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Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： yong-Chang Zeng Jun-Hong Wu Dan-Dan Xu Kang He Chang-Qing Liu Li-Fei Song Zheng-zhi Wu Qian-Qian Jiang Shao-Yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

Erosion behavior of a ship propeller material of QAl9-4 alloy

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Rare Metals 2023年第7期42卷 2390-2395页

作者： Wei-Jiu huang yong-Tao Zhou Zhen-Guo Wang zhi-Kang Liao School of Materials Science and Engineering Chongqing University of TechnologyChongqing400054China School of Materials Science and Engineering Beihang UniversityBeijing100191China

The erosion behavior of a QA19-4 alloy as a ship propeller material was *** effects of the solution,the impact angles and the sand content were *** test results demonstrate that the mass loss of the alloy in 3.5 wt%NaCl solution is 1.35 times that in tap water,due to the corrosive effect of Cl^(-).The mass loss of the alloy increases as the impact angle increases up to~30°and consequently decreases as the impact angle ***,this feature is typical for the ductile metal *** the impact angle of 0°,this feature is associated with the predominant erosion mechanisms,such as shallow plowing and surface fatigue;at 30°,this feature is micro-cutting,deep plowing and surface fatigue;and at 45°,it becomes indentation accompanied by extruded *** mass loss and surface roughness of the alloy increase as the sand content increases under the testing conditions.

关键词： Erosion QAl9-4 alloy Impact angle Sand content Erode surface

直接Z-型BAs/Ga_(2)SO范德华异质结光催化分解水研究

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原子与分子物理学报 2025年第6期42卷 10-16页

作者：许康黄欣杨志红南京邮电大学电子与光学工程学院、柔性电子(未来技术)学院南京210023 南京邮电大学理学院南京210023

基于第一性原理计算,系统研究了BAs/Ga_(2)SO异质结的光催化分解水性能.结果表明:BAs/Ga_(2)SO异质结具有良好的热力学稳定性并表现出交错的能带排列方式,带隙值为0.73 eV,界面处存在从BAs指向Ga_(2)SO的内建电场使其形成了直接Z-型异质... 详细信息

基于第一性原理计算,系统研究了BAs/Ga_(2)SO异质结的光催化分解水性能.结果表明:BAs/Ga_(2)SO异质结具有良好的热力学稳定性并表现出交错的能带排列方式,带隙值为0.73 eV,界面处存在从BAs指向Ga_(2)SO的内建电场使其形成了直接Z-型异质结,能够有效分离光生电子-空穴对.另外,异质结的带边位置可以跨越水的氧化还原电位,析氢反应发生在BAs侧而析氧反应发生在Ga_(2)SO侧.最后,基于吉布斯自由能变化计算,发现在有光照时,析氢和析氧反应在BAs/Ga_(2)SO异质结表面可自发进行.以上结果表明BAs/Ga_(2)SO异质结是有潜力的光催化分解水材料.

关键词：第一性原理计算直接Z型异质结光催化分解水吉布斯自由能

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IgA肾病308例临床与病理分析

中华全科医学 2011年第4期9卷 525-527页

作者：路杰许勇芝黄志清刘华锋广东医学院附属医院肾病研究所广东省湛江市524001

目的了解IgA肾病(IgAN)的临床与病理关系。方法回顾性分析1999年1月-2009年12月308例IgAN患者的临床与病理资料。结果本地区IgAN女性多见,发病高峰年龄为20～39岁,发病占同期原发性肾小球肾炎的16.9%,临床表现以无症状性尿检异常最常见... 详细信息

目的了解IgA肾病(IgAN)的临床与病理关系。方法回顾性分析1999年1月-2009年12月308例IgAN患者的临床与病理资料。结果本地区IgAN女性多见,发病高峰年龄为20～39岁,发病占同期原发性肾小球肾炎的16.9%,临床表现以无症状性尿检异常最常见,其次是肾病综合征和慢性肾炎,分别占36.0%、22.7%和22.5%。病理类型以系膜增生性肾小球肾炎常见,其次是局灶节段性肾小球硬化和局灶性肾小球肾炎,分别占47.5%3、3.1%和9.4%。本地区IgAN患者肾组织以IgA+IgM型免疫球蛋白沉积为主,各种临床类型和各种病理分型均与荧光类型无相关性(P>0.05)。结论 IgAN在青壮年期发生率高,临床病理表现多样化,临床以无症状尿检异常常见,病理以系膜增生性肾小球肾炎常见,定期尿检对于疾病的早期诊断和治疗具有重要作用。

关键词： IgA肾病刘盏床病理回顾性研究

Bending and free vibrational analysis of bi-directional functionally graded beams with circular cross-section

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Applied Mathematics and Mechanics(English Edition) 2020年第10期41卷 1497-1516页

作者： yong huang School of Mathematics and Big Data Foshan UniversityFoshan 528000Guangdong ProvinceChina

The bending and free vibrational behaviors of functionally graded(FG)cylindrical beams with radially and axially varying material inhomogeneities are *** on a high-order cylindrical beam model,where the shear deformation and rotary inertia are both considered,the two coupled governing differential motion equations for the deflection and rotation are *** analytical bending solutions for various boundary conditions are *** the vibrational analysis of FG cylindrical beams,the two governing equations are firstly changed to a single equation by means of an auxiliary function,and then the vibration mode is expanded into shifted Chebyshev *** examples are given to investigate the effects of the material gradient indices on the deflections,the stress distributions,and the eigenfrequencies of the cylindrical beams,*** comparing the obtained numerical results with those obtained by the three-dimensional(3D)elasticity theory and the Timoshenko beam theory,the effectiveness of the present approach is verified.

关键词： higher-order beam theory circular cross-section bi-directional functionally graded(FG)beam bending analysis free vibration

The role of innate immune cells in post-hepatectomy liver regeneration

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Hepatobiliary Surgery and Nutrition 2023年第2期12卷 267-268页

作者： yong-Fa huang zhi-Jun Zhu Liver Transplantation Center National Clinical Research Center for Digestive DiseasesBeijing Friendship HospitalCapital Medical UniversityBeijingChina Clinical Center for Pediatric Liver Transplantation Capital Medical UniversityBeijingChina

The fame of regeneration has been attributed to the liver ever since the era of Greek mythology,in which Prometheus’liver could grow back overnight against the daily predation of Zeus’*** is the very basis of liver surgery including liver transplantation,and post-hepatectomy liver regeneration remains the center of interest for both clinicians and *** tools for structural and functional assessment of liver regeneration have been constantly developed and validated,laying the groundwork for clinical management and scientific analysis(1).

关键词： Post-hepatectomy liver regeneration innate immune cell cytokine paracrine signaling

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鼻腔、鼻咽和副鼻窦恶性淋巴瘤CT诊断

实用医技杂志 2003年第7期10卷 723-724页

作者：曾庆勇何志辉黄少波惠州市中心人民医院广东惠州516001

目的 :研讨鼻腔、鼻咽和副鼻窦恶性淋巴瘤 CT表现 ,及时作出诊断和鉴别诊断。方法 :回顾分析经病理检查证实的 2 1例患者 CT资料。 19例使用岛津 SCT- 30 0 0 TF型 CT扫描机 ,3例使用西门子 Volume Zoom型多层螺旋CT扫描机 ,以 5 mm层厚... 详细信息

目的 :研讨鼻腔、鼻咽和副鼻窦恶性淋巴瘤 CT表现 ,及时作出诊断和鉴别诊断。方法 :回顾分析经病理检查证实的 2 1例患者 CT资料。 19例使用岛津 SCT- 30 0 0 TF型 CT扫描机 ,3例使用西门子 Volume Zoom型多层螺旋CT扫描机 ,以 5 mm层厚和 5 mm间隔作颅底及鼻咽部横断扫描 ,连续扫描 12～ 2 1层。结果 :原发于鼻腔者 12例 ,原发于鼻咽者 6例 ,原发于副鼻窦者 3例。结论 :CT是常规检查方法 ,能确定病变部位、范围和转移病灶 ,帮助临床估计病变预后和监测疗效。

关键词：鼻腔恶性淋巴瘤鼻咽恶性淋巴瘤副鼻窦恶性淋巴瘤 CT诊断鉴别诊断

SYNTHESIS AND PROPERTIES OF ACRYLIC-BASED SUPERABSORBENTS WITH ENHANCED CROSSLINKING ON PARTICLE SURFACE

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Chinese Journal of Polymer Science 2005年第5期23卷 463-469页

作者： Jian huang zhi-ming huang yong-zhong Bao zhi-xue Weng State Key Laboratory of Polymer Reaction Engineering,Zhejiang University,Hangzhou 310027,China State Key Laboratory of Polymer Reaction Engineering Zhejiang University Hangzhou 310027 China

A series of acrylic-based superabsorbent resins were synthesized by inverse suspension polymerization, using potassium persulfate as the initiator, N, N＇-methylene bisacrylamide （BIS） and divinylbenzene （DVB） as the multiple crosslinking agents. The morphology of the resulting superabsorbent resins revealed by SEM demonstrated that a hard shell layer was indeed formed due to surface crosslinking. The swelling and deswelling properties, and the mechanical strength of superabsorbents were investigated. The results indicated that the adding time of DVB and the amount of DVB participated in the crosslinking show a significant influence on the properties of superabsorbents. When DVB was added in polymerization later, the amount of DVB participated in reaction decreases and the surface crosslinked shell becomes thinner. It is suitable for DVB to be introduced in the later stage of the polymerization process, because the absorption rate of resin is efficiently improved in conjunction with higher water absorption. Furthermore, it was found that the mechanical strength of swollen superabsorbent with surface crosslinking was indeed enhanced in comparison with that of the conventional one.

关键词： Superabsorbet Inverse suspension polymerization Water absorption Surface crosslinking Mechanical strength.

EXPERIMENTAL STUDY ON THE SECOND-ORDER DIFFRACTION WAVE PRESSURE AND FORCE ON A CIRCULAR CYLINDER UNDER STOKES WAVE ACTION

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Journal of Hydrodynamics 1993年第2期5卷 94-103页

作者： Zhou, zhi-li Tian, yong-an Dai, Yi-shan huang, Wei-li Harbin Shipbuilding Engineering Inst Harbin China

This paper presents the model test to measure the second-order wave pressure and forces on a circular cylinder fixed in Stokes wave with a given draught. The distributions of second-order oscillating and steady wave pressure on the wet surface of the cylinder and second order oscillating wave forces were obtained in this test, but the second-order steady wave force was not able to be measured due to its very small magnitude. The test results also show that third-order wave force may be greater than the second-order force when wave frequencies are high. The experimental results were compared with the corresponding calculation results of Reference [3].

关键词： Cylinders (shapes) Diffraction Fluid structure interaction Force measurement Hydrodynamics Loads (forces) Mathematical models Pressure effects