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Comparison of clinical laboratory tests between bacterial sepsis and SARS-CoV-2-associated viral sepsis

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Military Medical Research 2021年第2期8卷 278-280页

作者： Chao Ren Ren-Qi Yao Di Ren Ying Li yong-wen feng yong-Ming Yao Department of Critical Care Medicine the Second People’s Hospital of ShenzhenShenzhen 518035GuangdongChina Department of Critical Care Medicine the Third People’s Hospital of ShenzhenShenzhen 518020GuangdongChina Trauma Research Center the Fourth Medical Center and Medical Innovation Research Department of the Chinese PLA General HospitalBeijing 100048China

Sepsis is a life-threatening condition that is characterized by multiple organ dysfunction due to abnormal host response to various pathogens,like bacteria,fungi and *** differences between viral and bacterial sepsis are indeed of great significance to deepen the understanding of the pathogenesis of sepsis,especially under pandemics of SARS-CoV-2 infection.

关键词： Severe acute respiratory syndrom coronavirus 2 Coronavirus disease 2019 Sepsis Bacteria Virus Infection Host response

Development of septic shock and prognostic assessment in critically ill patients with coronavirus disease outside Wuhan, China

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World Journal of Emergency Medicine 2021年第4期12卷 293-298页

作者： Ren-qi Yao Chao Ren Di Ren Jin-xiu Li Ying Li Xue-yan Liu Lei Huang yong Liu Mian Peng yong-wen feng yong-ming Yao Department of Critical Care Medicine the Second People’s Hospital of ShenzhenShenzhen 518035China Trauma Research Center the Fourth Medical Center and Medical Innovation Research Department of the Chinese PLA General HospitalBeijing 100048China Department of Critical Care Medicine the Third People’s Hospital of ShenzhenShenzhen 518020China Department of Critical Care Medicine the People’s Hospital of ShenzhenShenzhen 518020China Department of Critical Care Medicine Peking University Shenzhen HospitalShenzhen 518035China Department of Critical Care Medicine Shenzhen Hospital of Southern Medical UniversityShenzhen 518110China Department of Critical Care Medicine the Third Affiliated Hospital of Shenzhen UniversityShenzhen 518001China

BACKGROUND: The study aims to illustrate the clinical characteristics and development of septic shock in intensive care unit(ICU) patients confirmed with severe acute respiratory syndrome coronavirus 2(SARS-Co V-2) infection, and to perform a comprehensive analysis of the association between septic shock and clinical outcomes in critically ill patients with coronavirus disease(COVID-19).METHODS: Patients confirmed with SARS-Co V-2 infection, who were admitted to the ICU of the Third People's Hospital of Shenzhen from January 1 to February 7, 2020, were enrolled. Clinical characteristics and outcomes were compared between patients with and without septic ***: In this study, 35 critically ill patients with COVID-19 were included. Among them, the median age was 64 years(interquartile range [IQR] 59-67 years), and 10(28.4%) patients were female. The median ICU length of stay was 16 days(IQR 8-23 days). Three(8.6%) patients died during hospitalization. Nine(25.7%) patients developed septic shock in the ICU, and these patients had a significantly higher incidence of organ dysfunction and a worse prognosis than patients without septic ***: Septic shock is associated with a poor outcome in critically ill COVID-19 patients and is one of the hallmarks of the severity of patients receiving ICU care. A dysregulated immune response, uncontrolled infl ammation, and coagulation disorders are strongly associated with the development and progression of COVID-19-related septic shock.

关键词： Severe acute respiratory syndrome coronavirus 2 Coronavirus disease Intensive care unit Septic shock Immune response

Clinical diagnosis of severe COVID-19:A derivation and validation of a prediction rule

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World Journal of Clinical Cases 2021年第13期9卷 2994-3007页

作者： Ming Tang Xia-Xia Yu Jia Huang Jun-Ling Gao Fu-Lan Cen Qi Xiao Shou-Zhi Fu Yang Yang Bo Xiong yong-Jun Pan Ying-Xia Liu yong-wen feng Jin-Xiu Li yong Liu Department of Critical Care Medicine Shenzhen Third People’s HospitalThe Second Hospital Affiliated to Southern University of Science and TechnologyShenzhen 518114Guangdong ProvinceChina School of Biomedical Engineering Health Science CenterShenzhen UniversityShenzhen 518060Guangdong ProvinceChina Buddhism and Science Research Laboratory Centre of Buddhist StudiesThe University of Hong KongHong Kong 999077China Department of Critical Care Medicine Wuhan Third HospitalWuhan 433304Hubei ProvinceChina Shenzhen Key Laboratory of Pathogen and Immunity National Clinical Research Center for Infectious DiseaseState Key Discipline of Infectious DiseaseShenzhen Third People's HospitalThe Second Hospital Affiliated to Southern University of Science and TechnologyShenzhen 518114Guangdong ProvinceChina Department of Pediatrics Wuhan Asia General HospitalWuhan 430022Hubei ProvinceChina Department of Critical Care Medicine Southern University of Science and Technology HospitalShenzhen 518055Guangdong ProvinceChina Department of Critical Care Medicine The Second People's Hospital of ShenzhenShenzhen 518035Guangdong ProvinceChina Department of Critical Care Medicine The Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina Shenzhen Hospital Southern Medical UniversityShenzhen 518000Guangdong ProvinceChina

BACKGROUND The widespread coronavirus disease 2019(COVID-19)has led to high morbidity and ***,early risk identification of critically ill patients remains *** To develop predictive rules at the time of admission to identify COVID-19 patients who might require intensive care unit(ICU)*** This retrospective study included a total of 361 patients with confirmed COVID-19 by reverse transcription-polymerase chain reaction between January 19,2020,and March 14,2020 in Shenzhen Third People’s *** logistic regression was applied to develop the predictive *** performance of the predictive model was externally validated and evaluated based on a dataset involving 126 patients from the Wuhan Asia General Hospital between December 2019 and March 2020,by area under the receiver operating curve(AUROC),goodness-of-fit and the performance matrix including the sensitivity,specificity,and precision.A nomogram was also used to visualize the *** Among the patients in the derivation and validation datasets,38 and 9 participants(10.5%and 2.54%,respectively)developed severe COVID-19,*** univariate analysis,21 parameters such as age,sex(male),smoker,body mass index(BMI),time from onset to admission(>5 d),asthenia,dry cough,expectoration,shortness of breath,asthenia,and Rox index<18(pulse oxygen saturation,SpO2)/(FiO2×respiratory rate,RR)showed positive correlations with severe *** multivariate logistic regression analysis,only six parameters including BMI[odds ratio(OR)3.939;95%confidence interval(CI):1.409-11.015;P=0.009],time from onset to admission(≥5 d)(OR 7.107;95%CI:1.449-34.849;P=0.016),fever(OR 6.794;95%CI:1.401-32.951;P=0.017),Charlson index(OR 2.917;95%CI:1.279-6.654;P=0.011),PaO2/FiO2 ratio(OR 17.570;95%CI:1.117-276.383;P=0.041),and neutrophil/lymphocyte ratio(OR 3.574;95%CI:1.048-12.191;P=0.042)were found to be independent predictors of *** factors were found to be significant risk f

关键词： COVID-19 Communicable diseases Clinical decision rules Prognosis Nomograms

An Improvement in Electrical Properties of Asphalt Concrete

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Journal of Wuhan University of Technology(Materials Science) 2002年第4期17卷 69-72页

作者：吴少鹏 Key Laboratory for Silicate Materials Science and Engineering of Ministry of Education Wuhan University of Technology Wuhan China

Materials such as Koch AH-70,basalt aggregate,limestone powder and graphite particles were used to prepare conductive asphalt concrete,which is a new type of multifunctional *** mix proportion by weight was shown as *** aggregates (2.36-4.75 mm)∶fine aggregates (<2.36mm)∶limestone powder∶asphalt=120∶240∶14∶*** content of added graphite particles ranged from 0% to 20%(by the weight of asphalt concrete).A conductive asphalt concrete with a resistivity around 10-10 3Ω·m was *** attention was paid to the effects of graphite content,graphite physical-chemical properties,asphalt content and temperature on the ***,an attempt was made to develop an electrically conductive model for asphalt concrete.

关键词： conductive asphalt concrete electrical properties resistivity electrically conductive model

Severe COVID-19-associated sepsis is different from classical sepsis induced by pulmonary infection with carbapenem-resistant klebsiella pneumonia (CrKP)

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Chinese Journal of Traumatology 2022年第1期25卷 17-24页

作者： Ming Wu Zhi-Ye Zou Yan-Hong Chen Cong-LinWang yong-wen feng Zhi-feng Liu Department of Critical Care Medicine and Hospital Infection Prevention and Control Shenzhen Second People's HospitalShenzhen518035China Department of Critical Care Medicine First Affiliated Hospital of Shenzhen UniversityShenzhen 518035China Department of Critical Care Medicine General Hospital of Southern Theater Command of PLAGuangzhou510010China

Purpose::COVID-19 is also referred to as a typical viral septic pulmonary infection by ***,little is known regarding its characteristics in terms of systemic inflammation and organ injury,especially compared with classical bacterial *** article aims to investigate the clinical characteristics and prognosis between COVID-19-associated sepsis and classic bacterial-induced ***::In this retrospective cohort study,septic patients with COVID-19 in the intensive care unit(ICU)of a government-designed therapy center in Shenzhen,China between January 14,2020 and March 10,2020,and septic patients induced by carbapenem-resistant klebsiella pneumonia(CrKP)admitted to the ICU of the Second People's Hospital of Shenzhen,China between January 1,2014 and October 30,2019 were *** and clinical parameters including comorbidities,critical illness scores,treatment,and laboratory data,as well as prognosis were compared between the two *** factors for mortality and survival rate were analyzed using multivariable logistic regression and survival curve,***::A total of 107 patients with COVID-19 and 63 patients with CrKP were enrolled.A direct comparison between the two groups demonstrated more serious degrees of primary lung injury following 2019-nCoV infection(indicated by lower PaO 2/FiO 2),but milder systemic inflammatory response,lower sequential organ failure assessment score and better functions of the organs like heart,liver,kidney,coagulation,and ***,the acquired immunosuppression presented in COVID-19 patients was more severe,which presented as lower lymphocyte counts(0.8×109/L vs.0.9×109/L).Moreover,the proportion of COVID-19 patients treated with corticosteroid therapy and extracorporeal membrane oxygenation was larger compared with CrKP patients(78.5%vs.38.1%and 6.5%vs.0,respectively)who required less invasive mechanical ventilation(31.6%vs.54.0%).The incidence of hospitalized mortality an

关键词： Clinical characteristics Immunosuppression Mortality COVID-19 Carbapenem-resistant klebsiella pneumonia(CrKP)

太西煤中有害元素在洗选过程中的迁移行为与机理

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燃料化学学报 2002年第2期30卷 147-150页

作者：秦勇王文峰宋党育中国矿业大学资源与地球科学学院江苏徐州221008

通过对太西原煤及洗选产物样品中 19种有害元素的系统测试 ,分析了煤中有害元素在洗选过程中的迁移行为 ,初步讨论了其迁移机理。结果表明 :有害微量元素As、Sb、Se、Co、Sb、Mo、Pb、Br在太西原煤中明显富集 ,但洗选后得到很大程度的... 详细信息

通过对太西原煤及洗选产物样品中 19种有害元素的系统测试 ,分析了煤中有害元素在洗选过程中的迁移行为 ,初步讨论了其迁移机理。结果表明 :有害微量元素As、Sb、Se、Co、Sb、Mo、Pb、Br在太西原煤中明显富集 ,但洗选后得到很大程度的脱除。大粒精煤的洁净度最高 ,对环境的危害性相对较小 ;绝大多数有害元素在煤泥中相对富集 ,煤泥不适宜于用做燃料。煤中有害元素的迁移行为 ,与元素赋存状态、显微组分种类与含量。

关键词：太西煤有害元素赋存状态迁移机理

基于Kullback-Leibler分歧的变分滤波WSNs贝叶斯移动定位跟踪西

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计算机工程与科学 2017年第9期39卷 1645-1652页

作者：孟凡琨巨永锋文常保长安大学电子与控制工程学院陕西西安710064

为了在降低资源能耗和带宽占用情况下,提高无线传感器网络WSNs移动目标定位跟踪的精度,提出了基于Kullback-Leibler分歧的变分滤波的WSNs贝叶斯移动目标定位跟踪算法。首先,利用高斯和Wishart分布在不考虑速度限制和方向移动限制情况下... 详细信息

为了在降低资源能耗和带宽占用情况下,提高无线传感器网络WSNs移动目标定位跟踪的精度,提出了基于Kullback-Leibler分歧的变分滤波的WSNs贝叶斯移动目标定位跟踪算法。首先,利用高斯和Wishart分布在不考虑速度限制和方向移动限制情况下,构建WSNs移动定位的贝叶斯状态演化模型,并基于路径损耗模型构建移动目标定位的观测模型;其次,利用Kullback-Leibler分歧构建变分滤波的误差计算模型,通过周围激活节点实现移动节点目标的位置估计,设计了递归概率计算过程综合预测和更新两个过程,并实现了定位和目标跟踪的同步化;最后,通过仿真验证了所提模型在跟踪精度和资源节约上的优势。

关键词： Kullback—Leibler分歧变分滤波无线传感器网络移动目标定位跟踪

Prenatal ultrasonography and genetic analysis of fetal cleidocranial dysplasia:A case report

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World Journal of Clinical Cases 2025年第10期13卷 28-34页

作者： feng Wang Pei-feng Dai wen-Juan Gao Department of Ultrasonography Weifang People’s HospitalWeifang 261000Shandong ProvinceChina

BACKGROUND Cleidocranial dysplasia(CCD)is an infrequent clinical condition with an autosomal dominant inheritance *** is characterized by abnormal clavicles,patent sutures and fontanelles,supernumerary teeth,and short *** 60%-70%of patients with CCD have mutations in the RUNX family transcription factor 2 ***,prenatal diagnosis of CCD is difficult when the family history is *** SUMMARY We report a rare case of fetal CCD with an unknown family history,confirmed by prenatal ultrasonography and genetic testing at a gestational age of 16 *** genetic reports indicated that the fetus carried pathogenic mutations in the RUNX family transcription factor 2 gene(c.674G>A).After careful consideration,the pregnant woman and her family decided to continue the *** Definitive prenatal diagnosis of CCD should include family history,ultrasound diagnosis,and genetic analysis,especially if family history is unknown.

关键词： Cleidocranial dysplasia Genetic analysis Ultrasonic diagnosis Prenatal Case report

论南朝史书杂采奇闻轶事的叙事方式——以南朝范晔《后汉书》为例

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山西农业大学学报（社会科学版） 2009年第4期8卷 387-389页

作者：温永峰温永莲山西农业大学校长办公室山西太谷030801 山西省岚县梁家庄中学山西岚县033500

南朝所撰正史,喜好采录琐事异闻入史,成为一大鲜明的叙事特色。以《后汉书》为研究对象,分析南朝史书杂采奇闻轶事的叙事方式。极大地丰富了南朝史书的叙事内容,给南朝史书叙事注入了新鲜的活力。对全面展现这一段文学史发展的风貌,促... 详细信息

南朝所撰正史,喜好采录琐事异闻入史,成为一大鲜明的叙事特色。以《后汉书》为研究对象,分析南朝史书杂采奇闻轶事的叙事方式。极大地丰富了南朝史书的叙事内容,给南朝史书叙事注入了新鲜的活力。对全面展现这一段文学史发展的风貌,促使史书编撰者提高叙事艺术水平,具有一定的启迪和示范作用。

关键词：南朝史书杂采奇闻《后汉书》叙事方式