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Antibacterial applications of graphene oxides: structure-activity relationships, molecular initiating events and biosafety

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Science Bulletin 2018年第2期63卷 133-142页

作者： Huizhen Zheng Ronglin Ma Meng Gao Xin Tian yong-qiang li lingwen Zeng Ruibin li School for Radiological and Interdisciplinary Sciences (RAD-X) Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions Soochow University Institute of Environmental and Food Safety Wuhan Academy of Agricultural Science and Technology Guangzhou Institute of Biomedicine and Health Chinese Academy of Sciences

Bacterial infections may lead to diverse acute or chronic diseases （e.g., inflammation, sepsis and cancer）. New antibiotics against bacteria are rarely discovered in recent years, which necessitates the exploration of new antibacterial agents. Engineered nanomatetials {ENMs） have been extensively studied for antibacterial use because of their long lasting killing effects in wide spectra of bacteria. Graphene oxide （GO） is one of the most widely studied ENMs and exhibit strong bactericidal effects. The physicochemical properties of GO play important roles in bacterial killing by triggering a cascade of toxic events. Many studies have explored the signaling pathways of GO in bacteria. Although molecular initiating events （MIEs） of GO in bacteria dominate its killing efficiency as well as toxicity mechanisms, they have been rarely reviewed. In this report, we discussed the structure-activity relationships （SARs） involved in GOinduced bacterial killing and the MIEs including redox reaction with biomolecules, mechanical destruction of membranes and catalysis of extracellular metabolites. Furthermore, we summarized the clinical or commercial applications of GO-based antibacterial products and discussed their biosafety in mammal. Finally, we reviewed the remaining challenges in GO for antibacterial applications, which may offer new insights for the development of nano antibacterial studies.

关键词： 2D MaterialsPhysicochemical properties Nanotoxicity Infection Microbe

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Therapeutic advances in non-alcoholic fatty liver disease:A microbiota-centered view

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World Journal of Gastroenterology 2020年第16期26卷 1901-1911页

作者： Hui-Ting Chen Hong-li Huang yong-qiang li Hao-Ming Xu yong-Jian Zhou Department of Gastroenterology and Hepatology Guangzhou First People's HospitalSchool of MedicineSouth China University of TechnologyGuangzhou 510180Guangdong ProvinceChina Department of Gastroenterology and Hepatology Guangzhou Digestive Disease CenterGuangzhou First People’s HospitalGuangzhou Medical UniversityGuangzhou 510180Guangdong ProvinceChina

Non-alcoholic fatty liver disease(NAFLD)is a highly prevalent metabolic disorder with steadily increasing incidence rates worldwide,especially in the *** are no drugs available at present to treat NAFLD,and the primary therapeutic options include weight loss and the combination of healthy diet and ***,novel interventions are required that can target the underlying risk *** microbiota is an“invisible organ”of the human body and vital for normal metabolism and *** number and diversity of microbes differ across the gastrointestinal tract from the mouth to the anus,and is most abundant in the *** dysregulated gut microbiota is an underlying pathological factor of NAFLD,it is a viable therapeutic target that can be modulated by antibiotics,probiotics,prebiotics,synbiotics,fecal microbiota transplantation,and microbial *** this review,we summarize the most recent advances in gut microbiota-targeted therapies against NAFLD in clinical and experimental studies,and critically evaluate novel targets and strategies for treating NAFLD.

关键词： Non-alcoholic fatty liver disease Gut microbiota Probiotics Prebiotics Fecal microbiota transplantation Metabolites

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Visual-simulation region proposal and generative adversarial network based ground military target recognition

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Defence Technology（防务技术） 2022年第11期18卷 2083-2096页

作者： Fan-jie Meng yong-qiang li Fa-ming Shao Gai-hong Yuan Ju-ying Dai Department of Space Test and Launch Noncommissioned Officer SchoolSpace Engineering UniversityBeijing102299China Department of Mechanical Engineering College of Field EngineeringArmy Engineering University of PLANanjing210007China

Ground military target recognition plays a crucial role in unmanned equipment and grasping the battlefield dynamics for military applications, but is disturbed by low-resolution and noisyrepresentation. In this paper, a recognition method, involving a novel visual attention mechanismbased Gabor region proposal sub-network(Gabor RPN) and improved refinement generative adversarial sub-network(GAN), is proposed. Novel central-peripheral rivalry 3D color Gabor filters are proposed to simulate retinal structures and taken as feature extraction convolutional kernels in low-level layer to improve the recognition accuracy and framework training efficiency in Gabor RPN. Improved refinement GAN is used to solve the problem of blurry target classification, involving a generator to directly generate large high-resolution images from small blurry ones and a discriminator to distinguish not only real images vs. fake images but also the class of targets. A special recognition dataset for ground military target, named Ground Military Target Dataset(GMTD), is constructed. Experiments performed on the GMTD dataset effectively demonstrate that our method can achieve better energy-saving and recognition results when low-resolution and noisy-representation targets are involved, thus ensuring this algorithm a good engineering application prospect.

关键词： Deep learning Biological vision Military application Region proposal network Gabor filter Generative adversarial network

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Design, Syntheses and Biological Activities of Novel Anthranilic Diamide Insecticides Containing N-Pyridylpyrazole

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Chemical Research in Chinese Universities 2013年第1期29卷 51-56页

作者： ZHAO Yu li yong-qiang XIONG li-xia XU li-ping PENG li-na li Fang li Zheng-ming National Pesticidal Engineering Centre(Tianjin) State Key Laboratory of Elemento-organic Chemistry Nankai University Tianjin 300071 P. R. China

In search of environmentally benign insecticides with high activity, low toxicity and low residue, a series of novel anthranilic diamide derivatives containing N-pyridylpyrazole was designed and synthesized. All the compounds were characterized by H NMR spectroscopy and elemental analysis. The single crystal structure of com pound 8j was determined by X-ray diffraction. The insecticidal activities of the new compounds were evaluated. The results show that some compounds exhibited moderate insecticidal activities against Lepidoptera pests. Among this series of compounds, compounds 80 and 8p showed 100% larvicidal activity against Mythimna separate Walker, Plutella xylostella linnaeus and Laphygma exigua Hubner at a test concentration of 200 mg/kg, which is equal to the commercial chlorantraniliprole.

关键词： Anthranilic diamide Ryanodine receptor Insecticidal activity

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Role of relaxin in diastasis of the pubic symphysis peripartum

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World Journal of Clinical Cases 2021年第1期9卷 91-101页

作者： Yan Wang yong-qiang li Mei-Rong Tian Nan Wang Zun-Cheng Zheng Rehabilitation Medicine Taian City Central HospitalTaian 271000Shandong ProvinceChina Department of Otolaryngology Taian City Central HospitalTaian 271000Shandong ProvinceChina Department of Obstetrics Taian City Central HospitalTaian 271000Shandong ProvinceChina Rehabilitation Centre Qingdao Fuwai Cardiovascular HospitalQingdao 266034Shandong ProvinceChina Department of Rehabilitation Taian City Central HospitalTaian 271000Shandong ProvinceChina

BACKGROUND Separation of the pubic symphysis can occur during the peripartum ***(RLX)is a hormone primarily secreted by the corpus luteum that can mediate hemodynamic changes during pregnancy as well as loosen the pelvic ***,it is unknown whether RLX is associated with peripartum pubic symphysis separation and if the association is affected by other *** To study the association between RLX and peripartum pubic symphysis separation and evaluate other factors that might affect this *** We performed a cross-sectional study of pregnant women between April 2019 and January *** demographic characteristics,including gestational age,weight,neonatal weight,delivery mode and duration of the first and second stages of labor,were *** clinical symptoms were used as a screening index during pregnancy,and the patients with pubic symphysis and inguinal pain were examined by color Doppler ultrasonography to determine whether there was pubic symphysis *** RLX concentrations were evaluated 1 d after delivery using an enzyme-linked immunosorbent assay,and pubic symphysis separation was diagnosed based on postpartum X-ray *** used an independent-sample t test to analyze the association between serum RLX levels and peripartum pubic symphysis *** regression analysis was used to evaluate whether the association between RLX and peripartum pubic symphysis separation was confounded by other factors,and the association between RLX and the severity of pubic symphysis separation was also *** used Pearson correlation analysis to determine the factors related to RLX levels as well as the correlation between the degree of pubic symphysis separation and activities of daily living(ADL)and *** A total of 54 women were enrolled in the study,with 15 exhibiting(observational group)and 39 not exhibiting(control group)peripartum pubic symphysis *** were no statistica

关键词： Pregnancy Pubic symphysis separation Relaxin Neonatal weight Crosssectional study Activities of daily living

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Tuning the Water Desalination Performance of Graphenic Layered Nanomaterials by Element Doping and Inter-Layer Spacing

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Chinese Physics Letters 2020年第11期37卷 48-54页

作者： Fuxin Wang Chao Zhang Yanmei Yang Yuanyuan Qu yong-qiang li Baoyuan Man Weifeng li School of Physics and State Key Laboratory of Crystal Materials Shandong UniversityJinan 250100China Collaborative Innovation Center of light Manipulations and Applications Shandong Normal UniversityJinan 250358China College of Chemistry Chemical Engineering and Materials ScienceCollaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of ShandongKey Laboratory of Molecular and Nano Probes(Ministry of Education)Shandong Normal UniversityJinan 250014China

Through atomic molecular dynamics simulations,we investigate the performance of two graphenic materials,boron(BC3)and nitrogen doped graphene(C3 N),for seawater desalination and salt rejection,and take pristine graphene as a *** of inter-layer separation have been *** water is filtered along the transverse directions of three-layered nanomaterials,the optimal inter-layer separation is 0.7–0.9 nm,which results in high water permeability and salt obstruction *** water permeability is considerably higher than porous graphene filter,and is about two orders of magnitude higher than commercial reverse osmosis(RO)*** changing the inter-layer spacing,the water permeability of three graphenic layered nanomaterials follows an order of C3 N≥GRA>BC3 under the same working *** three nanomaterials,BC3 is more sensitive to inter-layer separation which offers a possibility to control the water desalination speed by mechanically changing the membrane *** is caused by the intrinsic charge transfer inside BC3 that results in periodic distributed water clusters around the layer *** present results reveal the high potentiality of multi-layered graphenic materials for controlled water *** is hopeful that the present work can guide design and fabrication of highly efficient and tunable desalination architectures.

关键词： separation layer filtered

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Decoy Nanozymes Enable Multitarget Blockade of Proinflammatory Cascades for the Treatment of Multi-Drug- Resistant Bacterial Sepsis

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Research 2023年第2期2022卷 187-201页

作者： Xuancheng Du Mingzhen Zhang Huiting Zhou Weijie Wang Chengmei Zhang Lei Zhang Yuanyuan Qu Weifeng li Xiangdong liu Mingwen Zhao Kangsheng Tu yong-qiang li Institute of Advanced Interdisciplinary Science School of PhysicsShandong UniversityJinan 250100China School of Basic Medical Sciences Xi'an Key Laboratory of Immune Related DiseasesXi'an Jiaotong UniversityXian 710061China Institute of Pediatric Research Children's Hospital of Soochow UniversitySuzhou 215025China Laboratory Animal Center of Shandong University Jinan 250012China Department of Critical Care Medicine the First Afliated Hospitalof Xi'an Jiaotong UniversityXi'an 70061China Dpartment of Hepatobiliary Surgery the First liated HospitalofXian JiaotongUniverstyXian 00China Suzhou Research Institute Shandong UniversitySuzhou 215123China College of Chemistry Chemical Engineering and Materials ScienceShandong Provincial Key Laboratory of Clean Production of Fine ChemicalsShandong Normal UniversityJinan 250014China

Sepsis is a life-threatening organ dysfunction characterized by severe systemic inflammatory response to *** treatment of bacterial sepsis remains a paramount clinical challenge,due to its astonishingly rapid progress... 详细信息

关键词： Sepsis clinical prevalence

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Arabidopsis PWWP domain proteins mediate H_3K_(27) trimethylation on FLC and regulate flowering time

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Journal of Integrative Plant Biology 2018年第5期60卷 362-368页

作者： Jin-Xing Zhou Zhang-Wei liu yong-qiang li lin li Bangjun Wang She Chen Xin-Jian He College of life Sciences Beijing Normal UniversityBeijing 100875China National Institute of Biological Sciences Beijing 102206China Key Laboratory of Eco-Environments in Three Gorges Reservoir Region(Ministry of Education) College of Life SciencesSouthwest UniversityChongqing 400715China

LHP1 mediates recruitment of the PRC2 histone methyltransferase complex to chromatin and thereby facilitates maintenance of H3K27me3 on FLC, a key flowering repressor gene. Here, we report that the PWWP domain proteins （PDPs） interact with FVE and MSI5 to suppress FLC expression and thereby promote flowering. We demonstrated that FVE, MSI5, and PDP3 were co-purified with LHP1. The H3K27me3 level on FLC was decreased in the pdp mutants as welt as in the fve/ msi5 double mutant. This study suggests that PDPs function together with FVE and MSI5 to regulate the function of the PRC2 complex on FLC.

关键词： PDP MSI trimethylation on FLC and regulate flowering time Arabidopsis PWWP domain proteins mediate H3K FLC

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Stem cells:a promising candidate to treat neurological disorders

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Neural Regeneration Research 2018年第7期13卷 1294-1304页

作者： Chang-Geng Song Yi-Zhe Zhang Hai-Ning Wu Xiu-li Cao Chen-Jun Guo yong-qiang li Min-Hua Zheng Hua Han Department of Medical Genetics and Developmental Biology Fourth Military Medical University Department of Biochemistry and Molecular Biology Fourth Military Medical University

Neurologic impairments are usually irreversible as a result of limited regeneration in the central nervous ***,based on the regenerative capacity of stem cells,transplantation therapies of various stem cells have been tested in basic research and preclinical trials,and some have shown great *** manuscript overviews the cellular and molecular characteristics of embryonic stem cells,induced pluripotent stem cells,neural stem cells,retinal stem/progenitor cells,mesenchymal stem/stromal cells,and their derivatives in vivo and in vitro as sources for regenerative *** cells have all been considered as candidates to treat several major neurological disorders and diseases,owing to their self-renewal capacity,multi-directional differentiation,neurotrophic properties,and immune modulation *** also review representative basic research and recent clinical trials using stem cells for neurodegenerative diseases,including Parkinson＇s disease,Alzheimer＇s disease,and age-related macular degeneration,as well as traumatic brain injury and *** spite of a few unsuccessful cases,risks of tumorigenicity,and ethical concerns,most results of animal experiments and clinical trials demonstrate efficacious therapeutic effects of stem cells in the treatment of nervous system *** summary,these emerging findings in regenerative medicine are likely to contribute to breakthroughs in the treatment of neurological ***,stem cells are a promising candidate for the treatment of nervous system diseases.

关键词： nerve regeneration stem cells transplantation stem cell therapy nervous system neurodegenerative disease neurological disorders animal experiment clinical trial regenerative medicine neural regeneration

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Design,synthesis and biological evaluation of novel glucokinase activators

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Chinese Chemical Letters 2011年第1期22卷 73-76页

作者： yong qiang li Yu liang Zhang Sheng Quan Hu Yu ling Wang Hong Rui Song Zhi qiang Feng Lei Lei Quan liu Zhu Fang Shen Institute of Materia Medica Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100050 China School of Pharmaceutical Engineering Shenyang Pharmaceutical University Shenyang 110016 China

A new series of benzamide derivatives as glucokinase activators （GKAs） were designed and synthesized, and their activation for glucokinase were evaluated by the preliminary glucokinase activity assay. The structure-activity relationship （SAR） is discussed. The result shows that compound 12d and 12h have potent activity reference drug RO-28-1675.

关键词： Diabetes Glueokinase activators Benzamide derivatives

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