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Characteristics of immune and inflammatory responses among different age groups of pediatric patients with COVID-19 in China

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World Journal of Pediatrics 2021年第4期17卷 375-384页

作者： Su-Qiong Ji Min Zhang yong Zhang Kun Xia Yuan Chen Qian Chu yong-chang wei Fu-Ling Zhou Bi-Tao Bu Hong-Lei Tu Ya-Yun Cao Li-Ya Hu Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Cardiovascular Medicine Wuhan Children’HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Geriatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Oncology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Radiation and Medical Oncology Hubei Key Laboratory of Tumor Biological BehaviorsHubei Cancer Clinical Study CenterZhongnan Hospital of Wuhan UniversityWuhanChina Department of Hematology Zhongnan Hospital of Wuhan UniversityWuhanChina

Background Severe cases of coronavirus disease 2019(COVID-19)among pediatric patients are more common in children less than 1 year of *** aim is to address the underlying role of immunity and inflammation conditions among different age groups of pediatric *** We recruited pediatric patients confirmed of moderate COVID-19 symptoms,admitted to Wuhan Children's Hospital from January 28th to April 1st in *** were divided into four age groups(≤1,1–6,7–10,and 11–15 years).Demographic information,clinical characteristics,laboratory results of lymphocyte subsets test,immune and inflammation related markers were all *** Analysis included 217/241(90.0%)of patients with moderate clinical stage *** recovery time of children more than 6 years old was significantly shorter than of children younger than 6 years(P=0.001).Reduced neutrophils and increased lymphocytes were significantly most observed among patients under 1 year old(P<0.01).CD19+B cells were the only significantly elevated immune cells,especially among patients under 1 year old(cell proportion:n=12,30.0%,P<0.001;cell count:n=13,32.5%,P<0.001).While,low levels of immune related makers,such as immunoglobulin(Ig)G(P<0.001),IgA(P<0.001),IgM(P<0.001)and serum complement C3c(P<0.001),were also mostly found among patients under 1 year old,together with elevated levels of inflammation related markers,such as tumor necrosis factor γ (P=0.007),interleukin(IL)-10(P=0.011),IL-6(P=0.008),lactate dehydrogenase(P<0.001),and procalcitonin(P=0.007).Conclusion The higher rate of severe cases and long course of COVID-19 among children under 1 year old may be due to the lower production of antibodies and serum complements of in this age group.

关键词： Age difference China Coronavirus disease 2019 Immune Inflammation Pediatric

面向信息可视化的语义Focus+Context人机交互技术

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计算机学报 2015年第12期38卷 2488-2498页

作者：任磊魏永长杜一张小龙戴国忠北京航空航天大学自动化科学与电气工程学院北京100191 中国科学院计算机网络信息中心科学数据中心北京100190 美国宾夕法尼亚州立大学信息科学技术学院美国宾夕法尼亚州州立大学城16802 中国科学院软件研究所人机交互北京市重点实验室北京100190

大数据成为继云计算和物联网之后,国际学术界和产业界所共同瞩目的又一个研究热点.信息可视化是辅助用户洞悉大数据背后隐藏的知识和规律的重要方法和有力工具.如何在图形用户界面中对大规模信息以符合认知规律的方式进行可视化,并且使... 详细信息

大数据成为继云计算和物联网之后,国际学术界和产业界所共同瞩目的又一个研究热点.信息可视化是辅助用户洞悉大数据背后隐藏的知识和规律的重要方法和有力工具.如何在图形用户界面中对大规模信息以符合认知规律的方式进行可视化,并且使得计算机能够智能化的理解用户意图以配合其进行高效的人机交互,是信息可视化面临的挑战之一.文中提出一种面向信息可视化的语义Focus+Context人机交互技术.首先,在基于空间距离的经典Focus+Context数学模型基础上对其进行语义建模和扩展,建立了面向信息空间和可视化表征空间的语义距离模型以及语义关注度模型,定义了交互中的焦点对象与语义上下文.其次,在此基础上建立了语义Focus+Context用户界面模型,给出了界面抽象元素和实体元素以及映射关系的形式化描述,同时建立了Focus+Context交互循环机制.最后,给出了应用于经典Focus+Context及鱼眼数学模型的描述,表明文中提出方法具有很好的兼容性描述能力;同时,给出了面向文件系统主题聚集的语义Focus+Context应用,给出了基于主题语义关注度与嵌套圆鱼眼视图的动态可视化实例,应用实例表明文中提出技术能够有效支持用户在信息可视化界面中对大规模信息进行智能化的可视化和交互探索.

关键词：信息可视化人机交互用户界面焦点+上下文大数据可视分析

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中国共产党反腐败斗争的成功实践

晋东南师范专科学校学报 2002年第1期19卷 48-49,79页

作者：魏永昌壶关县委党校山西壶关047300

党在不同的历史时期 ,同党内腐败现象做了坚决的斗争。

关键词：中国共产党建党思想反腐中央监察委员会 "三反"运动

MET receptor tyrosine kinase promotes the generation of functional synapses in adult cortical circuits

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Neural Regeneration Research 2025年第5期20卷 1431-1444页

作者： Yuehua Cui Xiaokuang Ma Jing wei chang Chen Neha Shakir Hitesch Guirram Zhiyu Dai Trent Anderson Deveroux Ferguson Shenfeng Qiu Basic Medical Sciences University of Arizona College of Medicine-PhoenixPhoenixAZUSA Department of Medicine University of Arizona College of Medicine-PhoenixPhoenixAZUSA

Loss of synapse and functional connectivity in brain circuits is associated with aging and neurodegeneration,however,few molecular mechanisms are known to intrinsically promote synaptogenesis or enhance synapse *** have previously shown that MET receptor tyrosine kinase in the developing cortical circuits promotes dendritic growth and dendritic spine *** investigate whether enhancing MET in adult cortex has synapse regenerating potential,we created a knockin mouse line,in which the human MET gene expression and signaling can be turned on in adult(10–12 months)cortical neurons through doxycycline-containing *** found that similar to the developing brain,turning on MET signaling in the adult cortex activates small GTPases and increases spine density in prefrontal projection *** findings are further corroborated by increased synaptic activity and transient generation of immature silent *** MET signaling resulted in an increasedα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/N-methyl-Daspartate(AMPA/NMDA)receptor current ratio,indicative of enhanced synaptic function and *** data reveal that enhancing MET signaling could be an interventional approach to promote synaptogenesis and preserve functional connectivity in the adult *** findings may have implications for regenerative therapy in aging and neurodegeneration conditions.

关键词： aging circuit connectivity cortical circuits molecular mechanisms neural regeneration neurodegeneration synapses

微囊化基因工程细胞移植技术在抗肿瘤研究中的应用

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国际肿瘤学杂志 2006年第12期33卷 912-914页

作者：魏永长西安交通大学第一附属医院肿瘤内科 710061

微囊化基因工程细胞移植技术是一种新的生物活性物质投递方式,能够在不用免疫抑制剂的情况下移植动物源性的细胞和组织。该技术已在多种肿瘤的治疗中显示出良好的应用前景,现对其进展及在恶性肿瘤研究中的应用作一综述。

关键词：肿瘤移植微囊化

Tranylcypromine upregulates Sestrin 2 expression to ameliorate NLRP3-related noise-induced hearing loss

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Neural Regeneration Research 2025年第5期20卷 1483-1494页

作者： Xihang Chen Zhifeng Chen Menghua Li weiwei Guo Shuolong Yuan Liangwei Xu chang Lin Xi Shi wei Chen Shiming Yang Senior Department of Otolaryngology Head and Neck Surgery Chinese PLA General HospitalChinese PLA Medical SchoolBeijingChina State Key Laboratory of Hearing and Balance Science BeijingChina National Clinical Research Center for Otolaryngologic Diseases BeijingChina Key Laboratory of Hearing Science Ministry of EducationBeijingChina Beijing Key Laboratory of Hearing Impairment Prevention and Treatment BeijingChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Otolaryngology Head and Neck Surgery The 940th Hospital of Joint Logistics Support Force of Chinese PLALanzhouGansu ProvinceChina Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikouHainan ProvinceChina Academician Workstation of Hainan University School of Pharmaceutical SciencesYazhou BaySanyaHainan ProvinceChina

Noise-induced hearing loss is the primary non-genetic factor contributing to auditory ***,there are currently no effective pharmacological interventions for patients with noise-induced hearing ***,we present evidence suggesting that the lysine-specific demethylase 1 inhibitor–tranylcypromine is an otoprotective agent that could be used to treat noise-induced hearing loss,and elucidate its underlying regulatory *** established a mouse model of permanent threshold shift hearing loss by exposing the mice to white broadband noise at a sound pressure level of 120 d B for 4 *** found that tranylcypromine treatment led to the upregulation of Sestrin2(SESN2)and activation of the autophagy markers light chain 3B and lysosome-associated membrane glycoprotein 1 in the cochleae of mice treated with *** noise exposure group treated with tranylcypromine showed significantly lower average auditory brainstem response hearing thresholds at click,4,8,and 16 k Hz frequencies compared with the noise exposure group treated with *** findings indicate that tranylcypromine treatment resulted in increased SESN2,light chain 3B,and lysosome-associated membrane glycoprotein 1 expression after noise exposure,leading to a reduction in levels of 4-hydroxynonenal and cleaved caspase-3,thereby reducing noise-induced hair cell ***,immunoblot analysis demonstrated that treatment with tranylcypromine upregulated SESN2 expression via the autophagy *** treatment also reduced the production of NOD-like receptor family pyrin domaincontaining 3(NLRP3)*** conclusion,our results showed that tranylcypromine treatment ameliorated cochlear inflammation by promoting the expression of SESN2,which induced autophagy,thereby restricting NLRP3-related inflammasome signaling,alleviating cochlear hair cell loss,and protecting hearing *** findings suggest that inhibiting lysine-specific demethylase 1 is a

关键词： 4-hydroxynonenal apoptosis autophagy cleaved caspase-3 inflammation NOD-like receptor family pyrin domain-containing 3(NLRP3) noise-induced hearing loss oxidative stress Sestrin2 tranylcypromine

初诊脑转移肺腺癌患者全身治疗联合脑部放疗的疗效和安全性

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中华肿瘤防治杂志 2021年第9期28卷 682-687页

作者：王淼张俊覃桂珍周芙玲魏永长武汉大学中南医院放化疗科湖北武汉430071 武汉大学中南医院血液科湖北武汉430071

目的探讨全身治疗联合脑部放疗治疗初诊脑转移肺腺癌患者的疗效及安全性。方法收集武汉大学中南医院2014-04-12-2018-12-25收治的58例初诊脑转移肺腺癌患者,其中34例有表皮生长因子受体(EGFR)突变,为EGFR(+)组;24例无驱动基因,为野生型... 详细信息

目的探讨全身治疗联合脑部放疗治疗初诊脑转移肺腺癌患者的疗效及安全性。方法收集武汉大学中南医院2014-04-12-2018-12-25收治的58例初诊脑转移肺腺癌患者,其中34例有表皮生长因子受体(EGFR)突变,为EGFR(+)组;24例无驱动基因,为野生型组。58例患者确诊脑转移后均行脑部放疗,同时根据患者驱动基因状态分别予以EGFR-TKIs和化疗作为一线全身治疗。脑部放疗结束后1个月,根据实体瘤疗效评价标准RECIST 1.1行颅内病灶的疗效评价。生存分析采用Kaplan-Meier法并行Log-rank检验,精确概率法比较2组患者的颅内治疗反应及疾病进展模式。结果58例患者颅内客观缓解率(ORR)和疾病控制率(DCR)分别为63.7%和100%;58例患者中位总体生存时间(OS)和无进展生存时间(IPFS)分别为24.33和19.03个月。EGFR(+)组患者总生存期优于野生型组,中位OS分别为28.40和17.93个月,差异有统计学意义,χ^(2)=4.208,P=0.040。野生型组患者的颅内IPFS(11.27个月)短于EGFR(+)组(21.53个月),差异无统计学意义,χ^(2)=1.853,P=0.173;但有重要的临床意义-中位IPFS延长10个月。一线治疗后46例患者出现疾病进展,其中71.7%(33/46)患者出现原发灶的进展,而颅内病灶控制稳定。不良反应可耐受可控,无患者死于治疗相关的不良反应。结论全身治疗联合脑部放疗是初诊脑转移肺腺癌患者的一种安全可行的治疗猊择,给患者带来了较好的颅内局部控制和生存获益。治疗后疾病主要进展模式是原发病灶进展,而颅内病灶稳定,提示肺部原发灶的局部治疗可能给这些患者带来生存获益。

关键词：全身治疗脑部放疗肺腺癌脑转移瘤

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压电雾化喷涂法制备纳米银线透明导电薄膜

电镀与涂饰 2017年第20期36卷 1085-1089页

作者：储成智魏顶王勇徐伟汝长海苏州大学机器人与微系统研究中心苏州大学江苏苏州215021 苏州纳米科技协同创新中心苏州大学江苏苏州215021

采用压电雾化喷涂法在聚对苯二甲酸乙二酯(PET)膜表面制备了纳米银线导电薄膜。通过控制纳米银线溶液的浓度和压电喷涂的层数,可以很好地控制导电薄膜的光学和电学性能。当银线质量浓度为0.625 mg/mL时,压电喷涂4层所得透明导电薄膜的... 详细信息

采用压电雾化喷涂法在聚对苯二甲酸乙二酯(PET)膜表面制备了纳米银线导电薄膜。通过控制纳米银线溶液的浓度和压电喷涂的层数,可以很好地控制导电薄膜的光学和电学性能。当银线质量浓度为0.625 mg/mL时,压电喷涂4层所得透明导电薄膜的方块电阻为27.8Ω/sq,可见光透过率在550 nm时为89.0%,表现出最佳的光学和电学综合性能,而且其方块电阻不均匀度为9.1%,表现出良好的均匀性。

关键词：纳米银线聚对苯二甲酸乙二酯透明导电薄膜压电雾化喷涂方块电阻可见光透过率均匀性

FOLFOX方案辅助复方苦参注射液治疗胃癌疗效及不良反应系统评价

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中华肿瘤防治杂志 2019年第12期26卷 881-887页

作者：覃桂珍王芦萍王淼魏永长武汉大学中南医院肿瘤放化疗科

目的复方苦参注射液辅助化疗可提高抗肿瘤疗效。本研究系统评价复方苦参注射液辅助FOLFOX方案对胃癌化疗疗效及不良反应。方法计算机检索The Cochrane Library、EMbase、PubMed、中国知网、VIP、万方和CBM数据库,检索时限为自建库至2018... 详细信息

目的复方苦参注射液辅助化疗可提高抗肿瘤疗效。本研究系统评价复方苦参注射液辅助FOLFOX方案对胃癌化疗疗效及不良反应。方法计算机检索The Cochrane Library、EMbase、PubMed、中国知网、VIP、万方和CBM数据库,检索时限为自建库至2018-10-29,试验组为FOLFOX方案化疗+复方苦参注射液,对照组为单用FOLFOX方案化疗,纳入符合标准的随机对照试验(randomized controlled trial,RCT),采用比值比(odds ratio,OR)作为Meta分析中的合并效应量。结果纳入18篇RCT,共1608例患者。Meta分析结果显示:试验组胃癌治疗有效率(OR=2.31,95%CI:1.79~2.98,P<0.001)和患者生存质量(OR=3.20,95%CI:2.30~4.45,P<0.001)高于对照组;试验组肝功能下降(OR=0.27,95%CI:0.18~0.39,P<0.001)、肾功能下降(OR=0.33,95%CI:0.15~0.74,P=0.007)、白细胞下降(OR=0.30,95%CI:0.22~0.41,P<0.001)、血小板下降(OR=0.39,95%CI:0.25~0.60,P<0.001)、血红蛋白下降(OR=0.38,95%CI:0.24~0.59,P<0.001)、恶心呕吐(OR=0.43,95%CI:0.32~0.59,P<0.001)和神经毒性(OR=0.41,95%CI:0.24~0.69,P<0.001)发生率低于对照组,且差异均有统计学意义。结论在单纯FOLFOX方案化疗基础上增加复方苦参注射液辅助治疗,可提高对胃癌疗效并减轻部分化疗不良反应。

关键词：复方苦参注射液胃癌 FOLFOX 化疗不良反应系统评价