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A single copy of large tumor suppressor 1 or large tumor suppressor 2 is sufficient for normal hematopoiesis

Chinese Medical Journal 2020年第16期133卷 1943-1951页

作者： Zhi-Gang Li Xue-Mei Fu Cheng-Yan Chai Fang-Fang Sun Fei-Fei Xiao yong-xiu huang Kai Yao Jie-Ping Chen Yu Hou Department of Hematology Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 430008China Medical Research Center Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 430008China College of Life Sciences and Health Wuhan University of Science and TechnologyWuhanHubei 430081China

Background:Hematopoietic stem cells(HSCs)have the ability to differentiate into all subsets of blood cells and *** tumor suppressor 1(LATS1)and large tumor suppressor 2(LATS2)kinases are essential for cell cycle regulation,organism fitness,genome integrity,and cancer ***,we investigated whether Lats1 and Lats2 are critical for the maintenance of the selfrenewal and quiescence capacities of HSCs in ***:Quantitative reverse transcription-polymerase chain reaction was used to determine the expression levels of Lats1 and Lats2 in subsets of progenitor cells and mature bone marrow cells.A clustered regularly interspaced short palindromic repeats system was used to generate Lats1 or Lats2 knockout *** blood cell counts were used to compare the absolute number of white blood cells,lymphocytes,monocytes,neutrophils,and platelets between Lats1 or Lats2 heterozygotes and *** cytometry was used to assess the size of hematopoietic progenitor cells(HPCs)and HSC pools in Lats1 or Lats2 heterozygotes and *** comparison between the two groups was analyzed using Student’s t ***:Lats1 and Lats2 were widely expressed in hematopoietic cells with higher expression levels in primitive hematopoietic cells than in mature ***1 or Lats2 knockout mice were generated,with the homozygotes showing embryonic *** size of the HPC and HSC pools in Lats1(HPC:wild-type[WT]***,220,426.77±54,384.796 vs.221,149.4±42,688.29,P=0.988;HSC:WT ***,2498.932±347.856 vs.3249.763±370.412,P=0.105)or Lats2(HPC:WT ***,425,540.52±99,721.86 vs.467,127.8±89,574.48,P=0.527;HSC:WT ***,4760.545±1518.01 vs.5327.437±873.297,P=0.502)heterozygotes were not ***,the depletion of Lats1 or Lats2 did not affect the overall survival of the heterozygotes(Lats1:P=0.654;Lats2:P=0.152).Conclusion:These results indicate that a single allele of Lats1 or Lats2 may be sufficient for nor

关键词： Hippo pathway Hematopoietic stem cells Stem cell self-renewal

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Zinc finger and BTB domain-containing protein 46 is essential for survival and proliferation of acute myeloid leukemia cell line but dispensable for normal hematopoiesis

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Chinese Medical Journal 2020年第14期133卷 1688-1695页

作者： Yuan-Yuan Liu Fei-Fei Xiao Bi-Jie Yang Xi Li Shuang-Nian Xu Zhi-Wei Chen Ping Li yong-xiu huang Xue-Mei Fu Xing-Qin huang Guang-Ling Zheng Jie-Ping Chen Yu Hou Department of Hematology Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Children's Hospital of Chongqing Medical University Chongqing 400014China Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases College of Traditional Chinese MedicineChongqing Medical UniversityChongqing 400016China Department of Radiology Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China

Background:Zinc finger and BTB domain-containing protein 46(Zbtb46)is a transcription factor identified in classical dendritic cells,and maintains dendritic cell quiescence in a steady ***46 has been reported to be a negative indicator of acute myeloid leukemia(AML).We found that Zbtb46 was expressed at a relatively higher level in hematopoietic stem and progenitor cells(HSPCs)compared to mature cells,and higher in AML cells compared to normal bone marrow(BM)***,the role of Zbtb46in HSPCs and AML cells remains ***,we sought to elucidate the effect of Zbtb46 in normal hematopoiesis and AML ***:We generated Zbtb46^fl/fl and Zbtb46^fl/fl Mx1-Cre *** deletion of Zbtb46 in Zbtb46^fl/fl Mx1-Cre mice was induced by intraperitoneal injection of double-stranded poly(I).poly(C)(poly(I:C)),and referred as Zbtb46 *** confirming the deletion of Zbtb46,the frequency and numbers of HSPCs and mature blood cells were analyzed by flow *** intraperitoneal injection of 5-fluorouracil was administrated to determine the repopulation ability of HSCs from Zbtb46^fl/fl and Zbtb46 cKO *** correlation between Zbtb46 expression and prognosis was analyzed using the data from the Cancer Genome *** investigate the role of Zbtb46 in AML cells,we knocked down the expression of Zbtb46 in THP-1 cells using lentiviral vectors expressing small hairpin RNAs targeting *** proliferation rate was determined by cell count *** apoptosis and bromodeoxyuridine incorporation were determined by flow ***:The percentages and absolute numbers of HSPCs and mature blood cells were comparable in Zbtb46 cKO mice and its Zbtb46^fl/fl littermates(Zbtb46^fl/fl ***46 cKO,HPC:801,310±84,282 vs.907,202±97,403,t=0.82,P=0.46;LSK:86,895±7802 vs.102,210±5025,t=1.65,P=0.17;HSC:19,753±3116 vs.17,608±3508,t=0.46,P=0.67).The repopulation ability of HSCs from Zbtb46^fl/fl Mx1-Cre mice was similar to those from Zbtb46^fl/fl cont

关键词： Zbtb46 transcription factor AML Hematopoietic stem cells

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Merging bound states in the continuum in an open acoustic resonator

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 124-131页

作者： Lujun huang Bin Jia Artem S.Pilipchuk Sibo huang Chen Shen Almas F.Sadreev yong Li Andrey E.Miroshnichenko School of Physics and Electronic Sciences East China Normal University Institute of Acoustics Tongji University L.V.Kirensky Institute of Physics Department of Mechanical Engineering Rowan University School of Engineering and Technology University of New South Wales at Canberra

Bound states in the continuum （BICs） are perfectly localized resonances despite embedding in the continuum ***,an isolated BIC is very sensitive to the structure ***,we report merging acoustic BICs in a single open resonator,robust against the structure *** find that both symmetry-protected BIC and Friedrich-Wintgen BIC are sustained in a single coupled waveguide-resonator *** varying the height and length of the resonator,these two BICs move toward each other and merge into a single one at a critical *** to an individual BIC,the merged BIC is robust against fabrication error because its Q-factor is proportional to ΔL-4,whereΔL embodies the structure *** essence of this extraordinary phenomenon is perfectly explained by the two-and three-level approximations of the effective nonHermitian ***,we present direct experimental demonstrations of the moving and merging of BICs in a coupled 3D waveguide-resonator,which are evidenced by the vanishing of the linewidth of Fano resonance in the transmission *** results may find exciting applications in designing high-quality acoustic sources,sensors and filters.

关键词： acoustic resonances bound state in the continuum high-Q resonances

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Deciphering the role of ultra-low-loaded rhodium in NiFe-MIL-53 for superior oxygen evolution reaction

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Journal of Energy Chemistry 2025年第1期100卷 77-86页

作者： Jinzhi Jia Jinhua Zhang Kailu Guo Lanyue Zhang Gening Du Hao You Junfeng huang Mudong Tu Hua Li yong Peng Wei Dou Cailing Xu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering School of Materials and Energy Lanzhou University College of Chemistry and Chemical Engineering Luoyang Normal University

Designing highly active and stable electrocatalysts of oxygen evolution reaction （OER） is one of the crucial *** this study,a novel OER electrocatalyst,NiFe-MIL-53 modified with ultra-low rhodium（Rh@NiFe-MIL-53）,is successfully prepared via the hydrothermal ***-situ Raman spectroscopy and electrochemical impedance spectroscopy reveal that the doped Rh accelerates the phase transformation of NiFe-MIL-53 and the in-situ formed Rh@NiFeOOH is the actual active *** importantly,the enhanced reversibility of electrochemical reconstruction between NiFeOOH and NiFe（OH）2after doping Rh is beneficial for improving the electrochemical stability of the catalyst.X-ray photoelectron spectroscopy spectra show the strong electronic interaction between single-atom Rh and Ni/Fe in Rh@***,theoretical calculations confirm that the integration of single-atom Rh into the NiFeOOH successfully reduces the band gap,regulates the d-band center （εd）,accelerates the charge transfer,and optimizes the adsorption behavior of oxygen-containing intermediates,thereby lowering the energy barrier of rate-determining ***,the optimized Rh@NiFe-MIL-53 exhibits excellent OER activity （240 mV） with a small Tafel slope of 48.2 mV dec-1and long-term durability (over1270 h at 10 m A cm-2and 110 h at 200 mA cm-2).This work presents a new perspective on designing highly efficient OER electrocatalysts.

关键词： NiFe-MIL-53 Rh Electrochemical reconstruction Catalytic mechanism Oxygen evolution reaction

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Cerebral fat embolism following autologous fat injection in facial reconstruction:A case report

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World Journal of Clinical Cases 2025年第2期13卷 50-58页

作者： xiu-Ying Chen Fa Shen Chang Cheng Yu-Han Wang Wen-Chao Cheng De-Zhi Yuan Wen huang Department of Neurology Chongqing Emergency Medical CenterChongqing University Central HospitalChongqing 400000China Department of Neurology Xinqiao HospitalThe Army Medical University(Third Military Medical University)Chongqing 400000China

BACKGROUND Autologous fat injection in facial reconstruction is a common cosmetic *** cerebral fat embolism(CFE)as a complication is rare,it carries serious health *** SUMMARY We present a case of a 29-year-old female patient who developed acute CFE following facial fat filling *** the surgery,the patient experienced symptoms including headache,nausea,vomiting,and difficulty breathing,which was followed by neurological symptoms such as slurred speech and left-sided *** physical examination and auxiliary investigations,including blood tests,head and neck computed tomography angiography,and cranial magnetic resonance diffusion-weighted imaging,were performed upon *** clinical diagnosis was acute cerebral embolism following facial fat filling *** included measures to improve cerebral circulation,dehydration for intracranial pressure reduction,nutritional support,and rehabilitation therapy for left limb *** patient showed a significant improvement in symptoms after 2 weeks of *** recovered left limb muscle strength to grade 5,had clear speech,and experienced complete relief of *** Our case highlights the potential occurrence of severe complications in patients undergoing fat injection in facial *** prevent these complications,plastic surgeons should enhance their professional knowledge and skills.

关键词： Cerebral fat embolism Mechanical thrombectomy Thrombolysis Steroid therapy Symptomatic treatment Case report

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Mass-Defect Effect in the Hellings-Nordtvedt Field

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Chinese Physics Letters 2002年第6期19卷 755-757页

作者： huang xiu-Ju and Wang yong-Jiu Institute of Physics Hu"nan Normal University

In the Hellings-Nordtvedt theory, we obtain some expressions of the mass-defect effect for a kind of charged celestial body. This is meaningful to calculate the energy radiation in the process of forming this kind of ... 详细信息

关键词： Astrophysics

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A general stabilizing strategy based on vitamin C for n-type organic semiconductors

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Science China Materials 2025年第01期 303-304页

作者： Hui huang College of Materials Science and Opto-Electronic Technology Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences

Organic semiconductors (OSCs), as an emerging next-generation semiconductor material, hold promising prospects in fields such as flexible displays, electronic skins, smart healthcare,and the Internet of Things, due to their excellent flexibility,solution processability, and tunable band structures [1,2]. These molecules are often classified into n-type and p-type, depending on whether the prevalent charge carriers are electrons or holes[3].

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Efficient white-light-emitting lead-free halide double perovskites enabling full-spectrum pc-WLEDs

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Science China Materials 2025年第1期 305-306页

作者： Xiaoyong huang College of Physics and Optoelectronics Taiyuan University of Technology

With the rapid development of solid-state lighting, an important goal of phosphor-converted white light-emitting diodes (pc-WLEDs) is to provide a healthy and comfortable fullspectrum artificial light source with a co...

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Quickly obtaining densely dispersed coherent particles in steel matrix and its related mechanical property

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 111-118页

作者： Xiaoxiao Wang Qingsong huang School of Chemical Engineering Sichuan UniversityChengdu 610065China

Densely distributed coherent nanoparticles(DCN)in steel matrix can enhance the work-hardening ability and ductility of steel *** the routes to this end can be generally classified into the liquid-solid route and the solid-solid ***,the formation of DCN structures in steel requires long processes and complex *** far,obtaining steel with coherent particle enhancement in a short time remains a bottleneck,and some necessary steps remain ***,we show a high-efficiency liquid-phase refining process reinforced by a dynamic magnetic ***-Y-Mn-O particles had an average size of around(3.53±1.21)nm and can be obtained in just around 180 *** small nanoparticles were coherent with the matrix,implying no accumulated dislocations between the particles and the steel *** findings have a potential application for improving material machining capacity,creep resistance,and radiation resistance.

关键词： ferritic steels coherent particles microstructure compression test work hardening

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左氧氟沙星联合常规抗痨治疗艾滋病合并肺结核的效果研究

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中国当代医药 2018年第13期25卷 35-37,41页

作者：陈廷宪陈勇毅黄修伙戴芬广东省阳江市公共卫生医院感染内科广东阳江529500 广东省阳江市公共卫生医院VCT咨询门诊广东阳江529500

目的探析对艾滋病合并肺结核患者行以左氧氟沙星联合常规抗痨治疗的临床效果。方法择取阳江市公共卫生医院感染内科2014年1月~2016年12月收治的艾滋病合并肺结核患者42例,随机分成对照组和治疗组,每组各21例。对照组行常规抗痨治疗,治... 详细信息

目的探析对艾滋病合并肺结核患者行以左氧氟沙星联合常规抗痨治疗的临床效果。方法择取阳江市公共卫生医院感染内科2014年1月~2016年12月收治的艾滋病合并肺结核患者42例,随机分成对照组和治疗组,每组各21例。对照组行常规抗痨治疗,治疗组行左氧氟沙星联合常规抗痨治疗,对两组的临床效果进行分析和比较。结果治疗组病灶吸收总有效率明显高于对照组(P0.05)。结论对艾滋病合并肺结核患者行以左氧氟沙星联合常规抗痨治疗不仅效果良好,而且不良反应少,可作为新一代抗结核药物,特别在特殊人群结核病治疗中,具有显著临床价值。

关键词：左氧氟沙星常规抗痨治疗艾滋病肺结核效果

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