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Enterococcus faecium NCIMB 10415 administration improves the intestinal health and immunity in neonatal piglets infected by enterotoxigenic Escherichia coli K88

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Journal of Animal Science and Biotechnology 2020年第1期11卷 132-146页

作者： Xie Peng Ru Wang liang Hu Qiang Zhou yang liu Min yang Zhengfeng Fang yan lin Shengyu Xu Bin Feng Jian li Xuemei Jiang yong Zhuo Hua li De Wu lianqiang Che Key Laboratory for Animal Disease-Resistant Nutrition of the Ministry of Education of China Institute of Animal NutritionSichuan Agricultural UniversityChengduSichuan 611130People’s Republic of China Animal Husbandry and Veterinary Department Chengdu Agricultural CollegeChengduSichuan 611130People’s Republic of China.

Background:This study aimed to investigate the effects of oral administration of Enterococcus faecium NCIMB10415(***)on intestinal development,immunological parameters and gut microbiota of neonatal piglets challenged with enterotoxigenic Escherichia coli K88(ETEC).A total of 961-day-old sow-reared piglets were randomly assigned to 2 groups,with 48 piglets in each *** piglets were from 16 litters(6 piglets each litter),and 3 piglets each litter were allocated to the ***-supplemented(PRO)group,while the other 3 piglets were allocated to the control(CON)*** colostrum intake,piglets in the PRO group were orally administrated with 3×10~9 CFU *** per day for a period of one *** day 8,one piglet per litter from each group was challenged(CON+ETEC,PRO+ETEC)or not(CON-ETEC,PRO-ETEC)with ETEC in a 2×2 factorial arrangement of *** day 10(2 days after challenge),blood and tissue samples were obtained from ***:Before ETEC challenge,there were no significant differences for the average daily gain(ADG)and fecal score between the two groups of *** ETEC challenge,the challenged piglets had greater fecal score compared to the non-challenged piglets,whereas *** administration was able to decrease the fecal *** challenged with ETEC had shorter villous height,deeper crypt depth,and reduced number of goblet cells in the jejunum and decreased m RNA abundance of claudin-1 in the ileum,whereas increased the percentage of lymphocytes,concentrations of IL-1βin the plasma and TNF-αin the ileal mucosa,as well as increased the m RNA abundances of innate immunity-related genes in the ileum *** deleterious effects caused by ETEC were partly alleviated by feeding *** addition,piglets in PRO-ETEC group had decreased the percentage of CD8^+T cells of the peripheral blood when compared to those in CON-ETEC ***,*** administration increased Verrucomicrobia at phylum level and decreased

关键词： Enterococcus faecium Enterotoxigenic Escherichia coli K88 Gut microbiota Immunity Intestine Neonatal piglets

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A GSH-responsive PET-based fluorescent probe for cancer cells imaging

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Chinese Chemical Letters 2021年第4期32卷 1541-1544页

作者： Xue li Huaying Wang Youhui Zhang Qianyong Cao yong Chen Chemical College Nanchang UniversityNanchang 330031 China Jiangxi Key Laboratory for Microscale Interdisciplinary Study Institute for Advanced Study.Nanchang UniversityNanchang 330031China

An efficient PET-based probe,in which the ferrocene quencher and the naphthalimide fluorophore are linked by a disulfide bond,has been *** probe can be activated by GSH with fluorescence a turn-on response for blockin... 详细信息

关键词： GSH sensing Photoinduced electron transfer Fluorescent sensor Cancer cells imaging

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Numerical Simulation on Radon Retardation Behavior of Covering Floats in Radon-Containing Water

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Biomedical and Environmental Sciences 2024年第4期37卷 406-417页

作者： liU Shu Yuan ZHANG li YE yong Jun DING Ku Ke National Institute for Radiological Protection Chinese Center for Disease Control and PreventionBeijing 100088China Office for Public Health Management Chinese Center for Disease Control and PreventionBeijing 102206China Key Discipline Laboratory for National Defense for Biotechnology in Uranium Mining and Hydrometallurgy University of South ChinaHengyang 421001HunanChina

Objective This study aimed to efficiently reduce the release of radon from water bodies to protect the *** Based on the sizes of the experimental setup and modular float,computational fluid dynamics(CFD)was used to assess the impact of the area coverage rate,immersion depth,diffusion coefficient,and radon transfer velocity at the gas–liquid interface on radon migration and exhalation of radon-containing *** on the numerical simulation results,an estimation model for the radon retardation rate was *** effectiveness of the CFD simulation was evaluated by comparing the experimental and simulated variation values of the radon retardation rate with the coverage area *** The effect of radon transfer velocity on radon retardation in water bodies was minor and insignificant according to the appropriate value;therefore,an estimation model of the radon retardation rate of the coverage of a radon-containing water body was constructed using the synergistic impacts of three factors:area coverage rate,immersion depth,and diffusion *** deviation between the experimental and simulated results was<4.3%.Conclusion Based on the numerical simulation conditions,an estimation model of the radon retardation rate of covering floats in water bodies under the synergistic effect of multiple factors was obtained,which provides a reference for designing covering floats for radon retardation in radoncontaining water.

关键词： Radon-containing water Radon retardation rate CFD Coverage experiment Optimized design

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Texture evolution and mechanical properties of Al-Mg-Si alloys at different intermediate annealing temperatures

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Rare Metals 2019年第10期38卷 937-945页

作者： yong li Qi-Pan Wang Guan-Jun Gao Jia-Dong li Zhao-Dong Wang Guang-Ming Xu State Key Laboratory of Rolling and Automation Northeastern University

Intermediate annealing treatment produces different effects on the state of particles in Al-Mg-Si alloy sheets,thereby affecting their recrystallization textures and *** improve the formability of the sheets,the effects of different intermediate annealing temperatures on the texture evolution and mechanical properties of these sheets for automotive applications were studied using optical microscope(OM),scanning electron microscope(SEM) and tensile *** results reveal that intermediate annealing temperature has a significant influence on the recrystallization textures and average plastic strain ratio(r).After solution treatment,all the alloy sheets possess similar recrystallization texture components comprising of cubeND {100} and P {011} orientations,whereas a characteristic strong cube-oriented {100} texture is observed only in the alloy annealed at a temperature of 380℃.However,in comparison with the alloy not annealed,and the alloy annealed at 550℃,the alloy annealed at 380℃ possesses a lower average r ***,the relationship between textures and r value was analyzed by using the Taylor full constraints model in this study.

关键词： Al-Mg-Si alloys Intermediate annealing Texture evolution Mechanical property

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Pattern of Refractive Correction and Timing of Stage Ⅱ IOL Implantation after Congenital Cataract Extraction

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Eye Science 2014年第4期29卷 237-242页

作者： yan li Haotian lin State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat-sen University

Congenital cataract occurs during infancy when the axial length and corneal and visual function are in the sensitive stages of rapid development..Inappropriate surgical intervention not only fails to restore visual function,.but also causes irreversible serious influences upon eyeball development in children diagnosed with congenital cataract. At present, the uncertainty of selection of intraocular lens(IOL) degrees during the eyeball development period is averted by using a main treatment of congenital cataract that includes two-stage surgery:.stage I cataract extraction and stage II IOL implantation. However, the accurate selection of a refractive correction method and the timing of IOL implantation during stage II surgery for aphakic eyes remains controversial following stage I cataract extraction..This review retrospectively summarizes the current progress and existing problems indicated by related recent studies focusing on refractive correction pattern and IOL implantation timing.

关键词：人工晶体屈光矫正白内障先天性摘除术植入舞台手术治疗

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Two-dimensional Modeling of the Tearing-mode-governed Magnetic Reconnection in the Large-scale Current Sheet above the Two-ribbon Flare

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Research in Astronomy and Astrophysics 2022年第8期22卷 125-139页

作者： Yining Zhang Jing Ye Zhixing Mei yan li Jun lin Yunnan Observatories Chinese Academy of SciencesKunming 650216China University of Chinese Academy of Sciences Beijing 100049China Center for Astronomical Mega-Science Chinese Academy of SciencesBeijing 100101China

We attempt to model magnetic reconnection during the two-ribbon flare in a gravitationally stratified solar atmosphere with the Lundquist number of S=10~6 using 2 D *** found that the tearing mode instability leads to inhomogeneous turbulence inside the reconnecting current sheet(CS)and invokes the fast phase of *** reconnection brings an extra dissipation of magnetic field which enhances the reconnection rate in an apparent *** energy spectrum in the CS shows a power law pattern and the dynamics of plasmoids govern the associated spectral *** noticed that the energy dissipation occurs at a scale l_(ko)of 100-200 km,and the associated CS thickness ranges from 1500 to 2500 km,which follows the Taylor scale l_(T)=l_(ko)S_(1/6).The termination shock(TS)appears in the turbulent region above flare loops,which is an important contributor to heating flare *** magnetic energy is converted into both kinetic and thermal energies via TS,and the cumulative heating rate is greater than the rate of the kinetic energy *** addition,the turbulence is somehow amplified by TS,in which the amplitude is related to the local geometry of the TS.

关键词： magnetic reconnection magnetohydrodynamics(MHD) Sun:flares turbulence

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The dynamics of landscape-scale ecological connectivity based on least-cost model in Dongshan Island,China

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Journal of Mountain Science 2017年第2期14卷 336-345页

作者： WU li-yun HE Dong-jin YOU Wei-bin JI Zhi-rong TAN yong ZHAO li-li Forestry College Fujian Agriculture and Forestry UniversityFuzhou 350002China

As a hot topic in Landscape Ecology study,ecological connectivity is an important indicator for regional land sustainable use and biological protection. This paper conducted a systematic assessment of ecological connectivity using remote sensing images of Dongshan Island in 1994, 2003 and2011. Based on least-cost modelling, the method takes into consideration the type of barrier, the distance impact, and the adjacent land use types to obtain the Barrier Effect Index(BEI) and Ecological Connectivity Index(ECI). The application of this method to Dongshan Island showed the ecological connectivity index(ECI) was low in 1994, improved in 2003, and decreased significantly in 2011. The results of the dynamic analysis of landscape structure showed farmland and roads were the main landscape classes that caused the low observed ECI in 1994 and 2003;these tended to divide the landscape and cause fragmentation. Construction land and roads were the main landscape classes resulting in low ECI in 2011,while forest and grassland had a high ECI. Trajectory analysis showed ECI tended to decrease in the low mountain forest zone of the northwestern and southeastern parts of Dongshan Island as well as in the coastal protection forest area. The areas where ECI became high were located in the northeastern part of Dongshan Island where cities and towns are concentrated with high human ***, rapid urbanization has been the most important factor driving changes in landscape structure and patterns during the last 17 years on Dongshan Island. The approach not only assists us in revealing the driving mechanism of landscape dynamics from another aspect, but also can assess the impacts of regional and urban plans on landscape structure and function.

关键词： Cost-distance model Dongshan Island Ecological connectivity Spatio-temporal dynamics

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Wireless Power Supply Based on MNG-MNZ Metamaterial for Cardiac Pacemakers

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CES Transactions on Electrical Machines and Systems 2024年第1期8卷 103-112页

作者： Weihua Chen Jingtao Jia Xiaoheng yan Yuhang Song Jiayi li Faculty of Electrical and Control Engineering Liaoning Technical UniversityNo.188Longwan South StreetXingchengHuludao 125105China CES

To solve the low power transfer efficiency and magnetic field leakage problems of cardiac pacemaker wireless powering, we proposed a wireless power supply system suitable for implanted cardiac pacemaker based on mu-negative(MNG) and mu-nearzero(MNZ) metamaterials. First, a hybrid metamaterial consisted of central MNG unit for magnetic field concentration and surrounding MNZ units for magnetic leakage shielding was established by theoretical calculation. Afterwards, the magnetic field distribution of wireless power supply system with MNG-MNZ metamaterial slab was acquired via finite element simulation and verified to be better than the distribution with conventional MNG slab deployed. Finally, an experimental platform of wireless power supply system was established with which power transfer experiment and system temperature rise experiment were *** and experimental results showed that the power transfer efficiency was improved from 44.44%,19.42%, 8.63% and 6.19% to 55.77%, 62.39%, 20.81%and 14.52% at 9.6 mm, 20 mm, 30 mm and 50 mm,respectively. The maximum SAR acquired by SAR simulation under human body environment was-7.14 dbm and maximum reduction of the magnetic field strength around the receiving coil was 2.82 A/m. The maximum temperature rise during 30min charging test was 3.85℃,and the safety requirements of human bodies were met.

关键词： Cardiac pacemaker MNG metamaterial MNZ metamaterial Wireless power supply system

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Multi-scale Analysis of the Relationships between Solar Activity, CO_(2) and Global Surface Temperature

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Research in Astronomy and Astrophysics 2022年第9期22卷 245-254页

作者： Zhen li lijun Chang Jiahui Lou Yi Shen Haoming yan College of Surveying and Geo-informatics North China University of Water Resources and Electric PowerZhengzhou 450046China State Key Laboratory of Geodesy and Earth’s Dynamics Innovation Academy for Precision Measurement Science and TechnologyCASWuhan 430077 China Geological Disaster Prevention and Control Center of Henan Geological Bureau Zhengzhou 450003China School of Geographic Sciences Xinyang Normal UniversityXinyang 464000China

To reveal whether the dynamics of solar activity precede those of global temperature, especially in terms of global warming, the relationship between total solar irradiance(TSI), which is treated as a proxy of solar activity, and global surface temperature(GST) is investigated in the frequency domain using wavelet coherence. The results suggest that the effect of TSI on GST is mainly reflected on the characteristic scale around 22 yr, and variations in TSI lead to changes in GST with some delay effect as shown by the phase difference arrows. However, this implicated relationship has been perturbed by excessive CO_(2) emissions since 1960. Through the combination of co-integration analysis and wavelet coherence, the hidden relationship between TSI and GST has been uncovered without the CO_(2) effect and the results further indicate that TSI has a positive effect on GST at the characteristic scale around 22 yr with a 3 yr lead.

关键词： Sun:activity planets and satellites:surfaces Earth

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An Investigation of Dislocation in Olivine Phenocrysts from the Hawaiian Basalts

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Journal of Earth Science 2020年第6期31卷 1183-1189页

作者： Zhuo-Yue li Da-Peng Wen yong-Feng Wang Xiangwen liu School of Earth Sciences State Key Laboratory of Geological Processes and Mineral ResourcesChina University of GeosciencesWuhan 430074China Global Tectonic Center School of Earth SciencesChina University of GeosciencesWuhan 430074China Engineering Research Center of Nano-Geo Materials of Ministry of Education China University of GeosciencesWuhan 430074China

Intracrystalline distortions(like undulose extinction,dislocations,and subgrain boundaries)in olivine from naturally-deformed peridotites are generally taken as signs of dislocation ***,similar features in olivine phenocrysts that have been found in basaltic magmas are still not well *** particular,whether subgrain boundaries in olivine phenocrysts arise from plastic deformation or grain growth is still debated(in the latter case,they are essentially grain boundaries but not subgrain ***,we used hereinafter subgrain-boundary-like structures instead of subgrain boundaries to name this kind of intracrystalline distortion).Here we carried out a detailed study on dislocations and subgrainboundary-like(SG-like)structures in olivine phenocrysts from two Hawaiian basaltic lavas by means of petrographic microscopy,scanning electron microscopy,and transmission electron microscopy(TEM).Abundant and complex dislocation substructures(free dislocations,dislocation walls,and dislocation tangles)were observed in the decorated olivine grains,similar to those in olivine from peridotite xenoliths entrained by the Hawaiian *** measured average dislocation density is(2.9±1.3)×1011 m-2,and is three to five orders of magnitude higher than that in laboratory-synthesized,undeformed *** observations on samples cut across the SG-like structures by FIB(focused ion beam)demonstrated that this kind of structures is made of an array of *** observations clearly indicate that these structures are real subgrain boundaries rather than grain *** facts suggest that the observed high dislocation densities and subgrain boundaries cannot result from crystal crystallization/growth,but can be formed by plastic *** deformation features do not prove that the olivine phenocrysts(and implicitly mantle xenoliths)were deformed after their capture by the basaltic magmas,but can be ascribed to a former deformation event

关键词： olivine phenocryst dislocation subgrain boundary deformation Hawaiian basalts

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