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Hydrogen sulfide reduces oxidative stress in Huntington's disease via Nrf2

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Neural Regeneration Research 2025年第6期20卷 1776-1788页

作者： Zige Jiang Dexiang liu Tingting li Chengcheng Gai Danqing Xin Yijing Zhao yan Song Yahong Cheng Tong li Zhen Wang Department of Physiology School of Basic Medical SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Medical Psychology and Ethics School of Basic Medicine SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Neurosurgery Surgery Qingdao Municipal HospitalQingdaoShandong ProvinceChina

The pathophysiology of Huntington's disease involves high levels of the neurotoxin quinolinic acid. Quinolinic acid accumulation results in oxidative stress, which leads to neurotoxicity. However, the molecular and cellular mechanisms by which quinolinic acid contributes to Huntington's disease pathology remain unknown. In this study, we established in vitro and in vivo models of Huntington's disease by administering quinolinic acid to the PC12 neuronal cell line and the striatum of mice, respectively. We observed a decrease in the levels of hydrogen sulfide in both PC12 cells and mouse serum, which was accompanied by down-regulation of cystathionine β-synthase, an enzyme responsible for hydrogen sulfide production. However, treatment with NaHS(a hydrogen sulfide donor) increased hydrogen sulfide levels in the neurons and in mouse serum, as well as cystathionine β-synthase expression in the neurons and the mouse striatum, while also improving oxidative imbalance and mitochondrial dysfunction in PC12 cells and the mouse striatum. These beneficial effects correlated with upregulation of nuclear factor erythroid 2-related factor 2 expression. Finally, treatment with the nuclear factor erythroid 2-related factor 2inhibitor ML385 reversed the beneficial impact of exogenous hydrogen sulfide on quinolinic acid-induced oxidative stress. Taken together, our findings show that hydrogen sulfide reduces oxidative stress in Huntington's disease by activating nuclear factor erythroid 2-related factor 2,suggesting that hydrogen sulfide is a novel neuroprotective drug candidate for treating patients with Huntington's disease.

关键词： apoptosis cystathionine-β-synthase nuclear factor erythroid 2-related factor 2 Huntington's disease hydrogen sulfide mitochondrion neuroplasticity oxidative stress quinolinic acid reactive oxygen species

地下土壤、水中DNAPLs污染的修复技术研究进展

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环境监测管理与技术 2007年第5期19卷 38-42页

作者：燕永利陈杰张宁生屈撑囤西安交通大学能源与动力工程学院陕西西安710049 西安石油大学化学化工学院陕西西安710065

综述了国内外地下土壤、含水层DNAPLs污染的迁移机理及其修复技术研究进展,对该领域的研究前景做了展望。

关键词：地下土壤地下水重质非水相流体污染物迁移修复技术

Enhancing m^(6)A modification in the motor cortex facilitates corticospinal tract remodeling after spinal cord injury

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Neural Regeneration Research 2025年第6期20卷 1749-1763页

作者： Tian Qin Yuxin Jin Yiming Qin Feifei Yuan Hongbin Lu Jianzhong Hu yong Cao Chengjun li Department of Spine Surgery and Orthopedics Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan ProvinceChangshaHunan ProvinceChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Sports Medicine Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Spinal cord injury typically causes corticospinal tract disruption. Although the disrupted corticospinal tract can self-regenerate to a certain degree, the underlying mechanism of this process is still unclear. N6-methyladenosine(m^(6)A) modifications are the most common form of epigenetic regulation at the RNA level and play an essential role in biological processes. However, whether m^(6)A modifications participate in corticospinal tract regeneration after spinal cord injury remains unknown. We found that expression of methyltransferase 14 protein(METTL14) in the locomotor cortex was high after spinal cord injury and accompanied by elevated m^(6)A levels. Knockdown of Mettl14 in the locomotor cortex was not favorable for corticospinal tract regeneration and neurological recovery after spinal cord injury. Through bioinformatics analysis and methylated RNA immunoprecipitation-quantitative polymerase chain reaction, we found that METTL14 regulated Trib2 expression in an m^(6)A-regulated manner, thereby activating the mitogen-activated protein kinase pathway and promoting corticospinal tract regeneration. Finally, we administered syringin, a stabilizer of METTL14, using molecular docking. Results confirmed that syringin can promote corticospinal tract regeneration and facilitate neurological recovery by stabilizing METTL14. Findings from this study reveal that m^(6)A modification is involved in the regulation of corticospinal tract regeneration after spinal cord injury.

关键词： corticospinal tract remodeling epigenetic regulations locomotor cortex m^(6)A modification methyltransferase 14 protein(METTL14) mitogen-activated protein kinase neural regeneration spinal cord injury syringin TRIB2

Boosting charge extraction and efficiency of inverted perovskite solar cells through coordinating group modification at the buffer layer/cathode interface

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Nano Research 2025年第1期18卷 415-423页

作者： Zhiqing liang Ziqiu Ren Ziyu Wang Nan yan ling li Bo Zhang yanlin Song College of Chemistry Zhengzhou UniversityZhengzhou 450052China Key Laboratory of Applied Surface and Colloid Chemistry Ministry of Education Shaanxi Key Laboratory for Advanced Energy DevicesShaanxi Engineering Lab for Advanced Energy Technology School of Materials Science and EngineeringShaanxi Normal UniversityXi’an 710119China Key Laboratory of Green Printing Institute of ChemistryChinese Academy of Sciences(ICCAS)Beijing Engineering Research Center of Nanomaterials for Green Printing TechnologyNational Laboratory for Molecular Sciences(BNLMS)Beijing 100190China

In inverted perovskite solar cells (PSCs),effective modification of the interface between the metalcathode and electron transport layer (ETL) is crucial forachieving high performance and stability. Herein, sulfonatedbathocuproine, commonly known as disodium bathocuproinedisulfonate (BCDS), was employed as a cathode buffer layerto address the interfacial issues at the [6,6]-phenyl-C61-butyricacid methyl ester (PCBM)/Ag interface. BCDS possesses theability to form coordinate bonds with Ag electrodes. Theutilization of the BCDS buffer layer enhanced the chargeextraction capability at the cathode interface whilesimultaneously achieving interfacial defect passivation,improving interfacial contact and increasing the built-in electricfield. Consequently, a power conversion efficiency (PCE) of25.06% was achieved. Furthermore, owing to the excellent filmforminguniformity of BCDS on PCBM, the stability of thedevice was also improved. After storage in dry air for morethan 2000 h, the device maintained 96% of its initial efficiency. This work underscores the remarkable potential of tailoringcoordination groups to enhance charge extraction efficiency at the ETL-cathode interface, unveiling a promising newfrontier in buffer layer development and performance optimization strategies for PSCs.

关键词： perovskite solar cells buffer layer bathocuproine disulfonate coordination group modification electron transport layer(ETL)-cathode interface

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地磁感应电流(GIC)的作用与评估

地球物理学报 2005年第6期48卷 1282-1287页

作者：马晓冰 Ian J.Ferguson 孔祥儒 Xianghong Wu 闫永利中国科学院地质与地球物理研究所北京100029University of ManitobaCanada R3T 2 N2 University of Manitoba Canada R3T 2 N2 中国科学院地质与地球物理研究所北京100029

地磁感应电流(GIC)可能对各种人工长距离导电体造成影响与危害.地磁扰动产生的感应电场的强度与地磁场强度、地下电阻率结构相关,在导电系统内生成的GIC的强度则同时与导电系统的内在结构有关.计算了加拿大Manitoba省三个典型地区在2000... 详细信息

地磁感应电流(GIC)可能对各种人工长距离导电体造成影响与危害.地磁扰动产生的感应电场的强度与地磁场强度、地下电阻率结构相关,在导电系统内生成的GIC的强度则同时与导电系统的内在结构有关.计算了加拿大Manitoba省三个典型地区在2000年7月15日的一个强烈磁暴期间产生的感应电场.通过对地磁活动性的统计分析,估计加拿大魁北克电网可能经受的最大GIC达每相78A(一年一次)和234A(每十年一次).

关键词：地磁感应电流地磁扰动感应电场

Deciphering the role of ultra-low-loaded rhodium in NiFe-MIL-53 for superior oxygen evolution reaction

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Journal of Energy Chemistry 2025年第1期100卷 77-86页

作者： Jinzhi Jia Jinhua Zhang Kailu Guo Lanyue Zhang Gening Du Hao You Junfeng Huang Mudong Tu Hua li yong Peng Wei Dou Cailing Xu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering School of Materials and Energy Lanzhou University College of Chemistry and Chemical Engineering Luoyang Normal University

Designing highly active and stable electrocatalysts of oxygen evolution reaction （OER） is one of the crucial *** this study,a novel OER electrocatalyst,NiFe-MIL-53 modified with ultra-low rhodium（Rh@NiFe-MIL-53）,is successfully prepared via the hydrothermal ***-situ Raman spectroscopy and electrochemical impedance spectroscopy reveal that the doped Rh accelerates the phase transformation of NiFe-MIL-53 and the in-situ formed Rh@NiFeOOH is the actual active *** importantly,the enhanced reversibility of electrochemical reconstruction between NiFeOOH and NiFe（OH）2after doping Rh is beneficial for improving the electrochemical stability of the catalyst.X-ray photoelectron spectroscopy spectra show the strong electronic interaction between single-atom Rh and Ni/Fe in Rh@***,theoretical calculations confirm that the integration of single-atom Rh into the NiFeOOH successfully reduces the band gap,regulates the d-band center （εd）,accelerates the charge transfer,and optimizes the adsorption behavior of oxygen-containing intermediates,thereby lowering the energy barrier of rate-determining ***,the optimized Rh@NiFe-MIL-53 exhibits excellent OER activity （240 mV） with a small Tafel slope of 48.2 mV dec-1and long-term durability (over1270 h at 10 m A cm-2and 110 h at 200 mA cm-2).This work presents a new perspective on designing highly efficient OER electrocatalysts.

关键词： NiFe-MIL-53 Rh Electrochemical reconstruction Catalytic mechanism Oxygen evolution reaction

中国大陆、中国香港、美国股市市场风险比较研究

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重庆工商大学学报（社会科学版） 2017年第3期34卷 34-38页

作者：林勇李艳超西北师范大学经济学院甘肃兰州730070

通过对中国大陆、中国香港、美国股市日收益率的分析,运用POT模型对三个股市的市场风险进行测度,得出以下结论:(1)三个股市在日收益率分布特征上具有一定的共性,但中国大陆股市的高收益是建立在高风险基础上的,中国香港股市中存在极端... 详细信息

通过对中国大陆、中国香港、美国股市日收益率的分析,运用POT模型对三个股市的市场风险进行测度,得出以下结论:(1)三个股市在日收益率分布特征上具有一定的共性,但中国大陆股市的高收益是建立在高风险基础上的,中国香港股市中存在极端收益的可能性大,美国股市的收益率波动性较小;(2)持有大陆股票存在的期望损失最大,持有美国股票面临的期望损失最小,所以我国各经济主体应共同努力以规避股市市场风险。

关键词：股票综合指数收益率 POT模型 VaR ES

补髓生血颗粒对慢性髓劳病IL-21和IL-21mRNA的影响

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世界中西医结合杂志 2019年第10期14卷 1339-1341,1371页

作者：雍彦礼孙凤黑龙江中医药大学

目的通过观察补髓生血颗粒对慢性髓劳病IL-21和IL-21mRNA的影响,分析IL-21和IL-21mRNA与慢性髓劳病发病的相关性,进一步探讨补髓生血颗粒调整免疫失衡的疗效机制。方法选取血液病科2013年8月至2015年3月期间门诊和住院的慢性髓劳病患者3... 详细信息

目的通过观察补髓生血颗粒对慢性髓劳病IL-21和IL-21mRNA的影响,分析IL-21和IL-21mRNA与慢性髓劳病发病的相关性,进一步探讨补髓生血颗粒调整免疫失衡的疗效机制。方法选取血液病科2013年8月至2015年3月期间门诊和住院的慢性髓劳病患者30例为试验组,口服补髓生血颗粒治疗,以同期10名健康志愿者为正常对照组。试验组应用EliSA法检测治疗前后IL-21表达变化,RT-PCR法检测治疗前后IL-21mRNA表达的变化。结果试验组慢性髓劳病IL-21和IL-21mRNA的表达高于正常对照组(P<0.05);试验组治疗后IL-21和IL-21mRNA的表达较治疗前下降(P<0.05),差异有统计学意义。结论IL-21和IL-21mRNA在慢性髓劳病中的异常表达,提示可能参与了慢性髓劳病的免疫发病过程;补髓生血颗粒通过下调IL-21和IL-21mRNA的表达,以调整异常的免疫反应,进而恢复骨髓的造血功能。

关键词：慢性髓劳病补髓生血颗粒 IL-21 IL-21mRNA

单孔腹腔镜与开放手术治疗小儿鞘状突未闭的疗效比较

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现代泌尿外科杂志 2017年第1期22卷 41-43,144页

作者：杨勇李燕琴西安交通大学医学部公共卫生学院陕西西安710061 西安市第九医院泌尿外科陕西西安710054

目的比较小儿鞘状突未闭经腹腔镜和开放手术治疗的临床效果。方法回顾性分析西安市第九医院自2012年1月至2015年12月行鞘状突高位结扎治疗12岁以下小儿腹股沟斜疝和鞘膜积液共92例,其中开放手术组45例,单孔腹腔镜组47例。对两组手术时... 详细信息

目的比较小儿鞘状突未闭经腹腔镜和开放手术治疗的临床效果。方法回顾性分析西安市第九医院自2012年1月至2015年12月行鞘状突高位结扎治疗12岁以下小儿腹股沟斜疝和鞘膜积液共92例,其中开放手术组45例,单孔腹腔镜组47例。对两组手术时间、出血量、切口长度、住院时间、治疗费用、切口感染、阴囊水肿、术后复发等情况进行比较分析。结果两组手术均顺利完成,术后随访3~6月无复发。腹腔镜组术中无中转开放,发现对侧鞘状突未闭9例,单侧手术时间[(21.6±5.6)min vs.(64.5±20.1)min]、平均出血量[(2.1±0.6)vs.(20.0±5.3)mL]、切口长度[(7.2±2.6)mmvs.(36.0±3.9)mm]、住院时间[(5.4±0.5)d]等各指标均少于开放组,而治疗费用[(5 250.22±478.31)元vs.(4 657.19±657.32)元]高于开放组,差异具有统计学意义。结论单孔腹腔镜下鞘状突高位结扎具有创伤小、住院时间短、可同时发现处理对侧隐性鞘状突未闭以及更为突出的美容效果等特点,值得在有条件的医院开展。

关键词：鞘膜积液腹腔镜鞘状突未闭