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Investigation of diagnosis and treatment of hemolysis-elevated liver enzymes-low platelet counts （HELLP） syndrome： clinical analysis of 59 cases

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Chinese Medical Journal 2010年第10期123卷 1273-1277页

作者： WANG yong-qing WANG Jing ye Rong-hua ZHAO Yang-yu Department of Obstetrics and Gynecology Peking University Third Hospital Beijing 100191 China

Background Hemolysis-elevated liver enzymes-low platelet counts （HELLP） syndrome is a clinical condition occurring in middle and late stage pregnancy. It is characterized by hemolysis, elevated liver enzymes and low platelet counts. This study involves the analysis of the diagnosis, clinical characteristics and treatment of 59 cases of HELLP syndrome as well as the clinical classification, method of delivery and gestational age at delivery. Methods Clinical data from 59 cases of HELLP syndrome occurring from January 2000 to December 2009 were analyzed retrospectively. Thirty-five cases were classified as complete HELLP syndrome and 24 cases were considered partial HELLP syndrome. Results Twenty-six of the 59 analyzed patients （44%） with complete HELLP syndrome showed rapid onset, severe signs, symptoms, and complications in addition to a poor clinical outcome. Complications included multiple organ dysfunction syndrome （MODS） occurring in 18 cases, eclampsia （3 cases）, placental abruption （3 cases）, and perinatal death （4 cases）. The remaining 33 cases （24 with partial and 9 with complete HELLP） were characterized by less severe signs, symptoms, complications and progression of the condition. Two of these cases were complicated with MODS （6.1%）, and 1 with perinatal death （3.0%）.Twelve non-radical-type cases received conservative treatment. The remaining 4 patients had recurring HELLP syndrome （6.78%）. Conclusions HELLP syndrome is classified as the radical type and non-radical-type according to clinical characteristics and outcome. Classification of HELLP syndrome cases according to clinical features can help in the monitoring and treatment of the disease. Active termination of pregnancy should be considered for radical-type cases. Non-radical-type cases can undergo conservative treatment with close monitoring in an attempt to improve perinatal outcome without increasing maternal morbidity.

关键词： HELLP syndrome severe preeclampsia diagnosis treatment

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Three-dimensional visualization technology for guiding one-step percutaneous transhepatic cholangioscopic lithotripsy for the treatment of complex hepatolithiasis

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World Journal of Gastroenterology 2024年第28期30卷 3393-3402页

作者： yong-qing ye Ya-Wen Cao Rong-Qi Li En-Ze Li Lei Yan Zhao-Wei Ding Jin-Ming Fan Ping Wang Yi-Xiang Wu Department of Hepatobiliary Surgery The Second People’s Hospital of FoshanFoshan 528000Guangdong ProvinceChina Department of Emergency Medicine Biomedical Innovation CenterThe Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655Guangdong ProvinceChina Department of Hepatobiliary Surgery Foshan Hospital of Traditional Chinese MedicineFoshan 528000Guangdong ProvinceChina Department of Hepatobiliary Surgery The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510282Guangdong ProvinceChina Department of Gastrointestinal Surgery The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510120Guangdong ProvinceChina

BACKGROUND Biliary stone disease is a highly prevalent condition and a leading cause of hospitalization *** with associated strictures has high residual and recurrence rates after traditional multisession percutaneous transhepatic cholangioscopic lithotripsy(PTCSL).AIM To study one-step PTCSL using the percutaneous transhepatic one-step biliary fistulation(PTOBF)technique guided by three-dimensional(3D)*** This was a retrospective,single-center study analyzing,140 patients who,between October 2016 and October 2023,underwent one-step PTCSL for *** patients were divided into two groups:The 3D-PTOBF group and the PTOBF *** clearance on choledochoscopy,complications,and long-term clearance and recurrence rates were *** Age,total bilirubin,direct bilirubin,Child-Pugh class,and stone location were similar between the 2 groups,but there was a significant difference in bile duct strictures,with biliary strictures more common in the 3D-PTOBF group(P=0.001).The median follow-up time was 55.0(55.0,512.0)*** immediate stone clearance ratio(88.6%vs 27.1%,P=0.000)and stricture resolution ratio(97.1%vs 78.6%,P=0.001)in the 3D-PTOBF group were significantly greater than those in the PTOBF *** complication(8.6%vs 41.4%,P=0.000)and stone recurrence rates(7.1%vs 38.6%,P=0.000)were significantly lower in the 3D-PTOBF *** Three-dimensional visualization helps make one-step PTCSL a safe,effective,and promising treatment for patients with complicated primary *** perioperative and long-term outcomes are satisfactory for patients with complicated primary *** minimally invasive method has the potential to be used as a substitute for hepatobiliary surgery.

关键词： Hepatolithiasis One-step percutaneous transhepatic cholangioscopic lithotripsy Biliary disease Three-dimensional visualization Clinical efficacy

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A case of aggravation of hemolytic anemia, elevated liver enzymes and low platelet count syndrome after delivery

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Chinese Medical Journal 2011年第8期124卷 1261-1263页

作者： JIANG Yuan-hui WANG yong-qing WANG Jing ye Rong-hua Department of Obstetrics and Gynecology Peking UniversityThird Hospital Beijing 100191 China

Background Hemolytic anemia, elevated liver enzymes and low platelet count （HELLP） syndrome is a severe obstetric complication which usually resolves in most patients after *** We report a rare case of aggravation of HELLP syndrome after *** The patient underwent the treatment for HELLP syndrome,.including glucocorticoid therapy. The symptoms of HELLP syndrome reappeared and became more severe than before the termination of pregnancy. The patient also had severe and persistent hypoproteinemia, hyponatremia and *** HELLP syndrome is an acute and critical obstetric syndrome which can have heterogeneous presentations and variable prognosis. We should be fully aware of the diverse clinical characteristics of this condition.

关键词： HELLP syndrome hypocalcemia hyponatremia hypoproteinemia

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当代中国文艺创作与文化传播的引导与规制

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艺术百家 2017年第4期33卷 7-18,188页

作者：景小勇叶青中国国家话剧院北京100055 北京大学中文系北京100871

文艺创作与文化传播独特的本质、表现和特点,决定了必须坚持以人民为中心的导向,坚持社会效益与经济效益的统一。对文艺创作与文化传播给予引导与规制具有必要性,因为文艺创作具有多种动因,传播也不总是往积极方面发展,同时文艺创作与... 详细信息

文艺创作与文化传播独特的本质、表现和特点,决定了必须坚持以人民为中心的导向,坚持社会效益与经济效益的统一。对文艺创作与文化传播给予引导与规制具有必要性,因为文艺创作具有多种动因,传播也不总是往积极方面发展,同时文艺创作与传播会对社会产生巨大影响,尤其当前全球化进程为中国的文艺创作与传播提出了新的考验。中国需要更积极地走向世界,互联网和新媒体技术改变了文艺创作和传播的传统形态,并催生了新的文艺作品类型,这使得整个社会的文化格局将面临着重要改变。对文艺创作进行引导与规制的具体对象可以分为需要促进和需要抑制两大类。以人民为中心、弘扬社会主义核心价值观的创作,文艺精品、原创作品、创新性的创作,群众创作,具有民族性的创作,雅俗共赏的创作和体现中国梦的创作应该积极引导。文艺废品,"三俗"作品,孤芳自赏的创作,急功近利的创作,价值观扭曲的创作,猎奇、炒作性的创作,崇洋媚外的创作和意图颠覆国家的创作需要有效规制。对文艺创作与传播引导与规制要遵循规律,明确途径:完善人才培养体系与创新推动机制;健全价值把关体系与法律规范体系;改进评价评论体系与激励机制;加强文艺队伍建设,发挥人民团体作用;加强文艺阵地建设,将公益与市场结合,完善基层文化服务体系;尊重文化传播规律,发展改进文化传播网络,充分发挥党的领导作用。对文艺创作与传播加以正确、有效的引导和规制需要党和政府、市场及社会在其中区别定位、综合发力。

关键词：文艺创作文化传播本质表现特点引导规制途径

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Evolution of surgical treatment for hepatolithiasis

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World Journal of Gastrointestinal Surgery 2024年第12期16卷 3666-3674页

作者： yong-qing ye Pei-Heng Li qing Wu Shang-Lin Yang Bao-Ding Zhuang Ya-Wen Cao Zhan-Yi Xiao Shun-Qian Wen Department of Hepatobiliary Surgery The Second People's Hospital of FoshanFoshan 528000Guangdong ProvinceChina Department of Oncology Foshan Nanhai District Fifth People's HospitalFoshan 528000Guangdong ProvinceChina Department of Emergency Medicine Biomedical Innovation CenterThe Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655Guangdong ProvinceChina

Hepatolithiasis is a common disease where stones are located in the intrahepatic bile *** is a disease with regional *** compli-cation and postoperative recurrence rates of the disease are *** intrahepatic cholangiocarcinoma and the incidence of liver cirrhosisare the main causes of death in patients with ***,it is difficult to *** majority of biliary stones are readily removed endoscopically,however complex intrahepatic or large refractory extrahepatic stones often require surgical or percutaneous interventions when standard endoscopic methods *** present,the main clinical treatment for hepatolithiasis is surgery,of which there are different methods depending on the patient’s *** the continuous updates and development of medical technology,the treatment of hepatolithiasis has *** this paper,several mainstream surgical methods including partial hepatectomy,choledochojejunostomy,biliary tract exploration and lithotomy,percutaneous transhepatic chledochoscopic lithotripsy and liver transplantation used in the clinic are reviewed for clinicians'*** on the charac-teristics of each case,a suitable surgical method is chosen to obtain the best treatment effect.

关键词： Hepatolithiasis Biliary disease Surgical treatment Minimally invasive treatment Clinical efficacy

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Trinuclear gold-catalyzed site-selective alkylation of peptides

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Science China Chemistry 2025年第01期 249-256页

作者： qing-Yun Fang Chengyihan Gu Yinghan Chen Wencheng Yan yong Liang Weipeng Li Chengjian Zhu Jie Han Jin Xie State Key Laboratory of Coordination Chemistry Jiangsu Key Laboratory of Advanced Organic Materials Chemistry and Biomedicine Innovation Center (Chem BIC) School of Chemistry and Chemical Engineering Nanjing University Green Catalysis Center College of Chemistry Zhengzhou University State Key Laboratory of Natural Medicines China Pharmaceutical University

Selective modification of peptides has always been a challenging issue. The selective alkylation of peptides can alter the biological activity and physical properties of molecules, and it has gained significant research interest. We herein disclose an intriguing gold-catalyzed alkylation of peptides using bench-stable unactivated alkyl bromides under photoredox catalysis. A wide range of structurally diverse primary, secondary and tertiary alkyl bromides serve as effective coupling partners to precisely connect with the α-C(sp3)–H in glycine residue of peptides. This protocol demonstrates an exceptionally broad scope for alkyl halides and excellent tolerance for a wide range of useful functional groups. A series of relay transformations to construct cyclic peptides, to proceed click reaction and to realize peptide fluorescence labeling further enhance its synthetic practicality. In addition, mechanistic studies and density functional theory(DFT) calculations reveal an inner-sphere and subsequent outersphere single electron transfer(SET) mechanism.

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The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

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Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： Yanxi Li Jing Xue Yuejia Ma Ke ye Xue Zhao Fangliang Ge Feifei Zheng Lulu Liu Xu Gao Dayong Wang qing Xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Key Laboratory of Heilongjiang Province for Genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation

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Numerical simulation of cook-off characteristics for AP/HTPB

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Defence Technology（防务技术） 2018年第5期14卷 451-456页

作者： qing ye yong-gang Yu School of Energy and Power Engineering Nanjing University of Science and TechnologyNanjing210094China

The present study is devoted to researching the thermal security problems of large-scale solid rocket motor with Ammonium perchlorate/Hydroxyl-terminated polybutadiene(AP/HTPB). A two-dimensional axisymmetric model for the cook-off of solid rocket motor is established. The reaction kinetics for the cook-off process of AP/HTPB is described by the two-step global chemical mechanism. Numerical predictions of the cook-off behavior for the propellant are conducted at fast heating rate of 1.45-2.45 K/s,and slow heating rate of 0.001-0.003 K/s, respectively. The results show that in the fast cook-off condition. the initial ignition position of AP/HTPB occurs in the annular region of the outer wall of propellant without exception, and the center point in the region is(889.1,149.5). For the region, the axial width is1.8 mm and radial thickness is 0.8 mm. However, in the slow cook-off condition, the ignition center position is shifted along the axial direction toward the right end face of the propellant with the increase of heating rate. Therefore, the influence of heating rate on ignition temperature and ignition delay time is nonnegligible within a certain range.

关键词： Cook-off Numerical simulation AP/HTPB

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Regularity Criteria for the Three-dimensional MHD Equations

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Acta Mathematicae Applicatae Sinica 2011年第4期27卷 581-594页

作者： Lan LUO yong-ye ZHAO qing YANG Institute for Mathematics and Information Sciences Guangzhou University Cuangzhou 510006 China School of Mathematics and Computional Science Xiangtan University Xiangtan 411105 China

In this paper, we consider regularity criteria for solutions to the 3D MHD equations with incompressible conditions. By using some classical inequalities, we obtain the regularity of strong solutions to the three-dimensional MHD equations under certain sufficient conditions in terms of one component of the velocity field and the magnetic field respectively.

关键词： MHD equations strong solution regularity

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新生儿脐血瘦素水平的初步研究

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江汉大学学报（自然科学版） 2003年第2期31卷 73-75页

作者：魏超平黄永兰叶青青广州市妇婴医院新生儿科广东广州510180

目的:研究脐血瘦素水平与新生儿性别、孕周、出生体重、身高、体重指数及胎盘重量的关系。方法:应用酶联免疫法(ELISA)测定脐血瘦素水平,共测定了46份样本,运用统计学方法分析其与新生儿性别、孕周、出生体重、身高、体重指数BMI(即体... 详细信息

目的:研究脐血瘦素水平与新生儿性别、孕周、出生体重、身高、体重指数及胎盘重量的关系。方法:应用酶联免疫法(ELISA)测定脐血瘦素水平,共测定了46份样本,运用统计学方法分析其与新生儿性别、孕周、出生体重、身高、体重指数BMI(即体重除以身高的平方,单位为kg·m^(-2)及与胎盘重量等的关系。结果:脐血瘦素水平与出生体重、身高、体重指数及胎盘的重量有着显著性相关,而男女性别间脐血瘦素水平无显著性差异。结论:脐血瘦素水平与新生儿孕周、出生体重、身高、体重指数及胎盘重量有密切关系,临床测定脐血瘦素水平对预测胎儿出生体重和生长发育有重要意义。

关键词：新生儿脐血瘦素水平性别孕周出生体重身高体重指数胎盘重量

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