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Effects of the extrusion parameters on microstructure,texture and room temperature mechanical properties of extruded Mg-2.49Nd-1.82Gd-0.2Zn-0.2Zr alloy

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 136-146页

作者： Chenjin Zhang Guangyu Yang Lei Xiao Zhiyong Kan Jing Guo qiang li Wanqi Jie State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an 710072China College of Materials Science and Engineering Fuzhou UniversityFuzhou 350108China College of Chemistry and Environmental Science Qujing Normal UniversityQujing 655011China

Microstructure,texture,and mechanical properties of the extruded Mg-2.49Nd-1.82Gd-0.2Zn-0.2Zr alloy were investigated at different extrusion temperatures(260 and 320℃),extrusion ratios(10:1,15:1,and 30:1),and extrusion speeds(3 and 6 mm/s).The experimental results exhibited that the grain sizes after extrusion were much finer than that of the homogenized alloy,and the second phase showed streamline distribution along the extrusion direction(ED).With extrusion temperature increased from 260 to 320℃,the microstructure,texture,and mechanical properties of alloys changed *** dynamic recrystallization(DRX)degree and grain sizes enhanced as the extrusion ratio increased from 10:1 to 30:1,and the strength gradually decreased but elongation(EL)*** the extrusion speed increased from 3 to 6 mm/s,the grain sizes and DRX degree increased significantly,and the samples presented the typical-rare-earth(RE)*** alloy extruded at 260℃ with extrusion ratio of 10:1 and extrusion speed of 3 mm/s showed the tensile yield strength(TYS)of 213 MPa and EL of 30.6%.After quantitatively analyzing the contribution of strengthening mechanisms,it was found that the grain boundary strengthening and dislocation strengthening played major roles among strengthening *** results provide some guidelines for enlarging the industrial application of extruded Mg-RE alloy.

关键词： Mg-rare earth alloys extrusion temperature extrusion ratio extrusion speed strengthening mechanisms

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Genetic Diversity and Phylogenetic Relationship of Setaria Species Detected by Inter Simple Sequence Repeat(ISSR)Polymorphism

Genetic Diversity and Phylogenetic Relationship of Setaria S...

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中国作物学会2006年学术年会

作者： li Wei ZHI Hui WANG yong-qiang li Hai-quan HE Wen-liang WANG yong-fang DIAO Xian-min~(**) (National Millet Improvement Center of China,Institute of MiLlet Crops,Hebei Academy of Agricultural and Forestry Sciences,Shijiazhuang,050031,China)

Inter simple sequence repeat(ISSR)analysis was applied to the genus of Seteria in order to detect the phylogenetic relationship among the species investigated and to look for foxtail millet domestication related geo- graphical structure.82 accessions of 10 species in Setaria originated from different regions in the world were used in this *** the 27 ISSR primers screened,14 of them gave proper amplification profile and a total of 156 markers were scored for all the accessions and a high level of polymorphism was *** based on UPGMA cluster analysis clearly classify the Setaria species into two groups,viridis group and glauca group. Viridis group includes *** ,*** ,*** ,*** ,***,***,and ***- landica,and the glauca group includes ***,*** and *** phylogenetic relationships a- mong different species were *** structure among foxtail millet and its wild ancestor green fox- tail in the dendrogram indicate that northern China is the domestication center for both Chinese and European foxtail millet *** result did not support the hypothesis that China and Europe are independent domes- tication centers for foxtail millet proposed by several studies based on morphological and isozymes data.

关键词： Sataria foxtail millet ISSR phylogenetic relationship domestication

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Rotenone-induced dopaminergic neuron apoptosis via mitochondrial oxidative stress

Rotenone-induced dopaminergic neuron apoptosis via mitochond...

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Neurotoxicity and Neurodegeneration:Local Effect and Global Impact--13th International Neurotoxicology Association Meeting & 11th International Symposium on Neurobehavioral Methods and Effects in Occupational and Environmental Health

作者： Xiao-feng Huang,Wen Yin,Shuang Wang,yong-qiang li Central Laboratory,School of Basic Medical Sciences,Fourth Military Medical University,Xi'an, Shanxi 710032,China

Purpose: Rotenone is the most used pesticide that can function as an environmental *** has been show that rats repeatedly given rotenone not only develop the symptoms of Parkinson's disease (PD),but also acquire a sig... 详细信息

关键词： apoptosis ROS Rotenone-induced dopaminergic neuron apoptosis via mitochondrial oxidative stress

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Magnetron sputtered nickel oxide with suppressed interfacial defect states for efficient inverted perovskite solar cells

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Journal of Energy Chemistry 2025年第1期100卷 348-355页

作者： Guoqiang Ma Qin Tan Zhaoning li Jingwei Xiu Jiafeng Wang Tianle Cheng Dong He qiang Sun Xuhang Ma Francesco Lamberti Zhubing He Department of Materials Science and Engineering Institute of Innovative Materials (I2M) Shenzhen Key Laboratory of Full Spectral Solar Electricity Generation (FSSEG)Southern University of Science and Technology (SUSTech) Core Research Facilities Southern University of Science and Technology Department of Chemical Sciences Department of Industrial Engineering University of Padova

Widely used spin-coated nickle oxide （NiOx） based perovskite solar cells often suffer from severe interfacial reactions between the NiOxand adjacent perovskite layers due to surface defect states,which inherently impair device performance in a long-term view,even with surface molecule *** this study,we developed high-quality magnetron-sputtered NiOxthin films through detailed process optimization,and compared systematically sputtered and spin-coated NiOxthin film surfaces from materials to *** sputtered NiOxfilms exhibit improved crystallinity,smoother surfaces,and significantly reduced Ni3+or Ni vacancies compared to their spin-coated ***,the interface between the perovskite and sputtered NiOxfilm shows a substantially reduced density of defect *** solar cells （PSCs） fabricated with our optimally sputtered NiOxfilms achieved a high power conversion efficiency （PCE） of up to 19.93%and demonstrated enhanced stability,maintaining 86.2% efficiency during 500 h of maximum power point tracking under one standard sun ***,with the surface modification using (4-(2,7-dibromo-9,9-dimethylacridin-10（9H）-yl)butyl)p hosphonic acid （DMAcPA）,the device PCE was further promoted to 23.07%,which is the highest value reported for sputtered NiOxbased PSCs so far.

关键词： Nickle oxide Magnetron sputter Defect Stability Perovskite solar cell

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生态经济型固沙林体系建立的研究

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中国沙漠 1999年第1期19卷 51-55页

作者：王北南炳辉白永强王力宁夏农林科学院林研所

通过盐池北部６个乡沙漠化土地综合治理，对林业治理技术措施，进行分析总结，提出生态经济型固沙林体系建设。其内容包括生态经济型固沙林体系含义，沙漠化土地类型划分及其治理生态型，将沙漠化土地划分成４个利用型、１９个类型及其... 详细信息

通过盐池北部６个乡沙漠化土地综合治理，对林业治理技术措施，进行分析总结，提出生态经济型固沙林体系建设。其内容包括生态经济型固沙林体系含义，沙漠化土地类型划分及其治理生态型，将沙漠化土地划分成４个利用型、１９个类型及其相应的治理生态型。并提出生态经济型固沙林和灌草型饲料林的营造、管护、利用和更新等配套技术。

关键词：固沙林体系生态经济型复壮更新沙化土地防治

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＂Collared Anastomosis＂ Technique Used in Arch Replacement Combined with Frozen Elephant Trunk Implantation Procedure for Giant Arch and Thoracic Aorta Dilatation

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Chinese Medical Journal 2015年第14期128卷 1982-1982页

作者： Chang-Wei Ren Chao-liang liu yong-qiang Lai li-Zhong Sun Shang-Dong Xu Department of Cardiovascular Surgery Center Beijing Anzhen Hospital Capital Medical University Beijing 100029 China

To the Editor： We report two cases of arch replacement combined with frozen elephant trunk implantation procedure using the collared anastomosis technique for giant arch and thoracic aorta dilatation.

关键词： Collared Anastomosis Technique Used Arch Replacement Combined

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Gamma-glutamyl transferase 5 overexpression in cerebrovascular endothelial cells improves brain pathology,cognition,and behavior in APP/PS1 mice

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Neural Regeneration Research 2025年第2期20卷 533-547页

作者： Yanli Zhang Tian li Jie Miao Zhina Zhang Mingxuan Yang Zhuoran Wang Bo Yang Jiawei Zhang Haiting li qiang Su Junhong Guo Department of Neurology First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Neurology Sixth Hospital of Shanxi Medical University(General Hospital of Tisco)TaiyuanShanxi ProvinceChina Department of Physiology Key Laboratory of Cellular PhysiologyMinistry of EducationShanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Hernia and Abdominal Wall Surgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Laboratory Medicine of Fenyang College Shanxi Medical UniversityFenyangShanxi ProvinceChina

In patients with Alzheimer’s disease,gamma-glutamyl transferase 5(GGT5)expression has been observed to be downregulated in cerebrovascular endothelial ***,the functional role of GGT5 in the development of Alzheimer’s disease remains *** study aimed to explore the effect of GGT5 on cognitive function and brain pathology in an APP/PS1 mouse model of Alzheimer’s disease,as well as the underlying *** observed a significant reduction in GGT5 expression in two in vitro models of Alzheimer’s disease(Aβ_(1-42)-treated hCMEC/D3 and bEnd.3 cells),as well as in the APP/PS1 mouse ***,injection of APP/PS1 mice with an adeno-associated virus encoding GGT5 enhanced hippocampal synaptic plasticity and mitigated cognitive ***,increasing GGT5 expression in cerebrovascular endothelial cells reduced levels of both soluble and insoluble amyloid-βin the brains of APP/PS1 *** effect may be attributable to inhibition of the expression ofβ-site APP cleaving enzyme 1,which is mediated by nuclear factor-kappa *** findings demonstrate that GGT5 expression in cerebrovascular endothelial cells is inversely associated with Alzheimer’s disease pathogenesis,and that GGT5 upregulation mitigates cognitive deficits in APP/PS1 *** findings suggest that GGT5 expression in cerebrovascular endothelial cells is a potential therapeutic target and biomarker for Alzheimer’s disease.

关键词： Alzheimer’s disease amyloid-β APP/PS1 mice cerebrovascular endothelial cells cognitive deficits gamma-glutamyl transferase 5 neurovascular unit nuclear factor‐kappa B synaptic plasticity β-site APP cleaving enzyme 1

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Mutual regulation of microglia and astrocytes after Gas6 inhibits spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 557-573页

作者： Jiewen Chen Xiaolin Zeng Le Wang Wenwu Zhang Gang li Xing Cheng Peiqiang Su yong Wan Xiang li Department of Spine Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Guangdong Province Key Laboratory of Orthopedics and Traumatology GuangzhouGuangdong ProvinceChina

Invasive inflammation and excessive scar formation are the main reasons for the difficulty in repairing nervous tissue after spinal cord *** and astrocytes play key roles in the spinal cord injury micro-environment and share a close ***,the mechanisms involved remain *** this study,we found that after spinal cord injury,resting microglia(M0)were polarized into pro-inflammatory phenotypes(MG1 and MG3),while resting astrocytes were polarized into reactive and scar-forming *** expression of growth arrest-specific 6(Gas6)and its receptor Axl were significantly down-regulated in microglia and astrocytes after spinal cord *** vitro experiments showed that Gas6 had negative effects on the polarization of reactive astrocytes and pro-inflammatory microglia,and even inhibited the cross-regulation between *** further demonstrated that Gas6 can inhibit the polarization of reactive astrocytes by suppressing the activation of the Yes-associated protein signaling ***,in turn,inhibited the polarization of pro-inflammatory microglia by suppressing the activation of the nuclear factor-κB/p65 and Janus kinase/signal transducer and activator of transcription signaling *** vivo experiments showed that Gas6 inhibited the polarization of pro-inflammatory microglia and reactive astrocytes in the injured spinal cord,thereby promoting tissue repair and motor function ***,Gas6 may play a role in the treatment of spinal cord *** can inhibit the inflammatory pathway of microglia and polarization of astrocytes,attenuate the interaction between microglia and astrocytes in the inflammatory microenvironment,and thereby alleviate local inflammation and reduce scar formation in the spinal cord.

关键词： astrocytes Axl cell polarization Gas6 Hippo signal inflammatory micro-environment intercellular interaction microglia single-cell sequencing spinal cord injury

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Safety of in vitro amplified HLA-haploidentical donor immune cell infusions for childhood malignancies

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Chinese Journal of Cancer 2013年第12期32卷 661-666页

作者： Fei Zhang Xiao-Fei Sun yong-qiang li Zi-Jun Zhen Hai-Xia Zheng Jia Zhu Qi-Jing Wang Su-Ying Lu Jia He Juan Wang Ke Pan Rui-Qing Cai Yan Chen De-Sheng Weng Fei-Fei Sun Jian-Chuan Xia State Key Laboratory of Oncology in South China Department of Pediatric Oncology Department of Biotherapy Sun Yat-sen University Cancer Center

In vitro amplified human leukocyte antigen(HLA)-haploidentical donor immune cell infusion(HDICI)is not commonly used in ***,our study sought to evaluate its safety for treating childhood *** September 2011 and September 2012,12 patients with childhood malignancies underwent HDICI in Sun Yat-sen University Cancer *** median patient age was 5.1 years(range,1.7-8.4 years).Of the 12 patients,9 had high-risk neuroblastoma(NB)[7 showed complete response(CR),1 showed partial response(PR),and 1 had progressive disease(PD)after multi-modal therapies],and 3 had Epstein-Barr virus(EBV)-positive lymphoproliferative disease(EBV-LPD).The 12 patients underwent a total of 92 HDICIs at a mean dose of 1.6×108immune cells/kg body weight:71 infusions with natural killer(NK)cells,8 with cytokine-induced killer(CIK)cells,and 13 with cascade primed immune cells(CAPRIs);83 infusions with immune cells from the mothers,whereas 9 with cells from the *** cases(21.7%)of fever,including 6 cases(6.5%)accompanied with chills and 1(1.1%)with febrile convulsion,occurred during infusions and were alleviated after symptomatic *** cases(5.4%)of mild emotion changes were *** other adverse events occurred during and after the completion of *** acute nor chronic graft versus host disease(GVHD)was observed following *** a median of 5.0 months(range,1.0-11.5 months)of follow-up,the 2 NB patients with PR and PD developed PD during *** the other 7 NB patients in CR,2 relapsed in the sixth month of HDICIs,and 5 maintained CR with disease-free survival(DFS)ranging from 4.5 to 11.5 months(median,7.2months).One EBV-LPD patient achieved PR,whereas 2 had stable disease(SD).Our results show that HDICI is a safe immunotherapy for childhood malignancies,thus warranting further studies.

关键词：免疫细胞恶性肿瘤体外扩增安全性 HLA 儿童人类白细胞抗原移植物抗宿主病

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Adjuvant cellular immunotherapy in patients with resected primary non-small cell lung cancer

Adjuvant cellular immunotherapy in patients with resected pr...

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第十四届全国肿瘤生物治疗大会

作者： Qiu-Zhong Pan Yan Tang Qi-Jing Wang yong-qiang li li Zhang Xiao-Dong li Jing-Jing Zhao De-Sheng Weng Qing liu li-Xi Huang Jia He Shi-Ping Chen Miao-La Ke Yi-Xin Zeng Jian-Chuan Xia Collaborative Innovation Center for Cancer Medicine State Key Laboratory of Oncology in South China Sun Yat-Sen University Cancer Center Department of Biotherapy Sun Yat-Sen University Cancer Center

Postoperative non-small cell lung cancer(NSCLC) patients require adjuvant therapy to improve their prognosis. In this study, we investigated the efficacy of a sequential combination of cellular immunotherapy(CIT) and chemotherapy for postoperative NSCLC. This retrospective study included 120 postoperative NSCLC patients: 60 cases received only chemotherapy;33 cases received chemotherapy and sequential CIT with cytokine-induced killer(CIK) cells;and 27 cases received chemotherapy and sequential CIT with alternate CIK cells and natural killer(NK) cells. Survival analysis showed significantly higher overall survival rates in the CIT group compared with the control group. Overall survival was higher in patients who received CIT with alternate CIK cells and NK cells than those who received treatment with only CIK cells. Multivariate analysis showed that adjuvant CIT was an independent prognostic factor for overall survival of patients with NSCLC. In subgroup analyses, adjuvant CIT significantly improved the overall survival of patients with less than 60 year old and positive lymph node. In conclusions, these data indicate that adjuvant CIT, especially with combined application of CIK cells and NK cells, is an effective therapeutic approach to prolong survival of patients with NSCLC, particularly for patients ≤60 years old with positive lymph nodes.

关键词： cellular immunotherapy cytokine-induced killer cells natural killer cells non-small cell lung cancer benefit

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