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Investigation of bubbles escape behavior from low basicity mold flux for high-Mn high-Al steels using 3D X-ray microscope

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 102-110页

作者： Qiang liu Xiang li Shen Du Ming Gao Yanbin yin Jiongming Zhang State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

During the continuous casting process of high-Mn high-Al steels,various types of gases such as Ar need to escape through the top of the *** which,the behavior of bubbles traversing the liquid slag serves as a restrictive link,closely associated with viscosity and the thickness of liquid *** contrast to two-dimensional surface observation,three-dimensional(3D)analysis method can offer a more intuitive,accurate,and comprehensive ***,this study employs a 3D X-ray microscope(3D-XRM)to obtained spatial distribution and 3D morphological characteristics of residual bubbles in mold flux under different basicity of liquid slag,different temperatures,and different holding *** results indicate that as basicity of slag increases from 0.52 to 1.03,temperature increases from 1423 to 1573 K,the viscosity of slag decreases,the floating rate of bubbles *** addition,when holding time increases from 10 to 30 s,the bubbles floating distance increases,and the volume fraction and average equivalent sphere diameter of the bubbles solidified in the mold flux gradually *** one word,increasing the basicity,temperature,and holding time leading to an increase in the removal rate of bubbles especially for the *** findings of bubbles escape behavior provide valuable insights into optimizing low basicity mold flux for high-Mn high-Al steels.

关键词： mold flux low basicity bubbles three-dimensional X-ray microscope viscosity

Inhibition of the NLRP3 inflammasome attenuates spiral ganglion neuron degeneration in aminoglycoside-induced hearing loss

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Neural Regeneration Research 2025年第10期20卷 3025-3039页

作者： Jia Fang Zhuangzhuang li Pengjun Wang Xiaoxu Zhang Song Mao yini li Dongzhen Yu Xiaoyan li Yazhi Xing Haibo Shi Shankai yin Department of Otolaryngology Head and Neck Surgery Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineOtolaryngology Institute of Shanghai Jiao Tong UniversityShanghai Key Laboratory of Sleep Disordered BreathingShanghaiChina Department of Otorhinolaryngology-Head and Neck Surgery Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

Aminoglycosides are a widely used class of antibacterials renowned for their effectiveness and broad antimicrobial ***,their use leads to irreversible hearing damage by causing apoptosis of hair cells as their direct *** addition,the hearing damage caused by aminoglycosides involves damage of spiral ganglion neurons upon *** investigate the mechanisms underlying spiral ganglion neuron degeneration induced by aminoglycosides,we used a C57BL/6J mouse model treated with *** found that the mice exhibited auditory deficits following the acute loss of outer hair *** ganglion neurons displayed hallmarks of pyroptosis and exhibited progressive degeneration over *** profiling of these neurons showed significant upregulation of genes associated with inflammation and immune response,particularly those related to the NLRP3 *** of the canonical pyroptotic pathway in spiral ganglion neurons was observed,accompanied by infiltration of macrophages and the release of proinflammatory *** intervention targeting NLRP3 using Mcc950 and genetic intervention using NLRP3 knockout ameliorated spiral ganglion neuron degeneration in the injury *** findings suggest that NLRP3 inflammasome-mediated pyroptosis plays a role in aminoglycoside-induced spiral ganglion neuron *** of this pathway may offer a potential therapeutic strategy for treating sensorineural hearing loss by reducing spiral ganglion neuron degeneration.

关键词： degeneration hearing loss macrophages Mcc950 neuroinflammation NLRP3 inflammasome ototoxicity pyroptosis sensorineural hearing loss spiral ganglion neuron

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王士禛与傅扆诗文交游述论

泰山学院学报 2024年第2期46卷 74-79页

作者：尹勇力巩曰国山东理工大学齐文化研究院山东淄博255000

王士禛是活跃于清初文坛的重要人物,一生交游广泛。在王士禛众多朋辈中,傅扆与他的关系较为密切。二人为同邑同年好友,有近三十年的交谊。在他们的长期交往中,诗文是重要媒介。入仕前王士禛与傅扆早有诗文交流,后因同上公车的经历而益... 详细信息

王士禛是活跃于清初文坛的重要人物,一生交游广泛。在王士禛众多朋辈中,傅扆与他的关系较为密切。二人为同邑同年好友,有近三十年的交谊。在他们的长期交往中,诗文是重要媒介。入仕前王士禛与傅扆早有诗文交流,后因同上公车的经历而益加密切。王士禛入仕后,与傅扆的诗文交游也未曾断绝。他不仅与傅扆相互赋诗酬赠,还曾为傅扆校订诗集、题写序跋、撰写墓志。深厚的同乡情谊、相近的处事原则、共同的兴趣爱好,是二人成为挚友的重要原因。梳理其交游情况,可以推进王士禛生平、交游及文学活动的研究,从而增进对清初山左诗坛的认识。

关键词：王士禛傅扆交游

Reduced mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor contributes to neurodegeneration in a model of spinal and bulbar muscular atrophy pathology

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Neural Regeneration Research 2025年第9期20卷 2655-2666页

作者： Yiyang Qin Wenzhen Zhu Tingting Guo Yiran Zhang Tingting Xing Peng yin Shihua li Xiao-Jiang li Su Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong–HongKong–Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina

Spinal and bulbar muscular atrophy is a neurodegenerative disease caused by extended CAG trinucleotide repeats in the androgen receptor gene,which encodes a ligand-dependent transcription facto *** mutant androgen receptor protein,characterized by polyglutamine expansion,is prone to misfolding and forms aggregates in both the nucleus and cytoplasm in the brain in spinal and bulbar muscular atrophy *** aggregates alter protein-protein interactions and compromise transcriptional *** this study,we reported that in both cultured N2a cells and mouse brain,mutant androgen receptor with polyglutamine expansion causes reduced expression of mesencephalic astrocyte-de rived neurotrophic *** n of mesencephalic astrocyte-derived neurotrophic factor amelio rated the neurotoxicity of mutant androgen receptor through the inhibition of mutant androgen receptor *** down endogenous mesencephalic astrocyte-derived neurotrophic factor in the mouse brain exacerbated neuronal damage and mutant androgen receptor *** findings suggest that inhibition of mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor is a potential mechanism underlying neurodegeneration in spinal and bulbar muscular atrophy.

关键词： androgen receptor mesencephalic astrocyte-derived neurotrophic factor mouse model neurodegeneration neuronal loss neurotrophic factor polyglutamine disease protein misfolding spinal and bulbar muscular atrophy transcription factor

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微重力环境中热厚材料着火特性研究

工程热物理学报 2018年第1期39卷 213-217页

作者：朱凤王双峰尹永利刘仁豪杨京松田柳中国科学院力学研究所中国科学院微重力重点实验室北京100190 中国科学院大学工程科学学院北京100049 中国航天员科研训练中心北京100094

在空间微重力环境中,对聚甲基丙烯酸甲酯(PMMA)试样进行点燃实验,研究了不同氧气浓度和环境压力条件下热厚材料的着火特性。结果表明,在研究涉及的实验条件下,材料均可被点燃。外加热源消失后,氧气浓度较高时,点火形成的材料表面火焰可... 详细信息

在空间微重力环境中,对聚甲基丙烯酸甲酯(PMMA)试样进行点燃实验,研究了不同氧气浓度和环境压力条件下热厚材料的着火特性。结果表明,在研究涉及的实验条件下,材料均可被点燃。外加热源消失后,氧气浓度较高时,点火形成的材料表面火焰可以自维持并稳定传播,而氧气浓度较低时,火焰不能自维持并最终熄灭。材料着火具有爆发性,材料热解形成的可燃气瞬间被点燃形成火焰。重复点火时,材料可以被点燃,但外加热源消失后火焰不能维持传播,材料着火过程中散发出大量的发光颗粒并随气流迁移,存在引燃周围易燃物的风险。材料着火后形成的稳定火焰总是朝着与气流流动相反的方向运动,即火焰逆风传播,没有出现顺风传播的现象。

关键词：热厚材料着火火焰传播微重力实践十号卫星

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某航天装置的动态特性分析及结构修改

航天医学与医学工程 2009年第6期22卷 412-416页

作者：王春旺傅岚高峰尹永利中国航天员科研训练中心北京100094

目的研究某航天装置的振动特性和动力响应特性,为其结构振动预测、动力学结构的修改与设计提供理论依据。方法利用有限元软件***/Nastran建立该航天装置的有限元模型,进行模态分析和频率响应分析,并与试验测量结果进行了比较,两者基本... 详细信息

目的研究某航天装置的振动特性和动力响应特性,为其结构振动预测、动力学结构的修改与设计提供理论依据。方法利用有限元软件***/Nastran建立该航天装置的有限元模型,进行模态分析和频率响应分析,并与试验测量结果进行了比较,两者基本相符。根据模态分析和频率响应分析结果对该航天装置的薄弱环节进行修改。结果有限元分析和试验相比频率误差在3.1%以内,加速度响应误差在11.9%以内,说明有限元模型的模拟形式是准确的。修改后结构的响应降低了50%左右。结论该方法为复杂结构振动特性分析提供了可行的技术途径,缩短了研制周期、降低了成本。

关键词：动态特性结构修改航天装置

Mutual regulation of microglia and astrocytes after Gas6 inhibits spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 557-573页

作者： Jiewen Chen Xiaolin Zeng Le Wang Wenwu Zhang Gang li Xing Cheng Peiqiang Su yong Wan Xiang li Department of Spine Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Guangdong Province Key Laboratory of Orthopedics and Traumatology GuangzhouGuangdong ProvinceChina

Invasive inflammation and excessive scar formation are the main reasons for the difficulty in repairing nervous tissue after spinal cord *** and astrocytes play key roles in the spinal cord injury micro-environment and share a close ***,the mechanisms involved remain *** this study,we found that after spinal cord injury,resting microglia(M0)were polarized into pro-inflammatory phenotypes(MG1 and MG3),while resting astrocytes were polarized into reactive and scar-forming *** expression of growth arrest-specific 6(Gas6)and its receptor Axl were significantly down-regulated in microglia and astrocytes after spinal cord *** vitro experiments showed that Gas6 had negative effects on the polarization of reactive astrocytes and pro-inflammatory microglia,and even inhibited the cross-regulation between *** further demonstrated that Gas6 can inhibit the polarization of reactive astrocytes by suppressing the activation of the Yes-associated protein signaling ***,in turn,inhibited the polarization of pro-inflammatory microglia by suppressing the activation of the nuclear factor-κB/p65 and Janus kinase/signal transducer and activator of transcription signaling *** vivo experiments showed that Gas6 inhibited the polarization of pro-inflammatory microglia and reactive astrocytes in the injured spinal cord,thereby promoting tissue repair and motor function ***,Gas6 may play a role in the treatment of spinal cord *** can inhibit the inflammatory pathway of microglia and polarization of astrocytes,attenuate the interaction between microglia and astrocytes in the inflammatory microenvironment,and thereby alleviate local inflammation and reduce scar formation in the spinal cord.

关键词： astrocytes Axl cell polarization Gas6 Hippo signal inflammatory micro-environment intercellular interaction microglia single-cell sequencing spinal cord injury

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水电解制氢在电力储能系统中的应用模式

电力电子技术 2020年第12期54卷 37-40,51页

作者：刘晓天尹永利郑尧任会平深圳市绿航星际太空科技研究院广东深圳518055 中国航天员科研训练中心人因工程重点实验室北京100094 四川航电微能源有限公司四川成都610051

随着可再生能源在国家能源体系中的比例越来越高,建立合理的可再生能源储能和应用体系十分重要。氢储能具有存储范围大、存储时间长等特点,很适合与可再生能源结合。这里从构建氢储能体系的角度出发,介绍并对比了不同水电解制氢技术的... 详细信息

随着可再生能源在国家能源体系中的比例越来越高,建立合理的可再生能源储能和应用体系十分重要。氢储能具有存储范围大、存储时间长等特点,很适合与可再生能源结合。这里从构建氢储能体系的角度出发,介绍并对比了不同水电解制氢技术的发展状况,质子交换膜(PEM)水电解制氢技术具有电流密度高、耐功率波动范围大、响应时间快、更适用于可再生能源的发电特点。此外,还对氢储能的应用模式进行了深入分析,分别针对用电侧和发电侧方向,描述了适合氢储能的多种应用模式,为推进可再生能源与氢储能的快速发展和市场化应用指明了方向。

关键词：氢储能可再生能源储能系统

Confining li_(2)O_(2) in tortuous pores of mesoporous cathodes to facilitate low charge overpotentials for li-O_(2) batteries

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Journal of Energy Chemistry 2021年第4期30卷 55-61页

作者： yin Zhou yong Zhao Zhenjie liu Zhangquan Peng li Wang Wei Chen Department of Chemistry National University of Singapore3 Science Drive 3117543Singapore Institute for Advanced Study and Department of Physics Nanchang UniversityNanchang 330031JiangxiChina National University of Singapore(Suzhou)Research Institute Suzhou 215123JiangsuChina State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022JilinChina Department of Physics National University of Singapore2 Science Drive 3117542Singapore Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityBinhai New CityFuzhou 350207FujianChina

Achieving low charge overpotentials represents one of the most critical challenges for pursuing highperformance lithium-oxygen(li-O_(2))***,we propose a strategy to realize low charge overpotentials by confining the growth of lithium peroxide(li_(2)O_(2))inside mesoporous channels of cathodes(CMK-8).The CMK-8 cathode with tortuous pore structures can extend the diffusion distance of lithium superoxide(liO_(2))in the mesoporous channels,facilitating the further reduction of liO_(2) to lithium peroxide(li_(2)O_(2))inside the pores and preventing them to be diffused out of the ***,li_(2)O_(2) is trapped in the mesoporous channels of CMK-8 cathodes,ensuring a good li_(2)O_(2)/CMK-8 contact *** CMK-8 electrode exhibits a low charge overpotential of 0.43 V and a good cycle life for 72 cycles with a fixed capacity of 500 m Ah g^(-1) at 0.1 A g^(-1).This study proposes a strategy to achieve a low charge overpotential by confining li_(2)O_(2) growth in the mesoporous channels of cathodes.

关键词： lithium-oxygen CMK-8 cathode Charge overpotential lithium superoxide Cycle performance