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S100A4 over-expression underlies lymph node metastasis and poor prognosis in colorectal cancer

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World Journal of Gastroenterology 2011年第1期17卷 69-78页

作者： Li-yong huang Department of Colorectal Surgery Fudan University Shanghai Cancer Center Shanghai 200032 China Department of Oncology Shanghai Medical College Fudan University Shanghai 200032 China Department of Pathology Fudan University Shanghai Cancer Center Shanghai 200032 China Department of Chemistry Fudan University Shanghai 200032 China Institute of Biomedical Sciences Fudan University Shanghai 200032 China

AIM:To develop lymph node metastasis(LNM)-associated biomarkers for colorectal cancer(CRC) using quantitative proteome ***:Differences in protein expression between primary CRC with LNM(LNM CRC) and without LNM(non-LNM CRC) were assessed using methyl esterification stable isotope labeling coupled with 2D liquid chromatography followed by tandem mass spectrometry(2D-LC-MS/MS).The relationship to clinicopathological parameters and prognosis of candidate biomarkers was examined using an independent sample ***:Forty-three proteins were found to be differentially expressed by at least 2.5-fold in two types of CRC.S100A4 was significantly upregulated in LNM CRC compared with non-LNM CRC,which was confirmed by Western blotting,immunohistochemistry and real-time quantitative polymerase chain *** immunohistochemistry on another 112 CRC cases showed that overexpression of S100A4 frequently existed in LNM CRC compared with non-LNM CRC(P < 0.001).Overexpression of S100A4 was significantly associated with LNM(P < 0.001),advanced TNM stage(P < 0.001),increased 5-year recurrence rate(P < 0.001) and decreased 5-year overall survival rate(P < 0.001).Univariate and multivariate analyses indicated that S100A4 expression was an independent prognostic factor for recurrence and survival of CRC patients(P < 0.05).CONCLUSION:S100A4 might serve as a powerful biomarker for LNM and a prognostic factor in CRC.

关键词： Colorectal cancer Lymph node metastasis Prognosis Proteome analysis S100A4

Linear Time Algorithms for Parallel Machine Scheduling

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Acta Mathematica Sinica,English Series 2007年第1期23卷 137-146页

作者： zhi Yi TAN yong HE Department of Mathematics State Key Lab of CAD & CG Zhejiang University Hangzhou 310027 P. R. China Department of Mathematics Zhejiang University Hangzhou 310027 P. R. China

This paper addresses linear time algorithms for parallel machine scheduling problems. We introduce a kind of threshold algorithms and discuss their main features. Three linear time threshold algorithm classes DT, PT and DTm are studied thoroughly. For all classes, we study their best possible algorithms among each class. We also present their application to several scheduling problems, The new algorithms are better than classical algorithms in time complexity and/or worst-case ratio. Computer-aided proof technique is used in the proof of main results, which greatly simplifies the proof and decreases case by case analysis.

关键词： scheduling design and analysis of algorithm worst-case ratio computer-aided proof

Comparison of rhizosphere and endophytic microbial communities of Chinese leek through high-throughput 16S rRNA gene Illumina sequencing

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Journal of Integrative Agriculture 2018年第2期17卷 359-367页

作者： huang yong-hong College of Horticulture Qingdao Agricultural University

Chinese leek（Allium tuberosum Rottler ex Sprengel） is a common vegetable in China. In our previous study, Chinese leek in rotation was found to have significant antifungal and nematicidal activity. This study＇s aim was to investigate the potential antifungal and nematicidal activity associated with rhizosphere or endophytic microbes of Chinese leek. Thus, a total of 79 261 high-quality sequences were obtained from Chinese leek rhizosphere soil, leaf and root samples. In the rhizosphere soil, the bacterial community comprised five dominant phyla： Proteobacteria（37.85%）, Acidobacteria（10.99%）, Bacteroidetes（8.24%）, Cyanobacteria（7.79%） and Planctomycetes（7.1%）. The leaf and root bacterial communities comprised two dominant phyla： Cyanobacteria（83.42% in leaf and 75.44% in root） and Proteobacteria（14.75% in leaf and 21.04% in root）. Microbial diversity, richness and evenness in the rhizosphere soil bacterial community were higher than that in the endophytic bacterial communities. The rhizosphere bacterial community was significantly different from the endophytic bacterial communities. The endophytic bacterial communities from the leaf and the root were slightly, but not significantly different from each other. This study＇s findings would contribute to the isolation and identification of nematicidal and antifungal bacterial communities in Chinese leek.

关键词： Allium tuberosum Rottler ex Sprengel rhizosphere soil endophyte bacterial community Illumina sequencing

Synthesis, Structure and DFT Investigation into a Copper(II) Compound Consisting of 4,7-diphenyl-1,10-phentheanthroline

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Chinese Journal of Structural Chemistry 2005年第12期24卷 1375-1380页

作者： LI Hao-Hong CHEN zhi-Rong REN yong-Gang LI Jun-Qian huang Chang-Cang ZHAO Bin College of Chemistry and Chemical Engineering Fuzhou University Fuzhou Fujian 350002 China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterThe Chinese Academy of SciencesFuzhou Fujian 35002 China

The copper（Ⅱ） DPP adduct Cu（DPP）（DMF）2（H2O）-（ClO4）2 1 （DPP = 4,7-diphenyl-1, 10-phentheanthroline, DMF = N,N＇-dimethyl formamide） has been prepared by a direct synthetic method and structurally characterized. It presents a mononuclear structure and crystallizes in triclinic, space group P1 with a = 9.8717（2）, b = 12.579, c = 14.7574（2） A, α = 67.976（6）,β = 82.031（9）, γ = 80.343（9）°, V = 1668.96（9）A, Z = 1, Dc= 1.495 g/cm^3,/t（MoKα） = 0.877 mm^-1, F（000） = 774, C60H64Cl4Cu2N8O221 Mr = 1502.09, the final R1= 0.0643 and wR2 = 0.1799 for 6153 observed reflections with 1 〉 2σ（1）. Structure analysis shows that copper atom presents an unusual fivecoordination of square pyramid geometry. The whole structure is stabilized by π-π stacking interactions and static attractive forces from [ClO4]-anions. Based on crystal data, quantum chemistry calculation on DFF/B3LPY level was used to reveal the electronic structure of 1.

关键词： Cu(Ⅱ) complexes 4,7-diphenyl-1,10-phentheanthroline DFT calculation

Gastrointestinal symptoms in patients undergoing peritoneal dialysis: Multivariate analysis of correlated factors

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World Journal of Gastroenterology 2010年第22期16卷 2812-2817页

作者： Dong, Rui Guo, zhi-yong Second Mil Med Univ Changhai Hosp Dept Nephrol Shanghai 200433 Peoples R China

AIM: To investigate gastrointestinal (GI) symptoms in peritoneal dialysis (PD) patients and to explore related factors contributing to GI symptoms. METHODS: One hundred and twelve patients undergoing PD participated in the study. The gastrointestinal symptom rating scale was used for measuring GI symptoms. Information on age, height, weight, body mass index, disease leading to chronic renal failure, history of corticosteroid therapy, presence of predialytic GI symptoms, daily dosage of pills, and duration, type and daily dialysate volume of PD was obtained by interviewing patients and/or reviewing the medical records. Hemoglobin, albumin and Kt/V data were obtained from follow-up database. We used multiple regression analysis with stepwise backward variable selection to test for factors predicting GSRS scores with significance level of selection entry at 0.05 and selection of stay at 0.10. RESULTS: The prevalence of eating dysfunction, reflux and indigestion in the PD patients was 44.2%, 32.7%,32.7%, respectively. A history of corticosteroid therapy (b = 8.93, P 0.05. CONCLUSION: Eating dysfunction, reflux and indigestion were common in PD patients. Daily dosage of pills and corticosteroid history predicted GI symptoms, while residual renal function prevented them.

关键词： Eating dysfunction Gastroesophageal reflux Dyspepsia Peritoneal dialysis Residual renal function

Microstructure and deformation mechanism of dual-phase Al_(0.5)CoCrNiFe high-entropy alloy

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Rare Metals 2023年第6期42卷 2020-2027页

作者： yong-Gang Tong Nan Tian Hong-Feng huang zhi-Bin Zhang Xiu-Bing Liang Xi-Xi Ji Jing-Zhong Fang yong-Le Hu College of Automotive and Mechanical Engineering Changsha University of Science and TechnologyChangsha410114China Key Laboratory of New Processing Technology for Nonferrous Metal and Materials Guilin University of TechnologyMinistry of EducationGuilin541004China National Institute of Defense Technology Innovation Academy of Military Sciences PLA ChinaBeijing100071China

Dual-phase high-entropy alloys containing facecentered cubic(fcc) and body-centered cubic(bcc) phases achieve a combination of high strength and high ductility,which attract extensive *** with singlephase high-entropy alloys,the dual-phase structure generates more complex deformation mechanisms such as structural transformation and interactions between grain boundaries and dislocations during *** order to understand the structural transformation of the dual-phase high-entropy alloy during deformation and its effect on mechanical properties,Al_(0.5)CoCrNiFe high-entropy alloy was prepared and its deformation mechanism was investigated by molecular dynamics simulations combined with *** results show that phase transformation occurred during deformation,and dislocation slip was the main deformation *** addition,there was significant dislocation pile-up at the interface between fcc and bcc phases after tensile *** and strain rates significantly affected the mechanical properties and deformation behavior of high-entropy *** low temperature and high strain rate,the dislocation density of the alloy increases after stretching,resulting in the enhancement of tensile strength.

关键词： Dual-phase high-entropy alloy(HEA) Microstructure Deformation behavior Dislocation

Normalized Solution for p-Kirchhoff Equation with a L2-supercritical Growth

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Acta Mathematicae Applicatae Sinica 2024年第2期40卷 414-429页

作者： zhi-min REN yong-yi LAN School of Sciences Jimei UniversityXiamen 361005China

In this paper,we investigate the following p-Kirchhoff equation{∫R^(N)|u|^(2)dx=ρ,(a+b)∫RN(|Δu}^(p)+|u|^(p))dx)(-Δpu+|u|^(p-2u)=|u|^(s-2)u+μu,x∈R^(N),where a>0,b≥0,p>0 are constants,constants,p*=N-P/Np is the ... 详细信息

关键词： p-Kirchhoff equation normalized solution mountain-pass lemma

PIV analysis and high-speed photographic observation of cavitating flow field behind circular multi-orifice plates

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Water Science and Engineering 2020年第2期13卷 145-153页

作者： zhi-ping Guo Xi-huan Sun zhi-yong Dong College of Hydro-Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China Department of Transportation Engineering Shanxi Conservancy Technical InstituteYuncheng 044004China College of Civil Engineering and Architecture Zhejiang University of TechnologyHangzhou 310014China

Based on a self-developed hydrodynamic cavitation device with different geometric parameters for circular multi-orifice plates,turbulence characteristics of cavitating flow behind multi-orifice plates,including the effects of orifice number and orifice layout on longitudinal velocity,turbulence intensity,and Reynolds stress,were measured with the particle image velocimetry(PIV)*** regimes of the cavitating flow were also observed with high-speed *** experimental results showed the following:(1)high-velocity multiple cavitating jets occurred behind the multi-orifice plates,and the cavitating flow fields were characterized by topological structures;(2)the longitudinal velocity at each cross-section exhibited a sawtooth-like distribution close to the multi-orifice plate,and each sawtooth indicated one jet issuing from one orifice;(3)there were similar magnitudes and forms for the longitudinal and vertical turbulence intensities at the same cross-section;(4)the variation in amplitude of Reynolds stress increased with an increase in orifice number;and(5)the cavitation clouds in the flow fields became denser with the increase in orifice number,and the clouds generated by the staggered layout of orifices were greater in number than those generated by the checkerboard-type one for the same orifice *** experimental results can be used to analyze the mechanism of killing pathogenic microorganisms through hydrodynamic cavitation.

关键词： Cavitating flow Circular multi-orifice plate PIV technique High-speed photography Turbulence characteristics

输尿管软镜碎石术与腹腔镜输尿管切开取石术在输尿管上段嵌顿性结石中的应用

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中国医学创新 2025年第1期22卷 56-60页

作者：丁鹏照黄勇贵州医科大学附属肿瘤医院泌尿外科贵州贵阳550000

目的:探讨输尿管软镜碎石术(FURL)与腹腔镜输尿管切开取石术(LU)在输尿管上段嵌顿性结石患者中的应用价值。方法:回顾性分析2018年3月—2022年3月贵州医科大学附属肿瘤医院收治的102例输尿管上段嵌顿性结石患者的临床资料,根据所用手术... 详细信息

目的:探讨输尿管软镜碎石术(FURL)与腹腔镜输尿管切开取石术(LU)在输尿管上段嵌顿性结石患者中的应用价值。方法:回顾性分析2018年3月—2022年3月贵州医科大学附属肿瘤医院收治的102例输尿管上段嵌顿性结石患者的临床资料,根据所用手术方式分A组(采用FURL治疗)、B组(采用LU治疗),各51例。比较两组手术相关情况、结石清除率、视觉模拟评分法(VAS)评分、白蛋白、血红蛋白、肌酐差值及术后并发症发生情况。结果:A组手术时间、术后住院时间均短于B组,术中出血量少于B组,差异均有统计学意义(P0.05)。两组白蛋白、血红蛋白、肌酐差值及并发症发生率比较,差异均无统计学意义(P>0.05)。结论:在输尿管上段嵌顿性结石患者中,FURL、LU治疗各有其优劣势,LU治疗的结石清除率更高,但FURL的用时更短,出血量更少,且患者术后恢复更加迅速,需根据患者的临床实际进行合理选择。

关键词：输尿管上段结石结石嵌顿软镜碎石术输尿管切开取石术