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Prevalence and risk factors for bone mineral density changes in antiretroviral therapy-naive human immunodeficiency virus-infected adults:a Chinese cohort study

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Chinese Medical Journal 2020年第24期133卷 2940-2946页

作者： yong-qin zeng Jiang Xiao Cui-Lin Li Yu Wang Ling Zhang Xiao-Li Pang Di Wang Juan Du Hong-Xin Zhao Department of Infection Beijing Ditan HospitalPeking UniversityBeijing 100015China Clinical and Research Center of Infectious Diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China

Background Studies have reported that low bone mineral density(BMD)is prevalent in human immunodeficiency virus(HIV)-infected patients;however,the factors that contribute to HIV-related BMD changes are yet to be fully *** to the application of dual X-ray absorptiometry(DXA)among a select group of hospitals only,the prevalence and risk factors of low BMD in HIV-infected populations have not been intensively investigated in ***,the aim of our study was to investigate the prevalence of and risk factors associated with BMD changes among antiretroviral therapy(ART)-naive HIV-positive patients in *** The assessment of the prevalence of and risk factors associated with BMD changes was conducted among 156 ART-naive HIV-infected *** and clinical data,as well as results of fasting blood tests were obtained from ***,all patients underwent DXA scans to determine BMD,which was then used to classify patients with osteopenia/*** risk factors of reduced BMD were then evaluated using binary logistic *** Among the 156 ART-naive HIV-infected participants,osteopenia and osteoporosis were diagnosed in 48.7%(76/156)and 4.5%(7/156)of patients,*** lumbar spine was most likely to have reduced BMD(49.4%[77/156]),and the proportion of osteopenia in the left hip(32.7%[51/156])was higher than in the right hip(24.4%[38/156]).In the lumbar spine,bone loss rate in the L1 section(60.9%[95/156])was the most significant(L2,53.2%[83/156];L3,45.5%[71/156];L4,52.6%[82/156]).Further analysis showed that,compared with the neck(26.9%[42/156]in the left,18.6%[29/156]in the right)and the interior(15.4%[24/156]in the left,13.5%[21/156]in the right),the trochanter had the greatest probability of reduced BMD(46.2%[72/156]in the left,28.8%[45/156]in the right).In the risk factor analysis,low body mass index(BMI:<18.5 kg/m2)was positively associated with reduced BMD(Exp(B)=39.743,95%confidence interval:3.234-488.399

关键词： Human immunodeficiency virus(HIV) Antiretroviral therapy-naive Bone mineral density Body mass index

Enhancing m^(6)A modification in the motor cortex facilitates corticospinal tract remodeling after spinal cord injury

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Neural Regeneration Research 2025年第6期20卷 1749-1763页

作者： Tian qin Yuxin Jin Yiming qin Feifei Yuan Hongbin Lu Jianzhong Hu yong Cao Chengjun Li Department of Spine Surgery and Orthopedics Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan ProvinceChangshaHunan ProvinceChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Sports Medicine Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Spinal cord injury typically causes corticospinal tract disruption. Although the disrupted corticospinal tract can self-regenerate to a certain degree, the underlying mechanism of this process is still unclear. N6-methyladenosine(m^(6)A) modifications are the most common form of epigenetic regulation at the RNA level and play an essential role in biological processes. However, whether m^(6)A modifications participate in corticospinal tract regeneration after spinal cord injury remains unknown. We found that expression of methyltransferase 14 protein(METTL14) in the locomotor cortex was high after spinal cord injury and accompanied by elevated m^(6)A levels. Knockdown of Mettl14 in the locomotor cortex was not favorable for corticospinal tract regeneration and neurological recovery after spinal cord injury. Through bioinformatics analysis and methylated RNA immunoprecipitation-quantitative polymerase chain reaction, we found that METTL14 regulated Trib2 expression in an m^(6)A-regulated manner, thereby activating the mitogen-activated protein kinase pathway and promoting corticospinal tract regeneration. Finally, we administered syringin, a stabilizer of METTL14, using molecular docking. Results confirmed that syringin can promote corticospinal tract regeneration and facilitate neurological recovery by stabilizing METTL14. Findings from this study reveal that m^(6)A modification is involved in the regulation of corticospinal tract regeneration after spinal cord injury.

关键词： corticospinal tract remodeling epigenetic regulations locomotor cortex m^(6)A modification methyltransferase 14 protein(METTL14) mitogen-activated protein kinase neural regeneration spinal cord injury syringin TRIB2

Mutual regulation of microglia and astrocytes after Gas6 inhibits spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 557-573页

作者： Jiewen Chen Xiaolin zeng Le Wang Wenwu Zhang Gang Li Xing Cheng Peiqiang Su yong Wan Xiang Li Department of Spine Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Guangdong Province Key Laboratory of Orthopedics and Traumatology GuangzhouGuangdong ProvinceChina

Invasive inflammation and excessive scar formation are the main reasons for the difficulty in repairing nervous tissue after spinal cord *** and astrocytes play key roles in the spinal cord injury micro-environment and share a close ***,the mechanisms involved remain *** this study,we found that after spinal cord injury,resting microglia(M0)were polarized into pro-inflammatory phenotypes(MG1 and MG3),while resting astrocytes were polarized into reactive and scar-forming *** expression of growth arrest-specific 6(Gas6)and its receptor Axl were significantly down-regulated in microglia and astrocytes after spinal cord *** vitro experiments showed that Gas6 had negative effects on the polarization of reactive astrocytes and pro-inflammatory microglia,and even inhibited the cross-regulation between *** further demonstrated that Gas6 can inhibit the polarization of reactive astrocytes by suppressing the activation of the Yes-associated protein signaling ***,in turn,inhibited the polarization of pro-inflammatory microglia by suppressing the activation of the nuclear factor-κB/p65 and Janus kinase/signal transducer and activator of transcription signaling *** vivo experiments showed that Gas6 inhibited the polarization of pro-inflammatory microglia and reactive astrocytes in the injured spinal cord,thereby promoting tissue repair and motor function ***,Gas6 may play a role in the treatment of spinal cord *** can inhibit the inflammatory pathway of microglia and polarization of astrocytes,attenuate the interaction between microglia and astrocytes in the inflammatory microenvironment,and thereby alleviate local inflammation and reduce scar formation in the spinal cord.

关键词： astrocytes Axl cell polarization Gas6 Hippo signal inflammatory micro-environment intercellular interaction microglia single-cell sequencing spinal cord injury

“全人教育”理念下高级英语混合式教学模式构建研究

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湖北函授大学学报 2017年第18期30卷 180-182页

作者：秦永丽曾景婷江苏科技大学外国语学院江苏镇江212003

全人教育强调人的全面发展,对英语专业高级英语教学混合式教学模式构建具有积极的指导作用。全人理念下的高级英语混合式教学模式以学生为中心,以教师为主导,发挥传统教学和网络资源的优势,通过对教学目标、学习模式和教学评价等要素的... 详细信息

全人教育强调人的全面发展,对英语专业高级英语教学混合式教学模式构建具有积极的指导作用。全人理念下的高级英语混合式教学模式以学生为中心,以教师为主导,发挥传统教学和网络资源的优势,通过对教学目标、学习模式和教学评价等要素的有效混合,努力把学生培养成为既有基本知识技能又有较高综合素质的"全人",实现高级英语教学"教单科、育全人"的教学目标。

关键词：全人教育混合式教学高级英语

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“基层卫生机构的能力建设”主题研讨

中国全科医学 2017年第2期20卷 127-132页

作者：贾勇秦丽霞曾玲王伟罗红艳许国藩余燕李勇成都市卫生和计划生育委员会成都市卫生和计划生育委员会基层卫生处成都市武侯区玉林社区卫生服务中心成都市成华区建设路社区卫生服务中心成都市青羊区新华少城社区卫生服务中心成都市青羊区草堂社区卫生服务中心成都市锦江区牛市口社区卫生服务中心成都市武侯区跳伞塔社区卫生服务中心

本文组织多位全科医学专家及社区医生对基层医疗卫生机构的能力建设展开主题研讨,贾勇整体介绍成都市基层卫生体系的构成及建设发展。秦丽霞主要介绍成都市试点家庭医生团队工作的做法,包括把握人员结构和全科医生能力培训。曾玲介绍家... 详细信息

本文组织多位全科医学专家及社区医生对基层医疗卫生机构的能力建设展开主题研讨,贾勇整体介绍成都市基层卫生体系的构成及建设发展。秦丽霞主要介绍成都市试点家庭医生团队工作的做法,包括把握人员结构和全科医生能力培训。曾玲介绍家庭医生的能力提升主要包括人才队伍建设、个性化服务、信息化的建设和改造以及加强全科医生的沟通能力。王伟重点分析创新社区健康管理,推行“家庭医生团队”服务模式;开展中医“治未病”工作,构建中西医结合的健康管理模式;建立自助式“健康小屋”,提升居民自我健康管理能力;关爱辖区特殊老年人群,提供居家养老爱心服务;开展门诊特殊疾病“一站式”服务,以提供优质便捷的服务。罗红艳介绍以家庭医生团队为核心,以重点人群为目标,全面推进免费签约;找准重点人群需求,设计个性化服务包,促进有偿签约服务;重视管理,优化绩效,为签约提供保障。许国藩提出提升基层卫生人员的能力应从基本医疗和公共卫生两方面来着手。余燕介绍锦江区签约服务推出3种服务包,即普通服务包、爱心服务包、个性的服务包。李勇探讨以家庭医生团队开展签约服务为抓手,做好慢性病患者的个性化、精细化服务;充分发挥信息化和“互联网+医疗”在慢性病管理中的积极作用;重视管理,优化绩效,为签约提供保障。专家们对基层医疗卫生机构能力建设中的全科医生能力提升及家庭医生签约服务进行分析,旨在促进社区卫生服务机构有效地开展家庭医生签约服务,探索适应新医改的工作模式,提升社区卫生服务机构家庭医生签约服务效果。

关键词：社区卫生中心家庭医生家庭医生签约

用Kane方法建立末敏弹减速和稳态扫描段模型

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上海航天 2003年第1期20卷 17-20页

作者：谢永高秦子增国防科技大学湖南长沙410073

引入多刚体运动模型 ,详细分析了伞刚体和弹刚体的受力和运动特性 ,运用Kane方法建立末敏弹在减速运动和稳态扫描段的完整运动模型 ,并进行数字仿真。仿真结果与实验结果有很好的一致性。

关键词： Kane方法末敏弹稳态扫描段伪速度减速运动运动模型

可从GPA参加方获得的采购规模的测算模型研究

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标准科学 2016年第10期 43-46页

作者：张晓瑞尹彦冯永琴曾凌云中国标准化研究院

本文构建了可从GPA参加方获得的采购规模的影响指标体系,提出了一种简化的测算方法模型,以我国可获得采购规模为例对测算模型进行了应用。该模型可用于分析GPA参加方采购市场的开放情况,评估GPA协议的有效性等。

关键词： GPA 采购规模测算模型

Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： yong-Chang zeng Jun-Hong Wu Dan-Dan Xu Kang He Chang-qing Liu Li-Fei Song Zheng-Zhi Wu Qian-Qian Jiang Shao-Yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

融合知识图谱和大模型的高校科研管理问答系统设计

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计算机科学与探索 2025年第1期19卷 107-117页

作者：王永秦嘉俊黄有锐邓江洲重庆邮电大学电子商务与现代物流重点实验室重庆400065

科研管理是高校管理中的重要组成部分,但现有的科研管理系统难以满足用户的个性化需求。以高校科研管理向智能化转型为需求导向,将知识图谱、传统模型和大语言模型相结合,共同构建新一代高校科研管理问答系统。采集科研知识用于构建科... 详细信息

科研管理是高校管理中的重要组成部分,但现有的科研管理系统难以满足用户的个性化需求。以高校科研管理向智能化转型为需求导向,将知识图谱、传统模型和大语言模型相结合,共同构建新一代高校科研管理问答系统。采集科研知识用于构建科研知识图谱。利用同时进行意图分类和实体提取的多任务模型进行语义解析。借助解析结果来生成查询语句,并从知识图谱中检索信息来回复常规问题。将大语言模型与知识图谱相结合,以辅助处理开放性问题。在意图和实体具有关联的数据集上的实验结果表明,采用的多任务模型在意图分类和实体识别任务上的F1值分别为0.958和0.937,优于其他对比模型和单任务模型。Cypher生成测试表明了自定义Prompt在激发大语言模型涌现能力方面的成效,利用大语言模型实现文本生成Cypher的准确率达到85.8%,有效处理了基于知识图谱的开放性问题。采用知识图谱、传统模型和大语言模型搭建的问答系统的准确性为0.935,很好地满足了智能问答的需求。

关键词：知识图谱多任务模型意图分类命名实体识别大语言模型

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