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The impact of the COVID-19 pandemic on nasopharyngeal carcinoma patients-a national cancer centre experience

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Holistic Integrative Oncology 2023年第1期2卷 160-169页

作者： Sharon S.Poh Boon Fei Tan Fang Yue yong Kam Weng Fong Joseph T.S.wee Terence W.K.Tan Melvin L.K.Chua Kiattisa Sommat Fu Qiang Wang Yoke Lim Soong Division of Radiation Oncology Duke-NUS Graduate Medical SchoolNational Cancer Centre SingaporeSingaporeSingapore Duke-NUS Graduate Medical School Oncology Academic Clinical ProgrammeSingaporeSingapore

Purpose or objective The COVID-19 pandemic has resulted in significant healthcare implications,with care for can-cer patients compromised due to resource diversion towards battling the *** aim to investigate the impact of the peak wave of the pandemic in 2020 on the delivery of cancer care in Singapore,specifically via our nasopharyn-geal carcinoma(NPC)treatment *** study applies real world numbers to the impact of COVID-19 on cancer care delivery in *** choice of nasopharyngeal cancer allows a good direct estimate of common treatment measures such as time to biopsy,time to staging scans,time to treatment commencement,due to its clear protocol and algorithms for staging and treatment;thus serving as an excellent surrogate for the effectiveness and timeliness of the different aspects of cancer care *** and methods In this retrospective study,we included all patients with newly diagnosed NPC from 1st January to 31st May from 2017 to 2020 at our *** time period was chosen as it coincided with the period in 2020 during the COVID-19 pandemic where there was the most strain on healthcare resources and the most restrictions on population movement within Singapore,which may impact on healthcare seeking *** down the time period to the first 5 months of the 4 respective years also allowed us to reduce the effect of annual seasonal variation in patient numbers seen as a result of holidays and festive periods such as the Lunar New Year and scheduled school *** medical records(EMR)were *** newly diagnosed NPC cases were included in our *** with second synchronous primary malignancies or NPC disease recurrence were *** analysis was carried out using a combination of SPSS and Microsoft *** Significantly,there was a reduction of 37-46.3%in newly diagnosed NPC cases during the peak of the COVID-19 pandemic from January to end May 2020 compared to the preceding t

关键词： COVID-19 Nasopharyngeal carcinoma Health services delivery

急性原发性闭角型青光眼视盘水肿的OCT检查

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美国医学会眼科杂志（中文版） 2005年第4期17卷 229-230页

作者： Leonard W. Yip Vernon K. Y. yong sek-Tien Hoh Hon-Tym Wong 陆遥（译）

急性原发性闭角型青光眼（APACG）属于眼科急诊，如果延误首诊诊断和治疗，则预后较差。由于角膜水肿，前房炎症，白内障和缩瞳药物的使用常导致后节体征难以检查。光学相干断层扫描（OCT）是一种非接触式无创性图象技术，可以获得眼后... 详细信息

急性原发性闭角型青光眼（APACG）属于眼科急诊，如果延误首诊诊断和治疗，则预后较差。由于角膜水肿，前房炎症，白内障和缩瞳药物的使用常导致后节体征难以检查。光学相干断层扫描（OCT）是一种非接触式无创性图象技术，可以获得眼后段组织结构高分辨率的断层图像。我们报告1例在APACG后发生视盘水肿和分支静脉阻塞的病例，进行了OCT和荧光素血管造影的检查。我们讨论了OCT图像上视盘的外观，在荧光素血管造影上还发现了静脉循环中的部分血栓。

关键词：急性原发性闭角型青光眼 CT检查视盘水肿荧光素血管造影光学相干断层扫描 OCT图像分支静脉阻塞眼科急诊首诊诊断角膜水肿

LncRNA wee2-AS1 knockdown inhibits the proliferation,migration and invasion of glioma cells via regulating miR-29b-2-5p/TPM3 axis

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Oncology Research 2021年第2期29卷 105-117页

作者： ZHEN JIA ZHENGTING QIAN yong TANG XIANG LI YAN SHI HENG XIN YOUWU FAN HEMING WU Nanjing Medical University Nanjing210000China Department of Neurosurgery Nanjing First HospitalNanjing Medical UniversityNanjing210006China

Glioma is a general malignant tumor with a dismal *** noncoding RNAs(lncRNAs)have been implicated in the initiation and processes of *** investigation of the GEPIA database revealed that long noncoding RNA wee2 antisense RNA 1(wee2-AS1)is upregulated in glioma tissues compared to normal brain tissues,and validation with quantitative real-time polymerase chain reaction(qRT–PCR)revealed that wee2-AS1 expression was consistent with the database *** in situ hybridization(FISH)assays revealed that wee2-AS1 was localized primarily in the *** formation experiment and EDU assay were used to detect cell proliferation ability,and Transwell assay was used to detect cell migration and invasion ability,Western-blot assay and immunofluorescence were used to determine TPM3 protein *** experiments revealed that the downregulation of wee2-AS1 impeded cell proliferation,migration,and invasion in glioma cell ***,downregulation of wee2-AS1 suppressed tumor growth in *** predictions and integrated experiments indicated that wee2-AS1 promoted tropomyosin 3(TPM3)expression by sponging miR-29b-2-5p.A dual-luciferase reporter assay was conducted to uncover the binding of wee2-AS1 and miR-29b-2-5p and that of miR-29b-2-5p and ***,a series of rescue assays showed that wee2-AS1 promotes proliferation,migration,and invasion by targeting miR-29b-2-5p to regulate TPM3 ***,the results of this study indicate that wee2-AS1 plays an oncogenic role in glioma and may promote further investigations of the diagnostic and prognostic value of wee2-AS1 in glioma.

关键词： LncRNA wee2-AS1 Glioma miR-29b-25p TPM3 Proliferation

Two Cancers Arising from Different Mesenchymal Origins: An Unexpected Connection over Time and Space

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Case Reports in Clinical Medicine 2019年第5期8卷 99-104页

作者： Natascha Putri Sze Min Lek Nicholas Brian Shannon Joey wee-Shan Tan Grace Hwei Ching Tan Claramae Shulyn Chia Melissa Ching Ching Teo Choon Hua Thng Timothy Kwang yong Tay Chin-Ann Johnny Ong Tina Puay Theng Koh Division of Surgical Oncology National Cancer Centre Singapore Singapore City Singapore Division of Oncologic Imaging National Cancer Centre Singapore Singapore City Singapore Department of Anatomical Pathology Singapore General Hospital Singapore City Singapore

Sarcomas are rare tumours, accounting for 1% of all malignancies. They are histologically diverse, presenting with more than 50 different subtypes. Sarcoma can be broadly divided into two categories—soft tissue sarcoma and bone sarcoma. Extraskeletal osteosarcoma is a unique subtype which is histologically similar to bone osteosarcoma but resides within soft tissue and has no attachments to bone. We present a rare case of a patient who initially presented with an extraskeletal osteosarcoma that was complicated by a chronic chest wall sinus and lymphedema of the left arm. He later developed enlarging left chest wall nodules at the same region that were proven to be dedifferentiated liposarcoma on biopsy 20 years later. We examine the occurrence of both extremely rare diseases of differing pathologies over the same site but separated by an extraordinarily long interval, and possible new associations to account for this phenomenon.

关键词： Sarcoma Extraskeletal Osteosarcoma Dedifferentiated Liposarcoma Osteogenic Sarcoma

Engineering immunosuppressive drug-resistant armored(IDRA)SARS-CoV-2 T cells for cell therapy

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Cellular & Molecular Immunology 2023年第11期20卷 1300-1312页

作者： Qi Chen Adeline Chia Shou Kit Hang Amy Lim wee Kun Koh Yanchun Peng Fei Gao Jili Chen Zack Ho Lu-En Wai Kamini Kunasegaran Anthony Tanoto Tan Nina Le Bert Chiew Yee Loh Yun Shan Goh Laurent Renia Tao Dong Anantharaman Vathsala Antonio Bertoletti Emerging Infectious Disease Program Duke-NUS Medical SchoolSingaporeSingapore National University Centre for Organ Transplantation National University HospitalSingaporeSingapore MRC Human Immunology Unit MRC Weatherall Institute of Molecular MedicineRadcliffe Department of MedicineUniversity of OxfordOxfordUK Lion TCR Pte Ltd SingaporeSingapore A*STAR ID labs Agency for ScienceTechnology and ResearchSingaporeSingapore Lee Kong Chian School of Medicine Nanyang Technological UniversitySingaporeSingapore Department of Medicine Yong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore Singapore Immunology Network A*STARSingaporeSingapore

Solid organ transplant(SOT)recipients receive immunosuppressive drugs(ISDs)and are susceptible to developing severe ***,we analyze the Spike-specific T-cell response after 3 doses of mRNA vaccine in a group of SOT patients(n=136)treated with different *** demonstrate that a combination of a calcineurin inhibitor(CNI),mycophenolate mofetil(MMF),and prednisone(Pred)treatment regimen strongly suppressed the mRNA vaccine-induced Spike-specific cellular *** defects have clinical consequences because the magnitude of vaccine-induced Spike-specific T cells was directly proportional to the ability of SOT patients to rapidly clear SARS-CoV-2 after breakthrough *** then compensate for the T-cell defects induced by immunosuppressive treatment and to develop an alternative therapeutic strategy for SOT patients,we describe production of 6 distinct SARS-CoV-2 epitope-specific ISD-resistant T-cell receptor(TCR)-T cells engineered using the mRNA electroporation method with reactivity minimally affected by mutations occurring in Beta,Delta,Gamma,and Omicron *** strategy with transient expression characteristics marks an improvement in the immunotherapeutic field and provides an attractive and novel therapeutic possibility for immunosuppressed COVID-19 patients.

关键词： T cell therapy Transplantation SARS-CoV-2 Immunosuppressive drug resistant T cells

Population trend and spatio-temporal distribution of Greater White-fronted (Anser albifrons) and Bean Geese (Anser fabalis) in Korea

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Avian Research 2024年第4期 458-465页

作者： Eun-Jeong Kim wee-Heang Hur Hwa-Jung Kim Yu-Seong Choi Dongwon Kim Who-Seung Lee Sejeong Han Hyerin Joo Chang-yong Choi Department of Agriculture Forestry and Bioresources Seoul National University Research Institute of Agriculture and Life Science Seoul National University National Migratory Birds Center National Institute of Biological Resources Division for Natural Environment Korea Environment Institute

Geese have undergone significant changes in their distribution and population size due to human-induced impacts. To improve our understanding of the two main geese populations in East Asia—Greater White-fronted(Anser albifrons; GWFG) and Bean Geese(Anser fabalis sensu lato; BEAG), which includes the Tundra A. f. serrirostris(TDBG) and Taiga Bean Geese A. f. middendorffii(TGBG), this study estimated their long-and short-term trends and the migration strategies based on their distribution during the migratory and wintering seasons, using nationwide census data collected over 24 years in South Korea. The TRIM(TRends and Indices for Monitoring data) analysis supported a robust long-term population increase since 1999, recently stabilizing around 150,000 individuals in GWFG and 100,000 in TDBG, respectively. But TGBG stabilized at around 7000 with no significant change of population over time. The shorter-term trends within a season suggested that wintering populations of GWFG and TDBG in China might stop over in Korea in their autumn migration before their sea-crossing, evidenced by the large congregation near the Yellow Sea coast followed by a gradual decrease. In contrast to autumn, there was no similar peak in spring migration, suggesting the potential for elliptical migration of some populations around the Yellow Sea. Our findings indicate a growing East Asian population and imply one of the migration strategies of the Greater White-fronted and Tundra Bean Geese. By collaborating with recent tracking data, long-term monitoring efforts could offer more detailed insights into population trends and migration strategies, thereby contributing to the effective management and conservation of goose species in East Asia.

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3D-QSAR and Docking Studies of Pyrido[2,3-d]pyrimidine Derivatives as weel Inhibitors

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Chinese Journal of Chemical Physics 2012年第3期25卷 297-307,373页

作者： Guo-hua Zeng Wen-juan Wu Rong Zhang Jun Sun Wen-guo Xie yong Shen Department of Physical Chemistry Guangdong Pharmaceutical College GuanEzhou 510005 China School of Chemistry and Chemical Engineering Sun Yat-Sen University Guangzhou 510275 China

In order to investigate the inhibiting mechanism and obtain some helpful information for designing functional inhibitors against wee1, three-dimensional quantitative structure-activity relationship （3D-QSAR） and docking studies have been performed on 45 pyrido[2,3-d] pyrimidine derivatives acting as wee1 inhibitors. Two optimal 3D-QSAR models with significant statistical quality and satisfactory predictive ability were established, including the CoMFA model （q2=0.707, R2=0.964） and CoMSIA model （q2=0.645, R2=0.972）. The external validation indicated that both CoMFA and CoMSIA models were quite robust and had high predictive power with the predictive correlation coefficient values of 0.707 and 0.794, essen- 2 values of 0.792 and 0.826, the leave-one-out r2m（LOO） values of 0.781 and tim parameter rm2 0.809, r2（ all） values of 0.787 and 0.810, respectively. Moreover, the appropriate binding orientations and conformations of these compounds interacting with wee1 were revealed by the docking studies. Based on the CoMFA and CoMSIA contour maps and docking analyses, several key structural requirements of these compounds responsible for inhibitory activity were identified as follows： simultaneously introducing high electropositive groups to the sub- stituents R1 and R5 may increase the activity, the substituent R2 should be smaller bulky and higher electronegative, moderate-size and strong electron-withdrawing groups for the substituent R3 is advantageous to the activity, but the substituent X should be medium-size and hydrophilic. These theoretical results help to understand the action mechanism and design novel potential wee1 inhibitors.

关键词： weel Pyrido[2 3-d]pyrimidine derivative Three-dimensional quantitativestructure-activity relationship Docking study

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白先勇小说同性恋者的悲剧命运探微

中南大学学报（社会科学版） 2007年第6期13卷 730-734页

作者：黄伟雄南京师范大学文学院

白先勇的小说脍炙人口,其中不乏以同性恋为题材的小说。1988年,白先勇公开了自己的性取向。因此,从白先勇的小说看同性恋的世界,不再是雾里看花。白先勇以他独特的小说技巧描述同性恋者的悲剧命运。同性恋者的命运是充满悲剧的,同性恋... 详细信息

白先勇的小说脍炙人口,其中不乏以同性恋为题材的小说。1988年,白先勇公开了自己的性取向。因此,从白先勇的小说看同性恋的世界,不再是雾里看花。白先勇以他独特的小说技巧描述同性恋者的悲剧命运。同性恋者的命运是充满悲剧的,同性恋者一生被流在血液里的生理欲望孽魔纠缠。年轻俊美时,尚能容易满足生理欲望孽魔的需要;随着时光流逝,年岁增长,面容逐渐衰老,再也无法轻易满足生理欲望孽魔的需要。为此,老同性恋者得奔波劳碌、伺机寻找可以满足他们生理欲望孽魔需要的青春鸟,不少的同性恋者也因着得了爱滋病而离开世界。同性恋者一生的命运是悲哀的,白先勇悲天悯人的情怀让读者更深入地了解了同性恋者的世界和他们黑暗的国度。

关键词：白先勇同性恋性取向黑暗的国度悲剧命运

金雀异黄素在去卵巢非酒精性脂肪性肝病小鼠模型中的保护作用及机制

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临床肝胆病杂志 2024年第4期40卷 706-711页

作者：朱项羽金涌苏州大学附属苏州九院药学部江苏苏州215200 安徽医科大学药学院合肥230032

目的探讨金雀异黄素(Genistein)在去卵巢(OVX)小鼠非酒精性脂肪性肝病(NAFLD)中的保护作用及机制。方法取40只6周龄雌性C57BL/6小鼠建立OVX小鼠模型,随机分为5组,每组8只,分别为对照组、模型4周组、模型6周组、模型8周组、模型10周组。... 详细信息

目的探讨金雀异黄素(Genistein)在去卵巢(OVX)小鼠非酒精性脂肪性肝病(NAFLD)中的保护作用及机制。方法取40只6周龄雌性C57BL/6小鼠建立OVX小鼠模型,随机分为5组,每组8只,分别为对照组、模型4周组、模型6周组、模型8周组、模型10周组。相同环境下,采用高脂饮食对5组OVX小鼠进行饮食造模,病理学检查显示,经10周高脂饮食诱导NAFLD成功。另取40只6周龄雌性C57BL/6小鼠随机分为5组:空白组、假手术(Sham)组、OVX组、OVX+L-Genistein(4 mg/kg体质量)组、OVX+H-Genistein(8 mg/kg体质量)组。Sham组进行相同的OVX手术过程,但不结扎卵巢动脉和切除卵巢。空白组小鼠正常饮食喂养,其余各组供给高脂饮食。将Genistein溶解在DMSO中,Sham组和OVX组的动物仅用溶媒溶液处理,所有小鼠每天灌胃给药1次,持续10周。记录小鼠体质量及脏器指数,处死小鼠并收集血清及肝组织。试剂盒检测血清ALT、AST活性及TG、TC水平。HE和油红O染色观察肝组织病理。通过Western Blot分析肝组织中脂质代谢相关的固醇调节元件结合蛋白1(SREBP-1c)、过氧化物酶体增殖物激活受体α(PPARα)的蛋白表达。计量资料多组间比较采用单因素方差分析,进一步两组间比较采用Dunnett-t检验。结果高脂饮食10周后,Genistein低、高剂量组的体质量、肝指数和肝质量均低于OVX组(P值均<0.05)。此外,Genistein显著下调了血清TC、TG水平(P值均<0.05),降低了血清中AST和ALT活性(P值均<0.05)。HE和油红O染色结果表明,Genistein低、高剂量组较OVX组脂滴累积明显减少。Western Blot分析结果显示,给予Genistein干预后,SREBP-1c的蛋白表达量明显下降,PPARα的蛋白表达量明显升高(P值均<0.05)。结论Genistein对OVX小鼠NAFLD具有保护作用,其部分作用机制可能与调节SREBP-1c、PPARα的表达有关,从而促进脂肪酸氧化和抑制肝脏脂质合成。

关键词：非酒精性脂肪性肝病卵巢切除术小鼠,近交C57BL 金雀异黄素