephrology Shandong University of Traditional Chinese Medicine Affiliated HospitalJinan 250011.Shandong ProvinceChina Department of Nephrology Daping HospitalArmy Medical UniversityChongqing 400042China Department of Nephrology Renji HospitalShanghai Jiao Tong UniversityShanghai 200127China Department of Nephrology Guang’anmen HospitalChina Academy of Traditional Chinese Medical SciencesBeijing 100053China Department of Nephrology Tianjin Medical University General HospitalTianjin 300052China Department of Nephrology Changhai Hospital of ShanghaiNaval Medical UniversityShanghai 200433China Department of Nephrology West China HospitalChengdu 610083Sichuan ProvinceChina Department of Nephrology First Affiliated Hospital of Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Department of Nephrology Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Department of Nephrology Shanxi Medical University Second Affiliated HospitalTaiyuan 030001Shanxi ProvinceChina Department of Nephrology Shandong Provincial HospitalJinan 250021Shandong ProvinceChina Department of Nephrology and Rheumatology Affiliated Sixth People’s HospitalShanghai Jiao Tong UniversityShanghai 200233China Department of Nephrology Shaanxi Traditional Chinese Medicine HospitalXi'an 710003Shaanxi ProvinceChina Department of Nephrology Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 200021China Department of Nephrology Jilin University Se

Background:Shenyankangfu Tablet(SYKFT)is a Chinese patent medicine that has been used widely to decrease proteinuria and the progression of chronic kidney ***:This trial compared the efficacy and safety of SYKFT,for the control of proteinuria in primary glomerulonephritis patients,against the standard drug,losartan ***,setting,participants and intervention:This was a multicenter,double-blind,randomized,controlled clinical *** glomerulonephritis patients,aged 18-70 years,with blood pressure≤140/90 mmHg,estimated glomerular filtration rate(eGFR)>45 mL/min per 1.73 ㎡,and 24-hour proteinuria level of 0.5-3.0 g,were recruited in 41 hospitals across 19 provinces in China and were randomly divided into five groups:SYKFT,losartan potassium 50 mg or 100 mg,SYKFT plus losartan potassium 50 mg or 100 *** outcome measu res:The primary outcome was change in the 24-hour proteinuria level,after 48 weeks of ***:A total of 735 participants were *** percent decline of urine protein quantification in the SYKFT group after 48 weeks was 8.78%±2.56%(P=0.006)more than that in the losartan 50 mg group,which was 0.51%±2.54%(P=1.000)less than that in the losartan 100 mg *** with the losartan potassium 50 mg group,the SYKFT plus losartan potassium 50 mg group had a 13.39%±2.49%(Phe losartan potassium 100 mg group,the SYKFT plus losartan potassium 100 mg group had a 9.77%±2.52%(P=0.001)greater reduction in urine *** a superiority threshold of 15%,neither was statistically ***,serum creatinine and serum albumin from the baseline did not change statistically *** average change in TCM syndrome score between the patients who took SYKFT(-3.00[-6.00,-2.00])and who did not take SYKFT(-2.00[-5.00,0])was statistically significant(P=0.003).No obvious adverse reactions were observed in any ***:SYKFT decreased the proteinur

关键词： herbal medicine,Chinese Shenyankangfu Tablet Primary glomerulonephritis Randomized controlled trial Double blind Double dummy

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Site testing campaign for the Large Optical/infrared Telescope of China:overview

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Research in Astronomy and Astrophysics 2020年第6期20卷 81-95页

作者： Lu Feng Jin-Xin Hao Zi-Huang Cao Jin-Min Bai Ji yang xu Zhou yong-Qiang Yao Jin-Liang Hou yong-heng Zhao Yu Liu Teng-Fei Song Li-yong Liu Jia Yin Hua-Lin Chen Chong Pei Ali Esamdin Lu ma Chun-Hai Bai Peng Wei jing xu Guang-Xin Pu guo-Jie Feng xuan zhang Liang Ming Abudusaimaitijiang Yisikandee Jian-Rong Shi Jian Li Yuan Tian Zheng Wang Xia Wang Xiao-Jun jiang Jian-Feng Wang Jian-Feng Tian yan-Jie xue Jian-Sheng Chen jing-Yao Hu Zhi-Xia Shen yun-Ying jiang National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China yunnan Observatories Chinese Academy of SciencesKunming 650216China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Nanjing Institute of Astronomical Optics&Technology Chinese Academy of SciencesNanjing 210042China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210033China University of Chinese Academy of Sciences Beijing 100049China

The Large Optical/infrared Telescope(LOT)is a ground-based 12 m diameter optical/infrared telescope which is proposed to be built in the western part of China in the next *** on satellite remote sensing data,along with geographical,logistical and political considerations,three candidate sites were chosen for ground-based astronomical performance *** sites include:Ali in Tibet,Daocheng in Sichuan and Muztagh-ata in *** until now,all three sites have continuously collected data for two *** this paper,we will introduce this site testing campaign,and present its monitoring results obtained during the period between march 2017 and march 2019.

关键词： techniques telescope-site testing

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Data processing and data products from 2017 to 2019 campaign of astronomical site testing at Ali,Daocheng and Muztagh-ata

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Research in Astronomy and Astrophysics 2020年第6期20卷 109-130页

作者： Zi-Huang Cao Jin-Xin Hao Lu Feng Hugh RAJones Jian Li jing xu Li-yong Liu Teng-Fei Song Jian-Feng Wang Hua-Lin Chen yan-Jie xue Huang Shen yong-heng Zhao Zhao-Xiang Qi Jian-Rong Shi Yuan Tian Zheng Wang Xia Wang Jin-Liang Hou Jin-Ming Bai Ji yang xu Zhou yong-Qiang Yao Jia Yin Ali Esamdin Guang-Xin Pu Peng Wei Chun-Hai Bai guo-Jie Feng Lu ma xuan zhang Yu Liu Chong Pei Zhi-Xia Shen yun-Ying jiang Jian-Feng Tian Xian-Qun Zeng Zhi-Gang Hou xu yang Jun-Bo zhang Shi-Long Liao Dong-Wei Fan yun-Fei xu Jian-Ping Xiong Tai-Sheng yan Xi zhang Chang-Hua Li Yi-Han Tao Si-Cheng Yu Zhi-Song Cao hong-Shuai Wang National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Centre for Astrophysics University of HertfordshireHatfieldUK School of Journalism Communication University of ChinaBeijing 100024China Nanjing Institute of Astronomical Optics&Technology Chinese Academy of SciencesNanjing 210042China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China yunnan Observatories Chinese Academy of SciencesKunming 650216China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210033China Beijing Kaiyang Space Technology Co. LtdBeijing 100085China

Based on previous site testing and satellite cloud data,Ali,Daocheng and Muztagh-ata have been selected as candidate sites for the Large Optical/Infrared Telescope(LOT) in *** present the data collection,processing,management and quality analysis for our site testing based on using similar *** analyze meteorological data,seeing,background light,cloud and precipitable water vapor data from 2017 march 10 to 2019 march *** also investigated the relative usefulness of our all-sky camera data in comparison to that from the meteorological TERRA satellite data based on a night-by-night comparison of the correlation and consistency between *** find a 6% discrepancy arising from a wide range of factors.

关键词： LOT Site-selection-data processing

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Long-term analysis of clear nights using satellite data considering astronomical sites in western China

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Research in Astronomy and Astrophysics 2020年第6期20卷 96-108页

作者： Zi-Huang Cao Li-yong Liu yong-heng Zhao Lu Feng Hugh RAJones Huang Shen Jin-Xin Hao yan-Jie xue yong-Qiang Yao jing xu Ali Esamdin Zhao-Xiang Qi Jian-Rong Shi Jian Li Yuan Tian Zheng Wang Tai-Sheng yan Xia Wang Jian-Ping Xiong Si-Cheng Yu Jun-Bo zhang Zhi-Xia Shen yun-Ying jiang Jia Yin Guang-Xin Pu Peng Wei Chun-Hai Bai guo-Jie Feng Lu ma Teng-Fei Song Jian-Feng Wang Jian-Feng Tian Xian-Qun Zeng Zhi-Gang Hou Shi-Long Liao Zhi-Song Cao Dong-Wei Fan yun-Fei xu Chang-Hua Li Yi-Han Tao National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Centre for Astrophysics University of HertfordshireHatfieldUK School of Journalism.Communication University of China Beijing 100024China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China yunnan Observatories Chinese Academy of SciencesKunming 650216China

A large ground-based optical/infrared telescope is being planned for a world-class astronomical site in *** cloud-free night percentage is the primary meteorological consideration for evaluating candidate *** data from GMS and NOAA satellites and the MODIS instrument were utilized in this research,covering the period from 1996 to *** data analysis benefits from overlapping results from different independent teams as well as a uniform analysis of selected sites using GMS+NOAA *** significant ground-based monitoring is needed to validate these findings,we identify three different geographical regions with a high percentage of cloud-free conditions(~83%on average),which is slightly lower than at mauna Kea and Cerro Armazones(~85%on average)and were chosen for the large international projects TMT and ELT *** study finds evidence that cloud distributions and the seasonal changes affected by the prevailing westerly winds and summer monsoons reduce the cloud cover in areas influenced by the *** is consistent with the expectations from climate change models and is suggestive that most of the identified sites will have reduced cloud cover in the future.

关键词： methods statistical-site testing-atmospheric effects-MODIS

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