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Synthesis of novel benzo[b]pyrimido[4',5':5,4]thieno[2,3-e][1,6]naphthyridine-8-ones via Pictet–Spengler cyclization

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Chinese Chemical Letters 2016年第2期27卷 261-264页

作者： Dao-Lin wang Xiao-Ce Shi yong-yang wang Jian Ma College of Chemistry and Chemical Engineering Liaoning Key Laboratory of Synthesis and Application of Functional Compound Bohai University

An efficient method for the synthesis of novel benzo[b]pyrimido[4′,5′：5,4]thieno[2,3e]-[1,6]naphthyridine-8-one derivatives via Pictet-Spengler cyclization is reported. The reaction of 4-（3-aminopyrimido[4,5-d]thieno-2-yl）quinoline-2-ones, which could be obtained from Thorpe-Ziegler isomerization of 4-bromomethylquinoline-2-ones and 5-cyano-1,6-dihydro-4-methyl-2-phenyl-6-thioxopyrimidine,with aromatic aldehydes in the presence of BF3·OEt2 gives pyrimidothieno[1,6]naphthyridines in good yields.

关键词： 4-Bromomethylquinoline-2-one 5-Cyano-6-thioxopyrimidine Pyrimido[4′,5′:5,4]thieno[2-3e]naphthyridine Thorpe-Ziegler reaction Pictet-Spengler reaction

An efficient synthesis of novel benzo[b]pyrido[3',2':4,5]thieno[2,3-e][1,6]naphthy-ridine-8-ones

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Chinese Chemical Letters 2015年第9期26卷 1109-1112页

作者： Dao-Lin wang yong-yang wang Xiao-Ce Shi Jian Ma College of Chemistry and Chemical Engineering Liaoning Key Laboratory of Synthesis and Application of Functional Compound Bohai University

An efficient method for the synthesis of novel benzo[b]pyrido[3＇,2＇：4,5]thieno[2,3-e][l,6]naphthyridine-8-one derivatives has been developed using a Pictet-Spengler reaction between 4-（3-aminothieno[2,3-b]pyridin-2-yl）quinoline-2-ones,which could be obtained from the alkylation of4-bromomethylquinoline-2-ones with 3-cyanopyridine-2-thione followed by a Thorpe-Ziegler isomerization,and aromatic aldehydes under p-TsOH as catalysis in good yields.

关键词： 4-Bromomethylquinoline-2-one 3-Cyanopyridine-2-thione Benzo[b]pyrido[3' 2':4 5 ]thieno[23-e][1 6] naphthyridine-8-one Thorpe-Ziegler reaction Pictet-Spengler reaction

Inverse Spin Hall Effect in Two-Terminal Device with Rashba Spin-Orbit Coupling

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Communications in Theoretical Physics 2009年第12期52卷 1107-1112页

作者： ZHANG Jing-Jing LIANG Feng yang yong-Hong wang Jun Department of Physics Southeast University Nanjing 211189 China

We report a theoretic study on the inverse spin-Hall effect （ISHE） in a two-terminal nano-device that consists of a two-dimensional electron gas （2DEG） with Rashba spin-orbit coupling （RSOC） and two ideal leads. Based on a two-site toy model and Keldysh Green＇s function method, we derive an analytic result of ISHE, which shows clearly that a nonzero transverse charge current stems from the combined effect of the RSOC, the spin bias, and its spin polarization direction in spin space. Our further numerical calculations in a larger system other than two-site lattice model demonstrate that the transverse charge current, dependent on the strength of the RSOC, the Fermi energy of the system, as well as the system size, can exhibit oscillating behavior and even reverse its sign due to Rashba spin precession. These properties may be helpful for eficient detection of the spin current （spin bias） by measuring the transverse charge current in a spin-orbital coupling system.

关键词： spin Hall effect spin-orbital coupling inverse spin-Hall effect Keldysh Green's function

Consensus of Second-order Multi-agent Systems with Nonsymmetric Interconnection and Heterogeneous Delays

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International Journal of Automation and computing 2011年第4期8卷 421-428页

作者： Hong-yong yang Fu-Cai wang Si-Ying Zhang School of Information Science and Engineering Ludong University Yantai 264025 PRC

In this paper, a consensus algorithm of multi-agent second-order dynamical systems with nonsymmetric interconnection and heterogeneous delays is studied. With the hypothesis of directed weighted topology graph with a globally reachable node, decentralized consensus condition is obtained by applying generalized Nyquist criterion. For the systems with both communication and input delays, it is shown that the consensus condition is dependent on input delays but independent of communication delays.

关键词： Consensus nonsymmetric interconnection second-order multi-agent systems heterogeneous delays.

An efficient synthesis of benzo[b]benzofurano[2,3-e]-[1,6]naphthyridine-8-ones

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Chinese Chemical Letters 2015年第2期26卷 251-254页

作者： Dao-Lin wang Dan Wu Wei Zhao yong-yang wang Jian-Ying Wu College of Chemistry and Chemical Engineering Liaoning Key Laboratory of Synthesis and Application of Functional CompoundBohai University

An efficient method for the synthesis of benzo[b]benzofurano[2,3-e][1,6]naphthyridine-8-one derivatives has been developed via Pictet-Spengler reaction of 4-（3-aminobenzofuran-2-yl）quinoline-2-ones,which could be obtained from alkylation of 4-bromomethylquinoline-2-ones with salicylonitrile and subsequent Thorpe-Ziegier isomerization,with aromatic aldehydes under p-TsOH as catalyst in good yields.

关键词： 4-Bromomethylquinoline-2-one Salicylonitrile Benzo[b]benzofurano[2 3e][1 6]naphthyridine-8-one Thorpe-Ziegler isomerization Pictet-Spengler reaction

EXPERIMENTAL STUDY ON VELOCITY PROFILE OF SUBMERGED ABRASIVE SUSPENSION JET FLOW

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Journal of Hydrodynamics 2002年第1期14卷 69-74页

作者： yang yong-yin, wang Rui-he, Shen Zhong-hou (Petroleum University, Dongying 257061, China) Petroleum Univ. Dongying 257061 China

Abrasive jet cutting, as a more efficient machining or cutting method, has emerged in recent years in mining and machining industries, but the knowledge about velocity profile of abrasive jet flow lacks in general. In practice, the Polyacrylamide (PAM) is generally applie d to jet fluid to increase the suspension of the abrasive particles. Als o, the effects of PAM on jet flow are not very clear. In this paper, velocity fi elds of both the abrasive particles and the fluid were systematically studied wi th the PIV technology. The slip velocity between the abrasive particle and the surrounding fluid was subtracted out to give a further description of abrasive suspension jet. Th e effects of polymer PAM on both the fluid flow and the movement of the suspendi ng abrasive particles were also measured. And it is found that the PAM is a prop er type of additive to improve velocity fields for both the abrasive particles and the fluid in a jet. The results of the PIV measurement can help give a bett er understanding about the basic physics of abrasive suspension jet flow, and a good guidance to validate and develop reliable computational models to describe the jet.

关键词： PIV technology Abrasive Suspension Jet (ASJ) velocity profile polymer PAM

Localization of phosphorylated TrkA in carrier vesicles involved in its nuclear translocation in U251 cell line

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Science China(Life Sciences) 2007年第2期50卷 141-146页

作者： GONG AiHua, ZHANG ZhiJian, XIAO DeSheng, yang yong, wang yongZhong & CHEN yongChang School of Medicine, Jiangsu University, Zhenjiang 212013, China School of Medicine Jiangsu University Zhenjiang China

A number of transmembrane receptors are targeted to the nucleus and convincingly localized therein. However, what remains a conundrum is how these cell-surface receptors end up in the nucleus. In this study, we reported that the transmembrane receptor phosphorylated TrkA was located in a series of carrier vesicles, including ring-like vesicles near the plasma membrane, large core vesicles and small dense core vesicles around the nuclei, as well as in the nucleus in human glioma cell line U251 using immunocytochemistry and immunofluorescence staining. Meanwhile, we also showed that small dense core vesicles budded from large core vesicles, and interacted with the nuclear envelope. Accordingly, our results suggested that such a series of membrane compartments might be involved in the pathway of nuclear translocation of the transmembrane receptor TrkA.

关键词： TrkA nuclear translocation vesicular transport large core vesicle small dense core vesicle

Simultaneous determination of flavonoids and anthraquinones in chrysanthemum by capillary electrophoresis with amperometry detection

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Chinese Chemical Letters 2010年第10期21卷 1231-1234页

作者： Yin Yan Zhang Zi Cheng Li Jin Kun Zhu Zhi yong yang Qing Jiang wang Pin Gang He Yu Zhi Fang Department of Chemistry East China Normal University Shanghai 200062 China

A high-performance capillary electrophoresis with amperometry detection method （CE-AD） has been developed for the analysis of flavonoids and anthraquinones （emodin, kaempferol, apigenin, luteolin and rhein） in chrysanthemum. Under optimum conditions, these five analytes were base-line separated within 17 min using a borate-phosphate running buffer （1.5 ×10^-2 mol/L borate-3× 10^-2 mol/L phosphate running buffer, pH 9.0） at a working potential of ＋0.90 V （vs. SCE） and a separation voltage of 19 kV. The linear relationship between concentration and current response was obtained with detection limits （S/N = 3） ranging from 1.0 × 10^-7 to 2.1 × 10^-7 g/mL for all analytes. This proposed method was successfully used in the analysis of four kinds of chrysanthemum with relatively simple extraction procedures, the assay results were satisfactory.

关键词： Capillary electrophoresis Amperometry detection Chrysanthemu Flavonoids Anthraquinones

Effects of competitive and noncompetitive 5α-reductase inhibitors on serum and intra-prostatic androgens in beagle dogs

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Chinese Medical Journal 2013年第4期126卷 711-715页

作者： ZHAO Xiao-feng yang yong wang Wei QIU Zhi ZHANG Peng wang Biao Department of Urology Beijing Chao-Yang Hospital Capital Medical University Beijing 100020 China

Background 5a-Reductase inhibitors （5a-RI） act by inhibiting the conversion of testosterone to dihydrotestosterone （DHT）, thereby preventing DHT induced benign prostatic hyperplasia. The existing 5a-RIs can be classified into two types： competitive and noncompetitive. Currently, limited evidence is available concerning the effect differences between the two types of 5a-RI on androgens. The purpose of this study was to assess the effects of competitive and noncompetitive 5a-RIs on serum and intra-prostatic androgens in beagle dogs. Methods Twenty beagles with spontaneous benign prostatic hyperplasia were randomly allocated into two groups： epristeride group （n=10） in which beagles were treated with epristeride at 1 mg/kg once a day for 3 months, and finasteride group （n=10） in which beagles were treated with finasteride at 1 mg/kg once a day for 3 months. The levels of intra-prostatic testosterone and DHT were measured before treatment and on day one after three months medication. Serum levels of testosterone and DHT were measured at the same time points. Changes in androgen levels before and after treatment were analyzed, and comparisons were made within each treatment group and between treatment groups. Results After 3-month treatment, serum and intra-prostatic DHT levels all decreased significantly in both the epristeride and finasteride groups. The change of DHT in serum was significantly higher in the finasteride group （-14% and -43% in epdsteride and finasteride groups respectively, with P〈0.001）; however there was no significant difference in the changes of intra-prostatic DHT between the two groups （-47% and -51% in epristeride and finasteride groups, respectively, P=0.304）. The decreases in DHT levels were accompanied by reciprocal increases in serum and intra-prostatic testosterone levels. Changes of testosterone were significantly higher in finasteride group both in serum （20% and 42% in epristeride and finasteride groups, respectively, P〈0.001） and in pro

关键词： 5a-reductase inhibitor androgen benign prostatic hyperplasia