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Correlations of the expression of Cx43,SCFFBXW7,p-cyclin E1(Ser73),p-cyclin E1(Thr77)and p-cyclin E1(Thr395)in colon cancer tissues

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 207-213页

作者： Rong-Gang Luan Ming-Da Liu Zi-Feng Deng Cong-Lan Lu Mei-Ling Yu Ming-Yu zhang Rong Liu Ran An You-Liang Yao Dong-Bei Guo yong-Xing zhang Lei Zhao Department of Gastrointestinal Surgery Air Force Hospital of Eastern TheaterAnhui Medical UniversityNanjing 230032Jiangsu ProvinceChina State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics School of Public HealthXiamen UniversityXiamen 361102Fujian ProvinceChina Trauma Surgery Air Force Hospital of Eastern TheaterAnhui Medical UniversityNanjing 230032Jiangsu ProvinceChina Department of Orthopaedics Air Force Hospital of Eastern TheaterAnhui Medical UniversityNanjing 230032Jiangsu ProvinceChina

BACKGROUND Previous cellular studies have demonstrated that elevated expression of Cx43 promotes the degradation of cyclin E1 and inhibits cell proliferation through ***,reduced expression results in a loss of this capacity to facilitate cyclin E *** ubiquitination and degradation of cyclin E1 may be associated with phosphorylation at specific sites on the protein,with Cx43 potentially enhancing this process by facilitating the phosphorylation of these critical *** To investigate the correlation between expression of Cx43,SKP1/Cullin1/F-box(SCF)FBXW7,p-cyclin E1(ser73,thr77,thr395)and clinicopathological indexes in colon *** Expression levels of Cx43,SCFFBXW7,p-cyclin E1(ser73,thr77,thr395)in 38 clinical colon cancer samples were detected by immunohistochemistry and were analyzed by statistical methods to discuss their *** Positive rate of Cx43,SCFFBXW7,p-cyclin E1(Ser73),p-cyclin E1(Thr77)and p-cyclin E1(Thr395)in detected samples were 76.32%,76.32%,65.79%,5.26%and 55.26%*** expressions of these proteins were not related to the tissue type,degree of tissue differentiation or lymph node ***43 and SCFFBXW7(r=0.749),p-cyclin E1(Ser73)(r=0.667)and p-cyclin E1(Thr395)(r=0.457),SCFFBXW7 and p-cyclin E1(Ser73)(r=0.703)and p-cyclin E1(Thr395)(0.415)were correlated in colon cancer(P<0.05),and expressions of the above proteins were positively correlated in colon *** Cx43 may facilitate the phosphorylation of cyclin E1 at the Ser73 and Thr195 sites through its interaction with SCFFBXW7,thereby influencing the ubiquitination and degradation of cyclin E1.

关键词： Colon cancer Cx43 SCFFBXW7 Phosphorylation of cyclin E1 Sites of cyclin E1 Correlation analysis

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侵犯商业秘密罪评价标准的修正与规范解读

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海南大学学报（人文社会科学版） 2025年第1期43卷 185-194页

作者：冯明昱张勇南京师范大学法学院江苏南京210023 华东政法大学刑事法学院上海200042

《刑法修正案(十一)》完成了侵犯商业秘密罪由数额犯到情节犯的全面转型,但未跟进更新的司法解释易使得司法实务将情节犯作数额犯化处理,仅关注数额要素对于犯罪评价的影响。侵犯商业秘密罪所保护的是复合法益:一是商业秘密权利人对商... 详细信息

《刑法修正案(十一)》完成了侵犯商业秘密罪由数额犯到情节犯的全面转型,但未跟进更新的司法解释易使得司法实务将情节犯作数额犯化处理,仅关注数额要素对于犯罪评价的影响。侵犯商业秘密罪所保护的是复合法益:一是商业秘密权利人对商业秘密享有的私权利,二是市场竞争秩序,后者又可还原为具体的个人法益——商业秘密权。以此为逻辑起点,侵犯商业秘密罪的评价体系应当坚持区分性、形式与实质相统一、强保护的原则,建构综合评价体系。各要素不可单独作为入罪标准,而应综合考量,建构起以数额要素为主,非数额要素为辅的“情节严重”解释体系。

关键词：侵犯商业秘密罪情节犯数额犯

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ImSpiRE: image feature-aided spatial resolution enhancement method

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Science China Life Sciences 2025年第01期 272-283页

作者： Yuwei Hua Yizhi zhang Zhenming Guo Shan Bian yong zhang State Key Laboratory of Cardiovascular Diseases and Medical Innovation Center Institute for Regenerative MedicineDepartment of NeurosurgeryShanghai East HospitalShanghai Key Laboratory of Signaling and Disease ResearchFrontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji University

The resolution of most spatially resolved transcriptomic technologies usually cannot attain the single-cell level, limiting their applications in biological discoveries. Here, we introduce ImSpiRE, an image feature-aided spatial resolution enhancement method for in situ capturing spatial transcriptome. Taking the information stored in histological images, ImSpiRE solves an optimal transport problem to redistribute the expression profiles of spots to construct new transcriptional profiles with enhanced resolution, together with extending the gene expression profiles into unmeasured regions. Applications to multiple datasets confirm that ImSpiRE can enhance spatial resolution to the subspot level while contributing to the discovery of tissue domains, signaling communication patterns, and spatiotemporal characterization.

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基于密度泛函理论研究Ag-Co团簇的结构、电子和光学性能

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原子与分子物理学报 2025年第2期42卷 63-69页

作者：李维银尚瑞咏王春勇张永莉北方民族大学电气信息工程学院物理与光电信息功能材料重点实验室微电子与固体电子器件研究中心银川750021

基于密度泛函理论研究了7个原子Ag-Co团簇结构的稳定性、电子和光学性能.研究结果表明,7个原子Ag-Co团簇的最稳定结构都是十面体结构,Co原子数量较少时,Co原子主要占据十面体的轴向位,Ag原子主要占据赤道位,随着Co原子数的增加,Co原子... 详细信息

基于密度泛函理论研究了7个原子Ag-Co团簇结构的稳定性、电子和光学性能.研究结果表明,7个原子Ag-Co团簇的最稳定结构都是十面体结构,Co原子数量较少时,Co原子主要占据十面体的轴向位,Ag原子主要占据赤道位,随着Co原子数的增加,Co原子逐渐替换了赤道位上的Ag原子.当Co原子数增加时,Ag-Co团簇的垂直电离势、垂直电子亲能和最高占据轨道与最低未占据轨道之间的能隙整体上都呈现出下降趋势,表明电子稳定性降低;Ag-Co团簇的吸收光谱整体出现了红移,吸收峰的强度逐渐减弱,吸收谱的宽度变窄.

关键词：银钴团簇几何结构电子性能光学性能

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A Chaotic System Based Image Encryption Scheme with Identical Encryption and Decryption Algorithm

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Chinese Journal of Electronics 2017年第5期26卷 1022-1031页

作者： zhang yong School of Software and Communication Engineering Jiangxi University of Finance and Economics

A new symmetric key image encryption scheme based on hyper-chaotic Lorenz system is *** encryption process and the decryption process are identical in the proposed *** both include two diffusion operations,one plaintext-related scrambling operation and three matrix rotating 180 degrees *** hyper-chaotic Lorenz system is employed to generate the secret code streams to encrypt the plain image,and to implement the diffusion process with XOR *** plaintext-related scrambling is used in this scheme to make different plain images correspond to different secret code streams even when the secret keys are the same,so that the scheme can fight against the chosen/known plaintext *** results show that the proposed scheme has the merits of high encryption speed,large key space,strong key sensitivity,strong plaintext sensitivity,good statistical properties of cipher-text,and etc.,and can be used in practical communications.

关键词： Image encryption Hyper-chaotic Lorenz system Identical encryption and decryption algorithm Plaintext-related scrambling Security analysis

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Electronic structures of impurities and point defects in semiconductors

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Chinese Physics B 2018年第11期27卷 358-371页

作者： yong zhang Department of Electrical and Computer Engineering University of North Carolina at Charlotte Charlotte NC 28223 US

A brief history of the impurity theories in semiconductors is provided. A bound exciton model is proposed for both donor-and acceptor-like impurities and point defects, which offers a unified understanding for ＂shallow＂ and ＂deep＂impurities and point defects. The underlying physics of computational results using different density-functional theorybased approaches are discussed and interpreted in the framework of the bound exciton model.

关键词： semiconductor shallow impurity deep impurity bound exciton density-functional theory effective-mass theory hydrogen model

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Research on physical layer traffic management schemes in serial RapidIO interconnect

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The Journal of China Universities of Posts and Telecommunications 2011年第1期18卷 64-69页

作者： zhang yong WANG yong zhang Ping Wireless Technology Innovation Institute Key Laboratory of Universal Wireless Communication Ministry of Education Beijing University of Posts and Telecommunications 13eijing 100876 China

A traffic management scheme in serial RapidlO （SR10） interconnect is proposed to deal with the performance degradation caused by noise and electromagnetic interference （EMI）, which is generated by hardly avoidable errors of hardware implementation and tough working environment. The main idea of this scheme includes adaptive speed transition and freeze-acknowledgement （freeze-ACK）. Adaptive speed transition can improve throughput and reduce delay in high bit error rate （BER） environment. Simultaneously, freeze-ACK is adopted to conquer frequent usage of feedback channel. Simulation shows that the scheme of combining adaptive speed transition with freeze-ACK offers great performance improvement in SRIO network.

关键词： serial RapidIO traffc management physical layer traffic management adaptive speed transition frecze-ACK

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Ground-State and Thermal Entanglement in Three-Spin Heisenberg-XXZ Chain with Three-Spin Interaction

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Communications in Theoretical Physics 2007年第2X期48卷 249-254页

作者： zhang yong Key Laboratory for Quantum Information and Measurements Department of Physics Tsinghua University Beijing 100084 China Department of Physics Beijing University of Posts and Telecommunications Beijing 100876 China Key Laboratory for Atomic and Molecular Nano-Sciences Tsinghua University Beijing 100084 China

The entanglement properties of a three-spin X X Z Heisenberg chain with three-spin interaction are studied by means of concurrence of pairwise entanglement. We show that ground-state pairwise entanglement, pairwise thermal entanglement, or quantum phase transition is not present in antiferromagnetic spin chain. For the ferromagnetic case, quantum phase transition takes place at A = 1 for anisotropic interaction and at some values of three-spin coupling strength, and pairwise thermal entanglement increases when the value of J/T increases and with anisotropic interaction and three-spin interaction decrease. In addition, we find that increasing the anisotropic interaction and the three-spin interaction will decrease critical temperature.

关键词： xspin chain thermal entanglement quantum phase transition

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A Note about Minimal Hypercones

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Acta Mathematica Sinica,English Series 2021年第11期37卷 1794-1802页

作者： yong Sheng zhang School of Mathematical Sciences&IAS Tongji UniversityShanghai 200092P.R.China

This short note is concerned with a measure version criterion for hypersurfaces to be *** natural flows and associated reflections for many minimal hypercones,including minimal isoparametric hypercones and area-minimi... 详细信息

关键词： Minimal hypercone measure invariant flow foliation

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Hydrothermal growth of Ni-based coatings on copper substrates

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International Journal of Minerals,Metallurgy and Materials 2012年第3期19卷 259-265页

作者： Fang Liu yong zhang School of Materials Science and Engineering Dalian Jiantong UniversityDalian 116028China

Ni-based coatings were deposited on copper substrates by a hydrothermal approach. The results showed that a Ni-based cellular microstructure was bridged by ＂fiber-like＂ products. A high microhardness of Hv 856 was achieved after 400℃ heat treatment, which is nine times that of copper substrates （Hv 95）. Nucleation, growth, and fusion of Ni atoms along the linear direction, induced by a linear-type cit- rate-metal structural ＂molecule template＂, led to in-situ growth of Ni-based fibers between cellular microspheres. After 400℃ heat treatment, the precipitation of NiP and Ni3P hard phases contributed to the high microhardness of Ni-based coatings.

关键词： nickel-based coatings fibers hydrothermal synthesis copper microhardness

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