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Glycine Attenuates Myocardial Fibrosis in Myocardial Infarction in Rats Partly through Modulating Signal Transducer and Activator of Transcription 3/Nuclear Factor-κB/Transforming Growth Factor-β axis

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World Journal of Traditional Chinese Medicine 2024年第2期10卷 263-270页

作者： Ning Li yong Wang Chun Li Xu Chen Xue-Feng Zhang Nan Nan Tan Yi-Qin Hong Ming-Yan Shao Bing-Hua Tang Dong-qing Guo School of Life Science Beijing University of Chinese MedicineBeijingChina College of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijingChina Modern Research Center of Traditional Chinese Medicine School of Traditional Chinese Material MedicaBeijing University of Chinese MedicineBeijingChina

Objective: Inflammation and fibrosis are strongly associated with each other. Glycine is present in various traditional Chinese medicines and exhibits anti-inflammatory activity. However, the effects of glycine on myocardial fibrosis(MF) in rats with myocardial infarction(MI) have not been reported. The purpose of this study is to investigate the effects of glycine therapy on MF and comprehend its underlying mechanisms. Materials and Methods: Left anterior descending artery ligation-induced MI in Sprague Dawley rats was leveraged to assess the therapeutic effects of Glycine. Rats received either normal saline or glycine(0.5 mg/g bodyweight) for 7 days. Results: Glycine upregulated cardiac ejection fraction and fractional shortening to improve cardiac function, as evaluated by echocardiography. Histological and immunohistochemical analyses demonstrated that glycine could decrease inflammatory cell infiltration and alleviate collagen deposition. Western blotting revealed that nuclear factor-κB(NF-κB)-mediated inflammatory signaling was also downregulated by glycine treatment. The expression of signal transducer and activator of transcription 3(STAT3), tumor necrosis factor-α, and transforming growth factor-β(TGF-β) was decreased significantly in the glycine-treated group compared to the model group. Thus, glycine plays a protective role against myocardial ischemia and subsequent MF. Conclusion: The protective effects of glycine were achieved partly through STAT3/NF-κB/TGF-β signaling pathway.

关键词： Glycine myocardial fibrosis signal transducer and activator of transcription 3/nuclear factor-κB/transforming growth factor-β

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Therapeutic potential of urine-derived stem cells in renal regeneration following acute kidney injury:A comparative analysis with mesenchymal stem cells

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World Journal of Stem Cells 2024年第5期16卷 525-537页

作者： Fang Li Bin Zhao Lei Zhang Guo-qing Chen Li Zhu Xiao-Ling Feng Meng-Jia Gong Cheng-Chen Hu Yuan-Yuan Zhang Ming Li yong-Qiang Liu Department of General Surgery Chongqing General HospitalChongqing 401147China Department of Pediatric Research Institute Children’s Hospital of Chongqing Medical UniversityChongqing 401147China

BACKGROUND Acute kidney injury(AKI)is a common clinical syndrome with high morbidity and mortality *** use of pluripotent stem cells holds great promise for the treatment of ***-derived stem cells(USCs)are a novel and versatile cell source in cell-based therapy and regenerative medicine that provide advantages of a noninvasive,simple,and low-cost approach and are induced with high multidifferentiation *** these cells could serve as a potential stem cell source for the treatment of AKI has not been *** Stem cell markers with multidifferentiation potential were isolated from human amniotic *** severe combined immune deficiency(SCID)mice models were induced by means of an intramuscular injection with *** isolated from human-voided urine were administered via tail *** functional changes in the kidney were assessed by the levels of blood urea nitrogen and serum *** histologic changes were evaluated by hematoxylin and eosin staining and transferase dUTP nick-end labeling ***,we compared the regenerative potential of USCs with bone marrow-derived mesenchymal stem cells(MSCs).RESULTS Treatment with USCs significantly alleviated histological destruction and functional *** renal function was rapidly restored after intravenous injection of 5×105 human USCs into SCID mice with glycerol-induced AKI compared with injection of *** from secretion assays conducted in vitro demonstrated that both stem cell varieties released a wide array of cytokines and growth *** suggests that a mixture of various mediators closely interacts with their biochemical *** types of stem cells showed enhanced tubular cell prolif-eration and decreased tubular cell apoptosis,although USC treatment was not more effective than MSC *** found that USC therapy significantly improved renal function and histological damage,inhibited inflammation and apoptosis processes in the kid

关键词： Urine-derived stem cells Regenerative medicine Acute kidney injury Renal function recovery Cell therapy

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化学絮凝与消泡材料对盾构渣土渗流性能的作用机理

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同济大学学报（自然科学版） 2024年第7期52卷 991-999页

作者：陈庆陈沈旖阳栋官林星同济大学先进土木工程材料教育部重点实验室上海201804 同济大学材料科学与工程学院上海201804 中国建筑第五工程局有限公司湖南长沙410004 上海市政工程设计研究总院(集团)有限公司上海200092

为促进盾构渣土的资源化利用,针对土压平衡盾构渣土成分复杂、含水率高且渗透性差等问题,结合渗透试验、压汞测试和计算机断层扫描(CT)等方法,分析盾构渣土的多尺度渗流特征,探究掺入絮凝剂阳离子型聚丙烯酰胺(CPAM)和消泡剂有机硅氧烷... 详细信息

为促进盾构渣土的资源化利用,针对土压平衡盾构渣土成分复杂、含水率高且渗透性差等问题,结合渗透试验、压汞测试和计算机断层扫描(CT)等方法,分析盾构渣土的多尺度渗流特征,探究掺入絮凝剂阳离子型聚丙烯酰胺(CPAM)和消泡剂有机硅氧烷对渣土渗透性能的影响和作用机理。结果表明:原状盾构渣土的水分渗流受土体内泡沫的影响,渗透系数最终稳定在7.72×10^(-6)cm·s^(-1)附近,土体孔隙率高且孔径小贯通性差。絮凝剂的掺入可以改善盾构渣土的渗透性能,这是因为CPAM的吸附架桥和电中和作用,但掺量过大则会抑制渗流;该试验中CPAM的最佳掺量为0.30%,渗透系数最高可达2.55×10^(-5)cm·s^(-1)。消泡剂有机硅氧烷的掺量越高,盾构渣土的渗透系数越大,消泡剂可以快速消破土体内部泡沫并提高渗流通道的连通性;本试验的最佳掺量为0.20%,渗透系数可达1.31×10^(-5)cm·s^(-1)。

关键词：盾构渣土渗流絮凝剂消泡剂

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Three-dimensional visualization technology for guiding one-step percutaneous transhepatic cholangioscopic lithotripsy for the treatment of complex hepatolithiasis

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World Journal of Gastroenterology 2024年第28期30卷 3393-3402页

作者： yong-qing Ye Ya-Wen Cao Rong-Qi Li En-Ze Li Lei Yan Zhao-Wei Ding Jin-Ming Fan Ping Wang Yi-Xiang Wu Department of Hepatobiliary Surgery The Second People’s Hospital of FoshanFoshan 528000Guangdong ProvinceChina Department of Emergency Medicine Biomedical Innovation CenterThe Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655Guangdong ProvinceChina Department of Hepatobiliary Surgery Foshan Hospital of Traditional Chinese MedicineFoshan 528000Guangdong ProvinceChina Department of Hepatobiliary Surgery The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510282Guangdong ProvinceChina Department of Gastrointestinal Surgery The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510120Guangdong ProvinceChina

BACKGROUND Biliary stone disease is a highly prevalent condition and a leading cause of hospitalization *** with associated strictures has high residual and recurrence rates after traditional multisession percutaneous transhepatic cholangioscopic lithotripsy(PTCSL).AIM To study one-step PTCSL using the percutaneous transhepatic one-step biliary fistulation(PTOBF)technique guided by three-dimensional(3D)*** This was a retrospective,single-center study analyzing,140 patients who,between October 2016 and October 2023,underwent one-step PTCSL for *** patients were divided into two groups:The 3D-PTOBF group and the PTOBF *** clearance on choledochoscopy,complications,and long-term clearance and recurrence rates were *** Age,total bilirubin,direct bilirubin,Child-Pugh class,and stone location were similar between the 2 groups,but there was a significant difference in bile duct strictures,with biliary strictures more common in the 3D-PTOBF group(P=0.001).The median follow-up time was 55.0(55.0,512.0)*** immediate stone clearance ratio(88.6%vs 27.1%,P=0.000)and stricture resolution ratio(97.1%vs 78.6%,P=0.001)in the 3D-PTOBF group were significantly greater than those in the PTOBF *** complication(8.6%vs 41.4%,P=0.000)and stone recurrence rates(7.1%vs 38.6%,P=0.000)were significantly lower in the 3D-PTOBF *** Three-dimensional visualization helps make one-step PTCSL a safe,effective,and promising treatment for patients with complicated primary *** perioperative and long-term outcomes are satisfactory for patients with complicated primary *** minimally invasive method has the potential to be used as a substitute for hepatobiliary surgery.

关键词： Hepatolithiasis One-step percutaneous transhepatic cholangioscopic lithotripsy Biliary disease Three-dimensional visualization Clinical efficacy

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Two aquaporins,PIP1;1 and PIP2;1,mediate the uptake of neonicotinoid pesticides in plants

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Plant Communications 2024年第5期5卷 176-188页

作者： Qun Wan Yixin Li Jinjin Cheng Ya Wang Jing Ge Tingli Liu Liya Ma yong Li Jianan Liu Chunli Zhou Haocong Li Xing Sun Xiaolong Chen qing X.Li Xiangyang Yu Key Laboratory of Food Quality and Safety of Jiangsu Province State Key Laboratory Breeding BaseNanjing 210014China Institute of Food Safety and Nutrition Jiangsu Academy of Agricultural Sciences50 Zhongling StreetNanjing 210014China Jiangsu Provincial Key Construction Laboratory of Special Biomass Resource Utilization Nanjing Xiaozhuang University3601 Hongjin AvenueNanjing 211171China Department of Molecular Biosciences and Bioengineering University of Hawaii at ManoaHonoluluHI 96822USA

Neonicotinoids(NEOs),a large class of organic compounds,are a type of commonly used pesticide for crop *** uptake and accumulation in plants are prerequisites for their intra-and intercellular move-ments,transformation,and *** the molecular mechanisms that underpin NEO uptake by plants is crucial for effective application,which remains ***,we demonstrate that NEOs enter plant cells primarily through the transmembrane symplastic pathway and accumulate mainly in the *** plasma membrane intrinsic proteins discovered in Brassica rapa,BraPIP1;1 and BraPIP2;1,were found to encode aquaporins(AQPs)that are highly permeable to NEOs in different plant species and facilitate NEO subcellular diffusion and *** conserved transport function was further demonstrated in Xenopus laevis oocyte and yeast ***1;1 and BraPIP2;1 gene knockouts and interaction as-says suggested that their proteins can form functional *** of the potential of mean force indicated a negative correlation between NEO uptake and the energy barrier of BraPIP1;1 *** study shows that AQPs transport organic compounds with greater osmolarity than previously thought,providing new insight into the molecular mechanisms of organic compound uptake and facilitating innovations in systemic pesticides.

关键词： neonicotinoid aquaporin Brassica rapa plasma membrane uptake systemic pesticide

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System design and validation of Queqiao-2 lunar relay communication satellite

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中国空间科学技术(中英文) 2024年第5期44卷 23-39页

作者： ZHANG Lihua XIONG Liang SUN Ji CHEN Luojing XIAO Chuan ZHOU Wenyan WANG yong LIU Wangwang guan Yifeng CHEN Tao YU Xiaochuan XU Jin CHEN Guohui CAO Xiaoping DFH Satellite Co. Ltd. Beijing Institute of Spacecraft System Engineering Beijing Institute of Control Engineering Academy of Space Information Systems

In order to provide relay communication supports for future Chinese lunar exploration program, Queqiao-2 relay communication satellite was ***-2 can perform scientific observations with three kinds of scientific instruments on *** system design of Queqiao-2,including mission orbit and transfer orbit design, configuration and layout design, housekeeping and information flow design, power supply and distribution design, GNC and propulsion system design, communication links design, etc.,was accomplished through comprehensive tradeoff and evaluation on technical maturity, availability, schedule, cost, and so *** a view to reducing development risk, both the platform and relay communication payloads were developed based on significant heritage from previous Queqiao relay satellite and other relevant ***-2 features flexible system architecture to support multiple frequencies, modulations, data rates and software reconfigurations to meet new user *** to a successful launch on March 20,2024,by means of 5 orbit maneuvers, Queqiao-2 was inserted into a highly elliptical frozen mission orbit around the moon with a 24h period on *** on-orbit tests and calibrations, Queqiao-2 has possessed the capacity to provide reliable relay communication services to multiple lunar exploration missions, as well as the capacity to perform scientific *** the support of Queqiao-2,Chang′e-6 achieved its ambitious mission goal to collect and return samples from the moon′s mysterious far *** the meanwhile, Queqiao-2 has also paved the way for the following Chinese lunar exploration missions including Chang′e-7 and Chang′*** design life time of Queqiao-2 is more than 8 *** from flexibility and extensibility of relay communication system design, it is convenient to provide relay communication services for future lunar exploration missions of both China and other *** addition, innovative

关键词： lunar explorations relay communication Queqiao system design test validation

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Alterations in Serum Lipids and Lipoproteins Induced by Neoadjuvant Chemotherapy in Patients with Osteosarcoma around the Knee Joint:A Retrospective Analysis

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Current Medical Science 2024年第4期44卷 741-747页

作者： Su-guo WANG yong-gang WANG Guo-wei QIAN Li-na TANG Xin ZHOU Dong-dong CHENG Chen-liang ZHOU qing-cheng YANG Zan SHEN Gao-zhong HUANG Hong-tao LI Department of General Medicine Shenzhen Third People's HospitalShenzhen 518112China Department of VIP Clinic Shanghai Jiao Tong University Afiliated Sixth People's HospitalShanghai 200233China Department of Oncology Shanghai Jiao Tong University Affiliated Sixth People's HospitalShanghai 200233China Cancer Research Institute of Jilin University the First Hospital of Jilin UniversityChangchun 130021China Department of Orthopedics Shanghai Jiao Tong University Afiliated Sixth People's HospitalShanghai 200233China

Objective To investigate the serum lipid profiles of patients with localized osteosarcoma around the knee joint before and after neoadjuvant *** After retrospectively screening the data of 742 patients between January 2007 and July 2020,50 patients aged 13 to 39 years with Enneking stage II disease were included in the *** lipid levels,including total cholesterol(TC),triglycerides(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),lipoprotein-α[Lp(a)],and apolipoprotein A1,B,and E(ApoA1,ApoB,and ApoE),and clinicopathological characteristics were collected before and after neoadjuvant *** The mean levels of TC,TG,and ApoB were significantly increased following neoadjuvant chemotherapy(16%,38%,and 20%,respectively,*** values;P<0.01).The mean levels of LDL-C and ApoE were also 19%and 16%higher,respectively(P<0.05).No correlation was found between the pretreatment lipid profile and the histologic response to *** increase in Lp(a)was strongly correlated with the Ki-67 index(R=0.31,P=0.023).Moreover,a trend toward longer disease-free survival(DFS)was observed in patients with decreased TG and increased LDL-C following chemotherapy,although this difference was not statistically significant(P=0.23 and P=0.24,respectively).Conclusion Significant elevations in serum lipids were observed after neoadjuvant chemotherapy in patients with localized *** was no prognostic significance of pretreatment serum lipid levels on histologic response to neoadjuvant *** scale of increase in serum Lp(a)might have a potential prognostic role in *** with increased LDL-C or reduced TG after chemotherapy seem to exhibit a trend toward favorable DFS.

关键词： osteosarcoma neoadjuvant chemotherapy serum lipids

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Hongjin Xiaojie Capsule,a Chinese patent medicine,for treating moderate to severe cyclical breast pain:A single-blind randomized controlled trial

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Journal of Integrative Medicine 2024年第5期22卷 552-560页

作者： Qiong Zhang Ying-yi Fan Xue-qing Wu Yan-dan Huo Chun-hui Wang Shi-bing Liang Ting Wang Rong Zhong Xuan Wang Bao-yong Lai Xiao-hua Pei Jian-ping Liu Graduate School Beijing University of Chinese MedicineBeijing 100029China Department of Breast Beijing University of Chinese Medicine Third Affiliated HospitalBeijing 100029China Department of Breast Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 200021China Department of Breast Sichuan Second Hospital of Traditional Chinese MedicineChengdu 610014Sichuan ProvinceChina Department of Breast Xiamen HospitalBeijing University of Chinese MedicineXiamen 361015Fujian ProvinceChina Center for Evidence-Based Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China

Background Moderate to severe breast pain has major effects on the quality of life for *** Chinese medicines are widely used in the treatment of breast pain due to their stable dosage form and good *** To evaluate the beneficial effects and safety of Hongjin Xiaojie Capsule(HJXJC),a Chinese patent medicine,for the treatment of cyclical breast ***,setting,participants and intervention This is a multicenter,single-blind randomized controlled trial conducted in 3 medical centers in China from 2019 to *** with moderate to severe cyclic breast pain were randomly divided into the intervention group(who took HJXJC,four capsules per dose,three times a day for 12 weeks)and the control group(waiting for the treatment)in a 1:1 *** outcome measures The primary outcome was pain duration,and the patients recorded measurements at baseline and at the end of weeks 4,8,12 and 16 on a patient log *** The full analysis set(FAS)population included 298 participants(intervention group,n=150;control group,n=148),while the per-protocol analysis set(PPS)included 274 *** 12 weeks,the duration of breast pain was significantly shorter in the intervention group(FAS:mean difference,–6.69;95%CI,–7.58 to–5.80;P0.05).At weeks 8 and 12,th

关键词： Hongjin Xiaojie Capsule Cyclical breast pain Randomized controlled trial Traditional Chinese medicine

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Unraveling the Stray Current-Induced Interfacial Transition Zone(ITZ)Effect on Sulfate Corrosion in Concrete

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Engineering 2024年第10期41卷 130-152页

作者： yong-qing Chen Lin-Ya Liu Da-Wei Huang qing-Song Feng Ren-Peng Chen Xin Kang School of Transportation Engineering East China Jiaotong UniversityNanchang 330013China College of Civil Engineering Hunan UniversityChangsha 410082China Key Laboratory of Building Safety and Energy Efficiency of Ministry of Education&National Center for International Research Collaboration in Building Safety and Environment Hunan UniversityChangsha 410082China

The rail transit in sulfate-rich areas faces the combined effects of stray current and salt corrosion;however,the sulfate ion transport and concrete degradation mechanisms under such conditions are still *** address this issue,novel sulfate transport and mesoscale splitting tests were designed,with a focus on considering the differences between the interfacial transition zone(ITZ)and cement *** the influence of stray current,the ITZ played a pivotal role in regulating the transport and mechanical failure processes of sulfate attack,while the tortuous and blocking effects of aggregates almost *** phenomenon was termed the“stray current-induced ITZ effect.”The experimental data revealed that the difference in sulfate ion transport attributed to the ITZ ranged from 1.90 to 2.31 times,while the difference in splitting strength ranged from 1.56 to 1.64 *** the real-time synchronization of splitting experiments and microsecond-responsive particle image velocimetry(PIV)technology,the mechanical properties were exposed to the consequences of the stray currentinduced ITZ *** number of splitting cracks in the concrete increased,rather than along the central axis,which was significantly different from the conditions without stray current and the ideal Brazilian disk ***,a sulfate ion mass transfer model that incorporates reactivity and electrodiffusion was meticulously *** embedded finite element calculation exhibited excellent agreement with the experimental results,indicating its reliability and ***,the stress field was determined utilizing analytical methods,and the mechanism underlying crack propagation was successfully *** to the cement matrix,a stray current led to more sulfates,more microstructure degradation,and greater increases in thickness and porosity in the ITZ,which was considered to be the essence of the stray current-induced ITZ effect.

关键词： Interfacial transition zone(ITZ)effect Stray current Sulfate attack Transport mechanism Splitting test Microstructure

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论新质生产力理论对马克思主义生产力理论的创新发展

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上海经济研究 2024年第5期 16-24页

作者：郭冠清谷雨涵中国社会科学院经济研究所 100836 中国社会科学院大学 102488

本文以唯物史观为方法论基础,首先对传统教科书的生产力范畴、生产力核心要素、生产力核心命题进行了批判性分析,并以此为基础搭建了马恩经典作家的生产力理论;然后,对马克思主义生产力理论中国化时代化历史进程进行了研究,概括了毛泽... 详细信息

本文以唯物史观为方法论基础,首先对传统教科书的生产力范畴、生产力核心要素、生产力核心命题进行了批判性分析,并以此为基础搭建了马恩经典作家的生产力理论;然后,对马克思主义生产力理论中国化时代化历史进程进行了研究,概括了毛泽东和邓小平对生产力理论的创新发展;最后从对符合新发展理念的先进生产力范畴进行了术语革命、对生产关系的内涵和形式进行了创新表述、对生产力和生产关系原理进行了创造性思考、构建了以科技创新为核心要素的高质量发展引擎等方面概括总结了新质生产力理论对马克思主义生产力理论的创新发展。

关键词：唯物史观新质生产力生产力理论生产力要素

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